Skip to main content
Top
Published in: BMC Public Health 1/2015

Open Access 01-12-2015 | Research article

Multimorbidity and the inequalities of global ageing: a cross-sectional study of 28 countries using the World Health Surveys

Authors: Sara Afshar, Paul J. Roderick, Paul Kowal, Borislav D. Dimitrov, Allan G. Hill

Published in: BMC Public Health | Issue 1/2015

Login to get access

Abstract

Background

Multimorbidity defined as the “the coexistence of two or more chronic diseases” in one individual, is increasing in prevalence globally. The aim of this study is to compare the prevalence of multimorbidity across low and middle-income countries (LMICs), and to investigate patterns by age and education, as a proxy for socio-economic status (SES).

Methods

Chronic disease data from 28 countries of the World Health Survey (2003) were extracted and inter-country socio-economic differences were examined by gross domestic product (GDP). Regression analyses were applied to examine associations of education with multimorbidity by region adjusted for age and sex distributions.

Results

The mean world standardized multimorbidity prevalence for LMICs was 7.8 % (95 % CI, 7.79 % - 7.83 %). In all countries, multimorbidity increased significantly with age. A positive but non–linear relationship was found between country GDP and multimorbidity prevalence. Trend analyses of multimorbidity by education suggest that there are intergenerational differences, with a more inverse education gradient for younger adults compared to older adults. Higher education was significantly associated with a decreased risk of multimorbidity in the all-region analyses.

