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BMC Pediatrics
Published in: BMC Pediatrics 1/2019

Open Access 01-12-2019 | Obesity | Research article

Changes in objectively measured physical activity after a multidisciplinary lifestyle intervention in children with abdominal obesity: a randomized control trial

Authors: Lydia Morell-Azanza, Ana Ojeda-Rodríguez, Amaia Ochotorena-Elicegui, Nerea Martín-Calvo, María Chueca, Amelia Marti, Cristina Azcona-San Julian

Published in: BMC Pediatrics | Issue 1/2019

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Abstract

Background

Physical activity (PA) is associated with changes in body composition that affect insulin sensitivity and leptin levels. Few studies have assessed the effect of lifestyle interventions on changes in objectively measured PA levels in obese children. To evaluate the effects of a multidisciplinary lifestyle intervention on anthropometric indices, biochemical parameters and accelerometer measured PA in abdominal obese children.

Methods

A randomized control trial was performed in 106 children and adolescents with abdominal obesity. Participants were randomly assigned to usual or intensive care group for 8-week. PA was measured by accelerometry over four days including, at least, two weekdays in all participants. Both groups were encouraged to accumulate an extra time of 200 min per week in their PA.

Results

At baseline, 75% of subjects do not fulfill the WHO recommendation of being more than 60 min/day on moderate-to-vigorous PA (MVPA). The intensive care group achieved a significant reduction in anthropometric indexes compared to the usual care but no significant change was found in biochemical or PA parameters. Both groups achieved a significant reduction in light PA. Interestingly, intensive care participants significantly increased MVPA in 5.5 min/day. Moreover, an inverse association between changes in MVPA and leptin levels was found.

Conclusion

The two lifestyle intervention reduced anthropometric indexes and lowered light PA in abdominal obese children. No significant differences were observed between intensive care and usual care in regard to PA. Intensive care participants significantly increase physical activity (MVPA) and, changes in MVPA were inversely associated with changes in leptin levels after the intervention.

