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BMC Cancer
Published in: BMC Cancer 1/2019

Open Access 01-12-2019 | Fertility | Research article

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Authors: Congcong Li, Qing Zhang, Siying Zhang, Ruifen Dong, Chenggong Sun, Chunping Qiu, Zhiwei Zhang, Xingsheng Yang, Beihua Kong

Published in: BMC Cancer | Issue 1/2019

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Abstract

Background

0.17–2% of mature cystic teratoma of the ovary (MCTO) undergo malignant transformation, of which 80% are squamous cell carcinoma (SCC) transformation in MCTO. We aim to investigate the clinical characteristics and treatment of SCC transformation in MCTO

Methods

We systematically searched PubMed database and individual patient data about SCC transformation in MCTO were extracted. The published cases were combined with 6 cases of SCC transformation in MCTO from Qilu Hospital, Shandong University.

Results

The incidence of SCC transformation in MCTO was 0.3%. A total of 435 cases of SCC transformation in MCTO were enrolled in the analysis. The mean age of diagnosis was 53.5 (range 19–87) years old. The most common clinical manifestations were abdominal pain (47.3%) and abdominal mass (26.0%). StageI,II, III and IV accounted for 50.0, 18.8, 26.8 and 4.4% of all cases, respectively. Patients with stage I had significantly better prognosis than stage II, III and IV patients (P < 0.01). Hysterectomy can improve overall survival (P < 0.01). For patients younger than 45 years old with stageIA orIC, there was no difference in mortality between fertility-sparing and radical surgery (P = 1.00). Adjuvant chemotherapy can improve survival in patients with advanced stage (P = 0.02), and chemotherapy with platinum was related to better prognosis (P = 0.02).

Conclusion

SCC transformation in MCTO is a rare malignancy mainly occurs in older age. FIGO stage is an independent prognostic factor. Hysterectomy and platinum-based chemotherapy are associated with better survival. Fertility-sparing surgery is feasible for young patients with early stage.
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Metadata
Title
Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review
Authors
Congcong Li
Qing Zhang
Siying Zhang
Ruifen Dong
Chenggong Sun
Chunping Qiu
Zhiwei Zhang
Xingsheng Yang
Beihua Kong
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2019
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-019-5393-y

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