Conclusions

Multimorbidity is a global phenomenon, not just affecting older adults in HICs. Policy makers worldwide need to address these health inequalities, and support the complex service needs of a growing multimorbid population.
Appendix
Available only for authorised users
Literature
2.
go back to reference Preparing for an Aging World. The Case for Cross-National Research. Washington DC: The National Academies Press; 2001. Preparing for an Aging World. The Case for Cross-National Research. Washington DC: The National Academies Press; 2001.
3.
go back to reference Almirall J, Fortin M. The coexistence of terms to describe the presence of multiple concurrent diseases. Journal of Comorbidity. 2013;3(1):4–9.CrossRef Almirall J, Fortin M. The coexistence of terms to describe the presence of multiple concurrent diseases. Journal of Comorbidity. 2013;3(1):4–9.CrossRef
4.
go back to reference Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012;380(9859):2224–60.CrossRef Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012;380(9859):2224–60.CrossRef
5.
go back to reference Garin N, Olaya B, Perales J, Moneta MV, Miret M, Ayuson-Mateos JL, Haro JM. Multimorbidity Patterns in a National Representative Sample of the Spanish Adult Population. PLoS ONE. 2014; doi:10.1371/journal.pone.0084794. Garin N, Olaya B, Perales J, Moneta MV, Miret M, Ayuson-Mateos JL, Haro JM. Multimorbidity Patterns in a National Representative Sample of the Spanish Adult Population. PLoS ONE. 2014; doi:10.​1371/​journal.​pone.​0084794.
6.
go back to reference Kirchberger I, Meisinger C, Heier M, Zimmermann AK, Thorand B, Autenrieth CS et al. Patterns of Multimorbidity in the Aged Population. Results from the KORA-Age Study. PLoS ONE. 2012; doi:10.1371/journal.pone.0030556. Kirchberger I, Meisinger C, Heier M, Zimmermann AK, Thorand B, Autenrieth CS et al. Patterns of Multimorbidity in the Aged Population. Results from the KORA-Age Study. PLoS ONE. 2012; doi:10.​1371/​journal.​pone.​0030556.
7.
go back to reference Fortin M, Hudon C, Haggerty J, van den Akker M, Almirall J. Prevalence estimates of multimorbidity: a comparative study of two sources. BMC Health Services Research. 2010;10:111.CrossRefPubMedPubMedCentral Fortin M, Hudon C, Haggerty J, van den Akker M, Almirall J. Prevalence estimates of multimorbidity: a comparative study of two sources. BMC Health Services Research. 2010;10:111.CrossRefPubMedPubMedCentral
8.
go back to reference Taylor AW, Price K, Gill TK, Adams R, Pilkington R, Carrangis N et al. Multimorbidity - not just an older person's issue. Results from an Australian biomedical study. BMC Public Health. 2010;10:718.CrossRefPubMedPubMedCentral Taylor AW, Price K, Gill TK, Adams R, Pilkington R, Carrangis N et al. Multimorbidity - not just an older person's issue. Results from an Australian biomedical study. BMC Public Health. 2010;10:718.CrossRefPubMedPubMedCentral
9.
go back to reference Ward BW, Schiller JS. Prevalence of multiple chronic conditions among US adults: estimates from the National Health Interview Survey, 2010. Prev Chronic Dis. 2010;10:E65. Ward BW, Schiller JS. Prevalence of multiple chronic conditions among US adults: estimates from the National Health Interview Survey, 2010. Prev Chronic Dis. 2010;10:E65.
10.
go back to reference Agborsangaya CB, Lau D, Lahtinen M, Cooke T, Johnson JA. Multimorbidity prevalence and patterns across socioeconomic determinants: a cross-sectional survey. BMC Public Health. 2012;12:201.CrossRefPubMedPubMedCentral Agborsangaya CB, Lau D, Lahtinen M, Cooke T, Johnson JA. Multimorbidity prevalence and patterns across socioeconomic determinants: a cross-sectional survey. BMC Public Health. 2012;12:201.CrossRefPubMedPubMedCentral
11.
go back to reference St John PD, Tyas SL, Menec V, Tate R. Multimorbidity, disability, and mortality in community-dwelling older adults. Can Fam Physician. 2014;60(5):e272–80.PubMedPubMedCentral St John PD, Tyas SL, Menec V, Tate R. Multimorbidity, disability, and mortality in community-dwelling older adults. Can Fam Physician. 2014;60(5):e272–80.PubMedPubMedCentral
12.
go back to reference Fortin M, Bravo G, Hudon C, Lapointe L, Almirall J, Dubois MF, et al. Relationship between multimorbidity and health-related quality of life of patients in primary care. Qual Life Res. 2006;15(1):83–91.CrossRefPubMed Fortin M, Bravo G, Hudon C, Lapointe L, Almirall J, Dubois MF, et al. Relationship between multimorbidity and health-related quality of life of patients in primary care. Qual Life Res. 2006;15(1):83–91.CrossRefPubMed
13.
go back to reference Dy SM, Pfoh ER, Salive ME, Boyd CM. Health-related quality of life and functional status quality indicators for older persons with multiple chronic conditions. J Am Geriatr Soc. 2013;61(12):2120–7.CrossRefPubMedPubMedCentral Dy SM, Pfoh ER, Salive ME, Boyd CM. Health-related quality of life and functional status quality indicators for older persons with multiple chronic conditions. J Am Geriatr Soc. 2013;61(12):2120–7.CrossRefPubMedPubMedCentral
