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Published in: BMC Psychiatry 1/2017

Open Access 01-12-2017 | Review

Adult ADHD and comorbid disorders: clinical implications of a dimensional approach

Authors: Martin A. Katzman, Timothy S. Bilkey, Pratap R. Chokka, Angelo Fallu, Larry J Klassen

Published in: BMC Psychiatry | Issue 1/2017

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Abstract

Attention-deficit/hyperactivity disorder (ADHD) in the adult population is frequently associated with comorbid psychiatric diseases that complicate its recognition, diagnosis and management.
The prevalence of ADHD in the general adult population is 2.5% and it is associated with substantial personal and individual burden. The most frequent comorbid psychopathologies include mood and anxiety disorders, substance use disorders, and personality disorders. There are strong familial links and neurobiological similarities between ADHD and the various associated psychiatric comorbidities. The overlapping symptoms between ADHD and comorbid psychopathologies represent challenges for diagnosis and treatment. Guidelines recommend that when ADHD coexists with other psychopathologies in adults, the most impairing condition should generally be treated first.
Early recognition and treatment of ADHD and its comorbidities has the potential to change the trajectory of psychiatric morbidity later in life. The use of validated assessment scales and high-yield clinical questions can help identify adults with ADHD who could potentially benefit from evidence-based management strategies.
Literature
1.
go back to reference Lange KW, Reichl S, Lange KM, Tucha L, Tucha O. The history of attention deficit hyperactivity disorder. Atten Defic Hyperact Disord. 2010;2(4):241–55.PubMedPubMedCentralCrossRef Lange KW, Reichl S, Lange KM, Tucha L, Tucha O. The history of attention deficit hyperactivity disorder. Atten Defic Hyperact Disord. 2010;2(4):241–55.PubMedPubMedCentralCrossRef
2.
go back to reference American Psychiatric Association. Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: 1994. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: 1994.
3.
go back to reference Heidbreder R. ADHD symptomatology is best conceptualized as a spectrum: a dimensional versus unitary approach to diagnosis. ADHD Atten Def Hyp Disord. 2015;7:249–69.CrossRef Heidbreder R. ADHD symptomatology is best conceptualized as a spectrum: a dimensional versus unitary approach to diagnosis. ADHD Atten Def Hyp Disord. 2015;7:249–69.CrossRef
4.
go back to reference Torgersen T, Gjervan B, Rasmussen K. ADHD in adults: a study of clinical characteristics, impairment and comorbidity. Nord J Psychiatry. 2006;60(1):38–43.PubMedCrossRef Torgersen T, Gjervan B, Rasmussen K. ADHD in adults: a study of clinical characteristics, impairment and comorbidity. Nord J Psychiatry. 2006;60(1):38–43.PubMedCrossRef
5.
go back to reference Sobanski E, Bruggemann D, Alm B, Kern S, Deschner M, Schubert T, et al. Psychiatric comorbidity and functional impairment in a clinically referred sample of adults with attention-deficit/hyperactivity disorder (ADHD). Eur Arch Psychiatry Clin Neurosci. 2007;257(7):371–7.PubMedCrossRef Sobanski E, Bruggemann D, Alm B, Kern S, Deschner M, Schubert T, et al. Psychiatric comorbidity and functional impairment in a clinically referred sample of adults with attention-deficit/hyperactivity disorder (ADHD). Eur Arch Psychiatry Clin Neurosci. 2007;257(7):371–7.PubMedCrossRef
6.
go back to reference Katzman MA, Bilkey T, Chokka P, Fallu A, Klassen L. Re: is adult attention-deficit/hyperactivity disorder being overdiagnosed? Can J Psychiatr 2016;61(1):60–1. Katzman MA, Bilkey T, Chokka P, Fallu A, Klassen L. Re: is adult attention-deficit/hyperactivity disorder being overdiagnosed? Can J Psychiatr 2016;61(1):60–1.
7.
go back to reference Biederman J, Monuteaux MC, Spencer T, Wilens TE, Faraone SV. Do stimulants protect against psychiatric disorders in youth with ADHD? A 10-year follow-up study. Pediatrics. 2009;124(1):71–8.PubMedPubMedCentralCrossRef Biederman J, Monuteaux MC, Spencer T, Wilens TE, Faraone SV. Do stimulants protect against psychiatric disorders in youth with ADHD? A 10-year follow-up study. Pediatrics. 2009;124(1):71–8.PubMedPubMedCentralCrossRef
8.
go back to reference Biederman J, Wilens T, Mick E, Spencer T, Faraone SV. Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder. Pediatrics. 1999;104(2):e20.PubMedCrossRef Biederman J, Wilens T, Mick E, Spencer T, Faraone SV. Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder. Pediatrics. 1999;104(2):e20.PubMedCrossRef
9.
go back to reference Spencer TJ, Biederman J, Mick E. Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology. J Pediatr Psychol. 2007;32(6):631–42.PubMedCrossRef Spencer TJ, Biederman J, Mick E. Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology. J Pediatr Psychol. 2007;32(6):631–42.PubMedCrossRef
10.
go back to reference Faraone SV, Biederman J, Mick E. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med. 2006;36(2):159–65.PubMedCrossRef Faraone SV, Biederman J, Mick E. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med. 2006;36(2):159–65.PubMedCrossRef
11.
go back to reference Caye A, Rocha TB, Anselmi L, Murray J, Menezes AM, Barros FC, et al. Attention-deficit/hyperactivity disorder trajectories from childhood to young adulthood: evidence from a birth cohort supporting a late-onset syndrome. JAMA Psychiatry. 2016;73(7):705–12.PubMedCrossRef Caye A, Rocha TB, Anselmi L, Murray J, Menezes AM, Barros FC, et al. Attention-deficit/hyperactivity disorder trajectories from childhood to young adulthood: evidence from a birth cohort supporting a late-onset syndrome. JAMA Psychiatry. 2016;73(7):705–12.PubMedCrossRef
12.
go back to reference Moffitt TE, Houts R, Asherson P, Belsky DW, Corcoran DL, Hammerle M, et al. Is adult ADHD a childhood-onset neurodevelopmental disorder? Evidence from a four-decade longitudinal cohort study. Am J Psychiatry. 2015;172(10):967–77.PubMedPubMedCentralCrossRef Moffitt TE, Houts R, Asherson P, Belsky DW, Corcoran DL, Hammerle M, et al. Is adult ADHD a childhood-onset neurodevelopmental disorder? Evidence from a four-decade longitudinal cohort study. Am J Psychiatry. 2015;172(10):967–77.PubMedPubMedCentralCrossRef
13.
go back to reference Agnew-Blais JC, Polanczyk GV, Danese A, Wertz J, Moffitt TE, Arseneault L. Evaluation of the persistence, remission, and emergence of attention-deficit/hyperactivity disorder in young adulthood. JAMA Psychiatry. 2016;73(7):713–20.PubMedPubMedCentralCrossRef Agnew-Blais JC, Polanczyk GV, Danese A, Wertz J, Moffitt TE, Arseneault L. Evaluation of the persistence, remission, and emergence of attention-deficit/hyperactivity disorder in young adulthood. JAMA Psychiatry. 2016;73(7):713–20.PubMedPubMedCentralCrossRef
14.
go back to reference Simon V, Czobor P, Bálint S, Mészáros A, Bitter I. Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry. 2009;194(3):204–11.PubMedCrossRef Simon V, Czobor P, Bálint S, Mészáros A, Bitter I. Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry. 2009;194(3):204–11.PubMedCrossRef
15.
go back to reference American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: 2013. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: 2013.
16.
go back to reference Bond DJ, Hadjipavlou G, Lam RW, McIntyre RS, Beaulieu S, Schaffer A, et al. The Canadian network for mood and anxiety treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid attention-deficit/hyperactivity disorder. Ann Clin Psychiatry. 2012;24(1):23–37.PubMed Bond DJ, Hadjipavlou G, Lam RW, McIntyre RS, Beaulieu S, Schaffer A, et al. The Canadian network for mood and anxiety treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid attention-deficit/hyperactivity disorder. Ann Clin Psychiatry. 2012;24(1):23–37.PubMed
17.
go back to reference Klassen LJ, Katzman MA, Chokka P. Adult ADHD and its comorbidities, with a focus on bipolar disorder. J Affect Disord. 2010;124(1–2):1–8.PubMedCrossRef Klassen LJ, Katzman MA, Chokka P. Adult ADHD and its comorbidities, with a focus on bipolar disorder. J Affect Disord. 2010;124(1–2):1–8.PubMedCrossRef
18.
go back to reference Ginsberg Y, Quintero J, Anand E, Casillas M, Upadhyaya HP. Underdiagnosis of attention-deficit/hyperactivity disorder in adult patients: a review of the literature. Prim Care Companion CNS Disord. 2014;16(3). Ginsberg Y, Quintero J, Anand E, Casillas M, Upadhyaya HP. Underdiagnosis of attention-deficit/hyperactivity disorder in adult patients: a review of the literature. Prim Care Companion CNS Disord. 2014;16(3).
