Skip to main content
Top
Published in: BMC Psychiatry 1/2018

Open Access 01-12-2018 | Research article

Functional recovery in patients with schizophrenia: recommendations from a panel of experts

Authors: Guillermo Lahera, José L. Gálvez, Pedro Sánchez, Miguel Martínez-Roig, J. V. Pérez-Fuster, Paz García-Portilla, Berta Herrera, Miquel Roca

Published in: BMC Psychiatry | Issue 1/2018

Login to get access

Abstract

Background

The management of schizophrenia is evolving towards a more comprehensive model based on functional recovery. The concept of functional recovery goes beyond clinical remission and encompasses multiple aspects of the patient’s life, making it difficult to settle on a definition and to develop reliable assessment criteria. In this consensus process based on a panel of experts in schizophrenia, we aimed to provide useful insights on functional recovery and its involvement in clinical practice and clinical research.

Methods

After a literature review of functional recovery in schizophrenia, a scientific committee of 8 members prepared a 75-item questionnaire, including 6 sections: (I) the concept of functional recovery (9 items), (II) assessment of functional recovery (23 items), (III) factors influencing functional recovery (16 items), (IV) psychosocial interventions and functional recovery (8 items), (V) pharmacological treatment and functional recovery (14 items), and (VI) the perspective of patients and their relatives on functional recovery (5 items). The questionnaire was sent to a panel of 53 experts, who rated each item on a 9-point Likert scale. Consensus was achieved in a 2-round Delphi dynamics, using the median (interquartile range) scores to consider consensus in either agreement (scores 7–9) or disagreement (scores 1–3). Items not achieving consensus in the first round were sent back to the experts for a second consideration.

Results

After the two recursive rounds, consensus was achieved in 64 items (85.3%): 61 items (81.3%) in agreement and 3 (4.0%) in disagreement, all of them from section II (assessment of functional recovery). Items not reaching consensus were related to the concepts of functional recovery (1 item, 1.3%), functional assessment (5 items, 6.7%), factors influencing functional recovery (3 items, 4.0%), and psychosocial interventions (2 items, 5.6%).

