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BMC Ophthalmology
Published in: BMC Ophthalmology 1/2017

Open Access 01-12-2017 | Research article

Analysis of novel Sjogren’s syndrome autoantibodies in patients with dry eyes

Authors: Sandra Everett, Sahana Vishwanath, Vanessa Cavero, Long Shen, Lakshmanan Suresh, Kishore Malyavantham, Norah Lincoff-Cohen, Julian L. Ambrus Jr.

Published in: BMC Ophthalmology | Issue 1/2017

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Abstract

Background

Dry eye is a common problem in Ophthalmology and may occur for many reasons including Sjogren’s syndrome (SS). Recent studies have identified autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and anti-parotid secretory protein (PSP), which occur early in the course of SS.
The current studies were designed to evaluate how many patients with idiopathic dry eye and no evidence of systemic diseases from a dry eye practice have these autoantibodies.

Methods

Patients from a dry eye clinic and normal controls were assessed by Schirmer’s test for tear flow. Sera were assessed for autoantibodies using ELISA assays. Statistics was performed with Prism 7 software and student’s unpaired t test.

Results

In this study 60% of the dry eye patients expressed one of these autoantibodies. Only 30% expressed one of the autoantibodies associated with long-standing SS, which are included in the diagnostic criteria for SS, anti-Ro and anti-La. Patients with disease for less than 2 years and mild dry eyes did not express anti-Ro or anti-La, while 25% expressed anti-SP1. Similar observations, with smaller numbers, were made when patients had not only dry eye but also dry mouth.