19.
go back to reference Gershon J. A meta-analytic review of gender differences in ADHD. J Atten Disord. 2002;5(3):143–54.PubMedCrossRef Gershon J. A meta-analytic review of gender differences in ADHD. J Atten Disord. 2002;5(3):143–54.PubMedCrossRef
20.
go back to reference Waite R. Women and attention deficit disorders: a great burden overlooked. J Am Acad Nurse Pract. 2007;19(3):116–25.PubMedCrossRef Waite R. Women and attention deficit disorders: a great burden overlooked. J Am Acad Nurse Pract. 2007;19(3):116–25.PubMedCrossRef
21.
go back to reference Bálint S, Czobor P, Komlósi S, Mészáros A, Simon V, Bitter I. Attention deficit hyperactivity disorder (ADHD): gender-and age-related differences in neurocognition. Psychol Med. 2009;39(8):1337–45.PubMedCrossRef Bálint S, Czobor P, Komlósi S, Mészáros A, Simon V, Bitter I. Attention deficit hyperactivity disorder (ADHD): gender-and age-related differences in neurocognition. Psychol Med. 2009;39(8):1337–45.PubMedCrossRef
22.
go back to reference Ossmann JM, Mulligan NW. Inhibition and attention deficit hyperactivity disorder in adults. Am J Psychol. 2003;116(1):35–50.PubMedCrossRef Ossmann JM, Mulligan NW. Inhibition and attention deficit hyperactivity disorder in adults. Am J Psychol. 2003;116(1):35–50.PubMedCrossRef
23.
go back to reference Boonstra AM, Oosterlaan J, Sergeant JA, Buitelaar JK. Executive functioning in adult ADHD: a meta-analytic review. Psychol Med. 2005;35(8):1097–108.PubMedCrossRef Boonstra AM, Oosterlaan J, Sergeant JA, Buitelaar JK. Executive functioning in adult ADHD: a meta-analytic review. Psychol Med. 2005;35(8):1097–108.PubMedCrossRef
24.
go back to reference Spencer TJ, Adler LA, Weisler RH, Youcha SH. Triple-bead mixed amphetamine salts (SPD465), a novel, enhanced extended-release amphetamine formulation for the treatment of adults with ADHD: a randomized, double-blind, multicenter, placebo-controlled study. J Clin Psychiatry. 2008;69(9):1437–48.PubMedCrossRef Spencer TJ, Adler LA, Weisler RH, Youcha SH. Triple-bead mixed amphetamine salts (SPD465), a novel, enhanced extended-release amphetamine formulation for the treatment of adults with ADHD: a randomized, double-blind, multicenter, placebo-controlled study. J Clin Psychiatry. 2008;69(9):1437–48.PubMedCrossRef
25.
go back to reference Mowinckel AM, Pedersen ML, Eilertsen E, Biele G. A meta-analysis of decision-making and attention in adults with ADHD. J Atten Disord. 2015;19(5):355–67.PubMedCrossRef Mowinckel AM, Pedersen ML, Eilertsen E, Biele G. A meta-analysis of decision-making and attention in adults with ADHD. J Atten Disord. 2015;19(5):355–67.PubMedCrossRef
26.
go back to reference Retz W, Stieglitz RD, Corbisiero S, Retz-Junginger P, Rösler M. Emotional dysregulation in adult ADHD: what is the empirical evidence? Expert Rev Neurother. 2012;12(10):1241–51.PubMedCrossRef Retz W, Stieglitz RD, Corbisiero S, Retz-Junginger P, Rösler M. Emotional dysregulation in adult ADHD: what is the empirical evidence? Expert Rev Neurother. 2012;12(10):1241–51.PubMedCrossRef
27.
go back to reference Das D, Cherbuin N, Butterworth P, Anstey KJ, Easteal S. A population-based study of attention deficit/hyperactivity disorder symptoms and associated impairment in middle-aged adults. PLoS One. 2012;7(2):e31500.PubMedPubMedCentralCrossRef Das D, Cherbuin N, Butterworth P, Anstey KJ, Easteal S. A population-based study of attention deficit/hyperactivity disorder symptoms and associated impairment in middle-aged adults. PLoS One. 2012;7(2):e31500.PubMedPubMedCentralCrossRef
28.
go back to reference Kirono E, Imagawa H, Goto T, Montgomery W. Sociodemographics, comorbidities, healthcare utilization and work productivity in Japanese patients with adult ADHD. PLoS One. 2015;10(7):e0132233.CrossRef Kirono E, Imagawa H, Goto T, Montgomery W. Sociodemographics, comorbidities, healthcare utilization and work productivity in Japanese patients with adult ADHD. PLoS One. 2015;10(7):e0132233.CrossRef
29.
go back to reference Biederman J, Faraone SV, Spencer TJ, Mick E, Monuteaux MC, Aleardi M. Functional impairments in adults with self-reports of diagnosed ADHD: a controlled study of 1001 adults in the community. J Clin Psychiatry. 2006;67(4):524–40.PubMedCrossRef Biederman J, Faraone SV, Spencer TJ, Mick E, Monuteaux MC, Aleardi M. Functional impairments in adults with self-reports of diagnosed ADHD: a controlled study of 1001 adults in the community. J Clin Psychiatry. 2006;67(4):524–40.PubMedCrossRef
30.
go back to reference Biederman J, Faraone SV, Monuteaux MC, Bober M, Cadogen E. Gender effects on attention-deficit/hyperactivity disorder in adults, revisited. Biol Psychiatry. 2004;55(7):692–700.PubMedCrossRef Biederman J, Faraone SV, Monuteaux MC, Bober M, Cadogen E. Gender effects on attention-deficit/hyperactivity disorder in adults, revisited. Biol Psychiatry. 2004;55(7):692–700.PubMedCrossRef
31.
go back to reference Wilens TE, Dodson W. A clinical perspective of attention-deficit/hyperactivity disorder into adulthood. J Clin Psychiatry. 2004;65(10):1301–13.PubMedCrossRef Wilens TE, Dodson W. A clinical perspective of attention-deficit/hyperactivity disorder into adulthood. J Clin Psychiatry. 2004;65(10):1301–13.PubMedCrossRef
32.
go back to reference DuPaul GJ, Weyandt LL, O'Dell SM, Varejao M. College students with ADHD current status and future directions. J Atten Disord. 2009;13(3):234–50.PubMedCrossRef DuPaul GJ, Weyandt LL, O'Dell SM, Varejao M. College students with ADHD current status and future directions. J Atten Disord. 2009;13(3):234–50.PubMedCrossRef
33.
go back to reference Nadeau KG. Career choices and workplace challenges for individuals with ADHD. J Clin Psychol. 2005;61(5):549–63.PubMedCrossRef Nadeau KG. Career choices and workplace challenges for individuals with ADHD. J Clin Psychol. 2005;61(5):549–63.PubMedCrossRef
34.
go back to reference Biederman J, Faraone SV. The effects of attention-deficit/hyperactivity disorder on employment and household income. MedGenMed. 2006;8(3):12.PubMedPubMedCentral Biederman J, Faraone SV. The effects of attention-deficit/hyperactivity disorder on employment and household income. MedGenMed. 2006;8(3):12.PubMedPubMedCentral
35.
go back to reference Barkley RA, Murphy KR, Dupaul GJ, Bush T. Driving in young adults with attention deficit hyperactivity disorder: knowledge, performance, adverse outcomes, and the role of executive functioning. J Int Neuropsychol Soc. 2002;8(5):655–72.PubMedCrossRef Barkley RA, Murphy KR, Dupaul GJ, Bush T. Driving in young adults with attention deficit hyperactivity disorder: knowledge, performance, adverse outcomes, and the role of executive functioning. J Int Neuropsychol Soc. 2002;8(5):655–72.PubMedCrossRef
36.
go back to reference Dalsgaard S, Østergaard SD, Leckman JF, Mortensen PB, Pedersen MG. Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. Lancet. 2015;385(9983):2190–6.PubMedCrossRef Dalsgaard S, Østergaard SD, Leckman JF, Mortensen PB, Pedersen MG. Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. Lancet. 2015;385(9983):2190–6.PubMedCrossRef
37.
go back to reference Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O, et al. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006;163(4):716–23.PubMedPubMedCentralCrossRef Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O, et al. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006;163(4):716–23.PubMedPubMedCentralCrossRef
38.
go back to reference Doshi JA, Hodgkins P, Kahle J, Sikirica V, Cangelosi MJ, Setyawan J, et al. Economic impact of childhood and adult attention-deficit/hyperactivity disorder in the United States. J Am Acad Child Adolesc Psychiatry. 2012;51:990–1002.PubMedCrossRef Doshi JA, Hodgkins P, Kahle J, Sikirica V, Cangelosi MJ, Setyawan J, et al. Economic impact of childhood and adult attention-deficit/hyperactivity disorder in the United States. J Am Acad Child Adolesc Psychiatry. 2012;51:990–1002.PubMedCrossRef
39.
