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BMC Public Health
Published in: BMC Public Health 1/2015

Open Access 01-12-2015 | Research article

Ever dispense of prescribed allergy medication in children growing up close to traffic: a registry-based birth cohort

Authors: Anna Lindgren, Emilie Stroh, Kristina Jakobsson

Published in: BMC Public Health | Issue 1/2015

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Abstract

Background

Epidemiologic studies have shown conflicting results regarding the role of traffic pollution in the development of allergic disease. This study investigated the relationship between living close to traffic and ever dispense of prescribed oral antihistamines or nasal anti-allergic medication, among young children. The underlying aim was to investigate if children growing up close to traffic pollution are at higher risk of developing allergy in early childhood.

Methods

We investigated a birth cohort in southern Sweden, consisting of N = 26 128 children (0–6 years) with health outcome and exposure data. Of these children, N = 7898, had additional covariate information. Traffic intensity and yearly averages of dispersion-modeled concentrations of NOX (100 × 100 m grid) at residential addresses, were linked with registry data on dispensed allergy medication (the Swedish Prescribed Drug Register). Individual level covariate information was obtained from questionnaires distributed to parents at Child Health Care-center visits, eight months after birth. Cox proportional hazards regression was used for the statistical analyses.

Results

Living in close proximity to a road with equal to or greater than 8640 cars/day (compared to 0–8639 cars/day), was not associated with higher incidence of ever dispensed oral antihistamine or nasal anti-allergic medication, with or without adjustment for confounders (sex, breastfeeding, parental allergy, parental origin, season, and year of birth). Similar results were found in relation to NOX.

