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BMC Ophthalmology

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Open Access 01-12-2024 | Epstein-Barr Virus | Case Report

Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing

Authors: Xiao-na Wang, Jing Hong, Yong-gen Xu, Pei Zhang, Ying-yu Li, Hong-liang Dou, Hai-ping Li

Published in: BMC Ophthalmology | Issue 1/2024

Abstract

Purpose

Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a relatively rare subtype of DLBCL. Herein, we report a case of a patient with EBV-positive iris DLBCL after undergoing penetrating keratoplasty and discuss its possible pathogenesis.

Methods

A 72-year-old male patient presented to our hospital with progressive blurring of vision in the left eye for the past 4 months. Small white nodular lesions were observed on the iris and retinal surface of the left eye, with a white cloud-like opacity in the vitreous cavity.

Results

The patient was eventually diagnosed with EBV-positive iris DLBCL after undergoing pathological and metagenomic tests. After injecting methotrexate in the left vitreous cavity and administering systemic and local antiviral treatments, the ocular lesions disappeared.

Conclusion

EBV infection, drug immunosuppression, and aging-related immune deterioration may play significant roles in the pathogenesis of EBV-positive iris DLBCL.

Synopsis

Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a new subtype of DLBCL, which rarely occurs. Herein, we report a case of a patient with EBV-positive iris DLBCL after undergoing penetrating keratoplasty and discuss its possible pathogenesis.

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Title: Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing
Authors: Xiao-na Wang
Jing Hong
Yong-gen Xu
Pei Zhang
Ying-yu Li
Hong-liang Dou
Hai-ping Li
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Epstein-Barr Virus
Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma
Lymphoma
Keratoplasty
Methotrexate
Methotrexate
Published in: BMC Ophthalmology / Issue 1/2024
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/s12886-024-03334-8

At a glance: The STEP trials

Springer Medicine

Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing

Abstract

Purpose

Methods

Results

Conclusion

Synopsis

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Synopsis

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