go back to reference Pratt TC, Cullen FT, Blevins KR, Daigle L. Relationship of attention deficit hyperactivity disorder to crime and delinquency: a meta-analysis. Int J Police Sci Manag. 2002;4:344.CrossRef Pratt TC, Cullen FT, Blevins KR, Daigle L. Relationship of attention deficit hyperactivity disorder to crime and delinquency: a meta-analysis. Int J Police Sci Manag. 2002;4:344.CrossRef
40.
go back to reference Ginsberg Y, Hirvikoski T, Lindefors N. Attention deficit hyperactivity disorder (ADHD) among longer-term prison inmates is a prevalent, persistent and disabling disorder. BMC Psychiatry. 2010;10:112.PubMedPubMedCentralCrossRef Ginsberg Y, Hirvikoski T, Lindefors N. Attention deficit hyperactivity disorder (ADHD) among longer-term prison inmates is a prevalent, persistent and disabling disorder. BMC Psychiatry. 2010;10:112.PubMedPubMedCentralCrossRef
41.
go back to reference Philipsen A, Graf E, Jans T, Matthies S, Borel P, Colla M, et al. A randomized controlled multicenter trial on the multimodal treatment of adult attention-deficit hyperactivity disorder: enrollment and characteristics of the study sample. Atten Defic Hyperact Disord. 2014;6(1):35–47.PubMedCrossRef Philipsen A, Graf E, Jans T, Matthies S, Borel P, Colla M, et al. A randomized controlled multicenter trial on the multimodal treatment of adult attention-deficit hyperactivity disorder: enrollment and characteristics of the study sample. Atten Defic Hyperact Disord. 2014;6(1):35–47.PubMedCrossRef
42.
go back to reference Spencer T, Biederman J, Wilens T, Doyle R, Surman C, Prince J, Mick E, Aleardi M, Herzig K, Faraone S. A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57(5):456–63.PubMedCrossRef Spencer T, Biederman J, Wilens T, Doyle R, Surman C, Prince J, Mick E, Aleardi M, Herzig K, Faraone S. A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57(5):456–63.PubMedCrossRef
43.
go back to reference Martinez-Raga J, Szerman N, Knecht C, de Alvaro R. Attention deficit hyperactivity disorder and dual disorders. Educational needs for an underdiagnosed condition. Int J Adolesc Med Health. 2013;25(3):231–43.PubMedCrossRef Martinez-Raga J, Szerman N, Knecht C, de Alvaro R. Attention deficit hyperactivity disorder and dual disorders. Educational needs for an underdiagnosed condition. Int J Adolesc Med Health. 2013;25(3):231–43.PubMedCrossRef
44.
go back to reference McIntyre RS, Kennedy SH, Soczynska JK, Nguyen HT, Bilkey TS, Woldeyohannes HO, et al. Attention-deficit/hyperactivity disorder in adults with bipolar disorder or major depressive disorder: results from the international mood disorders collaborative project. Prim Care Companion J Clin Psychiatry. 2010;12(3):e1–7. McIntyre RS, Kennedy SH, Soczynska JK, Nguyen HT, Bilkey TS, Woldeyohannes HO, et al. Attention-deficit/hyperactivity disorder in adults with bipolar disorder or major depressive disorder: results from the international mood disorders collaborative project. Prim Care Companion J Clin Psychiatry. 2010;12(3):e1–7.
45.
go back to reference Krause J. SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder. Expert Rev Neurother. 2008;8:611–25.PubMedCrossRef Krause J. SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder. Expert Rev Neurother. 2008;8:611–25.PubMedCrossRef
46.
go back to reference Volkow ND, Wang GJ, Tomasi D, Kollins SH, Wigal TL, Newcorn JH, et al. Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder. J Neurosci. 2012;32(3):841–9.PubMedPubMedCentralCrossRef Volkow ND, Wang GJ, Tomasi D, Kollins SH, Wigal TL, Newcorn JH, et al. Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder. J Neurosci. 2012;32(3):841–9.PubMedPubMedCentralCrossRef
47.
go back to reference Ongur D, Ferry AT, Price JL. Architectonic subdivision of the human orbital and medial prefrontal cortex. J Comp Neurol. 2003;460(3):425–49.PubMedCrossRef Ongur D, Ferry AT, Price JL. Architectonic subdivision of the human orbital and medial prefrontal cortex. J Comp Neurol. 2003;460(3):425–49.PubMedCrossRef
48.
go back to reference Drevets WC, Price JL, Furey ML. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct Funct. 2008;213(1–2):93–118.PubMedPubMedCentralCrossRef Drevets WC, Price JL, Furey ML. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct Funct. 2008;213(1–2):93–118.PubMedPubMedCentralCrossRef
49.
go back to reference Carlson PJ, Singh JB, Zarate CA Jr, Drevets WC, Manji HK. Neural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic agents. NeuroRx. 2006;3(1):22–41.PubMedPubMedCentralCrossRef Carlson PJ, Singh JB, Zarate CA Jr, Drevets WC, Manji HK. Neural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic agents. NeuroRx. 2006;3(1):22–41.PubMedPubMedCentralCrossRef
51.
go back to reference Sternat T, Lodzinski A, Katzman MA. Hedonic tone: a bridge between the psychobiology of depression and its comorbidities. J Depress Anxiety. 2014;3:147. Sternat T, Lodzinski A, Katzman MA. Hedonic tone: a bridge between the psychobiology of depression and its comorbidities. J Depress Anxiety. 2014;3:147.
52.
go back to reference Sternat T, Katzman MA. Neurobiology of hedonic tone: the relationship between treatment-resistant depression, attention deficit/hyperactivity disorder and substance abuse. Neuropsychiatr Dis Treat. 2016;12:2149–64.PubMedPubMedCentralCrossRef Sternat T, Katzman MA. Neurobiology of hedonic tone: the relationship between treatment-resistant depression, attention deficit/hyperactivity disorder and substance abuse. Neuropsychiatr Dis Treat. 2016;12:2149–64.PubMedPubMedCentralCrossRef
53.
go back to reference Admon R, Pizzagalli DA. Dysfunctional reward processing in depression. Curr Opin Psychol. 2015;4:114–8.PubMedCrossRef Admon R, Pizzagalli DA. Dysfunctional reward processing in depression. Curr Opin Psychol. 2015;4:114–8.PubMedCrossRef
54.
go back to reference Sagvolden T, Aase H, Zeiner P, Berger D. Altered reinforcement mechanisms in attention-deficit/hyperactivity disorder. Behav Brain Res. 1998;94(1):61–71.PubMedCrossRef Sagvolden T, Aase H, Zeiner P, Berger D. Altered reinforcement mechanisms in attention-deficit/hyperactivity disorder. Behav Brain Res. 1998;94(1):61–71.PubMedCrossRef
55.
go back to reference Dickstein SG, Bannon K, Castellanos FX, Milham MP. The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis. J Child Psychol Psychiatry. 2006;47(10):1051–62.PubMedCrossRef Dickstein SG, Bannon K, Castellanos FX, Milham MP. The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis. J Child Psychol Psychiatry. 2006;47(10):1051–62.PubMedCrossRef
56.
go back to reference Dunlop BW, Nemeroff CB. The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry. 2007;64(3):327–37.PubMedCrossRef Dunlop BW, Nemeroff CB. The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry. 2007;64(3):327–37.PubMedCrossRef
57.
go back to reference Garnock-Jones KP, Keating GM. Spotlight on atomoxetine in attention-deficit hyperactivity disorder in children and adolescents. CNS Drugs. 2010;24(1):85–8.PubMedCrossRef Garnock-Jones KP, Keating GM. Spotlight on atomoxetine in attention-deficit hyperactivity disorder in children and adolescents. CNS Drugs. 2010;24(1):85–8.PubMedCrossRef
58.
go back to reference Nigg JT, Casey BJ. An integrative theory of attention-deficit/ hyperactivity disorder based on the cognitive and affective neurosciences. Dev Psychopathol. 2005;17(3):785–806.PubMedCrossRef Nigg JT, Casey BJ. An integrative theory of attention-deficit/ hyperactivity disorder based on the cognitive and affective neurosciences. Dev Psychopathol. 2005;17(3):785–806.PubMedCrossRef
59.
go back to reference Sergeant JA, Geurts H, Huijbregts S, Scheres A, Oosterlaan J. The top and the bottom of ADHD: a neuropsychological perspective. Neurosci Biobehav Rev. 2003;27(7):583–92.PubMedCrossRef Sergeant JA, Geurts H, Huijbregts S, Scheres A, Oosterlaan J. The top and the bottom of ADHD: a neuropsychological perspective. Neurosci Biobehav Rev. 2003;27(7):583–92.PubMedCrossRef
60.
