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BMC Psychiatry
Published in: BMC Psychiatry 1/2018

Open Access 01-12-2018 | Research article

Abnormal resting state activity of left middle occipital gyrus and its functional connectivity in female patients with major depressive disorder

Authors: Changjun Teng, Jing Zhou, Hui Ma, Yarong Tan, Xin Wu, Chengbin Guan, Huifen Qiao, Jijun Li, Yuan Zhong, Chun Wang, Ning Zhang

Published in: BMC Psychiatry | Issue 1/2018

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Abstract

Background

Women are more susceptible to major depressive disorder (MDD). A possible explanation is that women have a trait tendency to engage in a ruminative response style. Depending on cognitive model of depression, attention bias, memory bias and self-referential bias were closely related among depressed patients. Previous studies have explored the neural mechanism of the cognitive biases by using amplitude of low frequency fluctuations (ALFF) or functional connectivity (FC), and few combined these two metrics, especially focusing on female patients.

Methods

We assessed 25 female patients diagnosed with MDD and 13 well matched healthy controls (HCs) using Rs-fMRI. Two metrics ALFF and FC based on abnormal ALFF were explored and made comparisons.

Results

Compared with HCs, female patients with MDD showed that one cluster with significantly decreased ALFF in the left middle occipital gyrus(L-MOG). Furtherly we founded depressed female subjects showed significantly lower FC between the L-MOG seed and left orbitofrontal cortex, and significantly higher FC between the L-MOG seed and left medial prefrontal gyrus and left hippocampus.

Conclusions

Our results showed L-MOG may act as a connection, which involved in the processing of cognitive biases of MDD by connected with limbic-cortical regions in resting state. These findings may enhance the understanding of the neurobiological mechanism in female patients with MDD.
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Metadata
Title
Abnormal resting state activity of left middle occipital gyrus and its functional connectivity in female patients with major depressive disorder
Authors
Changjun Teng
Jing Zhou
Hui Ma
Yarong Tan
Xin Wu
Chengbin Guan
Huifen Qiao
Jijun Li
Yuan Zhong
Chun Wang
Ning Zhang
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2018
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-018-1955-9

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