Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
BMC Pediatrics
Published in: BMC Pediatrics 1/2018

Open Access 01-12-2018 | Research article

Comparison of two bone markers with growth evolution in 74 girls with central precocious puberty

Authors: Audrey Vincent, Jean-Claude Souberbielle, Raja Brauner

Published in: BMC Pediatrics | Issue 1/2018

Login to get access

Abstract

Background

The bone markers bone alkaline phosphatase (BAP) and C-terminal telopeptide of type I collagen crosslinks (CTX) are correlated with growth rate during normal puberty. The objective of this study was to evaluate the relationship between the serum concentrations of BAP and CTX and growth evolution in girls with idiopathic central precocious puberty (CPP) to help predict adult height.

Methods

A retrospective single-center study was conducted in 74 girls with CPP for whom a serum sample at initial evaluation was available to retrospectively measure BAP and CTX concentrations; 66.2% of them were untreated.

Results

The serum BAP concentrations showed significant positive correlations with height in standard deviations (SDS) at the initial evaluation (n = 62; r = 0.31; p = 0.015) and with the difference between bone and chronological ages (n = 61; r = 0.39; p = 0.002). BAP was also positively correlated with adult height as measured in both cm and SDS in untreated patients (n = 19; r = 0.58; p = 0.009).
The serum CTX concentrations showed significant positive correlations with growth rate the year before the initial evaluation as measured in both cm and SDS (n = 65; r = 0.34; p = 0.006).