Conclusions

Traffic-related exposure was not associated with higher incidence of ever dispensed medication against allergy, in children 0–6 years in southern Sweden. These results indicates that traffic-related exposure may not be a risk factor for early onset allergy in children in southern Sweden. However, children with dispense of prescribed allergy medication may be a selected subgroup, and the results for this group may not be generalizable to all children with allergy.
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Literature
1.
Salvi S. Pollution and allergic airways disease. Curr Opin Allergy Clin Immunol. 2001;1(1):35–41.CrossRefPubMed
2.
Bowatte G, Lodge C, Lowe AJ, Erbas B, Perret J, Abramson MJ, et al. The influence of childhood traffic related air pollution exposure on asthma, allergy and sensitization: a systematic review and a meta-analysis of birth cohort studies. Allergy. 2014. doi:10.​1111/​all.​12561.
3.
Gruzieva O, Gehring U, Aalberse R, Agius R, Beelen R, Behrendt H, et al. Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts. J Allergy Clin Immunol. 2014;133(3):767–76.e7.CrossRefPubMed
4.
5.
Matsumoto K, Saito H. Epicutaneous immunity and onset of allergic diseases - per-“eczema”tous sensitization drives the allergy march. Allergol Int. 2013;62(3):291–6.CrossRefPubMed
6.
7.
8.
Crump C, Sundquist K, Sundquist J, Winkleby MA. Gestational age at birth and risk of allergic rhinitis in young adulthood. J Allergy Clin Immunol. 2011;127(5):1173–9.CrossRefPubMedPubMedCentral
9.
Arnlind MH, Wettermark B, Nokela M, Hjemdahl P, Rehnberg C, Jonsson EW. Regional variation and adherence to guidelines for drug treatment of asthma. Eur J Clin Pharmacol. 2010;66(2):187–98.CrossRefPubMed
10.
11.
12.
Stroh E, Oudin A, Gustafsson S, Pilesjo P, Harrie L, Stromberg U, et al. Are associations between socio-economic characteristics and exposure to air pollution a question of study area size? An example from Scania, Sweden. Int J Health Geogr. 2005;4:30. doi:10.​1186/​1476-072x-4-30.CrossRefPubMedPubMedCentral
13.
Wettermark B, Hammar N, Fored CM, Leimanis A, Otterblad Olausson P, Bergman U, et al. The new Swedish prescribed drug register--opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiol Drug Saf. 2007;16(7):726–35.CrossRefPubMed
14.
15.
16.
17.
18.
19.
20.
Morgenstern V, Zutavern A, Cyrys J, Brockow I, Koletzko S, Kramer U, et al. Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. Am J Respir Crit Care Med. 2008;177(12):1331–7.CrossRefPubMed
21.
Nordling E, Berglind N, Melen E, Emenius G, Hallberg J, Nyberg F, et al. Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology (Cambridge, Mass). 2008;19(3):401–8.CrossRef
22.
Brauer M, Hoek G, Smit HA, de Jongste JC, Gerritsen J, Postma DS, et al. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Respir J. 2007;29(5):879–88.CrossRefPubMed
23.
Gruzieva O, Bellander T, Eneroth K, Kull I, Melen E, Nordling E, et al. Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life. J Allergy Clin Immunol. 2012;129(1):240–6.CrossRefPubMed
24.
Bowatte G, Lodge C, Lowe AJ, Erbas B, Perret J, Abramson MJ, et al. The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization: a systematic review and a meta-analysis of birth cohort studies. Allergy. 2015;70(3):245–56.CrossRefPubMed
25.
26.
Porebski G, Wozniak M, Czarnobilska E. Residential proximity to major roadways is associated with increased prevalence of allergic respiratory symptoms in children. Ann Agric Environ Med. 2014;21(4):760–6.CrossRefPubMed
27.
Duhme H, Weiland SK, Keil U, Kraemer B, Schmid M, Stender M, et al. The association between self-reported symptoms of asthma and allergic rhinitis and self-reported traffic density on street of residence in adolescents. Epidemiology (Cambridge, Mass). 1996;7(6):578–82.CrossRef
28.
Weiland SK, Mundt KA, Ruckmann A, Keil U. Self-reported wheezing and allergic rhinitis in children and traffic density on street of residence. Ann Epidemiol. 1994;4(3):243–7.CrossRefPubMed
29.
Lee YL, Shaw CK, Su HJ, Lai JS, Ko YC, Huang SL, et al. Climate, traffic-related air pollutants and allergic rhinitis prevalence in middle-school children in Taiwan. Eur Respir J. 2003;21(6):964–70.CrossRefPubMed
30.
Hoek G, Pattenden S, Willers S, Antova T, Fabianova E, Braun-Fahrlander C, et al. PM10, and children’s respiratory symptoms and lung function in the PATY study. Eur Respir J. 2012;40(3):538–47.CrossRefPubMed