go back to reference Kim BN, Lee JS, Cho SC, Lee DS. Methylphenidate increased regional cerebral blood flow in subjects with attention deficit/hyperactivity disorder. Yonsei Med J. 2001;42(1):19–29.PubMedCrossRef Kim BN, Lee JS, Cho SC, Lee DS. Methylphenidate increased regional cerebral blood flow in subjects with attention deficit/hyperactivity disorder. Yonsei Med J. 2001;42(1):19–29.PubMedCrossRef
61.
go back to reference Lee JS, Kim BN, Kang E, Lee DS, Kim YK, Chung JK, et al. Regional cerebral blood flow in children with attention deficit hyperactivity disorder: comparison before and after methylphenidate treatment. Hum Brain Mapp. 2005;24(3):157–64.PubMedCrossRef Lee JS, Kim BN, Kang E, Lee DS, Kim YK, Chung JK, et al. Regional cerebral blood flow in children with attention deficit hyperactivity disorder: comparison before and after methylphenidate treatment. Hum Brain Mapp. 2005;24(3):157–64.PubMedCrossRef
62.
go back to reference Matochik JA, Nordahl TE, Gross M, et al. Effects of acute stimulant medication on cerebral metabolism in adults with hyperactivity. Neuropsychopharmacology. 1993;8(4):377–86.PubMedCrossRef Matochik JA, Nordahl TE, Gross M, et al. Effects of acute stimulant medication on cerebral metabolism in adults with hyperactivity. Neuropsychopharmacology. 1993;8(4):377–86.PubMedCrossRef
63.
go back to reference Matochik JA, Liebenauer LL, King AC, Szymanski HV, Cohen RM, Zametkin AJ. Cerebral glucose metabolism in adults with attention deficit hyperactivity disorder after chronic stimulant treatment. Am J Psychiatry. 1994;151(5):658–64.PubMedCrossRef Matochik JA, Liebenauer LL, King AC, Szymanski HV, Cohen RM, Zametkin AJ. Cerebral glucose metabolism in adults with attention deficit hyperactivity disorder after chronic stimulant treatment. Am J Psychiatry. 1994;151(5):658–64.PubMedCrossRef
64.
go back to reference Vaidya CJ, Austin G, Kirkorian G, Ridlehuber HW, Desmond JE, Glover GH, et al. Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study. Proc Natl Acad Sci U S A. 1998;95(24):14494–9.PubMedPubMedCentralCrossRef Vaidya CJ, Austin G, Kirkorian G, Ridlehuber HW, Desmond JE, Glover GH, et al. Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study. Proc Natl Acad Sci U S A. 1998;95(24):14494–9.PubMedPubMedCentralCrossRef
65.
go back to reference Volkow ND, Wang GJ, Telang F, Fowler JS, Logan J, Jayne M, et al. Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. J Neurosci. 2007;27(46):12700–6.PubMedCrossRef Volkow ND, Wang GJ, Telang F, Fowler JS, Logan J, Jayne M, et al. Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. J Neurosci. 2007;27(46):12700–6.PubMedCrossRef
66.
go back to reference Barkley RA, Brown TE. Unrecognized attention-deficit/hyperactivity disorder in adults presenting with other psychiatric disorders. CNS Spectr. 2008;13(11):977–84.PubMedCrossRef Barkley RA, Brown TE. Unrecognized attention-deficit/hyperactivity disorder in adults presenting with other psychiatric disorders. CNS Spectr. 2008;13(11):977–84.PubMedCrossRef
67.
go back to reference Reimherr FW, Marchant BK, Strong RE, Hedges DW, Adler L, Spencer TJ, et al. Emotional dysregulation in adult ADHD and response to atomoxetine. Biol Psychiatry. 2005;58(2):125–31.PubMedCrossRef Reimherr FW, Marchant BK, Strong RE, Hedges DW, Adler L, Spencer TJ, et al. Emotional dysregulation in adult ADHD and response to atomoxetine. Biol Psychiatry. 2005;58(2):125–31.PubMedCrossRef
68.
go back to reference Rösler M, Retz W, Fischer R, Ose C, Alm B, Deckert J, et al. Twenty-four-week treatment with extended release methylphenidate improves emotional symptoms in adult ADHD. World J Biol Psychiatry. 2010;11(5):709–18.PubMedCrossRef Rösler M, Retz W, Fischer R, Ose C, Alm B, Deckert J, et al. Twenty-four-week treatment with extended release methylphenidate improves emotional symptoms in adult ADHD. World J Biol Psychiatry. 2010;11(5):709–18.PubMedCrossRef
69.
go back to reference McIntosh D, Kutcher S, Binder C, Levitt A, Fallu A, Rosenbluth M. Adult ADHD and comorbid depression: a consensus-derived diagnostic algorithm for ADHD. Neuropsychiatr Dis Treat. 2009;5:137–50.PubMedPubMedCentral McIntosh D, Kutcher S, Binder C, Levitt A, Fallu A, Rosenbluth M. Adult ADHD and comorbid depression: a consensus-derived diagnostic algorithm for ADHD. Neuropsychiatr Dis Treat. 2009;5:137–50.PubMedPubMedCentral
70.
go back to reference Alexander SJ, Harrison AG. Cognitive responses to stress, depression, and anxiety and their relationship to ADHD symptoms in first year psychology students. J Atten Disord. 2013;17(1):29–37.PubMedCrossRef Alexander SJ, Harrison AG. Cognitive responses to stress, depression, and anxiety and their relationship to ADHD symptoms in first year psychology students. J Atten Disord. 2013;17(1):29–37.PubMedCrossRef
71.
go back to reference Kooij SJ, Bejerot S, Blackwell A, Caci H, Casas-Brugué M, Carpentier PJ, et al. European consensus statement on diagnosis and treatment of adult ADHD: the European network adult ADHD. BMC Psychiatry. 2010;10(1):67.PubMedPubMedCentralCrossRef Kooij SJ, Bejerot S, Blackwell A, Caci H, Casas-Brugué M, Carpentier PJ, et al. European consensus statement on diagnosis and treatment of adult ADHD: the European network adult ADHD. BMC Psychiatry. 2010;10(1):67.PubMedPubMedCentralCrossRef
72.
go back to reference Weiss MD, Weiss JR. A guide to the treatment of adults with ADHD. J Clin Psychiatry. 2004;65:27–37.PubMedCrossRef Weiss MD, Weiss JR. A guide to the treatment of adults with ADHD. J Clin Psychiatry. 2004;65:27–37.PubMedCrossRef
73.
go back to reference Paris J, Bhat V, Thombs B. Adult attention-deficit/hyperactivity disorder is being overdiagnosed. Can J Psychiatr. 2016;61(1):62.CrossRef Paris J, Bhat V, Thombs B. Adult attention-deficit/hyperactivity disorder is being overdiagnosed. Can J Psychiatr. 2016;61(1):62.CrossRef
74.
go back to reference Regier DA. Dimensional approaches to psychiatric classification: refining the research agenda for DSM-V: an introduction. Int J Methods Psychiatr Res. 2007;16(S1):S1–5.PubMedCrossRef Regier DA. Dimensional approaches to psychiatric classification: refining the research agenda for DSM-V: an introduction. Int J Methods Psychiatr Res. 2007;16(S1):S1–5.PubMedCrossRef
76.
go back to reference Wingo AP, Ghaemi SN. A systematic review of rates and diagnostic validity of comorbid adult attention-deficit/hyperactivity disorder and bipolar disorder. J Clin Psychiatry. 2007;68(11):1776–84.PubMedCrossRef Wingo AP, Ghaemi SN. A systematic review of rates and diagnostic validity of comorbid adult attention-deficit/hyperactivity disorder and bipolar disorder. J Clin Psychiatry. 2007;68(11):1776–84.PubMedCrossRef
77.
go back to reference Tamam L, Karakus G, Ozpoyraz N. Comorbidity of adult attention-deficit hyperactivity disorder and bipolar disorder: prevalence and clinical correlates. Eur Arch Psychiatry Clin Neurosci. 2008;258(7):385–93.PubMedCrossRef Tamam L, Karakus G, Ozpoyraz N. Comorbidity of adult attention-deficit hyperactivity disorder and bipolar disorder: prevalence and clinical correlates. Eur Arch Psychiatry Clin Neurosci. 2008;258(7):385–93.PubMedCrossRef
78.
go back to reference Nierenberg AA, Miyahara S, Spencer T, Wisniewski SR, Otto MW, Simon N, et al. Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants. Biol Psychiatry. 2005;57(11):1467–73.PubMedCrossRef Nierenberg AA, Miyahara S, Spencer T, Wisniewski SR, Otto MW, Simon N, et al. Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants. Biol Psychiatry. 2005;57(11):1467–73.PubMedCrossRef
79.
