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BMC Psychiatry
Published in: BMC Psychiatry 1/2019

Open Access 01-12-2019 | Schizophrenia | Research article

Amplitude of low-frequency fluctuation (ALFF) may be associated with cognitive impairment in schizophrenia: a correlation study

Authors: Pengshuo Wang, Jian Yang, Zhiyang Yin, Jia Duan, Ran Zhang, Jiaze Sun, Yixiao Xu, Luyu Liu, Xuemei Chen, Huizi Li, Jiahui Kang, Yue Zhu, Xin Deng, Miao Chang, Shengnan Wei, Yifang Zhou, Xiaowei Jiang, Fei Wang, Yanqing Tang

Published in: BMC Psychiatry | Issue 1/2019

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Abstract

Background

Cognitive impairments are prominent in schizophrenia (SZ). Imaging studies have demonstrated that functional changes of several areas of the brain exist in SZ patients. The relationships between these two indexes are largely unexplored in SZ. The MATRICS Consensus Cognitive Battery (MCCB) was used to measure cognitive impairment in multi-dimensional cognitive fields of SZ patients. This study was conducted to explore the relationship between cognitive functional impairment and the amplitude of low-frequency fluctuation (ALFF) in SZ patients.

Method

A total of 104 participants (44 SZ patients and 60 age- and gender-matched healthy controls (HC)) were recruited for this study. The MCCB was used to assess cognitive function of the participants, while brain activity was assessed using the ALFF. The relationship between the MCCB and the ALFF was investigated by using a correlation analysis.

Results

There were significant differences between SZ patients and HC in MCCB total and domain scores as well as in ALFF results. The reduction of ALFF in the bilateral postcentral gyri and paracentral lobule in SZ patients has a negative correlation with the MCCB sub-test of symbol coding.

Conclusion

These findings suggest that the reduction of ALFF in bilateral postcentral gyri and paracentral lobule may be related to cognitive impairment in SZ patients.
Appendix
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Metadata
Title
Amplitude of low-frequency fluctuation (ALFF) may be associated with cognitive impairment in schizophrenia: a correlation study
Authors
Pengshuo Wang
Jian Yang
Zhiyang Yin
Jia Duan
Ran Zhang
Jiaze Sun
Yixiao Xu
Luyu Liu
Xuemei Chen
Huizi Li
Jiahui Kang
Yue Zhu
Xin Deng
Miao Chang
Shengnan Wei
Yifang Zhou
Xiaowei Jiang
Fei Wang
Yanqing Tang
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Schizophrenia
Published in
BMC Psychiatry / Issue 1/2019
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-018-1992-4

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