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BMC Public Health
Published in: BMC Public Health 1/2017

Open Access 01-12-2017 | Research article

Healthy dietary patterns decrease the risk of colorectal cancer in the Mecca Region, Saudi Arabia: a case-control study

Authors: Firas S. Azzeh, Eyad M. Alshammari, Awfa Y. Alazzeh, Abdelelah S. Jazar, Ibrahim R. Dabbour, Hani A. El-Taani, Ahmed A. Obeidat, Fayrooz A. Kattan, Sufyan H. Tashtoush

Published in: BMC Public Health | Issue 1/2017

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Abstract

Background

Colorectal cancer (CRC) is the first most common cancer in males and the third most common cancer in females in Saudi Arabia. Dietary habits are strongly associated with the inhibition or proliferation of malignancy. Therefore, this study is aiming to investigate the risks and protective benefits of dietary factors affecting CRC in the Mecca region of Saudi Arabia.

Methods

A case-control study was conducted from June 2014 to March 2015. One hundred thirty-seven patients with colon and/or rectal cancer were recruited in the case group, while 164 healthy participants were recruited in the control group. A questionnaire was completed with the help of trained dietitians to study the effects of several dietary patterns on the risk of CRC.

Results

Dairy product intake of 1–5 servings/day, legume intake of 3–5 servings/week, leafy vegetables intake of 1–5 servings/week, olive oil intake of 1–5 servings/week, black tea intake of three or more cups/day, and coffee intake of one or more cups/day was found to decrease the risk of CRC in participants.

