Skip to main content
Top
Published in: BMC Psychiatry 1/2019

Open Access 01-12-2019 | Schizophrenia | Research article

Sexual dysfunction in Chinese rural patients with schizophrenia

Authors: Ying-Hua Huang, Cai-Lan Hou, C. H. Ng, Xie Chen, Qian-Wen Wang, Zhuo-Hui Huang, Fu-Jun Jia

Published in: BMC Psychiatry | Issue 1/2019

Login to get access

Abstract

Background

Sexual dysfunction is common in patients with schizophrenia, however it is poorly studied in China, especially in primary health care institutions in rural areas. We investigated the prevalence of sexual dysfunction and its correlates including quality of life (QoL), in schizophrenia patients treated in primary care in a rural area in China.

Method

By using a random numbers table, 21 small town primary care service centers (from 63 totally) were selected in the study. Data of 720 community-dwelling patients with schizophrenia in rural area with diagnoses according to DSM –IV or ICD-10 were collected by interviews. Data on socio-demographic and clinical characteristics including sexual dysfunction and quality of life (QoL) were collected using a standardized protocol and data collection procedure. Data were analyzed using chi-square tests, t-tests, U-tests, ANCOVA and multiple logistic regression as appropriate by SPSS 21.0.The level of significance was set at 0.05 (two-tailed).

Results

In this sample, sexual dysfunction was found in 71.3% of the whole sample, 82.7% of female patients and 64.5% of male patients. Multiple logistic regression analysis showed that older age (OR = 1.06, P<0.001, 95%CI: 1.04–1.09) and higher Brief Psychotic Rating Scale (negative domain) score (OR = 1.16, P = 0.01, 95%CI: 1.02–1.31) were significantly associated with sexual dysfunction. Contrary to previous findings, sexual dysfunction was not associated with quality of life after controlling for confounding variables.