go back to reference Carlson PJ, Merlock MC, Suppes T. Adjunctive stimulant use in patients with bipolar disorder: treatment of residual depression and sedation. Bipolar Dis. 2004;6(5):416–20.CrossRef Carlson PJ, Merlock MC, Suppes T. Adjunctive stimulant use in patients with bipolar disorder: treatment of residual depression and sedation. Bipolar Dis. 2004;6(5):416–20.CrossRef
80.
go back to reference Dell’Osso B, Ketter TA. Use of adjunctive stimulants in adult bipolar depression. Int J Neuropsychopharmacol. 2013;16(1):55–68.PubMedCrossRef Dell’Osso B, Ketter TA. Use of adjunctive stimulants in adult bipolar depression. Int J Neuropsychopharmacol. 2013;16(1):55–68.PubMedCrossRef
81.
go back to reference Wingo AP, Ghaemi SN. Frequency of stimulant treatment and of stimulant-associated mania/hypomania in bipolar disorder patients. Psychopharmacol Bull. 2008;41(4):37–47.PubMed Wingo AP, Ghaemi SN. Frequency of stimulant treatment and of stimulant-associated mania/hypomania in bipolar disorder patients. Psychopharmacol Bull. 2008;41(4):37–47.PubMed
82.
go back to reference Sternat T, Mohamed M, Furtado M, et al. SSRI treatment response may predict undetected attention deficit hyperactivity disorder in depressed patients. Presented at the Anxiety and Depression Association of America (ADAA) Conference 2016; 2 April 2016 (Abstract S2–10). Sternat T, Mohamed M, Furtado M, et al. SSRI treatment response may predict undetected attention deficit hyperactivity disorder in depressed patients. Presented at the Anxiety and Depression Association of America (ADAA) Conference 2016; 2 April 2016 (Abstract S2–10).
83.
go back to reference Trivedi MH, Hollander E, Nutt D, Blier P. Clinical evidence and potential neurobiological underpinnings of unresolved symptoms in depression. J Clin Psychiatry. 2008;69(2):246–58.PubMedCrossRef Trivedi MH, Hollander E, Nutt D, Blier P. Clinical evidence and potential neurobiological underpinnings of unresolved symptoms in depression. J Clin Psychiatry. 2008;69(2):246–58.PubMedCrossRef
84.
go back to reference Mao AR, Findling RL. Comorbidities in adult attention-deficit/hyperactivity disorder: a practical guide to diagnosis in primary care. Postgrad Med. 2014;126(5):42–51.PubMedCrossRef Mao AR, Findling RL. Comorbidities in adult attention-deficit/hyperactivity disorder: a practical guide to diagnosis in primary care. Postgrad Med. 2014;126(5):42–51.PubMedCrossRef
85.
go back to reference Mancini C, Van Ameringen M, Oakman JM, Figueiredo D. Childhood attention deficit/hyperactivity disorder in adults with anxiety disorders. Psychol Med. 1999;29(03):515–25.PubMedCrossRef Mancini C, Van Ameringen M, Oakman JM, Figueiredo D. Childhood attention deficit/hyperactivity disorder in adults with anxiety disorders. Psychol Med. 1999;29(03):515–25.PubMedCrossRef
86.
go back to reference Braaten EB, Beiderman J, Monuteaux MC, Mick E, Calhoun E, Cattan G, Faraone SV. Revisiting the association between attention-deficit/hyperactivity disorder and anxiety disorders: a familial risk analysis. Biol Psychiatry. 2003;53(1):93–9.PubMedCrossRef Braaten EB, Beiderman J, Monuteaux MC, Mick E, Calhoun E, Cattan G, Faraone SV. Revisiting the association between attention-deficit/hyperactivity disorder and anxiety disorders: a familial risk analysis. Biol Psychiatry. 2003;53(1):93–9.PubMedCrossRef
87.
go back to reference Schatz DB, Rostain AL. ADHD with comorbid anxiety a review of the current literature. J Atten Disord. 2006;10(2):141–9.PubMedCrossRef Schatz DB, Rostain AL. ADHD with comorbid anxiety a review of the current literature. J Atten Disord. 2006;10(2):141–9.PubMedCrossRef
88.
go back to reference Kerns JG, Cohen JD, MacDonald AW, Cho RY, Stenger VA, Carter CS. Anterior cingulate conflict monitoring and adjustments in control. Science. 2004;303:1023–6.PubMedCrossRef Kerns JG, Cohen JD, MacDonald AW, Cho RY, Stenger VA, Carter CS. Anterior cingulate conflict monitoring and adjustments in control. Science. 2004;303:1023–6.PubMedCrossRef
89.
go back to reference Roelofs A, van Turennout M, Coles MG. Anterior cingulate cortex activity can be independent of response conflict in Stroop-like tasks. Proc Natl Acad Sci U S A. 2006;103:13884–9.PubMedPubMedCentralCrossRef Roelofs A, van Turennout M, Coles MG. Anterior cingulate cortex activity can be independent of response conflict in Stroop-like tasks. Proc Natl Acad Sci U S A. 2006;103:13884–9.PubMedPubMedCentralCrossRef
90.
go back to reference Aarts E, Roelofs A, van Turennout M. Anticipatory activity in anterior cingulate cortex can be independent of conflict and error likelihood. J Neurosci. 2008;28:4671–8.PubMedCrossRef Aarts E, Roelofs A, van Turennout M. Anticipatory activity in anterior cingulate cortex can be independent of conflict and error likelihood. J Neurosci. 2008;28:4671–8.PubMedCrossRef
91.
go back to reference Nee DE, Wager TD, Jonides J. Interference resolution: insights from a meta-analysis of neuroimaging tasks. Cogn Affect Behav Neurosci. 2007;7:1–17.PubMedCrossRef Nee DE, Wager TD, Jonides J. Interference resolution: insights from a meta-analysis of neuroimaging tasks. Cogn Affect Behav Neurosci. 2007;7:1–17.PubMedCrossRef
92.
go back to reference Whelan R, Conrod PJ, Poline JB, Lourdusamy A, Banaschewski T, Barker GJ, et al. Adolescent impulsivity phenotypes characterized by distinct brain networks. Nat Neurosci. 2012;15:920–5.PubMedCrossRef Whelan R, Conrod PJ, Poline JB, Lourdusamy A, Banaschewski T, Barker GJ, et al. Adolescent impulsivity phenotypes characterized by distinct brain networks. Nat Neurosci. 2012;15:920–5.PubMedCrossRef
93.
go back to reference Cieslik EC, Mueller VI, Eickhoff CR, Langner R, Eickhoff SB. Three key regions for supervisory attentional control: evidence from neuroimaging meta-analyses. Neurosci Biobehav Rev. 2015;48:22–34.PubMedCrossRef Cieslik EC, Mueller VI, Eickhoff CR, Langner R, Eickhoff SB. Three key regions for supervisory attentional control: evidence from neuroimaging meta-analyses. Neurosci Biobehav Rev. 2015;48:22–34.PubMedCrossRef
94.
go back to reference Shaw P, Eckstrand K, Sharp W, Blumenthal J, Lerch JP, Greenstein D, et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci U S A. 2007;104(49):19649–54.PubMedPubMedCentralCrossRef Shaw P, Eckstrand K, Sharp W, Blumenthal J, Lerch JP, Greenstein D, et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci U S A. 2007;104(49):19649–54.PubMedPubMedCentralCrossRef
95.
go back to reference Klassen LJ, Bilkey TS, Katzman MA, Chokka P. Comorbid attention deficit/hyperactivity disorder and substance use disorder: treatment considerations. Curr Drug Abuse Rev. 2012;5(3):190–8.PubMedCrossRef Klassen LJ, Bilkey TS, Katzman MA, Chokka P. Comorbid attention deficit/hyperactivity disorder and substance use disorder: treatment considerations. Curr Drug Abuse Rev. 2012;5(3):190–8.PubMedCrossRef
96.
go back to reference Wilens TE, Vitulano M, Upadhyaya H, Adamson J, Sawtelle R, Utzinger L, et al. Cigarette smoking associated with attention deficit hyperactivity disorder. J Pediatr. 2008;153(3):414–9.PubMedPubMedCentralCrossRef Wilens TE, Vitulano M, Upadhyaya H, Adamson J, Sawtelle R, Utzinger L, et al. Cigarette smoking associated with attention deficit hyperactivity disorder. J Pediatr. 2008;153(3):414–9.PubMedPubMedCentralCrossRef
97.