14.
go back to reference Marengoni A, von Strauss E, Rizzuto D, Winblad B, Fratiglioni L. The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study. J Intern Med. 2009;265(2):288–95.CrossRefPubMed Marengoni A, von Strauss E, Rizzuto D, Winblad B, Fratiglioni L. The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study. J Intern Med. 2009;265(2):288–95.CrossRefPubMed
15.
go back to reference Steiner CA, Friedman B. Hospital Utilization, Costs, and Mortality for Adults With Multiple Chronic Conditions, Nationwide Inpatient Sample, 2009. Prev Chronic Dis. 2013;10:120292.CrossRef Steiner CA, Friedman B. Hospital Utilization, Costs, and Mortality for Adults With Multiple Chronic Conditions, Nationwide Inpatient Sample, 2009. Prev Chronic Dis. 2013;10:120292.CrossRef
16.
go back to reference Van den Bussche H, Schon G, Kolonko T, Hansen H, Wegscheider K, Glaeske G, et al. Patterns of ambulatory medical care utilization in elderly patients with special reference to chronic diseases and multimorbidity - Results from a claims data based observational study in Germany. BMC Geriatrics. 2011;11:54.CrossRefPubMedPubMedCentral Van den Bussche H, Schon G, Kolonko T, Hansen H, Wegscheider K, Glaeske G, et al. Patterns of ambulatory medical care utilization in elderly patients with special reference to chronic diseases and multimorbidity - Results from a claims data based observational study in Germany. BMC Geriatrics. 2011;11:54.CrossRefPubMedPubMedCentral
17.
go back to reference Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. The Lancet. 2012;380(9836):37–43.CrossRef Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. The Lancet. 2012;380(9836):37–43.CrossRef
18.
go back to reference Khanam MA, Streatfield PK, Kabir ZN, Qiu C, Cornelius C, Wahlin A. Prevalence and patterns of multimorbidity among elderly people in rural Bangladesh: a cross-sectional study. J Health, Population Nutri. 2011;29(4):406–14. Khanam MA, Streatfield PK, Kabir ZN, Qiu C, Cornelius C, Wahlin A. Prevalence and patterns of multimorbidity among elderly people in rural Bangladesh: a cross-sectional study. J Health, Population Nutri. 2011;29(4):406–14.
20.
go back to reference Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B. Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet. 2007;370(9590):851–8.CrossRefPubMed Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B. Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet. 2007;370(9590):851–8.CrossRefPubMed
21.
go back to reference Ustun TB, Chatterji S, Villanueva M, Bendib L, Celik C, Sandana R et al. Chapter 57: WHO Multi-Country Survey Study on Health and Responsiveness 2000–2001. In: Murray CJL, David BE, editors. Health Systems Performance Assessment. Geneva: World Health Organization; 2003. p. 761. Ustun TB, Chatterji S, Villanueva M, Bendib L, Celik C, Sandana R et al. Chapter 57: WHO Multi-Country Survey Study on Health and Responsiveness 2000–2001. In: Murray CJL, David BE, editors. Health Systems Performance Assessment. Geneva: World Health Organization; 2003. p. 761.
22.
go back to reference Smith SM, Soubhi H, Fortin M, Hudon C, O'Dowd T. Managing patients with multimorbidity: systematic review of interventions in primary care and community settings. BMJ. 2012;345:e5205.CrossRefPubMedPubMedCentral Smith SM, Soubhi H, Fortin M, Hudon C, O'Dowd T. Managing patients with multimorbidity: systematic review of interventions in primary care and community settings. BMJ. 2012;345:e5205.CrossRefPubMedPubMedCentral
23.
go back to reference The World Bank. World Development Report 2003: Sustainable Development in a Dynamic World -- Transforming Insitutions, Growth and Quality of Life. Washington DC, USA: World Bank; 2003 The World Bank. World Development Report 2003: Sustainable Development in a Dynamic World -- Transforming Insitutions, Growth and Quality of Life. Washington DC, USA: World Bank; 2003
24.
go back to reference Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJL, Lozano R, Inoue M. Age Standardisation of rates: A New WHO Standard. Geneva, Switzerland: GPE Discussion Paper Series; No.31, 2001. Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJL, Lozano R, Inoue M. Age Standardisation of rates: A New WHO Standard. Geneva, Switzerland: GPE Discussion Paper Series; No.31, 2001.
26.
go back to reference Sen A. Development as freedom. Oxford, UK: OUP; 2001. Sen A. Development as freedom. Oxford, UK: OUP; 2001.
27.
