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Open Access 01-12-2019 | Melanoma | Research article

Eosinophil-cationic protein - a novel liquid prognostic biomarker in melanoma

Authors: Annika Krückel, Alvaro Moreira, Waltraud Fröhlich, Gerold Schuler, Lucie Heinzerling

Published in: BMC Cancer | Issue 1/2019

Abstract

Background

The role of eosinophils in cancer is not yet completely understood, but patients with eosinophilia show a trend towards longer survival in several types of cancer, including melanoma. However, eosinophil count at initial diagnosis of metastatic melanoma does not predict survival. Since eosinophil cationic protein (ECP) mediates anticancer effects, such as tissue remodelling and cytotoxic activity, we investigated this marker as an early prognostic marker in metastatic melanoma.

Methods

Serum of 56 melanoma patients was collected at the time of diagnosis of metastatic disease. ECP levels as measured by ELISA were correlated with overall survival (OS) in patients before systemic therapy with immunotherapy or chemotherapy. Statistical analyses were performed using the Log–Rank (Mantel–Cox) test.

Results

The median OS for patients with high serum ECP above 12.2 ng/ml was 12 months (n = 39), compared to 28 months for patients with ECP below this threshold (n = 17; p = 0.0642). In patients with cutaneous melanoma, excluding patients with uveal and mucosal melanoma, the survival difference was even more striking (p = 0.0393). ECP’s effect size on OS was observed independently of the consecutive therapy. ECP levels were not correlated with LDH levels.

Conclusion

ECP seems to be a novel prognostic serum marker for the outcome of melanoma patients, which is independent of LDH and easy to perform in clinical practice. The striking negative prognostic value of high ECP level is unanticipated and can guide patient management.

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Title: Eosinophil-cationic protein - a novel liquid prognostic biomarker in melanoma
Authors: Annika Krückel
Alvaro Moreira
Waltraud Fröhlich
Gerold Schuler
Lucie Heinzerling
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Melanoma
Melanoma
Eosinophilia
Mucosal Melanoma
Biomarkers
Published in: BMC Cancer / Issue 1/2019
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-019-5384-z

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