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BMC Ophthalmology
Published in: BMC Ophthalmology 1/2020

01-12-2020 | Pharmacokinetics | Correspondence

Povidone-iodine pharmacokinetics and study design

Authors: Jagger Koerner, Andrzej Grzybowski

Published in: BMC Ophthalmology | Issue 1/2020

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Abstract

Dr. Gnanasekaran et al. reported the bactericidal activity of various concentrations of povidone iodine (PI) solution in an agar plate experiment of respiratory flora. The study design and the pharmacokinetic properties of PI solution ensured that dilute PI would not be effective in this study. These results may not replicate the typical clinical situation and are significantly different than a previously reported agar plate experiment, again owing to subtle but very significant differences in methodology.
Literature
1.
Gnanasekaran S, Rogers S, Wickremasinghe S, Sandhu SS. The effect of diluting povidone-iodine on bacterial growth associated with speech. BMC Ophthalmol. 2019;19(1):62.PubMedPubMedCentralCrossRef
2.
Silas MR, Schroeder RM, Thomson RB, Myers WG. Optimizing the antisepsis protocol: effectiveness of 3 povidone-iodine 1.0% applications versus a single application of povidone-iodine 5.0. J Cataract Refract Surg. 2017;43(3):400–4.PubMedCrossRef
3.
Koerner JC, George MJ, Kissam EA, Rosco MG. Povidone-iodine concentration and in vitro killing time of bacterial corneal ulcer isolates. Digit J Ophthalmol. 2018;24(4):24–6 Povidone-iodine concentration and in vitro killing time of bacterial corneal ulcer isolates.PubMedPubMedCentralCrossRef
4.
Grzybowski A, Kanclerz P, Myers WG. The use of povidone-iodine in ophthalmology. Curr Opin Ophthalmol. 2018;29(1):19–32.PubMedCrossRef
Metadata
Title
Povidone-iodine pharmacokinetics and study design
Authors
Jagger Koerner
Andrzej Grzybowski
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2020
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-020-1313-9

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