Conclusions

Antibodies to SP1, CA6 and PSP occur in some patients with idiopathic dry eyes. Further studies will be needed to determine how many of these patients go on to develop systemic manifestations of SS. Testing for these autoantibodies may allow early recognition of patients with SS. This will lead to improved management of the patients and the development of new strategies to maintain normal lacrimal and salivary gland function in patients with SS.
Literature
1.
2.
Chen KS, Jiang MC, Li CJ, Liu OK, Tsai CSS. Discrimination between Sjogren’s and non-Sjogren’s sicca syndrome by sialoscintigraphy and antibodies against alpha-fodrin and Ro/La autoantigens. J Int Med Res. 2009;37(4):1088–96.CrossRefPubMed
3.
Akpek EK, Klimava A, Thorne JE, Martin D, Lekhanont K, Ostrovsky A. Evaluation of patients with dry eye for presence of underlying Sjogren syndrome. Cornea. 2009;28(5):493–7.CrossRefPubMedPubMedCentral
4.
Liew MS, Zhang M, Kim E, Akpek EK. Prevalence and predictors of Sjogren’s syndrome in a prospective cohort of patients with aqueous-deficient dry eye. Br J Ophthalmol. 2012;96(12):1498–503.CrossRefPubMed
5.
Baldini C, Talarico R, Tzioufas AG, Bombardieri S. Classification criteria for Sjogren’s syndrome: a critical review. J Autoimmun. 2012;39(1–2):9–14.CrossRefPubMed
6.
Peri Y, Agmon-Levin N, Theodor E, Shoenfeld Y. Sjogren’s syndrome, the old and the new. Best Pract Res Clin Rheumatol. 2012;26(1):105–17.CrossRefPubMed
7.
Shen L, Suresh L, Lindemann M, Xuan J, Kowal P, Malyavantham K, Ambrus Jr JL. Novel autoantibodies in Sjogren’s syndrome. Clin Immunol. 2012;145(3):251–5.CrossRefPubMed
8.
Ambrus JJ, Shen L, Lindemann M, Kowal P, Suresh L. Changes in autoantibody production during different stages of Sjogren’s DIsease. 8th Internation Congress on Autoimmunity. 2012;8:474.
9.
Kitagawa T, Shibasaki K, Toya S. Clinical significance and diagnostic usefulness of anti-centromere antibody in Sjogren’s syndrome. Clin Rheumatol. 2012;31(1):105–12.CrossRefPubMed
10.
Suresh L, Malyavantham K, Shen L, Ambrus JL. Investigation of novel autoantibodies in Sjogren’s syndrome utilizing Sera from the Sjogren’s international collaborative clinical alliance cohort. BMC Ophthalmol. 2015;15:38.CrossRefPubMedPubMedCentral
11.
Valim V, Trevisani VFM, de Sousa JM, Vilela V, Belfort R. Current approach to dry eye disease. Clin Rev Allergy Immunol. 2015;49(3):288–97.CrossRefPubMed
12.
Shen L, Suresh L, Malyavantham K, Kowal P, Xuan J, Lindemann MJ, Ambrus Jr JL. Different stages of primary Sjogren’s syndrome involving lymphotoxin and type 1 IFN. J Immunol. 2013;191(2):608–13.CrossRefPubMed
13.
Henrich CF, Ramulu PY, Akpek EK. Association of dry eye and inflammatory systemic diseases in a tertiary care-based sample. Cornea. 2014;33(8):819–25.CrossRefPubMed
14.
Shen L, Suresh L, Li H, Zhang C, Kumar V, Pankewycz O, Ambrus JJ. IL-14alpha, the nexus for primary Sjogren’s disease in mice and humans. Clin Immunol. 2009;130:304–12.CrossRefPubMed
15.
Jonsson R, Theander E, Sjostrom B, Brokstad K, Henriksson G. Autoantibodies present before symptom onset in primary Sjogren syndrome. JAMA. 2013;310(17):1854–5.CrossRefPubMed
16.
Theander E, Jonsson R, Sjostrom B, Brokstad K, Olsson P, Henriksson G. Prediction of Sjogren’s syndrome years before diagnosis and identification of patients with early onset and severe disease course by autoantibody profiling. Arthritis Rheumatol. 2015;67(9):2427–36.CrossRefPubMed
17.
Kallenberg CGM, Vissink A, Kroese FGM, Abdulahad WH, Bootsma H. What have we learned from clinical trials in primary Sjogren’s syndrome about pathogenesis? Arthritis Res Ther. 2011;13(1):205.CrossRefPubMedPubMedCentral
18.
Ng WF, Bowman SJ. Biological therapies in primary Sjoogren’s syndrome. Expert Opin Biol Ther. 2011;11(7):921–36.CrossRefPubMed
19.
Meiners P, Vissink A, Kroese F, Spijkervet F, Haacke E, Abdulahad W, Smitt-Kamminga NS, Brouwer E, Arends S, Bootsma H. Abatacept treatment reduces disease activity in early primary Sjogren’s syndrome (phase Ii open label asap study). Ann Rheum Dis. 2013;72:89.CrossRef
20.
Shen L, Suresh L, Wu J, Jingxiu X, Li H, Zhang C, Pankewycz O, Ambrus JJ. A role for lymphotoxin in primary Sjogren’s disease. J Immunol. 2010;185(10):6355–63.CrossRefPubMed
21.
Gatumu MK, Skarstein K, Papandile A, Browning JL, Fava RA, Bolstad AI. Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjogren’s syndrome in salivary glands of non-obese diabetic mice. Arthritis Res Ther. 2009;11(1):R24.CrossRefPubMedPubMedCentral
22.
Ambrus JJ, Shen L, Suresh L. Distinct Roles for Lymphotoxin and Type 1 Interferon in Sjogren’s Disease. 11th Int Symp Sjogren’s Syndrome. 2011:OP021.
Metadata
Title
Analysis of novel Sjogren’s syndrome autoantibodies in patients with dry eyes
Authors
Sandra Everett
Sahana Vishwanath
Vanessa Cavero
Long Shen
Lakshmanan Suresh
Kishore Malyavantham
Norah Lincoff-Cohen
Julian L. Ambrus Jr.
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2017
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-017-0412-8

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