98.
go back to reference Arias AJ, Gelernter J, Chan G, Weiss RD, Brady KT, Farrer L, et al. Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders. Addict Behav. 2008;33(9):1199–207.PubMedPubMedCentralCrossRef Arias AJ, Gelernter J, Chan G, Weiss RD, Brady KT, Farrer L, et al. Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders. Addict Behav. 2008;33(9):1199–207.PubMedPubMedCentralCrossRef
99.
go back to reference Kooij SJ, Rösler M, Philipsen A, Wächter S, Dejonckheere J, van der Kolk A, et al. Predictors and impact of non-adherence in adults with attention-deficit/hyperactivity disorder receiving OROS methylphenidate: results from a randomized, controlled trial. BMC Psychiatry. 2013;13:36.PubMedPubMedCentralCrossRef Kooij SJ, Rösler M, Philipsen A, Wächter S, Dejonckheere J, van der Kolk A, et al. Predictors and impact of non-adherence in adults with attention-deficit/hyperactivity disorder receiving OROS methylphenidate: results from a randomized, controlled trial. BMC Psychiatry. 2013;13:36.PubMedPubMedCentralCrossRef
100.
go back to reference Olsen JL, Reimherr FW, Marchant BK, Wender PH, Robison RJ. The effect of personality disorder symptoms on response to treatment with methylphenidate transdermal system in adults with attention-deficit/hyperactivity disorder. Prim Care Companion CNS Disord. 2012;14(5). doi:10.4088/PCC.12m01344. Olsen JL, Reimherr FW, Marchant BK, Wender PH, Robison RJ. The effect of personality disorder symptoms on response to treatment with methylphenidate transdermal system in adults with attention-deficit/hyperactivity disorder. Prim Care Companion CNS Disord. 2012;14(5). doi:10.​4088/​PCC.​12m01344.
101.
go back to reference Robison RJ, Reimherr FW, Gale PD, Marchant BK, Williams ED, Soni P, et al. Personality disorders in ADHD part 2: the effect of symptoms of personality disorder on response to treatment with OROS methylphenidate in adults with ADHD. Ann Clin Psychiatry. 2010;22(2):94–102.PubMed Robison RJ, Reimherr FW, Gale PD, Marchant BK, Williams ED, Soni P, et al. Personality disorders in ADHD part 2: the effect of symptoms of personality disorder on response to treatment with OROS methylphenidate in adults with ADHD. Ann Clin Psychiatry. 2010;22(2):94–102.PubMed
102.
go back to reference Gift TE, Reimherr FW, Marchant BK, Steans TA, Wender PH. Personality disorder in adult attention-deficit/hyperactivity disorder: attrition and change during long-term treatment. J Nerv Ment Dis. 2016;204(5):355–63.PubMedCrossRef Gift TE, Reimherr FW, Marchant BK, Steans TA, Wender PH. Personality disorder in adult attention-deficit/hyperactivity disorder: attrition and change during long-term treatment. J Nerv Ment Dis. 2016;204(5):355–63.PubMedCrossRef
103.
go back to reference Reimherr FW, Marchant BK, Gift TE, Steans TA, Wender PH. Types of adult attention-deficit/hyperactivity disorder (ADHD): baseline characteristics, initial response, and long-term response to treatment with methylphenidate. ADHD Atten Def Hyp Disord. 2015;7:115–28.CrossRef Reimherr FW, Marchant BK, Gift TE, Steans TA, Wender PH. Types of adult attention-deficit/hyperactivity disorder (ADHD): baseline characteristics, initial response, and long-term response to treatment with methylphenidate. ADHD Atten Def Hyp Disord. 2015;7:115–28.CrossRef
104.
go back to reference National Collaborating Centre for Mental Health (UK). In: Antisocial personality disorder: Treatment, management and prevention. Leicester (UK): British Psychological Society; 2010. (NICE Clinical Guidelines, No. 77). 7, Interventions for people with antisocial personality disorder and associated symptoms and behaviours. https://www.ncbi.nlm.nih.gov/books/NBK55350/. Accessed 2 May 2016. National Collaborating Centre for Mental Health (UK). In: Antisocial personality disorder: Treatment, management and prevention. Leicester (UK): British Psychological Society; 2010. (NICE Clinical Guidelines, No. 77). 7, Interventions for people with antisocial personality disorder and associated symptoms and behaviours. https://www.​ncbi.​nlm.​nih.​gov/​books/​NBK55350/​. Accessed 2 May 2016.
105.
go back to reference American Psychiatric Association. Diagnostic and statistical manual of mental disorders (4th ed. text rev). Washington, DC: 2000. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (4th ed. text rev). Washington, DC: 2000.
106.
go back to reference Surman C, Bilkey T. FAST MINDS: how to thrive if you have ADHD (or think you might). New York: Berkley; 2013. Surman C, Bilkey T. FAST MINDS: how to thrive if you have ADHD (or think you might). New York: Berkley; 2013.
107.
go back to reference Canadian Attention Deficit Hyperactivity Disorder Resource Alliance (CADDRA): Canadian ADHD Practice Guidelines. 3rd Ed. Toronto ON: CADDRA; 2011. Canadian Attention Deficit Hyperactivity Disorder Resource Alliance (CADDRA): Canadian ADHD Practice Guidelines. 3rd Ed. Toronto ON: CADDRA; 2011.
108.
go back to reference Rösler M, Ginsberg Y, Arngrim T, Adamou M, Niemelä A, Dejonkheere J, et al. Correlation of symptomatic improvements with functional improvements and patient-reported outcomes in adults with attention-deficit/hyperactivity disorder treated with OROS methylphenidate. World J Biol Psychiatry. 2013;14(4):282–90.PubMedCrossRef Rösler M, Ginsberg Y, Arngrim T, Adamou M, Niemelä A, Dejonkheere J, et al. Correlation of symptomatic improvements with functional improvements and patient-reported outcomes in adults with attention-deficit/hyperactivity disorder treated with OROS methylphenidate. World J Biol Psychiatry. 2013;14(4):282–90.PubMedCrossRef
109.
go back to reference Banaschewski T, Roessner V, Dittmann RW, Santosh PJ, Rothenberger A. Non–stimulant medications in the treatment of ADHD. Eur Child Adolesc Psychiatry. 2004;13(1):i102–16.PubMed Banaschewski T, Roessner V, Dittmann RW, Santosh PJ, Rothenberger A. Non–stimulant medications in the treatment of ADHD. Eur Child Adolesc Psychiatry. 2004;13(1):i102–16.PubMed
110.
go back to reference Peterson K, McDonagh MS, Fu R. Comparative benefits and harms of competing medications for adults with attention-deficit hyperactivity disorder: a systematic review and indirect comparison meta-analysis. Psychopharmacology. 2008;197(1):1–11.PubMedCrossRef Peterson K, McDonagh MS, Fu R. Comparative benefits and harms of competing medications for adults with attention-deficit hyperactivity disorder: a systematic review and indirect comparison meta-analysis. Psychopharmacology. 2008;197(1):1–11.PubMedCrossRef
111.
go back to reference Adler LA, Liebowitz M, Kronenberger W, Qiao M, Rubin R, Hollandbeck M, et al. Atomoxetine treatment in adults with attention-deficit/hyperactivity disorder and comorbid social anxiety disorder. Depress Anxiety. 2009;26(3):212–21.PubMedCrossRef Adler LA, Liebowitz M, Kronenberger W, Qiao M, Rubin R, Hollandbeck M, et al. Atomoxetine treatment in adults with attention-deficit/hyperactivity disorder and comorbid social anxiety disorder. Depress Anxiety. 2009;26(3):212–21.PubMedCrossRef
112.
go back to reference Spencer TJ, Faraone SV, Michelson D, Adler LA, Reimherr FW, Glatt SJ, et al. Atomoxetine and adult attention-deficit/hyperactivity disorder: the effects of comorbidity. J Clin Psychiatry. 2006;67(3):415–20.PubMedCrossRef Spencer TJ, Faraone SV, Michelson D, Adler LA, Reimherr FW, Glatt SJ, et al. Atomoxetine and adult attention-deficit/hyperactivity disorder: the effects of comorbidity. J Clin Psychiatry. 2006;67(3):415–20.PubMedCrossRef
113.
go back to reference Biederman J, Mick E, Spencer T, Surman C, Faraone SV. Is response to OROS-methylphenidate treatment moderated by treatment with antidepressants or psychiatric comorbidity? A secondary analysis from a large randomized double blind study of adults with ADHD. CNS Neurosci Ther. 2012;18(2):126–32.PubMedCrossRef Biederman J, Mick E, Spencer T, Surman C, Faraone SV. Is response to OROS-methylphenidate treatment moderated by treatment with antidepressants or psychiatric comorbidity? A secondary analysis from a large randomized double blind study of adults with ADHD. CNS Neurosci Ther. 2012;18(2):126–32.PubMedCrossRef
114.
go back to reference Gabriel A. The mixed amphetamine salt extended release (Adderall XR, max-XR) as an adjunctive to SSRIs or SNRIs in the treatment of adult ADHD patients with comorbid partially responsive generalized anxiety: an open-label study. Atten Defic Hyperact Disord. 2010;2(2):87–92.PubMedCrossRef Gabriel A. The mixed amphetamine salt extended release (Adderall XR, max-XR) as an adjunctive to SSRIs or SNRIs in the treatment of adult ADHD patients with comorbid partially responsive generalized anxiety: an open-label study. Atten Defic Hyperact Disord. 2010;2(2):87–92.PubMedCrossRef
115.
