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Open Access 01-12-2021 | osteosarcoma | Research article

Number of metastases and their response to chemotherapy impact survival of patients with isolated lung metastases from bone-derived sarcoma

Authors: Theresa Stork, Rebecca Boemans, Jendrik Hardes, Arne Streitbürger, Uta Dirksen, Christoph Pöttgen, Hans-Ulrich Schildhaus, Sebastian Bauer, Stéphane Collaud, Clemens Aigner

Published in: BMC Cancer | Issue 1/2021

Abstract

Background

Pulmonary metastasectomy (PM) is an established treatment for selected patients with metastatic sarcomas. The aim of this study was to examine our institutional experience and evaluate factors predicting outcome.

Methods

We retrospectively reviewed all patients undergoing PM for bone sarcoma in our center from 2001 to 2019. Survival was calculated from the date of PM. Impact on survival of clinical parameters was assessed.

Results

Thirty-eight patients (27 males, 71%) were included. Histology was osteosarcoma (n = 20, 53%), Ewing sarcoma (n = 13, 34%) and chondrosarcoma (n = 5, 13%). Twelve patients (31.5%) had synchronous metastases, all received chemotherapy before PM. Median number of metastases was 3 (1 to 29). Twenty (53%) patients had mediastinal lymph node sampling. One patient had positive lymph nodes. Ninety-day mortality was 0%. Three and 5-year PFS were 24.5 and 21%, respectively. Three and 5-year OS were 64.5 and 38.5%, respectively. More than three metastases and progression under chemotherapy were significant independent predictors for OS.

Conclusion

PM is a safe procedure and encouraging long-term outcome can be achieved. Patients with progression of pulmonary metastases under chemotherapy as well as patients with more than three metastases had significantly worse OS.

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Title: Number of metastases and their response to chemotherapy impact survival of patients with isolated lung metastases from bone-derived sarcoma
Authors: Theresa Stork
Rebecca Boemans
Jendrik Hardes
Arne Streitbürger
Uta Dirksen
Christoph Pöttgen
Hans-Ulrich Schildhaus
Sebastian Bauer
Stéphane Collaud
Clemens Aigner
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: osteosarcoma
Metastasis
Osteosarcoma
Sarcoma
Chondrosarcoma
Cytostatic Therapy
Published in: BMC Cancer / Issue 1/2021
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-021-08073-3

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