Conclusion

This study highlights the importance of changing dietary habits to decrease CRC incidence in the Mecca region.
Literature
1.
2.
Al-Ahwal MS, Shafik YH, Al-Ahwal HM, et al. First national survival data for colorectal cancer among Saudis between 1994 and 2004: what’s next? BMC Public Health. 2013;13:73.CrossRefPubMedPubMedCentral
3.
Alsanea N, Abduljabbar AS, Alhomoud S, Ashari LH, Hibbert D, Bazarbashi S. Colorectal cancer in Saudi Arabia: incidence, survival, demographics and implications for national policies. Ann Saudi Med. 2015;35:196–202.CrossRefPubMed
4.
Tayyem RF, Bawadi HA, Shehadah I, et al. Dietary patterns and colorectal cancer. Clin Nutr. 2017. In Press.
5.
Tayyem RF, Bawadi HA, Shehadah IN, et al. Macro- and micronutrients consumption and the risk for colorectal cancer among Jordanians. Nutrients. 2015;7:1769–86.CrossRefPubMedPubMedCentral
6.
Murphy N, Norat T, Ferrari P, et al. Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS One. 2012;7:e39361.CrossRefPubMedPubMedCentral
7.
8.
Alamri FA, Saeedi MY, Kassim KA. Dietary and other risk factors for colo-rectal cancer in Saudi Arabia. J Med Med Sci. 2014;5:222–9.CrossRef
9.
Deng L, Gui Z, Zhao L, Wang J, Shen L. Diabetes mellitus and the incidence of colorectal cancer: an updated systematic review and meta-analysis. Dig Dis Sci. 2012;57:1576–85.CrossRefPubMed
10.
Aleksandrova K, Pischon T, Jenab M, et al. Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study. BMC Med. 2014;12:168.CrossRefPubMedPubMedCentral
11.
12.
Tayyem RF, Bawadi HA, Shehadah I, et al. Meats, milk and fat consumption in colorectal cancer. J Hum Nutr Diet. 2016:1–11.
13.
Aune D, Lau R, Chan DSM, et al. Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. Ann Oncol. 2012;23:37–45.CrossRefPubMed
14.
Maskarinec G, Jacobs S, Harmon BE, et al. Four a priori-defined diet quality indexes and survival among men and women with colorectal cancer: The multiethnic cohort. FASEB J. 2016;30:42.2.
15.
Nashar RM, Almurshed KS. Colorectal cancer: a case control study of dietary factors, king faisal specialist hospital and researh center, riyadh, saudi arabia. J Family Community Med. 2008;15:57–64.PubMedPubMedCentral
16.
Mosli MH, Al-Ahwal MS. Colorectal cancer in the Kingdom of Saudi Arabia: need for screening. Asian Pacific J Cancer Prev. 2012;13:3809–13.CrossRef
17.
Davoodi H, Esmaeili S, Mortazavian AM. Effects of milk and milk products consumption on cancer: a review. Compr Rev Food Sci Food Saf. 2013;12:249–64.CrossRef
18.
Huncharek M, Muscat J, Kupelnick B. Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutr Cancer. 2009;61:47–69.CrossRefPubMed
19.
Pericleous M, Mandair D, Caplin ME. Diet and supplements and their impact on colorectal cancer. J Gastrointest Oncol. 2013;4:409–23.PubMedPubMedCentral
20.
Bassaganya-Riera J, Hontecillas R, Horne WT, et al. Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn’s disease. Clin Nutr. 2012;31:721–7.CrossRefPubMed
21.
Bergsma-Kadijk JA, van Veer P, Kampman E, Burema J. Calcium does not protect against colorectal neoplasia. Epidemiology. 1996;7:590–7.CrossRefPubMed
22.
Martinez ME, Willett WC. Calcium, vitamin D, and colorectal cancer: a review of the epidemiologic evidence. Cancer Epidemiol Biomark Prev. 1998;7:163–8.
23.
Larsen CA, Bisson WH, Dashwood RH. Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. J Med Chem. 2009;52:6543–5.CrossRefPubMedPubMedCentral
24.
Du G-J, Zhang Z, Wen X-D, et al. Epigallocatechin gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea. Nutrients. 2012;4:1679–91.CrossRefPubMedPubMedCentral
25.
Koňariková K, Ježovičová M, Keresteš J, Gbelcová H, Ďuračková Z, Žitňanová I. Anticancer effect of black tea extract in human cancer cell lines. Spring. 2015;4:127.CrossRef
26.
27.
Ar G, En Jao DL, Huang M-T, et al. Effects of the black tea polyphenol theaflavin-2 on apoptotic and inflammatory pathways in vitro and in vivo. Mol Nutr Food Res. 2011;55:198–208.CrossRef
28.
Hartman TJ, Tangrea JA, Pietinen P, et al. Tea and coffee consumption and risk of colon and rectal cancer in middle-aged Finnish men. Nutr Cancer. 1998;31:41–8.CrossRefPubMed
29.
Baron JA. Gerhardsson de Verdier M, Ekbom A. Coffee, tea, tobacco, and cancer of the large bowel. Cancer Epidemiol Biomarkers Prev. 1994;3:565–70.
30.
Su LJ, Arab L. Tea consumption and the reduced risk of colon cancer - results from a national prospective cohort study. Public Health Nutr. 2002;5:419–25.CrossRefPubMed
31.
Woolcott CG, King WD, Marrett LD. Coffee and tea consumption and cancers of the bladder, colon and rectum. Eur J Cancer Prev. 2002;11:137–45.CrossRefPubMed
32.
Terry P, Wolk A. Tea consumption and the risk of colorectal cancer in Sweden. Nutr Cancer. 2001;39:176–9.CrossRefPubMed
33.
Michels KB, Willett WC, Fuchs CS, Giovannucci E. Coffee, tea, and caffeine consumption and incidence of colon and rectal cancer. J Natl Cancer Inst. 2005;97:282–92.CrossRefPubMedPubMedCentral
34.
Tavani A, Pregnolato A, La Vecchia C, Negri E, Talamini R, Franceschi S. Coffee and tea intake and risk of cancers of the colon and rectum: a study of 3,530 cases and 7,057 controls. Int J Cancer. 1997;73:193–7.CrossRefPubMed