go back to reference Leon DA, Chenet L, Shkolnikov VM, Zakharov S, Shapiro J, Rakhmanaova G et al. Huge variation in Russian mortality rates 1984–94: artefact, alcohol, or what? Lancet. 1997;350:383–88.CrossRefPubMed Leon DA, Chenet L, Shkolnikov VM, Zakharov S, Shapiro J, Rakhmanaova G et al. Huge variation in Russian mortality rates 1984–94: artefact, alcohol, or what? Lancet. 1997;350:383–88.CrossRefPubMed
28.
go back to reference Gilmore A, McKee M. Moving east: how the transnational tobacco companies gained entry to the emerging markets of the former Soviet Union. Part I: Establishing cigarette imports. Tobacco Control. 2004;13:143–50.CrossRefPubMedPubMedCentral Gilmore A, McKee M. Moving east: how the transnational tobacco companies gained entry to the emerging markets of the former Soviet Union. Part I: Establishing cigarette imports. Tobacco Control. 2004;13:143–50.CrossRefPubMedPubMedCentral
30.
go back to reference Lochner KA, Cox CS. Prevalence of Multiple Chronic Conditions among Medicare Beneficiaries, United States, 2010. Prev Chronic Dis. 2013;10:120137.CrossRef Lochner KA, Cox CS. Prevalence of Multiple Chronic Conditions among Medicare Beneficiaries, United States, 2010. Prev Chronic Dis. 2013;10:120137.CrossRef
31.
go back to reference Rizza A, Kaplan V, Senn O, Rosemann T, Bhend H, Tandjung R. Age- and gender-related prevalence of multimorbidity in primary care: the swiss fire project. BMC Fam Pract. 2012;13:113.CrossRefPubMedPubMedCentral Rizza A, Kaplan V, Senn O, Rosemann T, Bhend H, Tandjung R. Age- and gender-related prevalence of multimorbidity in primary care: the swiss fire project. BMC Fam Pract. 2012;13:113.CrossRefPubMedPubMedCentral
32.
go back to reference Orueta JF, Nuno-Solinis R, Garcia-Alvarez A, Alonso-Moran E. Prevalence of multimorbidity according to the deprivation level among the elderly in the Basque Country. BMC Public Health. 2013;13:918.CrossRefPubMedPubMedCentral Orueta JF, Nuno-Solinis R, Garcia-Alvarez A, Alonso-Moran E. Prevalence of multimorbidity according to the deprivation level among the elderly in the Basque Country. BMC Public Health. 2013;13:918.CrossRefPubMedPubMedCentral
33.
go back to reference Mustard CA, Kaufert P, Kozyrskyj A, Mayer T. Sex differences in the use of health care services. N Engl J Med. 1998;338(23):1678–83.CrossRefPubMed Mustard CA, Kaufert P, Kozyrskyj A, Mayer T. Sex differences in the use of health care services. N Engl J Med. 1998;338(23):1678–83.CrossRefPubMed
34.
go back to reference Green CA, Pope CR. Gender, psychosocial factors and the use of medical services: a longitudinal analysis. Soc Sci Med. 1999;48(10):1363–72.CrossRefPubMed Green CA, Pope CR. Gender, psychosocial factors and the use of medical services: a longitudinal analysis. Soc Sci Med. 1999;48(10):1363–72.CrossRefPubMed
35.
go back to reference Poblador-Plou B, van den Akker M, Vos R, Calderon-Larranaga A, Metsemakers J, Prados-Torres A. Similar Multimorbidity Patterns in Primary Care Patients from Two European Regions: Results of a Factor Analysis. PLoS ONE. 2014; doi:10.1371/journal.pone.0100375. Poblador-Plou B, van den Akker M, Vos R, Calderon-Larranaga A, Metsemakers J, Prados-Torres A. Similar Multimorbidity Patterns in Primary Care Patients from Two European Regions: Results of a Factor Analysis. PLoS ONE. 2014; doi:10.​1371/​journal.​pone.​0100375.
36.
go back to reference Chun H, Khang YH, Kim IH, Cho SI. Explaining gender differences in ill-health in South Korea: the roles of socio-structural, psychosocial, and behavioral factors. Soc Sci Med. 2008;67(6):988–1001.CrossRefPubMed Chun H, Khang YH, Kim IH, Cho SI. Explaining gender differences in ill-health in South Korea: the roles of socio-structural, psychosocial, and behavioral factors. Soc Sci Med. 2008;67(6):988–1001.CrossRefPubMed
37.
go back to reference Abad-Diez JM, Calderon-Larranaga A, Poncel-Falco A, Poblador-Plou B, Calderon-Meza JM, Sicras-Mainar A et al. Age and gender differences in the prevalence and patterns of multimorbidity in the older population. BMC Geriatrics. 2014;14:75.CrossRefPubMedPubMedCentral Abad-Diez JM, Calderon-Larranaga A, Poncel-Falco A, Poblador-Plou B, Calderon-Meza JM, Sicras-Mainar A et al. Age and gender differences in the prevalence and patterns of multimorbidity in the older population. BMC Geriatrics. 2014;14:75.CrossRefPubMedPubMedCentral
38.
39.
go back to reference Po JYT, Finlay JE, Brewster MB, Canning D. Estimating Household Permanent Income from Ownership of Physical Assets, in Working Paper Series. Harvard University: Center for Population & Development Studies; 2012. Po JYT, Finlay JE, Brewster MB, Canning D. Estimating Household Permanent Income from Ownership of Physical Assets, in Working Paper Series. Harvard University: Center for Population & Development Studies; 2012.
40.
