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BMC Public Health
Published in: BMC Public Health 1/2018

Open Access 01-12-2018 | Research article

The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies

Authors: Jie You, Yafei Sun, Yacong Bo, Yiwei Zhu, Dandan Duan, Han Cui, Quanjun Lu

Published in: BMC Public Health | Issue 1/2018

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Abstract

Background

Isoflavones, a class of phytoestrogenic compounds, are abundant in soybeans. A number of epidemiological studies have investigated the association between dietary isoflavones intake and the risk of gastric cancer. However, the results are inconclusive. Therefore, the meta-analysis was conducted to evaluate the effect of dietary isoflavones intake on the risk of gastric cancer.

Methods

Relevant studies from May 1992 to May 2017 were identified through searching PubMed and Web of Science. Additional articles were identified from the reference lists of relevant review articles. Pooled risk ratios (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed-effects model. Funnel plot and Egger’s test were used to evaluate publication bias.

Results

Seven articles reporting 12 studies were included in the current meta-analysis. We found no significant association between dietary isoflavones intake and gastric cancer risk with the highest versus the lowest categories of dietary isoflavones intake (OR = 0.97, 95% CI = 0.87–1.09, I2 = 27.5%). Subgroup analyses generally yield similar results.

Conclusions

Higher dietary isoflavones intake is not associated with a decline in the risk of gastric cancer.
Appendix
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Metadata
Title
The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies
Authors
Jie You
Yafei Sun
Yacong Bo
Yiwei Zhu
Dandan Duan
Han Cui
Quanjun Lu
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2018
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-018-5424-7

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