35.
Cavin C, Holzhaeuser D, Scharf G, Constable A, Huber WW, Schilter B. Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food Chem Toxicol. 2002;40:1155–63.CrossRefPubMed
36.
Green CJ, de Dauwe P, Boyle T, Tabatabaei SM, Fritschi L, Heyworth JS. Tea, coffee, and milk consumption and colorectal cancer risk. J Epidemiol. 2014;24:146–53.CrossRefPubMedPubMedCentral
37.
Sinha R, Cross AJ, Daniel CR, et al. Caffeinated and decaffeinated coffee and tea intakes and risk of colorectal cancer in a large prospective study. Am J Clin Nutr. 2012;96:374–81.CrossRefPubMedPubMedCentral
38.
Li G, Ma D, Zhang Y, et al. Coffee consumption and risk of colorectal cancer: a meta-analysis of observational studies. Public Health Nutr. 2013;16:346–57.CrossRefPubMed
39.
Bidel S, Hu G, Jousilahti P, et al. Coffee consumption and risk of colorectal cancer. Eur J Clin Nutr. 2010;64:917–23.CrossRefPubMed
40.
Bamia C, Lagiou P, Buckland G, et al. Mediterranean diet and colorectal cancer risk: Results from a European cohort. Eur J Epidemiol. 2013;28:317–28.CrossRefPubMed
41.
Khanam U, Oba S, Yanase E, Murakami Y. Phenolic acids, flavonoids and total antioxidant capacity of selected leafy vegetables. J Funct Foods. 2012;4:979–87.CrossRef
42.
Deng G, Lin X, Xu X, Gao L, Xie J, Li H. Antioxidant capacities and total phenolic contents of 56 vegetables. J Funct Foods. 2013;5:260–6.CrossRef
43.
Zhu B, Sun Y, Qi L, Zhong R, Miao X. Dietary legume consumption reduces risk of colorectal cancer: evidence from a meta-analysis of cohort studies. Sci Rep. 2015;5:8797.CrossRefPubMedPubMedCentral
44.
45.
Michels KB, Edward GE, Joshipura KJ, et al. Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. J Natl Cancer Inst. 2000;92:1740–52.CrossRefPubMed
46.
Constantinou A, Kiguchi K, Huberman E. Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein. Cancer Res. 1990;50:2618–24.PubMed
47.
Stephen AM, Cummings JH. Mechanism of action of dietary fibre in the human colon. Nature 1980;284:283–4.
48.
Papas MA, Giovannucci E, Platz EA. Fiber from fruit and colorectal neoplasia. Cancer Epidemiol Biomark Prev. 2004;13:1267–70.
49.
Fleming SE, O’Donnell AU, Perman JA. Influence of frequent and long-term bean consumption on colonic function and fermentation. Am J Clin Nutr. 1985;41:909–18.PubMed
50.
Bingham SA, Day NE, Luben R, et al. Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet. 2003;361:1496–501.CrossRefPubMed
51.
Emenaker NJ, Calaf GM, Cox D, Basson MD, Qureshi N. Short-chain fatty acids inhibit invasive human colon cancer by modulating uPA, TIMP-1, TIMP-2, mutant p53, Bcl-2, Bax, p21 and PCNA protein expression in an in vitro cell culture model. J Nutr. 2001;131:3041S–6S.PubMed
52.
Jang Y, Lee JH, Kim OY, Park HY, Lee SY. Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial. Arterioscler Thromb Vasc Biol. 2001;21:2065–71.CrossRefPubMed
53.
Lima AIG, Mota J, Monteiro SAVS, Ferreira RMSB. Legume seeds and colorectal cancer revisited: Protease inhibitors reduce MMP-9 activity and colon cancer cell migration. Food Chem. 2016;197:30–8.CrossRefPubMed
54.
Mook ORF, Frederiks WM, Van Noorden CJF. The role of gelatinases in colorectal cancer progression and metastasis. Biochim Biophys Acta - Rev Cancer. 2004;1705:69–89.CrossRef
55.
Herszényi L, Hritz I, Lakatos G, Varga M, Tulassay Z. The behavior of matrix metalloproteinases and their inhibitors in colorectal cancer. Int J Mol Sci. 2012;13:13240–63.CrossRefPubMedPubMedCentral
56.
Pelucchi C, Bosetti C, Negri E, Lipworth L, La Vecchia C. Olive oil and cancer risk: an update of epidemiological findings through 2010. Curr Pharm Des. 2011;17:805–12.CrossRefPubMed
57.
Terzuoli E, Giachetti A, Ziche M, Donnini S. Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation. Mol Nutr Food Res. 2016;60:519–29.CrossRefPubMed
58.
Llor X, Pons E, Roca A, et al. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Clin Nutr. 2003;22:71–9.CrossRefPubMed
59.
Stoneham M, Goldacre M, Seagroatt V, Gill L. Olive oil, diet and colorectal cancer: an ecological study and a hypothesis. J Epidemiol Community Health. 2000;54:756–60.CrossRefPubMedPubMedCentral
60.
Trock B, Lanza E, Greenwald P. Dietary fiber, vegetables, and colon cancer: critical review and meta-analyses of the epidemiologic evidence. J Natl Cancer Inst. 1990;82:650–61.CrossRefPubMed
61.
Thun MJ, Calle EE, Namboodiri MM, et al. Risk factors for fatal colon cancer in a large prospective study. J Natl Cancer Inst. 1992;84:1491–500.CrossRefPubMed
62.
63.
Filomeno M, Bosetti C, Bidoli E, et al. Mediterranean diet and risk of endometrial cancer: a pooled analysis of three Italian case-control studies. Br J Cancer. 2016:1–4.
Metadata
Title
Healthy dietary patterns decrease the risk of colorectal cancer in the Mecca Region, Saudi Arabia: a case-control study
Authors
Firas S. Azzeh
Eyad M. Alshammari
Awfa Y. Alazzeh
Abdelelah S. Jazar
Ibrahim R. Dabbour
Hani A. El-Taani
Ahmed A. Obeidat
Fayrooz A. Kattan
Sufyan H. Tashtoush
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2017
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-017-4520-4

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