go back to reference Wamani H, Tylleskar T, Astrom AN, Tumwine JK, Peterson S. Mothers' education but not fathers' education, household assets or land ownership is the best predictor of child health inequalities in rural Uganda. Int J Equity Health. 2004;3:9.CrossRefPubMedPubMedCentral Wamani H, Tylleskar T, Astrom AN, Tumwine JK, Peterson S. Mothers' education but not fathers' education, household assets or land ownership is the best predictor of child health inequalities in rural Uganda. Int J Equity Health. 2004;3:9.CrossRefPubMedPubMedCentral
41.
go back to reference Ustun TB, Chatterji S, Mechbal A, Murray CJL. Chapter 58: The World Health Surveys. In: Murray CJL, David BE, editors. Health Systems Performance Assessment. Geneva: World Health Organization; 2003. p. 761. Ustun TB, Chatterji S, Mechbal A, Murray CJL. Chapter 58: The World Health Surveys. In: Murray CJL, David BE, editors. Health Systems Performance Assessment. Geneva: World Health Organization; 2003. p. 761.
42.
go back to reference Harlow SD, Linet MS. Agreement between questionnaire data and medical records. The evidence for accuracy of recall. Am J Epidemiol. 1989;129(2):233–48.PubMed Harlow SD, Linet MS. Agreement between questionnaire data and medical records. The evidence for accuracy of recall. Am J Epidemiol. 1989;129(2):233–48.PubMed
43.
go back to reference Bush T, Miller SR, Golden A, Hale WE. Self-report and medical record report agreement of selected medical conditions in the elderly. Am J Public Health. 1989;79(11):1554–6.CrossRefPubMedPubMedCentral Bush T, Miller SR, Golden A, Hale WE. Self-report and medical record report agreement of selected medical conditions in the elderly. Am J Public Health. 1989;79(11):1554–6.CrossRefPubMedPubMedCentral
44.
go back to reference Horwitz RI. Comparison of epidemiological data from multiple sources. J Chron Dis. 1986;79:1554–6. Horwitz RI. Comparison of epidemiological data from multiple sources. J Chron Dis. 1986;79:1554–6.
45.
go back to reference Vellakkal S, Subramanian SV, Millet C, Basu S, Stuckler D, Ebrahim S. Socioeconomic Inequalities in Non-Communicable Diseases Prevalence in India: Disparities between Self-Reported Diagnoses and Standardized Measures. PLoS ONE. 2013; doi:10.1371/journal.pone.0068219. Vellakkal S, Subramanian SV, Millet C, Basu S, Stuckler D, Ebrahim S. Socioeconomic Inequalities in Non-Communicable Diseases Prevalence in India: Disparities between Self-Reported Diagnoses and Standardized Measures. PLoS ONE. 2013; doi:10.​1371/​journal.​pone.​0068219.
46.
go back to reference Rose G, McCartney P, Reid DD. Self-administration of a questionnaire on chest pain and intermittent claudication. Br J Prev Soc Med. 1977;31(1):42–8.PubMedPubMedCentral Rose G, McCartney P, Reid DD. Self-administration of a questionnaire on chest pain and intermittent claudication. Br J Prev Soc Med. 1977;31(1):42–8.PubMedPubMedCentral
47.
go back to reference Desai S, Alva S. Maternal education and child health: Is there a strong causal relationship? Demography. 1998;35(1):71–8.CrossRefPubMed Desai S, Alva S. Maternal education and child health: Is there a strong causal relationship? Demography. 1998;35(1):71–8.CrossRefPubMed
48.
go back to reference Basu AM. Maternal education, fertility and child mortality: Disentangling verbal relationships. Health Transition Review. 1994;4:207–15. Basu AM. Maternal education, fertility and child mortality: Disentangling verbal relationships. Health Transition Review. 1994;4:207–15.
49.
go back to reference Baker DP, Leon J, Smith Greenaway EG, Collins J, Movit M. The Education effect on population health: a reassessment. Popul Dev Rev. 2011;37(2):307–32.CrossRefPubMedPubMedCentral Baker DP, Leon J, Smith Greenaway EG, Collins J, Movit M. The Education effect on population health: a reassessment. Popul Dev Rev. 2011;37(2):307–32.CrossRefPubMedPubMedCentral
50.
go back to reference Nations U. Political declaration of the high-level meeting of the General Assembly on the prevention and control of non-communicable diseases (Document A/RES/66.2). in High Level Meeting on Prevention and Control of Non-communicable Diseases. New York: United Nations; 2011. Available from: http://www.un.org/en/ga/ncdmeeting2011. Nations U. Political declaration of the high-level meeting of the General Assembly on the prevention and control of non-communicable diseases (Document A/RES/66.2). in High Level Meeting on Prevention and Control of Non-communicable Diseases. New York: United Nations; 2011. Available from: http://​www.​un.​org/​en/​ga/​ncdmeeting2011.
Metadata
Title
Multimorbidity and the inequalities of global ageing: a cross-sectional study of 28 countries using the World Health Surveys
Authors
Sara Afshar
Paul J. Roderick
Paul Kowal
Borislav D. Dimitrov
Allan G. Hill
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2015
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-015-2008-7

Other articles of this Issue 1/2015

BMC Public Health 1/2015 Go to the issue