Conclusions

More than 2/3 of schizophrenia patients living in a rural area complained of sexual dysfunction, which was associated with older age and more negative psychotic symptoms. Primary care physicians should pay attention to sexual dysfunction during the assessment and treatment of patients with schizophrenia in rural areas in China.
Literature
3.
go back to reference Heiman JR. Sexual dysfunction: overview of prevalence, etiological factors, and treatments. J Sex Res. 2002;39. Heiman JR. Sexual dysfunction: overview of prevalence, etiological factors, and treatments. J Sex Res. 2002;39.
5.
go back to reference Kokoszka A. A prevalence of subjectively assessed symptoms of sexual disorders in schizophrenia. Arch Psychiatry Psychother. 2010;3:47–55. Kokoszka A. A prevalence of subjectively assessed symptoms of sexual disorders in schizophrenia. Arch Psychiatry Psychother. 2010;3:47–55.
7.
go back to reference Costa AMN. A systematic review on clinical management of antipsychotic-induced sexual dysfunction in schizophrenia. Sao Paulo Med J. 2006;124:7.CrossRef Costa AMN. A systematic review on clinical management of antipsychotic-induced sexual dysfunction in schizophrenia. Sao Paulo Med J. 2006;124:7.CrossRef
10.
go back to reference Hocaoglu C, Celik FH, Kandemir G, Guveli H, Bahceci B. Sexual dysfucntion in outpatients with schizophrenia in Turkey a cross sectional study. Shanghai Arch Psychiatry. 2014;26:347–54.PubMedPubMedCentral Hocaoglu C, Celik FH, Kandemir G, Guveli H, Bahceci B. Sexual dysfucntion in outpatients with schizophrenia in Turkey a cross sectional study. Shanghai Arch Psychiatry. 2014;26:347–54.PubMedPubMedCentral
11.
go back to reference Macdonald S. Nithsdale Schizophrenia Surveys 24 sexual dysfunction. Br J Psychiatry. 2003;182:50–6.CrossRef Macdonald S. Nithsdale Schizophrenia Surveys 24 sexual dysfunction. Br J Psychiatry. 2003;182:50–6.CrossRef
15.
go back to reference Xiang Y-T, Wang C-Y, Si T-M, Lee EHM, He Y-L, Ungvari GS, et al. The low frequency of reported sexual dysfunction in Asian patients with schizophrenia (2001-2009): low occurrence or ignored side effect? Hum Psychopharmacol Clin Exp. 2011;26:352–7. https://doi.org/10.1002/hup.1213.CrossRef Xiang Y-T, Wang C-Y, Si T-M, Lee EHM, He Y-L, Ungvari GS, et al. The low frequency of reported sexual dysfunction in Asian patients with schizophrenia (2001-2009): low occurrence or ignored side effect? Hum Psychopharmacol Clin Exp. 2011;26:352–7. https://​doi.​org/​10.​1002/​hup.​1213.CrossRef
18.
go back to reference Olfson M. Male sexual dysfunction and quality of life in schizophrenia. J Clin Psychiatry. 2005;66:8. Olfson M. Male sexual dysfunction and quality of life in schizophrenia. J Clin Psychiatry. 2005;66:8.
20.
go back to reference M C. The neurobiology of sexual function. Arch Gen Psychiatry. 2000;57:18. M C. The neurobiology of sexual function. Arch Gen Psychiatry. 2000;57:18.
23.
go back to reference Zhu RXZX, Hou G, Yuan YG. The psychometric properties of the Chinese version of the Arizona sexual experience scale in the schizophrenia patients (in Chinese). Papers Series of Tenth National Conferfence of Chinese Medical Association of Psychiatry. 2012. Zhu RXZX, Hou G, Yuan YG. The psychometric properties of the Chinese version of the Arizona sexual experience scale in the schizophrenia patients (in Chinese). Papers Series of Tenth National Conferfence of Chinese Medical Association of Psychiatry. 2012.
24.
go back to reference Zhu RX, Hou G. The influence of antipsychotics treatment on sexual functionin remitted male schizophrenic patients and the correlation with plasma prolactin concentration (in Chinese). J Clin Psychiatry. 2010;20:3. Zhu RX, Hou G. The influence of antipsychotics treatment on sexual functionin remitted male schizophrenic patients and the correlation with plasma prolactin concentration (in Chinese). J Clin Psychiatry. 2010;20:3.
25.
go back to reference Overall JE, Beller SA. The brief psychiatric rating scale (BPRS) in geropsychiatric research: I factor structure on an inpatient unit. J Gerontol. 1984;39(2):187–93.CrossRef Overall JE, Beller SA. The brief psychiatric rating scale (BPRS) in geropsychiatric research: I factor structure on an inpatient unit. J Gerontol. 1984;39(2):187–93.CrossRef
26.
go back to reference MY Z. Montgomery-Asberg depression scale. Psychiatric rating scale manual. 2016;4. MY Z. Montgomery-Asberg depression scale. Psychiatric rating scale manual. 2016;4.