Conclusions

Despite the lack of a well-defined concept of functional recovery, we identified a trend towards a common archetype of the definition and factors associated with functional recovery, as well as its applicability in clinical practice and clinical research.
Appendix
Available only for authorised users
Literature
2.
go back to reference Bellack AS. Scientific and consumer models of recovery in schizophrenia: concordance, contrasts. and implications Schizophr Bull. 2006;32:432–42.CrossRef Bellack AS. Scientific and consumer models of recovery in schizophrenia: concordance, contrasts. and implications Schizophr Bull. 2006;32:432–42.CrossRef
4.
go back to reference Harvey PD, Bellack AS. Toward a terminology for functional recovery in schizophrenia: is functional remission a viable concept? Schizophr Bull. 2009;35:300–6.CrossRefPubMedCentralPubMed Harvey PD, Bellack AS. Toward a terminology for functional recovery in schizophrenia: is functional remission a viable concept? Schizophr Bull. 2009;35:300–6.CrossRefPubMedCentralPubMed
5.
7.
go back to reference Lieberman JA, Drake RE, Sederer LI, Belger A, Keefe R, Perkins D, et al. Science and recovery in schizophrenia. Psychiatr Serv. 2008;59:487–96.CrossRef Lieberman JA, Drake RE, Sederer LI, Belger A, Keefe R, Perkins D, et al. Science and recovery in schizophrenia. Psychiatr Serv. 2008;59:487–96.CrossRef
8.
go back to reference Slade M, Schrank B. Recovery in psychiatry. Psychiatr Bull. 2007;31:321–5.CrossRef Slade M, Schrank B. Recovery in psychiatry. Psychiatr Bull. 2007;31:321–5.CrossRef
9.
go back to reference Crespo-Facorro B, Bernardo M, Argimon JM, Arrojo M, Bravo-Ortiz MF, Cabrera-Cifuentes A, et al. Effectiveness, efficiency and efficacy in the multidimensional treatment of schizophrenia: rethinking project [article in Spanish]. Rev Psiquiatr Salud Ment. 2017;10:4–20.CrossRef Crespo-Facorro B, Bernardo M, Argimon JM, Arrojo M, Bravo-Ortiz MF, Cabrera-Cifuentes A, et al. Effectiveness, efficiency and efficacy in the multidimensional treatment of schizophrenia: rethinking project [article in Spanish]. Rev Psiquiatr Salud Ment. 2017;10:4–20.CrossRef
10.
go back to reference Liberman RP, Kopelowicz A, Ventura J, Gutkind D. Operational criteria and factors related to recovery from schizophrenia. Int Rev Psychiatry. 2002;14:256–72.CrossRef Liberman RP, Kopelowicz A, Ventura J, Gutkind D. Operational criteria and factors related to recovery from schizophrenia. Int Rev Psychiatry. 2002;14:256–72.CrossRef
11.
go back to reference Anthony WA. Recovery from mental illness: the guiding vision of the mental health service system in the 1990s. Psychosoc Rehabil J. 1993;16:11. Anthony WA. Recovery from mental illness: the guiding vision of the mental health service system in the 1990s. Psychosoc Rehabil J. 1993;16:11.
12.
go back to reference Liberman RP. Recovery from disability. Man. Psychiatr. Rehabil. Washington: apa; 2008. Liberman RP. Recovery from disability. Man. Psychiatr. Rehabil. Washington: apa; 2008.
13.
go back to reference Menendez-Miranda I, Garcia-Portilla MP, Garcia-Alvarez L, Arrojo M, Sanchez P, Sarramea F, et al. Predictive factors of functional capacity and real-world functioning in patients with schizophrenia. Eur Psychiatry. 2015;30:622–7.CrossRef Menendez-Miranda I, Garcia-Portilla MP, Garcia-Alvarez L, Arrojo M, Sanchez P, Sarramea F, et al. Predictive factors of functional capacity and real-world functioning in patients with schizophrenia. Eur Psychiatry. 2015;30:622–7.CrossRef
14.
go back to reference Harvey PD. Assessment of everyday functioning in schizophrenia: implications for treatments aimed at negative symptoms. Schizophr Res. 2013;150:353–5.CrossRef Harvey PD. Assessment of everyday functioning in schizophrenia: implications for treatments aimed at negative symptoms. Schizophr Res. 2013;150:353–5.CrossRef
15.