Trial registration

ClinicalTrials.​gov, Identifier: NCT03147261. Registered 10 May 2017. Retrospectively registered.
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Literature
1.
Morell-Azanza L, García-Calzón S, Rendo-Urteaga T, Martin-Calvo N, Chueca M, Martínez JA, et al. Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents. Pediatr Diabetes. 2017;18(5):392–8.CrossRef
2.
Bassali R, Waller JL, Gower B, Allison J, Davis CL. Utility of waist circumference percentile for risk evaluation in obese children. Int J Pediatr Obes. 2011;5:97–101.CrossRef
3.
Velásquez-Rodriguez CM, Velásquez-Villa M, Gómez-Ocampo L, Bermudez-Cardona L. Abdominal obesity and low physical activity are associated with insulin resistance in overweight adolescents: a cross-sectional study. BMC Pediatr. 2014;14:1–9.CrossRef
4.
Maddison R, Foley L, Mhurchu CN, Jiang Y, Jull A, Prapavessis H, et al. Effects of active video games on body composition: a randomized. Am J Clin Nutr. 2011;94:156–63.CrossRef
5.
Who WHO. Global recommendations on physical activity for health. Geneva World Heal Organ. 2010;60.
6.
Borde R, Smith JJ, Sutherland R, Nathan N, Lubans DR. Methodological considerations and impact of school-based interventions on objectively measured physical activity in adolescents: a systematic review and meta-analysis. Obes Rev. 2017;18:476–90.CrossRef
7.
Laguna M, Ruiz JR, Gallardo C, García-Pastor T, Lara MT, Aznar S. Obesity and physical activity patterns in children and adolescents. J Paediatr Child Health. 2013;49:942–9.CrossRef
8.
Rendo-Urteaga T, García-Calzón S, Martínez-Ansó E, Chueca M, Oyarzabal M, Azcona-Sanjulián MC, et al. Decreased cardiotrophin-1 levels are associated with a lower risk of developing the metabolic syndrome in overweight/obese children after a weight loss program. Metabolism. 2013;62:1429–36.CrossRef
9.
Marqués M, Moleres A, Rendo-Urteaga T, Gómez-Martínez S, Zapatera B, Romero P, et al. Design of the nutritional therapy for overweight and obese Spanish adolescents conducted by registered dieticians: the EVASYON study. Nutr Hosp. 2012;27:165–76.PubMed
10.
Jáuregui A, Villalpando S, Rangel-Baltazar E, Lara-Zamudio YA, Castillo-García MM. Physical activity and fat mass gain in Mexican school-age children: a cohort study. BMC Pediatr. 2012;12.
11.
Sirico F, Bianco A, D’Alicandro G, Castaldo C, Montagnani S, Spera R, et al. Effects of physical exercise on adiponectin, leptin, and inflammatory markers in childhood obesity: systematic review and meta-analysis. Child Obes. 2018;14:207–17.CrossRef
12.
Carnier J, Lofrano MC, Prado WL, Caranti DA, De Piano A, Tock L, et al. Hormonal alteration in obese adolescents with eating disorder: effects of multidisciplinary therapy. Horm Res. 2008;70:79–84.CrossRef
13.
Elia CA, Carnier J, Buengo C, Campos R, Sanchez P, Clemente A, et al. Effects of different physical exercises on leptin concentration in obese adolescents. Sport Med. 2014:164–71.
14.
Nurnazahiah A, Lua PL, Shahril MR. Adiponectin, leptin and objectively measured physical activity in adults: a narrative review. Malaysian J Med Sci. 2016;23:7–24.CrossRef
15.
Davis AM, Daldalian MC, Mayfield CA, Dean K, Black WR, Sampilo ML, et al. Outcomes from an urban pediatric obesity program targeting minority youth: the healthy hawks program. Child Obes. 2013;9:492–500.CrossRef
16.
Boudreau ADA, Kurowski DS, Gonzalez WI, Dimond MA, Oreskovic NM. Latino families, primary care, and childhood obesity: a randomized controlled trial. Am J Prev Med. 2013;44:S247–57.CrossRef
17.
Taylor RW, Cox A, Knight L, Brown DA, Meredith-Jones K, Haszard JJ, et al. A tailored family-based obesity intervention: a randomized trial. Pediatrics. 2015;136:281–9.CrossRef
18.
Hughes AR, Stewart L, Chapple J, McColl JH, Donaldson MDC, Kelnar CJH, et al. Randomized, controlled trial of a best-practice individualized behavioral program for treatment of childhood overweight: Scottish childhood overweight treatment trial (SCOTT). Pediatrics. 2008;121:e539–46.CrossRef
19.
Mead E, Brown T, Rees K, Lb A, Whittaker V, Jones D, et al. Diet , physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years ( review ) diet , physical activity and behavioural interventions for the treatment of overweight or obese children from. Cochrane Database Syst Rev. 2017.
20.
Sobradillo B, Aguirre A, Uresti U, Bilbao A, Fernández-Ramos C, Lizarraga A, et al. Curvas y tablas de crecimiento. Estudios longitudinal y transversal Bilbao: Fundación Faustino Orbegozo Eizaguirre [Internet]. Isbn 84-607-9967-0. 2004. 1-31 p.
