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BMC Pediatrics

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Open Access 01-12-2021 | Whooping Cough | Case report

Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report

Authors: Gilbert Paul, Rudnick Chad

Published in: BMC Pediatrics | Issue 1/2021

Abstract

Background

Maternal vaccination for Influenza and Tetanus, Diphtheria, acellular Pertussis (TDaP) have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy.

Case presentation

A vigorous, healthy, full-term female was born to a COVID-19 naïve mother who had received a single dose of messenger RNA (mRNA) vaccine for SARS-CoV-2 3 weeks prior to delivery. IgG cord blood antibodies were detected to SARS-CoV-2 at the time of birth.

Conclusion

Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.

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Hardy-Fairbanks AJ, et al. Immune responses in infants whose mother received tdap vaccine during pregnancy. Pediatr Infect Dis J. 2013;32(11):1257–60.CrossRef

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The American College of Obstetricians and Gynecologists. Vaccinating Pregnant and Lactating Patients Against COVID-19. Acog.orgPractice Advisory. https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2020/12/vaccinating-pregnant-and-lactating-patients-against-covid-19

Edlow AG, Li JZ, Collier AY, et al. Assessment of maternal and neonatal SARS-CoV-2 viral load, Transplacental antibody transfer, and placental pathology in pregnancies during the COVID-19 pandemic. JAMA Netw Open. 2020;3(12):e2030455.CrossRef

Title: Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report
Authors: Gilbert Paul
Rudnick Chad
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Whooping Cough
COVID-19 Vaccination
Vaccination
SARS-CoV-2
Influenza
COVID-19
Tetanus
Diphtheria
Published in: BMC Pediatrics / Issue 1/2021
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-021-02618-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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