go back to reference P a L, Kopelowicz A, Ventura J, Gutkind D. Operational criteria and factors related to recovery from schizophrenia. Int Rev psychiatry. 2002;14:256–72.CrossRef P a L, Kopelowicz A, Ventura J, Gutkind D. Operational criteria and factors related to recovery from schizophrenia. Int Rev psychiatry. 2002;14:256–72.CrossRef
16.
go back to reference Onken SJ, Craig CM, Ridgway P, Ralph RO, Cook JA. An analysis of the definitions and elements of recovery: a review of the literature. Psychiatr. Rehabil. J. 2007;31:9.CrossRef Onken SJ, Craig CM, Ridgway P, Ralph RO, Cook JA. An analysis of the definitions and elements of recovery: a review of the literature. Psychiatr. Rehabil. J. 2007;31:9.CrossRef
17.
go back to reference Peña J, Ibarretxe-Bilbao N, Sánchez P, Iriarte MB, Elizagarate E, Garay MA, et al. Combining social cognitive treatment, cognitive remediation, and functional skills training in schizophrenia: a randomized controlled trial. npj Schizophr. 2016;2:16037.CrossRefPubMedCentralPubMed Peña J, Ibarretxe-Bilbao N, Sánchez P, Iriarte MB, Elizagarate E, Garay MA, et al. Combining social cognitive treatment, cognitive remediation, and functional skills training in schizophrenia: a randomized controlled trial. npj Schizophr. 2016;2:16037.CrossRefPubMedCentralPubMed
18.
go back to reference Bond GR, Drake RE, Becker DR. An update on randomized controlled trials of evidence-based supported employment. Psychiatr. Rehabil. J. 2008;31:280.CrossRef Bond GR, Drake RE, Becker DR. An update on randomized controlled trials of evidence-based supported employment. Psychiatr. Rehabil. J. 2008;31:280.CrossRef
20.
go back to reference Rog DJ. The evidence on supported housing. Psychiatr Rehabil J. 2004;27:334.CrossRef Rog DJ. The evidence on supported housing. Psychiatr Rehabil J. 2004;27:334.CrossRef
21.
go back to reference Tsemberis S, Gulcur L, Nakae M. Housing first, consumer choice, and harm reduction for homeless individuals with a dual diagnosis. Am J Public Health. 2004;94:651–6.CrossRefPubMedCentralPubMed Tsemberis S, Gulcur L, Nakae M. Housing first, consumer choice, and harm reduction for homeless individuals with a dual diagnosis. Am J Public Health. 2004;94:651–6.CrossRefPubMedCentralPubMed
22.
go back to reference Lahera G, Pérez-Fuster V, Gálvez JL, Martínez M, Sánchez P. Roca M. Is it possible to achieve functional recovery in schizophrenia? A qualitative and quantitative analysis of psychiatrist’s opinion. Actas Esp Psiquiatr palabras clave Recuper. Func. Actas Esp Psiquiatr. 2016;4444:97–106. Lahera G, Pérez-Fuster V, Gálvez JL, Martínez M, Sánchez P. Roca M. Is it possible to achieve functional recovery in schizophrenia? A qualitative and quantitative analysis of psychiatrist’s opinion. Actas Esp Psiquiatr palabras clave Recuper. Func. Actas Esp Psiquiatr. 2016;4444:97–106.
23.
go back to reference Green KC, Armstrong JS, Graefe A. Methods to elicit forecasts from groups: Delphi and prediction markets compared. 2007; Green KC, Armstrong JS, Graefe A. Methods to elicit forecasts from groups: Delphi and prediction markets compared. 2007;
24.
go back to reference Rowe G, Wright G. Expert opinions in forecasting: the role of the Delphi technique. In: Principles of forecasting. Boston: Springer; 2001. pp.125–44. Rowe G, Wright G. Expert opinions in forecasting: the role of the Delphi technique. In: Principles of forecasting. Boston: Springer; 2001. pp.125–44.
25.
go back to reference Sinha IP, Smyth RL, Williamson PR. Using the Delphi technique to determine which outcomes to measure in clinical trials: recommendations for the future based on a systematic review of existing studies. PLoS Med. 2011;8:e1000393.CrossRefPubMedCentralPubMed Sinha IP, Smyth RL, Williamson PR. Using the Delphi technique to determine which outcomes to measure in clinical trials: recommendations for the future based on a systematic review of existing studies. PLoS Med. 2011;8:e1000393.CrossRefPubMedCentralPubMed
