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BMC Ophthalmology
Published in: BMC Ophthalmology 1/2016

Open Access 01-12-2016 | Research article

Changes of retinal flow volume after intravitreal injection of bevacizumab in branch retinal vein occlusion with macular edema: a case series

Authors: Hidetaka Noma, Kanako Yasuda, Terumi Minezaki, Sho Watarai, Masahiko Shimura

Published in: BMC Ophthalmology | Issue 1/2016

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Abstract

Background

Although intravitreal injection of bevacizumab (IVB) is effective for macular edema in patients with branch retinal vein occlusion (BRVO), the changes of retinal hemodynamics remain unclear. We investigated retinal hemodynamic changes in BRVO patients after IVB by performing laser speckle flowgraphy (LSFG).

Methods

In 35 BRVO patients with macular edema, the relative flow volume (RFV) of the retinal artery and vein passing through the optic disc was measured in both the occluded and non-occluded regions of the retina before IVB and 1 month after IVB by LSFG. The ischemic region of retina was measured with the Scion Image program and the severity of retinal ischemia was assessed by dividing the non-perfused area by the disc area.

Results

Macular edema improved significantly by 1 month after IVB. The venous RFV ratio showed a significant increase in the non-occluded region at 1 month after IVB. There was a significant negative correlation between the venous RFV ratio and the severity of retinal ischemia in the occluded region. On the other hand, arterial RFV ratio showed no significant change after IVB in either the occluded or non-occluded region. In addition, there was no significant correlation between the arterial RFV ratio and the severity of retinal ischemia in either the occluded or non-occluded region.

Conclusions

These results suggest that an increase of retinal venous outflow after IVB may possibly influence the resolution of macular edema and that the response of venous outflow after IVB depends on the severity of retinal ischemia in the occluded region.
Literature
1.
Christoffersen NL, Larsen M. Pathophysiology and hemodynamics of branch retinal vein occlusion. Ophthalmology. 1999;106:2054–62.CrossRefPubMed
2.
Wu L, Arevalo JF, Roca JA, Maia M, Berrocal MH, Rodriguez FJ, Evans T, Costa RA, Cardillo J. Comparison of two doses of intravitreal bevacizumab (Avastin) for treatment of macular edema secondary to branch retinal vein occlusion: results from the Pan-American Collaborative Retina Study Group at 6 months of follow-up. Retina. 2008;28:212–9.CrossRefPubMed
3.
Sugiyama T, Araie M, Riva CE, Schmetterer L, Orgul S. Use of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol. 2010;88:723–9.CrossRefPubMed
4.
Shiga Y, Asano T, Kunikata H, Nitta F, Sato H, Nakazawa T, Shimura M. Relative flow volume, a novel blood flow index in the human retina derived from laser speckle flowgraphy. Invest Ophthalmol Vis Sci. 2014;55:3899–904.CrossRefPubMed
5.
Noma H, Funatsu H, Yamasaki M, Tsukamoto H, Mimura T, Sone T, Jian K, Sakamoto I, Nakano K, Yamashita H, Minamoto A, Mishima HK. Pathogenesis of macular edema with branch retinal vein occlusion and intraocular levels of vascular endothelial growth factor and interleukin-6. Am J Ophthalmol. 2005;140:256–61.CrossRefPubMed
6.
Isono H, Kishi S, Kimura Y, Hagiwara N, Konishi N, Fujii H. Observation of choroidal circulation using index of erythrocytic velocity. Arch Ophthalmol. 2003;121:225–31.CrossRefPubMed
7.
Shiga Y, Shimura M, Asano T, Tsuda S, Yokoyama Y, Aizawa N, Omodaka K, Ryu M, Yokokura S, Takeshita T, Nakazawa T. The influence of posture change on ocular blood flow in normal subjects, measured by laser speckle flowgraphy. Curr Eye Res. 2013;38:691–8.CrossRefPubMed
8.
Riva CE, Titze P, Hero M, Petrig BL. Effect of acute decreases of perfusion pressure on choroidal blood flow in humans. Invest Ophthalmol Vis Sci. 1997;38:1752–60.PubMed
9.
Okuno T, Sugiyama T, Kohyama M, Kojima S, Oku H, Ikeda T. Ocular blood flow changes after dynamic exercise in humans. Eye (Lond). 2006;20:796–800.CrossRef
10.
Anderson DR. Glaucoma, capillaries and pericytes. 1. Blood flow regulation. Ophthalmologica. 1996;210:257–62.CrossRefPubMed
11.
Noma H, Minamoto A, Funatsu H, Tsukamoto H, Nakano K, Yamashita H, Mishima HK. Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated with macular edema in branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2006;244:309–15.CrossRefPubMed
12.
Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol. 2006;7:359–71.CrossRefPubMed
13.
14.
Shimura M, Yasuda K. Macular ischaemia after intravitreal bevacizumab injection in patients with central retinal vein occlusion and a history of diabetes and vascular disease. Br J Ophthalmol. 2010;94:381–3.CrossRefPubMed
15.
Pournaras CJ, Rungger-Brandle E, Riva CE, Hardarson SH, Stefansson E. Regulation of retinal blood flow in health and disease. Prog Retin Eye Res. 2008;27:284–330.CrossRefPubMed
16.
Nagaoka T, Mori F, Yoshida A. Retinal artery response to acute systemic blood pressure increase during cold pressor test in humans. Invest Ophthalmol Vis Sci. 2002;43:1941–5.PubMed
17.
Arnarsson A, Stefansson E. Laser treatment and the mechanism of edema reduction in branch retinal vein occlusion. Invest Ophthalmol Vis Sci. 2000;41:877–9.PubMed
18.
Stefansson E. The therapeutic effects of retinal laser treatment and vitrectomy. A theory based on oxygen and vascular physiology. Acta Ophthalmol Scand. 2001;79:435–40.CrossRefPubMed
Metadata
Title
Changes of retinal flow volume after intravitreal injection of bevacizumab in branch retinal vein occlusion with macular edema: a case series
Authors
Hidetaka Noma
Kanako Yasuda
Terumi Minezaki
Sho Watarai
Masahiko Shimura
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2016
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-016-0239-8

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