go back to reference Wilens TE, Adamson J, Monuteaux MC, Faraone SV, Schillinger M, Westerberg D, et al. Effect of prior treatment for attention-deficit/hyperactivity disorder on subsequent risk for cigarette smoking and alcohol and drug use disorders in adolescents. Arch Pediatr Adolesc Med. 2008;162(10):916–21.PubMedPubMedCentralCrossRef Wilens TE, Adamson J, Monuteaux MC, Faraone SV, Schillinger M, Westerberg D, et al. Effect of prior treatment for attention-deficit/hyperactivity disorder on subsequent risk for cigarette smoking and alcohol and drug use disorders in adolescents. Arch Pediatr Adolesc Med. 2008;162(10):916–21.PubMedPubMedCentralCrossRef
116.
go back to reference Tcheremissine OV, Salazar JO. Pharmacotherapy of adult attention deficit/hyperactivity disorder: review of evidence-based practices and future directions. Expert Opin Pharmacother. 2008;9(8):1299–310.PubMedCrossRef Tcheremissine OV, Salazar JO. Pharmacotherapy of adult attention deficit/hyperactivity disorder: review of evidence-based practices and future directions. Expert Opin Pharmacother. 2008;9(8):1299–310.PubMedCrossRef
117.
go back to reference Philipsen A, Jans T, Graf E, Matthies S, Borel P, Colla M, Gentschow L, et al. Effects of group psychotherapy, individual counseling, methylphenidate, and placebo in the treatment of adult attention-deficit/hyperactivity disorder: a randomized clinical trial. JAMA Psychiatry. 2015;72(12):1199–210.PubMedCrossRef Philipsen A, Jans T, Graf E, Matthies S, Borel P, Colla M, Gentschow L, et al. Effects of group psychotherapy, individual counseling, methylphenidate, and placebo in the treatment of adult attention-deficit/hyperactivity disorder: a randomized clinical trial. JAMA Psychiatry. 2015;72(12):1199–210.PubMedCrossRef
118.
go back to reference Safren SA, Sprich S, Mimiaga MJ, Surman C, Knouse L, Groves M, et al. Cognitive behavioral therapy vs relaxation with educational support for medication-treated adults with ADHD and persistent symptoms: a randomized controlled trial. JAMA. 2010;304(8):875–80.PubMedPubMedCentralCrossRef Safren SA, Sprich S, Mimiaga MJ, Surman C, Knouse L, Groves M, et al. Cognitive behavioral therapy vs relaxation with educational support for medication-treated adults with ADHD and persistent symptoms: a randomized controlled trial. JAMA. 2010;304(8):875–80.PubMedPubMedCentralCrossRef
119.
go back to reference Knouse LE, Zvorsky I, Safren SA. Depression in adults with attention-deficit/hyperactivity disorder (ADHD): the mediating role of cognitive-behavioral factors. Cognit Ther Res. 2013;37(6):1220–32.PubMedPubMedCentralCrossRef Knouse LE, Zvorsky I, Safren SA. Depression in adults with attention-deficit/hyperactivity disorder (ADHD): the mediating role of cognitive-behavioral factors. Cognit Ther Res. 2013;37(6):1220–32.PubMedPubMedCentralCrossRef
120.
go back to reference Emilsson B, Gudjonsson G, Sigurdsson JF, Baldursson G, Einarsson E, Olafsdottir H, et al. Cognitive behaviour therapy in medication-treated adults with ADHD and persistent symptoms: a randomized controlled trial. BMC Psychiatry. 2011;11:116.PubMedPubMedCentralCrossRef Emilsson B, Gudjonsson G, Sigurdsson JF, Baldursson G, Einarsson E, Olafsdottir H, et al. Cognitive behaviour therapy in medication-treated adults with ADHD and persistent symptoms: a randomized controlled trial. BMC Psychiatry. 2011;11:116.PubMedPubMedCentralCrossRef
121.
go back to reference Schubiner H, Downey KK, Arfken CL, Johanson CE, Schuster CR, Lockhart N, et al. Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence. Exp Clin Psychopharm. 2002;10(3):286.CrossRef Schubiner H, Downey KK, Arfken CL, Johanson CE, Schuster CR, Lockhart N, et al. Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence. Exp Clin Psychopharm. 2002;10(3):286.CrossRef
122.
go back to reference Weisler RH. Review of long-acting stimulants in the treatment of attention deficit hyperactivity disorder. Exp Opin Pharmacother. 2007;8(6):745–58.CrossRef Weisler RH. Review of long-acting stimulants in the treatment of attention deficit hyperactivity disorder. Exp Opin Pharmacother. 2007;8(6):745–58.CrossRef
123.
go back to reference Levin FR, Mariani JJ, Specker S, Mooney M, Mahony A, Brooks DJ, et al. Extended-release mixed amphetamine salts vs placebo for comorbid adult attention-deficit/hyperactivity disorder and cocaine use disorder: a randomized clinical trial. JAMA Psychiatry. 2015;72(6):593–602.PubMedPubMedCentralCrossRef Levin FR, Mariani JJ, Specker S, Mooney M, Mahony A, Brooks DJ, et al. Extended-release mixed amphetamine salts vs placebo for comorbid adult attention-deficit/hyperactivity disorder and cocaine use disorder: a randomized clinical trial. JAMA Psychiatry. 2015;72(6):593–602.PubMedPubMedCentralCrossRef
124.
go back to reference Lisdahl KM, Wright NE, Kirchner-Medina C, Maple KE, Shollenbarger S. Considering cannabis: the effects of regular cannabis use on neurocognition in adolescents and young adults. Curr Addict Rep. 2014;1(2):144–56.PubMedPubMedCentralCrossRef Lisdahl KM, Wright NE, Kirchner-Medina C, Maple KE, Shollenbarger S. Considering cannabis: the effects of regular cannabis use on neurocognition in adolescents and young adults. Curr Addict Rep. 2014;1(2):144–56.PubMedPubMedCentralCrossRef
125.
go back to reference Broyd SJ, van Hell HH, Beale C, Yücel M, Solowij N. Acute and chronic effects of cannabinoids on human cognition - a systematic review. Biol Psychiatry. 2016;79(7):557–67.PubMedCrossRef Broyd SJ, van Hell HH, Beale C, Yücel M, Solowij N. Acute and chronic effects of cannabinoids on human cognition - a systematic review. Biol Psychiatry. 2016;79(7):557–67.PubMedCrossRef
126.
go back to reference Schier AR, Ribeiro NP, Silva AC, Hallak JE, Crippa JA, Nardi AE, et al. Cannabidiol, a Cannabis Sativa constituent, as an anxiolytic drug. Rev Bras Psiquiatr. 2012;34(Suppl 1):S104–10.PubMedCrossRef Schier AR, Ribeiro NP, Silva AC, Hallak JE, Crippa JA, Nardi AE, et al. Cannabidiol, a Cannabis Sativa constituent, as an anxiolytic drug. Rev Bras Psiquiatr. 2012;34(Suppl 1):S104–10.PubMedCrossRef
127.
go back to reference Wright MJ Jr, Vandewater SA, Taffe MA. Cannabidiol attenuates deficits of visuospatial associative memory induced by Δ(9) tetrahydrocannabinol. Br J Pharmacol. 2013;170(7):1365–73.PubMedPubMedCentralCrossRef Wright MJ Jr, Vandewater SA, Taffe MA. Cannabidiol attenuates deficits of visuospatial associative memory induced by Δ(9) tetrahydrocannabinol. Br J Pharmacol. 2013;170(7):1365–73.PubMedPubMedCentralCrossRef
129.
go back to reference Morgan CJ, Freeman TP, Schafer GL, et al. Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis. Neuropsychopharmacology. 2010;35:1879–85.PubMedPubMedCentralCrossRef Morgan CJ, Freeman TP, Schafer GL, et al. Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis. Neuropsychopharmacology. 2010;35:1879–85.PubMedPubMedCentralCrossRef
130.
go back to reference Campos AC, Brant F, Miranda AS, Machado FS, Teixeira AL. Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria. Neuroscience. 2015;289:166–80.PubMedCrossRef Campos AC, Brant F, Miranda AS, Machado FS, Teixeira AL. Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria. Neuroscience. 2015;289:166–80.PubMedCrossRef
131.
go back to reference Hayakawa K, Mishima K, Nozako M, et al. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. J Neurochem. 2007;102(5):1488–96.PubMedCrossRef Hayakawa K, Mishima K, Nozako M, et al. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. J Neurochem. 2007;102(5):1488–96.PubMedCrossRef
132.