26.
go back to reference Emsley R, Chiliza B, Asmal L, Lehloenya K. The concepts of remission and recovery in schizophrenia. Curr Opin Psychiatry. 2011;24:114–21. Emsley R, Chiliza B, Asmal L, Lehloenya K. The concepts of remission and recovery in schizophrenia. Curr Opin Psychiatry. 2011;24:114–21.
27.
go back to reference Harrow M, Grossman LS, Jobe TH, Herbener ES. Do patients with schizophrenia ever show periods of recovery? A 15-year multi-follow-up study. Schizophr Bull. 2005;31:723–34.CrossRef Harrow M, Grossman LS, Jobe TH, Herbener ES. Do patients with schizophrenia ever show periods of recovery? A 15-year multi-follow-up study. Schizophr Bull. 2005;31:723–34.CrossRef
28.
go back to reference Browne J, Penn DL, Meyer-Kalos PS, Mueser KT, Estroff SE, Brunette MF, et al. Psychological well-being and mental health recovery in the NIMH RAISE early treatment program. Schizophr Res. 2016;11:174–81. Browne J, Penn DL, Meyer-Kalos PS, Mueser KT, Estroff SE, Brunette MF, et al. Psychological well-being and mental health recovery in the NIMH RAISE early treatment program. Schizophr Res. 2016;11:174–81.
30.
go back to reference Farkas M. The vision of recovery today: what it is and what it means for services. World Psychiatry. 2007;6:4–10. Farkas M. The vision of recovery today: what it is and what it means for services. World Psychiatry. 2007;6:4–10.
31.
go back to reference Sabbag S, Twamley EM, Vella L, Heaton RK, Patterson TL, Harvey PD. Assessing everyday functioning in schizophrenia: not all informants seem equally informative. Schizophr Res. 2011;131:250–5.CrossRefPubMedCentralPubMed Sabbag S, Twamley EM, Vella L, Heaton RK, Patterson TL, Harvey PD. Assessing everyday functioning in schizophrenia: not all informants seem equally informative. Schizophr Res. 2011;131:250–5.CrossRefPubMedCentralPubMed
32.
go back to reference Bowie CR, Twamley EW, Anderson H, Halpern B, Patterson TL, Harvey PD. Self-assessment of functional status in schizophrenia. J Psychiatr Res. 2007;41:1012–8.CrossRef Bowie CR, Twamley EW, Anderson H, Halpern B, Patterson TL, Harvey PD. Self-assessment of functional status in schizophrenia. J Psychiatr Res. 2007;41:1012–8.CrossRef
33.
go back to reference Harvey PD, Sabbag S, Prestia D, Durand D, Twamley EW, Patterson TL. Functional milestones and clinician ratings of everyday functioning in people with schizophrenia: overlap between milestones and specificity of ratings. J Psychiatr Res. 2012;46:1546–52.CrossRefPubMedCentralPubMed Harvey PD, Sabbag S, Prestia D, Durand D, Twamley EW, Patterson TL. Functional milestones and clinician ratings of everyday functioning in people with schizophrenia: overlap between milestones and specificity of ratings. J Psychiatr Res. 2012;46:1546–52.CrossRefPubMedCentralPubMed
34.
go back to reference Leifker FR, Bowie CR, Harvey PD. Determinants of everyday outcomes in schizophrenia: the influences of cognitive impairment, functional capacity, and symptoms. Schizophr Res. 2009;115:82–7.CrossRef Leifker FR, Bowie CR, Harvey PD. Determinants of everyday outcomes in schizophrenia: the influences of cognitive impairment, functional capacity, and symptoms. Schizophr Res. 2009;115:82–7.CrossRef
35.
go back to reference McKibbin C, Patterson TL, Jeste DV. Assessing disability in older patients with schizophrenia. Results From the WHODAS-II J Nerv Ment Dis. 2004;192:405–13.CrossRef McKibbin C, Patterson TL, Jeste DV. Assessing disability in older patients with schizophrenia. Results From the WHODAS-II J Nerv Ment Dis. 2004;192:405–13.CrossRef
36.
go back to reference Strauss JS, Breier A. The Vermont longitudinal study of persons with severe mental illness, I: methodology, study sample, and overall status 32 years later. Am J Psychiatry. 1987;144:718–26.CrossRef Strauss JS, Breier A. The Vermont longitudinal study of persons with severe mental illness, I: methodology, study sample, and overall status 32 years later. Am J Psychiatry. 1987;144:718–26.CrossRef