21.
Serra Majem L, Aranceta Bartrina J, Ribas Barba L, Pérez Rodrigo C, García Closas R. Estudio enKid: objetivos y metodología. Crecimiento y desarrollo. Estudio enKid, vol. 4: Masson S.A. Barcelona; 2000.
22.
De Miguel-Etayo P, Muro C, Santabárbara J, López-Antón R, Morandé G, Martín-Matillas M, et al. Behavioral predictors of attrition in adolescents participating in a multidisciplinary obesity treatment program: EVASYON study. Int J Obes. 2016;40:84–7.CrossRef
23.
Ford AL, Hunt LP, Cooper A, Shield JPH. What reduction in BMI SDS is required in obese adolescents to improve body composition and cardiometabolic health? Arch Dis Child. 2010;95:256–61.CrossRef
24.
Knop C, Singer V, Uysal Y, Schaefer A, Wolters B, Reinehr T. Extremely obese children respond better than extremely obese adolescents to lifestyle interventions. Pediatr Obes. 2015;10:7–14.CrossRef
25.
Ojeda-Rodríguez A, Zazpe I, Morell-Azanza L, Chueca MJ, Azcona-Sanjulian MC, Marti A. Improved diet quality and nutrient adequacy in children and adolescents with abdominal obesity after a lifestyle intervention. Nutrients. 2018;10.
26.
Burke JP, Hale DE, Hazuda HP, Stern MP. A quantitative scale of acanthosis nigricans. Diabetes Care. 1999;22:1655–9.CrossRef
27.
Konstabel K, Veidebaum T, Verbestel V, Moreno LA, Bammann K, Tornaritis M, et al. Objectively measured physical activity in European children: the IDEFICS study. Int J Obes. 2014;38:S135–43.CrossRef
28.
Sadeh A, Sharkey KM, Carskadon MA. Activity-based sleep-wake identification: an empirical test of methodological issues. Sleep. 1994;17:201–7.CrossRef
29.
Kinder JR, Lee KA, Thompson H, Hicks K, Topp K, Madsen KA. Validation of a hip-worn accelerometer in measuring sleep time in children. J Pediatr Nurs. 2012;27:127–33.CrossRef
30.
García-Cervantes L, Rodríguez-Romo G, Esteban-Cornejo I, Cabanas-Sanchez V, Alfonso AD, Castro-Piñero J, et al. Perceived environment in relation to objective and self-reported physical activity in Spanish youth. The UP&DOWN study. J Sports Sci. 2016;34:1423–9.CrossRef
31.
Martinez-Gomez D, Tucker J, Heelan KA, Welk GJ, Eisenmann JC. Associations between sedentary behavior and blood pressure in young children. Arch Pediatr Adolesc Med. 2009;163:724–30.CrossRef
32.
Moliner-Urdiales D, Ruiz JR, Ortega FB, Rey-Lopez JP, Vicente-Rodriguez G, Espãa-Romero V, et al. Association of objectively assessed physical activity with total and central body fat in Spanish adolescents; the HELENA study. Int J Obes. 2009;33:1126–35.CrossRef
33.
Brooke HL, Atkin AJ, Corder K, Brage S, van Sluijs EM. Frequency and duration of physical activity bouts in school-aged children: a comparison within and between days. Prev Med Reports. 2016;4:585–90.CrossRef
34.
De Baere S, Lefevre J, De Martelaer K, Philippaerts R, Seghers J. Temporal patterns of physical activity and sedentary behavior in 10-14 year-old children on weekdays. BMC Public Health. 2015;15:1–13.CrossRef
35.
Dishman RK, Motl RW, Saunders R, Felton G, Ward DS, Dowda M, et al. Self-efficacy partially mediates the effect of a school-based physical-activity intervention among adolescent girls. Prev Med (Baltim). 2004;38:628–36.CrossRef
36.
Gubelmann C, Marques-Vidal P, Bringolf-Isler B, Suggs LS, Vollenweider P, Kayser B. Correlates of weekday compliance to physical activity recommendations in Swiss youth non-compliant in weekend days. Prev Med Reports. 2018;9:86–91.CrossRef
37.
Malakou E, Linardakis M, Armstrong MEG, Zannidi D, Foster C, Johnson L, et al. The combined effect of promoting the Mediterranean diet and physical activity on metabolic risk factors in adults: a systematic review and meta-analysis of randomised controlled trials. Nutrients. 2018;10.
38.
Berge JM, Everts JC. Family-based interventions targeting childhood obesity: a meta-analysis. Child Obes. 2011;7:110–21.CrossRef
Metadata
Title
Changes in objectively measured physical activity after a multidisciplinary lifestyle intervention in children with abdominal obesity: a randomized control trial
Authors
Lydia Morell-Azanza
Ana Ojeda-Rodríguez
Amaia Ochotorena-Elicegui
Nerea Martín-Calvo
María Chueca
Amelia Marti
Cristina Azcona-San Julian
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2019
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-019-1468-9

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