go back to reference Levin FR, Evans SM, McDowell DM, Brooks DJ, Nunes E. Bupropion treatment for cocaine abuse and adult attention-deficit/hyperactivity disorder. J Addict Disord. 2002;21(2):1–16.CrossRef Levin FR, Evans SM, McDowell DM, Brooks DJ, Nunes E. Bupropion treatment for cocaine abuse and adult attention-deficit/hyperactivity disorder. J Addict Disord. 2002;21(2):1–16.CrossRef
133.
go back to reference Gabriel A, Violato C. Adjunctive atomoxetine to SSRIs or SNRIs in the treatment of adult ADHD patients with comorbid partially responsive generalized anxiety (GA): an open-label study. Atten Defic Hyperact Disord. 2011;3(4):319–26.PubMedCrossRef Gabriel A, Violato C. Adjunctive atomoxetine to SSRIs or SNRIs in the treatment of adult ADHD patients with comorbid partially responsive generalized anxiety (GA): an open-label study. Atten Defic Hyperact Disord. 2011;3(4):319–26.PubMedCrossRef
134.
go back to reference Mattos P, Louzã MR, Palmini AL, de Oliveira IR, Rocha FL. A multicenter, open-label trial to evaluate the quality of life in adults with ADHD treated with long-acting methylphenidate (OROS MPH): Concerta quality of life (CONQoL) study. J Atten Disord. 2013;17(5):444–8.PubMedCrossRef Mattos P, Louzã MR, Palmini AL, de Oliveira IR, Rocha FL. A multicenter, open-label trial to evaluate the quality of life in adults with ADHD treated with long-acting methylphenidate (OROS MPH): Concerta quality of life (CONQoL) study. J Atten Disord. 2013;17(5):444–8.PubMedCrossRef
135.
go back to reference Nemeroff CB. Prevalence and management of treatment-resistant depression. J Clin Psychiatry. 2007;68(8):17.PubMed Nemeroff CB. Prevalence and management of treatment-resistant depression. J Clin Psychiatry. 2007;68(8):17.PubMed
136.
go back to reference Patkar AA, Masand PS, Pae CU, Peindl K, Hooper-Wood C, Mannelli P, Ciccone P. A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression. J Clin Psychopharmacol. 2006;26(6):653–6.PubMedCrossRef Patkar AA, Masand PS, Pae CU, Peindl K, Hooper-Wood C, Mannelli P, Ciccone P. A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression. J Clin Psychopharmacol. 2006;26(6):653–6.PubMedCrossRef
137.
go back to reference Trivedi MH, Cutler AJ, Richards C, Lasser R, Geibel BB, Gao J, et al. A randomized controlled trial of the efficacy and safety of lisdexamfetamine dimesylate as augmentation therapy in adults with residual symptoms of major depressive disorder after treatment with escitalopram. J Clin Psychiatry. 2013;74(8):802–9.PubMedCrossRef Trivedi MH, Cutler AJ, Richards C, Lasser R, Geibel BB, Gao J, et al. A randomized controlled trial of the efficacy and safety of lisdexamfetamine dimesylate as augmentation therapy in adults with residual symptoms of major depressive disorder after treatment with escitalopram. J Clin Psychiatry. 2013;74(8):802–9.PubMedCrossRef
138.
go back to reference Madhoo M, Keefe RS, Roth RM, Sambunaris A, Wu J, Trivedi MH, et al. Lisdexamfetamine dimesylate augmentation in adults with persistent executive dysfunction after partial or full remission of major depressive disorder. Neuropsychopharmacology. 2014;39(6):1388–98.PubMedPubMedCentralCrossRef Madhoo M, Keefe RS, Roth RM, Sambunaris A, Wu J, Trivedi MH, et al. Lisdexamfetamine dimesylate augmentation in adults with persistent executive dysfunction after partial or full remission of major depressive disorder. Neuropsychopharmacology. 2014;39(6):1388–98.PubMedPubMedCentralCrossRef
139.
go back to reference Richards C, McIntyre RS, Weisler R, Sambunaris A, Brawman-Mintzer O, Gao J, et al. Lisdexamfetamine dimesylate augmentation for adults with major depressive disorder and inadequate response to antidepressant monotherapy: results from 2 phase 3, multicenter, randomized, double-blind, placebo-controlled studies. J Affect Disord. 2016;206:151–60.PubMedCrossRef Richards C, McIntyre RS, Weisler R, Sambunaris A, Brawman-Mintzer O, Gao J, et al. Lisdexamfetamine dimesylate augmentation for adults with major depressive disorder and inadequate response to antidepressant monotherapy: results from 2 phase 3, multicenter, randomized, double-blind, placebo-controlled studies. J Affect Disord. 2016;206:151–60.PubMedCrossRef
140.
go back to reference McIntyre RS, Filteau MJ, Martin L, Patry S, Carvalho A, Cha DS, et al. Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach. J Affect Disord. 2014;156:1–7.PubMedCrossRef McIntyre RS, Filteau MJ, Martin L, Patry S, Carvalho A, Cha DS, et al. Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach. J Affect Disord. 2014;156:1–7.PubMedCrossRef
141.
go back to reference Halmøy A, Fasmer OB, Gillberg C, Haavik J. Occupational outcome in adult ADHD: impact of symptom profile, comorbid psychiatric problems, and treatment a cross-sectional study of 414 clinically diagnosed adult ADHD patients. J Atten Disord. 2009;13(2):175–87.PubMedCrossRef Halmøy A, Fasmer OB, Gillberg C, Haavik J. Occupational outcome in adult ADHD: impact of symptom profile, comorbid psychiatric problems, and treatment a cross-sectional study of 414 clinically diagnosed adult ADHD patients. J Atten Disord. 2009;13(2):175–87.PubMedCrossRef
142.
go back to reference Wilens TE, Faraone SV, Biederman J, Gunawardene S. Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature. Pediatrics 2003;111(1):179–185. Wilens TE, Faraone SV, Biederman J, Gunawardene S. Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature. Pediatrics 2003;111(1):179–185.
143.
go back to reference Faraone SV, Wilens T. Does stimulant treatment lead to substance use disorders? J Clin Psychiatry. 2003;64(suppl 11):9–13.PubMed Faraone SV, Wilens T. Does stimulant treatment lead to substance use disorders? J Clin Psychiatry. 2003;64(suppl 11):9–13.PubMed
144.
go back to reference Wilens TE, Adler LA, Adams J, Sgambati S, Rotrosen J, Sawtelle R, et al. Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature. J Am Acad Child Psychiatry. 2008;47(1):21–31.CrossRef Wilens TE, Adler LA, Adams J, Sgambati S, Rotrosen J, Sawtelle R, et al. Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature. J Am Acad Child Psychiatry. 2008;47(1):21–31.CrossRef
145.
go back to reference Kollins SH. Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patient. J Clin Psychiatry. 2003;64(suppl 11):14–8.PubMed Kollins SH. Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patient. J Clin Psychiatry. 2003;64(suppl 11):14–8.PubMed
146.
go back to reference Kollins SH. ADHD, substance use disorders, and psychostimulant treatment current literature and treatment guidelines. J Atten Disord. 2008;12(2):115–25.PubMedCrossRef Kollins SH. ADHD, substance use disorders, and psychostimulant treatment current literature and treatment guidelines. J Atten Disord. 2008;12(2):115–25.PubMedCrossRef
148.
go back to reference Rabiner DL, Anastopoulos AD, Costello EJ, Hoyle RH, McCabe SE, Swartzwelder HS. Motives and perceived consequences of nonmedical ADHD medication use by college students: are students treating themselves for attention problems? J Atten Disord. 2009;13(3):259–70.PubMedCrossRef Rabiner DL, Anastopoulos AD, Costello EJ, Hoyle RH, McCabe SE, Swartzwelder HS. Motives and perceived consequences of nonmedical ADHD medication use by college students: are students treating themselves for attention problems? J Atten Disord. 2009;13(3):259–70.PubMedCrossRef
149.
go back to reference Searight HR, Burke JM, Rottnek F. Adult ADHD: Evaluation and treatment in family medicine. Am Fam Physician 2000;62(9):2077–2086. Searight HR, Burke JM, Rottnek F. Adult ADHD: Evaluation and treatment in family medicine. Am Fam Physician 2000;62(9):2077–2086.
150.
go back to reference Culpepper L, Mattingly G. A practical guide to recognition and diagnosis of ADHD in adults in the primary care setting. Postgrad Med. 2008;120(3):16–26.PubMedCrossRef Culpepper L, Mattingly G. A practical guide to recognition and diagnosis of ADHD in adults in the primary care setting. Postgrad Med. 2008;120(3):16–26.PubMedCrossRef
Metadata
Title
Adult ADHD and comorbid disorders: clinical implications of a dimensional approach
Authors
Martin A. Katzman
Timothy S. Bilkey
Pratap R. Chokka
Angelo Fallu
Larry J Klassen
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2017
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-017-1463-3

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