37.
go back to reference Torgalsbøen A-K, Rund BR. Lessons learned from three studies of recovery from schizophrenia. Int. Rev. Psychiatry. 2002;14:312–7.CrossRef Torgalsbøen A-K, Rund BR. Lessons learned from three studies of recovery from schizophrenia. Int. Rev. Psychiatry. 2002;14:312–7.CrossRef
38.
go back to reference Giraud-Baro E, Dassa D, De Vathaire F, Garay RP, Obeid J. Schizophrenia-spectrum patients treated with long-acting injectable risperidone in real-life clinical settings: functional recovery in remitted versus stable, non-remitted patients (the EVeREST prospective observational cohort study). BMC Psychiatry. 2016;16:8.CrossRefPubMedCentralPubMed Giraud-Baro E, Dassa D, De Vathaire F, Garay RP, Obeid J. Schizophrenia-spectrum patients treated with long-acting injectable risperidone in real-life clinical settings: functional recovery in remitted versus stable, non-remitted patients (the EVeREST prospective observational cohort study). BMC Psychiatry. 2016;16:8.CrossRefPubMedCentralPubMed
39.
go back to reference Hopper K, Wanderling J. Revisiting the developed versus developing country distinction in course and outcome in schizophrenia: results from ISoS, the WHO collaborative followup project. Schizophr Bull. 2000;26:835–46.CrossRef Hopper K, Wanderling J. Revisiting the developed versus developing country distinction in course and outcome in schizophrenia: results from ISoS, the WHO collaborative followup project. Schizophr Bull. 2000;26:835–46.CrossRef
40.
go back to reference Bowie CR, Reichenberg A, Patterson TL, Heaton RK, Harvey PD. Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms. Am J Psychiatry. 2006;163:418–25.CrossRef Bowie CR, Reichenberg A, Patterson TL, Heaton RK, Harvey PD. Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms. Am J Psychiatry. 2006;163:418–25.CrossRef
41.
go back to reference Robinson DG, Woerner MG, McMeniman M, Mendelowitz A, Bilder RM. Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry. 2004;161:473–9.CrossRef Robinson DG, Woerner MG, McMeniman M, Mendelowitz A, Bilder RM. Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry. 2004;161:473–9.CrossRef
42.
go back to reference Remington G, Foussias G, Fervaha G, Agid O, Takeuchi H, Lee J, et al. Treating negative symptoms in schizophrenia: an update. Curr Treat Options Psychiatry. 2016;3:133–50.CrossRefPubMedCentralPubMed Remington G, Foussias G, Fervaha G, Agid O, Takeuchi H, Lee J, et al. Treating negative symptoms in schizophrenia: an update. Curr Treat Options Psychiatry. 2016;3:133–50.CrossRefPubMedCentralPubMed
43.
go back to reference Link BG, Struening EL, Neese-Todd S, Asmussen S, Phelan JC. Stigma as a barrier to recovery: the consequences of stigma for the self-esteem of people with mental illnesses. Psychiatr Serv. 2001;52:1621–6.CrossRef Link BG, Struening EL, Neese-Todd S, Asmussen S, Phelan JC. Stigma as a barrier to recovery: the consequences of stigma for the self-esteem of people with mental illnesses. Psychiatr Serv. 2001;52:1621–6.CrossRef
44.
go back to reference Pattyn E, Verhaeghe M, Sercu C, Bracke P. Public stigma and sell-stigma: differential association with attitudes toward formal and informal help seeking. Psychiatr Serv. 2014;65:232–8.CrossRef Pattyn E, Verhaeghe M, Sercu C, Bracke P. Public stigma and sell-stigma: differential association with attitudes toward formal and informal help seeking. Psychiatr Serv. 2014;65:232–8.CrossRef
45.
go back to reference Sánchez P, Peña J, Bengoetxea E, Ojeda N, Elizagárate E, Ezcurra J, et al. Improvements in negative symptoms and functional outcome after a new generation cognitive remediation program: a randomized controlled trial. Schizophr Bull. 2014;40:707–15.CrossRef Sánchez P, Peña J, Bengoetxea E, Ojeda N, Elizagárate E, Ezcurra J, et al. Improvements in negative symptoms and functional outcome after a new generation cognitive remediation program: a randomized controlled trial. Schizophr Bull. 2014;40:707–15.CrossRef
