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European Journal of Nutrition

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01-02-2016 | Original Contribution

Soy and isoflavone consumption and risk of gastrointestinal cancer: a systematic review and meta-analysis

Authors: Genevieve Tse, Guy D. Eslick

Published in: European Journal of Nutrition | Issue 1/2016

Abstract

Purpose

Evidence suggests that soy foods have chemoprotective properties that may reduce the risk of certain cancers such as breast and prostate cancer. However, data involving gastrointestinal (GI) have been limited, and the evidence remains controversial. This study aims to determine the potential relationship between dietary soy intake and GI cancer risk with an evaluation of the effects of isoflavone as an active soy constituent.

Methods

Relevant studies were identified after literature search via electronic databases through May 2014. Subgroup analysis for isoflavone intake (studies n = 10) was performed. Covariants including gender types, anatomical subsites and preparation methods were also evaluated. Pooled adjusted odds ratios (ORs) comparing highest and lowest categories of dietary pattern scores were calculated using a random effects model.

Results

Twenty-two case–control and 18 cohort studies were included for meta-analysis, which contained a total of 633,476 participants and 13,639 GI cancer cases. The combined OR was calculated as 0.93 (95 % CI 0.87–0.99; p value heterogeneity = 0.01), showing only a slight decrease in risk, the association was stronger for colon cancer (OR 0.92; 95 % CI 0.96–0.99; p value heterogeneity = 0.163) and colorectal cancer (CRC) (OR 0.92; 95 % CI 0.87–0.97; p value heterogeneity = 0.3). Subgroup analysis for isoflavone intake showed a statistically significant risk reduction with a risk estimate of 0.73 (95 % CI 0.59–0.92; p value heterogeneity = 0), and particularly for CRC (OR 0.76; 95 % CI 0.59–0.98; p value heterogeneity = 0).

Conclusion

This study provides evidence that soy intake as a food group is only associated with a small reduction in GI cancer risk. Separate analysis for dietary isoflavone intakes suggests a stronger inverse association.

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Title: Soy and isoflavone consumption and risk of gastrointestinal cancer: a systematic review and meta-analysis
Authors: Genevieve Tse
Guy D. Eslick
Publication date: 01-02-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 1/2016
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-014-0824-7

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