28.
go back to reference Zhogn BL, Wang Y, Chen HH, Wang XH. Reliability,validity and sensitivity of Montgomery Asberg depression rating scale for patients with current major depression disorder. China J Behav Med & Brain Sci. 2011;20:85–7. Zhogn BL, Wang Y, Chen HH, Wang XH. Reliability,validity and sensitivity of Montgomery Asberg depression rating scale for patients with current major depression disorder. China J Behav Med & Brain Sci. 2011;20:85–7.
29.
go back to reference Simpson G. A Rating Scale for Extrapyramidal Side Effects. Simpson G. A Rating Scale for Extrapyramidal Side Effects.
30.
go back to reference Hao YTFJ. The introduce and usage of WHOQOL instrument in Chinese modern. Rehabilitation. 2000;4:1127–9. Hao YTFJ. The introduce and usage of WHOQOL instrument in Chinese modern. Rehabilitation. 2000;4:1127–9.
35.
go back to reference Ronald W. Lewis M, a Kersten S. Fugl-Meyer, PhD, b R. Bosch, MD, c Axel R. Fugl-Meyer, PhD, b Edward O. Laumann, PhD, d E. Lizza, MD, e and Antonio Martin-Morales, MDf Epidemiology, Risk Factors of Sexual Dysfunction. Sexual Medicine: Sexual Dysfunctions in Men and Women. 2004:35–9. Ronald W. Lewis M, a Kersten S. Fugl-Meyer, PhD, b R. Bosch, MD, c Axel R. Fugl-Meyer, PhD, b Edward O. Laumann, PhD, d E. Lizza, MD, e and Antonio Martin-Morales, MDf Epidemiology, Risk Factors of Sexual Dysfunction. Sexual Medicine: Sexual Dysfunctions in Men and Women. 2004:35–9.
37.
go back to reference Edward O, Laumann PAP, Raymond MA, Rosen C. PhD sexual dysfunction in the United States prevalence and predictors. JAMA. 1999;281:537–44.CrossRef Edward O, Laumann PAP, Raymond MA, Rosen C. PhD sexual dysfunction in the United States prevalence and predictors. JAMA. 1999;281:537–44.CrossRef
44.
go back to reference Hou C. Sexual dysfunction and its impact on quality of life in Chinese patients with schizophrenia treated in primary care. Compr Psychiatry. 2016;65:5.CrossRef Hou C. Sexual dysfunction and its impact on quality of life in Chinese patients with schizophrenia treated in primary care. Compr Psychiatry. 2016;65:5.CrossRef
46.
go back to reference Morisky EAA, Wood M. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008;10:7.CrossRef Morisky EAA, Wood M. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008;10:7.CrossRef
48.
50.
go back to reference Lieberman JA, Stroup TS, JP ME, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis SM, Davis CE, Lebowitz BD, Severe J, Severe J, Hsiao JK. Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia. N Engl J Med. 2005;353:1209–23.CrossRef Lieberman JA, Stroup TS, JP ME, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis SM, Davis CE, Lebowitz BD, Severe J, Severe J, Hsiao JK. Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia. N Engl J Med. 2005;353:1209–23.CrossRef
51.
go back to reference Jones PB, Barnes TR, Davies L, Dunn G, Lloyd H, Hayhurst KP, Murray RM, Markwick A, Lewis SW. Randomized Controlled Trial of the Effect on Quality of Life of Second vs First Generation Antipsychotic Drugs in Schizophrenia. Arch Gen Psychiatry. 2006;63. Jones PB, Barnes TR, Davies L, Dunn G, Lloyd H, Hayhurst KP, Murray RM, Markwick A, Lewis SW. Randomized Controlled Trial of the Effect on Quality of Life of Second vs First Generation Antipsychotic Drugs in Schizophrenia. Arch Gen Psychiatry. 2006;63.
52.
go back to reference Hummer M, Kemmler G, Kurz M, Kurzthaler I, Oberbauer H, Fleischhacker WW. Sexual Disturbances During Clozapine and Haloperidol Treatment for Schizophrenia. Am J Psychiatry. 1999;156:631–3.PubMed Hummer M, Kemmler G, Kurz M, Kurzthaler I, Oberbauer H, Fleischhacker WW. Sexual Disturbances During Clozapine and Haloperidol Treatment for Schizophrenia. Am J Psychiatry. 1999;156:631–3.PubMed
57.
go back to reference Naber D. The importance of treatment acceptability to patients. Int J Psychiatry Clin Pract. 2000;4:10.CrossRef Naber D. The importance of treatment acceptability to patients. Int J Psychiatry Clin Pract. 2000;4:10.CrossRef
Metadata
Title
Sexual dysfunction in Chinese rural patients with schizophrenia
Authors
Ying-Hua Huang
Cai-Lan Hou
C. H. Ng
Xie Chen
Qian-Wen Wang
Zhuo-Hui Huang
Fu-Jun Jia
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Schizophrenia
Published in
BMC Psychiatry / Issue 1/2019
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-019-2205-5

Other articles of this Issue 1/2019

BMC Psychiatry 1/2019 Go to the issue