46.
go back to reference Marder SR, Lebell M, Zimmerman K, Liberman RP. Two-year outcome of social skills training and group psychotherapy for outpatients with schizophrenia. Age. 1996;38:37–9. Marder SR, Lebell M, Zimmerman K, Liberman RP. Two-year outcome of social skills training and group psychotherapy for outpatients with schizophrenia. Age. 1996;38:37–9.
47.
go back to reference Glynn SM, Marder SR, Liberman RP, Blair K, Wirshing WC, Wirshing DA, et al. Supplementing clinic-based skills training with manual-based community support sessions: effects on social adjustment of patients with schizophrenia. Am J Psychiatry. 2002;159:829–37.CrossRef Glynn SM, Marder SR, Liberman RP, Blair K, Wirshing WC, Wirshing DA, et al. Supplementing clinic-based skills training with manual-based community support sessions: effects on social adjustment of patients with schizophrenia. Am J Psychiatry. 2002;159:829–37.CrossRef
48.
go back to reference Nowak I, Sabariego C, Świtaj P, Anczewska M. Disability and recovery in schizophrenia: a systematic review of cognitive behavioral therapy interventions. BMC Psychiatry. 2016;16:228.CrossRefPubMedCentralPubMed Nowak I, Sabariego C, Świtaj P, Anczewska M. Disability and recovery in schizophrenia: a systematic review of cognitive behavioral therapy interventions. BMC Psychiatry. 2016;16:228.CrossRefPubMedCentralPubMed
49.
go back to reference Färdig R, Fredriksson A, Lewander T, Melin L, Mueser KT. Neurocognitive functioning and outcome of the illness management and recovery program for clients with schizophrenia and schizoaffective disorder. Nord J Psychiatry. 2016;70:430–5.CrossRef Färdig R, Fredriksson A, Lewander T, Melin L, Mueser KT. Neurocognitive functioning and outcome of the illness management and recovery program for clients with schizophrenia and schizoaffective disorder. Nord J Psychiatry. 2016;70:430–5.CrossRef
50.
go back to reference Wunderink L, Nieboer RM, Wiersma D, Sytema S, Nienhuis FJ. Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction/discontinuation or maintenance treatment strategy long-term follow-up of a 2-year randomized clinical trial. JAMA Psychiatry. 2013;70:913–20.CrossRef Wunderink L, Nieboer RM, Wiersma D, Sytema S, Nienhuis FJ. Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction/discontinuation or maintenance treatment strategy long-term follow-up of a 2-year randomized clinical trial. JAMA Psychiatry. 2013;70:913–20.CrossRef
51.
go back to reference Undurraga J, Murru A, Vieta E. Early medication discontinuation on long-term recovery outcome in first-episode psychosis. JAMA Psychiatry. 2014;71:206–7.CrossRef Undurraga J, Murru A, Vieta E. Early medication discontinuation on long-term recovery outcome in first-episode psychosis. JAMA Psychiatry. 2014;71:206–7.CrossRef
52.
go back to reference Rosenheck R, Tekell J, Peters J, Cramer J, Fontana A, Xu W, et al. Does participation in psychosocial treatment augment the benefit of clozapine? Department of Veterans Affairs Cooperative Study Group on clozapine in refractory schizophrenia. Arch Gen Psychiatry. 1998;55:618–25. Rosenheck R, Tekell J, Peters J, Cramer J, Fontana A, Xu W, et al. Does participation in psychosocial treatment augment the benefit of clozapine? Department of Veterans Affairs Cooperative Study Group on clozapine in refractory schizophrenia. Arch Gen Psychiatry. 1998;55:618–25.
53.
go back to reference Schooler NR, Keith SJ, Severe JB, Matthews SM. Maintenance treatment of schizophrenia: a review of dose reduction and family treatment strategies. Psychiatr Q. 1995;66:279–92.CrossRef Schooler NR, Keith SJ, Severe JB, Matthews SM. Maintenance treatment of schizophrenia: a review of dose reduction and family treatment strategies. Psychiatr Q. 1995;66:279–92.CrossRef
54.