Conclusions

This study revealed significant correlations of serum BAP and CTX concentrations with growth evolution in girls with CPP. The high positive correlation between serum BAP and adult height in untreated girls suggests that BAP can possibly be used to optimize models of adult height prediction in girls with CPP.
Literature
1.
Delmas PD, Eastell R, Garnero P, Seibel MJ, Stepan J, Committee of Scientific Advisors of the International Osteoporosis Foundation]. The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Foundation. Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA. 2000;11(Suppl 6):S2–17.CrossRef
2.
Szulc P, Seeman E, Delmas PD. Biochemical measurements of bone turnover in children and adolescents. Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA. 2000;11(4):281–94.CrossRef
3.
Blumsohn A, Hannon RA, Wrate R, Barton J, al-Dehaimi AW, Colwell A, et al. Biochemical markers of bone turnover in girls during puberty. Clin Endocrinol. 1994;40(5):663–70.CrossRef
4.
van Coeverden SCCM, Netelenbos JC, de Ridder CM, Roos JC, Popp-Snijders C, Delemarre-van de Waal HA. Bone metabolism markers and bone mass in healthy pubertal boys and girls. Clin Endocrinol. 2002;57(1):107–16.CrossRef
5.
Chailurkit L, Suthutvoravut U, Mahachoklertwattana P, Charoenkiatkul S, Rajatanavin R. Biochemical markers of bone formation in Thai children and adolescents. Endocr Res. 2005;31(3):159–69.CrossRefPubMed
6.
Rauchenzauner M, Schmid A, Heinz-Erian P, Kapelari K, Falkensammer G, Griesmacher A, et al. Sex- and age-specific reference curves for serum markers of bone turnover in healthy children from 2 months to 18 years. J Clin Endocrinol Metab. 2007;92(2):443–9.CrossRefPubMed
7.
Alberti C, Chevenne D, Mercat I, Josserand E, Armoogum-Boizeau P, Tichet J, et al. Serum concentrations of insulin-like growth factor (IGF)-1 and IGF binding Protein-3 (IGFBP-3), IGF-1/IGFBP-3 ratio, and markers of bone turnover: reference values for French children and adolescents and z-score comparability with other references. Clin Chem. 2011;57(10):1424–35.CrossRefPubMed
8.
Carel J-C, Eugster EA, Rogol A, Ghizzoni L, Palmert MR. ESPE-LWPES GnRH analogs consensus conference group, et al. consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics. 2009;123(4):e752–62.CrossRefPubMed
9.
Chemaitilly W, Trivin C, Adan L, Gall V, Sainte-Rose C, Brauner R. Central precocious puberty: clinical and laboratory features. Clin Endocrinol. 2001;54(3):289–94.CrossRef
10.
de Vries L, Kauschansky A, Shohat M, Phillip M. Familial central precocious puberty suggests autosomal dominant inheritance. J Clin Endocrinol Metab. 2004;89(4):1794–800.CrossRefPubMed
11.
12.
Giabicani E, Allali S, Durand A, Sommet J, Couto-Silva A-C, Brauner R. Presentation of 493 consecutive girls with idiopathic central precocious puberty: a single-center study. PLoS One. 2013;8(7):e70931.CrossRefPubMedPubMedCentral
13.
Brauner R, Adan L, Malandry F, Zantleifer D. Adult height in girls with idiopathic true precocious puberty. J Clin Endocrinol Metab. 1994;79(2):415–20.PubMed
14.
Palmert MR, Malin HV, Boepple PA. Unsustained or slowly progressive puberty in young girls: initial presentation and long-term follow-up of 20 untreated patients. J Clin Endocrinol Metab. 1999;84(2):415–23.PubMed
15.
Fontoura M, Brauner R, Prevot C, Rappaport R. Precocious puberty in girls: early diagnosis of a slowly progressing variant. Arch Dis Child. 1989;64(8):1170–6.CrossRefPubMedPubMedCentral
16.
Willemsen RH, Elleri D, Williams RM, Ong KK, Dunger DB. Pros and cons of GnRHa treatment for early puberty in girls. Nat Rev Endocrinol. 2014;10(6):352–63.CrossRefPubMed
17.
Cassio A, Cacciari E, Balsamo A, Bal M, Tassinari D. Randomised trial of LHRH analogue treatment on final height in girls with onset of puberty aged 7.5-8.5 years. Arch Dis Child. 1999;81(4):329–32.CrossRefPubMedPubMedCentral
18.
Klein KO, Barnes KM, Jones JV, Feuillan PP, Cutler GB. Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience. J Clin Endocrinol Metab. 2001;86(10):4711–6.CrossRefPubMed
19.
Giabicani E, Lemaire P, Brauner R. Models for predicting the adult height and age at first menstruation of girls with idiopathic central precocious puberty. Wolfe A, editor PLOS ONE. 2015;10(4):e0120588.CrossRef
20.
Rolland-Cachera MF, Cole TJ, Sempé M, Tichet J, Rossignol C, Charraud A. Body mass index variations: centiles from birth to 87 years. Eur J Clin Nutr. 1991;45(1):13–21.PubMed
21.
Sempé A, Pedron G, Roy-Pernot M-P. Auxologie, méthode et séquences, Paris. Laboratoire Théraplix; 1979.
22.
23.
Greulich WW, Pyle SI. Radiographic atlas of skeletal development of the hand and wrist. 2nd edition. I volume-atlante di 256 pagine. Stanford University press, Stanford, California, 1959. Acta Genet Med Gemellol. 1959;8(04):513.CrossRef
24.
Tanner JM, Goldstein H, Whitehouse RH. Standards for Children’s height at age 2 to 9 years allowing for height of parents. Arch Dis Child. 1970;45(244):819.CrossRefPubMedPubMedCentral
25.
Hopkins WG, Marshall SW, Batterham AM, Hanin J. Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc. 2009;41(1):3–13.CrossRefPubMed
26.
Mora S, Cafarelli L, Erba P, Puzzovio M, Zamproni I, Giacomet V, et al. Differential effect of age, gender and puberty on bone formation rate assessed by measurement of bone-specific alkaline phosphatase in healthy Italian children and adolescents. J Bone Miner Metab. 2009;27(6):721–6.CrossRefPubMed
27.
28.
Bayley N, Pinneau SR. Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr. 1952;40(4):423–41.CrossRefPubMed
29.
Pasquino AM, Pucarelli I, Accardo F, Demiraj V, Segni M, Di Nardo R. Long-term observation of 87 girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analogs: impact on adult height, body mass index, bone mineral content, and reproductive function. J Clin Endocrinol Metab. 2008;93(1):190–5.CrossRefPubMed
30.
Oostdijk W, Rikken B, Schreuder S, Otten B, Odink R, Rouwé C, et al. Final height in central precocious puberty after long term treatment with a slow release GnRH agonist. Arch Dis Child. 1996;75(4):292–7.CrossRefPubMedPubMedCentral
31.
Metadata
Title
Comparison of two bone markers with growth evolution in 74 girls with central precocious puberty
Authors
Audrey Vincent
Jean-Claude Souberbielle
Raja Brauner
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2018
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-018-1194-8

Other articles of this Issue 1/2018

BMC Pediatrics 1/2018 Go to the issue

Case report

Cardiac, bone and growth plate manifestations in hypocalcemic infants: revealing the hidden body of the vitamin D deficiency iceberg

Research article

Downstream consequences of diagnostic error in pediatric anaphylaxis

Case report

Extragonadal germ cell tumor of the posterior mediastinum in a child complicated with spinal cord compression: a case report

Research article

No effect of adding dairy lipids or long chain polyunsaturated fatty acids on formula tolerance and growth in full term infants: a randomized controlled trial

Case report

A novel mutation of WFS1 gene in a Chinese patient with Wolfram syndrome: a case report

Research article

Henoch-Schönlein purpura with acute pancreatitis: analysis of 13 cases