31.
Hirsch T, Weiland SK, von Mutius E, Safeca AF, Grafe H, Csaplovics E, et al. Inner city air pollution and respiratory health and atopy in children. Eur Respir J. 1999;14(3):669–77.CrossRefPubMed
32.
Wyler C, Braun-Fahrlander C, Kunzli N, Schindler C, Ackermann-Liebrich U, Perruchoud AP, et al. Exposure to motor vehicle traffic and allergic sensitization. The Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Epidemiology (Cambridge, Mass). 2000;11(4):450–6.CrossRef
33.
Nicolai T, Carr D, Weiland SK, Duhme H, von Ehrenstein O, Wagner C, et al. Urban traffic and pollutant exposure related to respiratory outcomes and atopy in a large sample of children. Eur Respir J. 2003;21(6):956–63.CrossRefPubMed
34.
Ramadour M, Burel C, Lanteaume A, Vervloet D, Charpin D, Brisse F, et al. Prevalence of asthma and rhinitis in relation to long-term exposure to gaseous air pollutants. Allergy. 2000;55(12):1163–9.CrossRefPubMed
35.
Codispoti CD, LeMasters GK, Levin L, Reponen T, Ryan PH, Biagini Myers JM, et al. Traffic pollution is associated with early childhood aeroallergen sensitization. Ann Allergy Asthma Immunol. 2014. doi:10.​1016/​j.​anai.​2014.​10.​020.
36.
Azalim S, Camargos P, Alves AL, Senna MI, Sakurai E, Schwabe KW. Exposure to environmental factors and relationship to allergic rhinitis and/or asthma. Ann Agric Environ Med. 2014;21(1):59–63.PubMed
37.
Fuhrman C, Sarter H, Thibaudon M, Delmas MC, Zeghnoun A, Lecadet J, et al. Short-term effect of pollen exposure on anti-allergic drug consumption. Ann Allergy Asthma Immunol. 2007;99(3):225–31.CrossRefPubMed
38.
Caillaud DM, Martin S, Segala C, Vidal P, Lecadet J, Pellier S, et al. Airborne pollen levels and drug consumption for seasonal allergic rhinoconjunctivitis: a 10-year study in France. Allergy. 2015;70(1):99–106. doi:10.​1111/​all.​12522.CrossRefPubMed
39.
40.
41.
Cuinica LG, Abreu I, EstevesdaSilva J. Effect of air pollutant NO(2) on Betula pendula, Ostrya carpinifolia and Carpinus betulus pollen fertility and human allergenicity. Environ Pollut (Barking, Essex: 1987). 2014;186:50–5.CrossRef
42.
Cuinica LG, Cruz A, Abreu I, da Silva JC. Effects of atmospheric pollutants (CO, O, SO) on the allergenicity of Betula pendula, Ostrya carpinifolia, and Carpinus betulus pollen. Int J Environ Health Res. 2014:1–10. doi:10.​1080/​09603123.​2014.​938031.
43.
Yoshino S, Hayashi H, Taneda S, Takano H, Sagai M, Mori Y. Effect of diesel exhaust particle extracts on induction of oral tolerance in mice. Toxicol Sci. 2002;66(2):293–7.CrossRefPubMed
44.
Yang SN, Hsieh CC, Kuo HF, Lee MS, Huang MY, Kuo CH, et al. The effects of environmental toxins on allergic inflammation. Allergy Asthma Immunol Res. 2014;6(6):478–84.CrossRefPubMedPubMedCentral
45.
46.
47.
Poulsen LK, Hummelshoj L. Triggers of IgE class switching and allergy development. Ann Med. 2007;39(6):440–56.CrossRefPubMed
48.
Holt PG, McMenamin C. Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance. Clin Exp Allergy. 1989;19(3):255–62.CrossRefPubMed
49.
Davila I, Mullol J, Bartra J, Del Cuvillo A, Ferrer M, Jauregui I, et al. Effect of pollutants upon patients with respiratory allergies. J Investig Allergol Clin Immunol. 2007;17 Suppl 2:9–20.PubMed
50.
Bartra J, Mullol J, del Cuvillo A, Davila I, Ferrer M, Jauregui I, et al. Air pollution and allergens. J Investig Allergol Clin Immunol. 2007;17 Suppl 2:3–8.PubMed
51.
Simpson A, Custovic A. Early pet exposure: friend or foe? Curr Opin Allergy Clin Immunol. 2003;3(1):7–14.CrossRefPubMed
52.
Custovic A. To what extent is allergen exposure a risk factor for the development of allergic disease? Clin Exp Allergy. 2015;45(1):54–62.CrossRefPubMed
53.
Ziska LH, Gebhard DE, Frenz DA, Faulkner S, Singer BD, Straka JG. Cities as harbingers of climate change: common ragweed, urbanization, and public health. J Allergy Clin Immunol. 2003;111(2):290–5.CrossRefPubMed
Metadata
Title
Ever dispense of prescribed allergy medication in children growing up close to traffic: a registry-based birth cohort
Authors
Anna Lindgren
Emilie Stroh
Kristina Jakobsson
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2015
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-015-2356-3

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