go back to reference Schooler NR, Keith SJ, Severe JB, Matthews SM, Bellack AS, Glick ID, et al. Relapse and rehospitalization during maintenance treatment of schizophrenia. The effects of dose reduction and family treatment. Arch Gen Psychiatry. 1997;54:453–63.CrossRef Schooler NR, Keith SJ, Severe JB, Matthews SM, Bellack AS, Glick ID, et al. Relapse and rehospitalization during maintenance treatment of schizophrenia. The effects of dose reduction and family treatment. Arch Gen Psychiatry. 1997;54:453–63.CrossRef
55.
go back to reference Crespo-Facorro B, Roiz-Santiáñez R, Pérez-Iglesias R, Pelayo-Terán JM, Rodríguez-Sánchez JM, Tordesillas-Gutiérrez D, et al. Effect of antipsychotic drugs on brain morphometry. Prog Neuro-Psychopharmacology Biol Psychiatry. 2008;32:1936–43.CrossRef Crespo-Facorro B, Roiz-Santiáñez R, Pérez-Iglesias R, Pelayo-Terán JM, Rodríguez-Sánchez JM, Tordesillas-Gutiérrez D, et al. Effect of antipsychotic drugs on brain morphometry. Prog Neuro-Psychopharmacology Biol Psychiatry. 2008;32:1936–43.CrossRef
56.
go back to reference Lieberman JA, Tollefson GD, Charles C, Zipursky R, Sharma T, Kahn RS, et al. Antipsychotic drug effects on brain morphology in first-episode psychosis. Arch Gen Psychiatry. 2005;62:361.CrossRef Lieberman JA, Tollefson GD, Charles C, Zipursky R, Sharma T, Kahn RS, et al. Antipsychotic drug effects on brain morphology in first-episode psychosis. Arch Gen Psychiatry. 2005;62:361.CrossRef
57.
go back to reference Koshikawa Y, Takekita Y, Kato M, Sakai S, Onohara A, Sunada N, et al. The comparative effects of risperidone long-acting injection and paliperidone palmitate on social functioning in schizophrenia: a 6-month, open-label, randomized controlled pilot trial. Neuropsychobiology. 2016;73:35–42.CrossRef Koshikawa Y, Takekita Y, Kato M, Sakai S, Onohara A, Sunada N, et al. The comparative effects of risperidone long-acting injection and paliperidone palmitate on social functioning in schizophrenia: a 6-month, open-label, randomized controlled pilot trial. Neuropsychobiology. 2016;73:35–42.CrossRef
58.
go back to reference Pandina G, Bilder R, Turkoz I, Alphs L. Identification of clinically meaningful relationships among cognition, functionality, and symptoms in subjects with schizophrenia or schizoaffective disorder. Schizophr Res. 2013;143:312–8.CrossRef Pandina G, Bilder R, Turkoz I, Alphs L. Identification of clinically meaningful relationships among cognition, functionality, and symptoms in subjects with schizophrenia or schizoaffective disorder. Schizophr Res. 2013;143:312–8.CrossRef
59.
go back to reference Correll CU, Leucht S, Kane JM. Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies. Am J Psychiatry. 2004;161:414–25.CrossRef Correll CU, Leucht S, Kane JM. Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies. Am J Psychiatry. 2004;161:414–25.CrossRef
60.
go back to reference Leucht S, Pitschel-Walz G, Abraham D, Kissling W. Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials. Schizophr Res. 1999;35:51–68.CrossRef Leucht S, Pitschel-Walz G, Abraham D, Kissling W. Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials. Schizophr Res. 1999;35:51–68.CrossRef
61.
go back to reference Leucht S, Corves C, Arbter D, Engel RR, Li C, Davis JM. Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet. 2009;373:31–41.CrossRef Leucht S, Corves C, Arbter D, Engel RR, Li C, Davis JM. Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet. 2009;373:31–41.CrossRef
Metadata
Title
Functional recovery in patients with schizophrenia: recommendations from a panel of experts
Authors
Guillermo Lahera
José L. Gálvez
Pedro Sánchez
Miguel Martínez-Roig
J. V. Pérez-Fuster
Paz García-Portilla
Berta Herrera
Miquel Roca
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2018
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-018-1755-2

Other articles of this Issue 1/2018

BMC Psychiatry 1/2018 Go to the issue