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Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Research article

Health utility scores of family caregivers for leukemia patients measured by EQ-5D-3L: a cross-sectional survey in China

Authors: Hongjuan Yu, Huan Zhang, Jinjin Yang, Chaojie Liu, Chengfang Lu, Hongbin Yang, Weidong Huang, Jin Zhou, Wenqi Fu, Linmei Shi, Yan Yan, Guoxiang Liu, Limin Li

Published in: BMC Cancer | Issue 1/2018

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Abstract

Background

This study assessed the health related quality of life of family caregivers (FCs) of leukemia patients by using the health utility scores derived from the EuroQol five-dimensional (EQ-5D) questionnaire.

Methods

A cross-sectional survey was undertaken on 306 family caregivers of leukemia patients to assess their health utility using the EQ-5D-3L. Participants were recruited from three hospitals in China’s Heilongjiang province. The health utility scores of the participants were estimated based on the Chinese EQ-5D-3L value set and compared with those of the local general population. Factors predicting the health utility scores were identified through the Kruskal-Wallis analysis of variance and median regression analyses.

Results

FCs had lower health utility scores than the general population (p < 0.001). The participants with a lower socioeconomic status had lower utility scores and reported more problems than those with a higher socio-economic status. Better family function and higher social support were associated with higher health utility scores. The type of leukemia, household income, and social support are significant predictors of health utility scores of the FCs. Chronic lymphocytic leukemia, low socio-economic status, and low social support are associated with lower health utility scores of the FCs.

Conclusions

FCs for leukemia patients have lower health utility scores than the local general population, as measured by the EQ-5D-3L. There is an immediate need to address the health concerns of FCs, who play an important role in the Chinese health care system.
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Literature
1.
go back to reference Awadalla AW, Ohaeri JU, Gholoum A, Khalid AOA, Hamad HMA, Jacob A. Factors associated with quality of life of outpatients with breast cancer and gynecologic cancers and their family caregivers: a controlled study. BMC Cancer. 2007;7:102.CrossRef Awadalla AW, Ohaeri JU, Gholoum A, Khalid AOA, Hamad HMA, Jacob A. Factors associated with quality of life of outpatients with breast cancer and gynecologic cancers and their family caregivers: a controlled study. BMC Cancer. 2007;7:102.CrossRef
2.
go back to reference Bharmal M, Rd TJ. Comparing the EQ-5D and the SF-6D descriptive systems to assess their ceiling effects in the US general population. Value Health. 2006;9:262.CrossRef Bharmal M, Rd TJ. Comparing the EQ-5D and the SF-6D descriptive systems to assess their ceiling effects in the US general population. Value Health. 2006;9:262.CrossRef
3.
go back to reference Bultz BD, Speca M, Brasher PM, Geggie PHS, Page SA. A randomized controlled trial of a brief psychoeducational support group for partners of early stage breast cancer patients. Psycho-Oncology. 2000;9:303–13.CrossRef Bultz BD, Speca M, Brasher PM, Geggie PHS, Page SA. A randomized controlled trial of a brief psychoeducational support group for partners of early stage breast cancer patients. Psycho-Oncology. 2000;9:303–13.CrossRef
4.
go back to reference Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–32.CrossRef Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–32.CrossRef
5.
go back to reference Choi YS, Hwang SW, Hwang IC, Lee YJ, Kim YS, Kim HM, Youn CH, Ahn HY, Koh S-J. Factors associated with quality of life among family caregivers of terminally ill cancer patients. Psycho-Oncology. 2016;25:217–24.CrossRef Choi YS, Hwang SW, Hwang IC, Lee YJ, Kim YS, Kim HM, Youn CH, Ahn HY, Koh S-J. Factors associated with quality of life among family caregivers of terminally ill cancer patients. Psycho-Oncology. 2016;25:217–24.CrossRef
6.
go back to reference de Oliveira C, Bremner KE, Liu N, Greenberg ML, Nathan PC, McBride ML, Krahn MD. Costs of cancer care in children and adolescents in Ontario, Canada. Pediatr Blood Cancer. 2017;64(11). de Oliveira C, Bremner KE, Liu N, Greenberg ML, Nathan PC, McBride ML, Krahn MD. Costs of cancer care in children and adolescents in Ontario, Canada. Pediatr Blood Cancer. 2017;64(11).
7.
go back to reference Doubova SV, Infante-Castañeda C. Factors associated with quality of life of caregivers of Mexican cancer patients. Qual Life Res. 2016;(11):2931–40.CrossRef Doubova SV, Infante-Castañeda C. Factors associated with quality of life of caregivers of Mexican cancer patients. Qual Life Res. 2016;(11):2931–40.CrossRef
8.
go back to reference Fan L, Guang Z, Songyuan L, Tianlun Z, Zhiqiang Z. A study on validity and reliability of the family APGAR. Chin J Public Health. 1999;15:27–8. Fan L, Guang Z, Songyuan L, Tianlun Z, Zhiqiang Z. A study on validity and reliability of the family APGAR. Chin J Public Health. 1999;15:27–8.
9.
go back to reference Fan L, Yuan G. The family APGAR questionnaire and its clinical application foreign medical sciences( series of hospital management), vol. 11; 1995. p. 56–9. Fan L, Yuan G. The family APGAR questionnaire and its clinical application foreign medical sciences( series of hospital management), vol. 11; 1995. p. 56–9.
10.
go back to reference Ge C, Yang X, Fu J, Chang Y, Wei J, Zhang F, Nutifafa AE, Wang L. Reliability and validity of the Chinese version of the caregiver reaction assessment. Psychiatry Clin Neurosci. 2011;65:254–63.CrossRef Ge C, Yang X, Fu J, Chang Y, Wei J, Zhang F, Nutifafa AE, Wang L. Reliability and validity of the Chinese version of the caregiver reaction assessment. Psychiatry Clin Neurosci. 2011;65:254–63.CrossRef
11.
go back to reference Group EQC. EuroQol--a new facility for the measurement of health-related quality of life. Health Policy. 1990;16:199–208.CrossRef Group EQC. EuroQol--a new facility for the measurement of health-related quality of life. Health Policy. 1990;16:199–208.CrossRef
12.
go back to reference Guyatt G, Jaeschke R, Feeny D, Patrick D (1996) Measurement in clinical trials: choosing the right approach. Guyatt G, Jaeschke R, Feeny D, Patrick D (1996) Measurement in clinical trials: choosing the right approach.
13.
go back to reference Huang W, Yu H, Liu C, Liu G, Wu Q, Zhou J, Zhang X, Zhao X, Shi L, Xu X. Assessing health-related quality of life of Chinese adults in Heilongjiang using EQ-5D-3L. Int J Environ Res Public Health. 2017;14(3):224.CrossRef Huang W, Yu H, Liu C, Liu G, Wu Q, Zhou J, Zhang X, Zhao X, Shi L, Xu X. Assessing health-related quality of life of Chinese adults in Heilongjiang using EQ-5D-3L. Int J Environ Res Public Health. 2017;14(3):224.CrossRef
14.
go back to reference Khanna R, Jariwala K, Bentley JP. Health utility assessment using EQ-5D among caregivers of children with autism. Value Health. 2013;16:778–88.CrossRef Khanna R, Jariwala K, Bentley JP. Health utility assessment using EQ-5D among caregivers of children with autism. Value Health. 2013;16:778–88.CrossRef
15.
go back to reference Klassen AF, Klaassen R, Dix D, Pritchard S, Yanofsky R, O’Donnell M, Scott A, Sung L. Impact of caring for a child with cancer on parents’ health-related quality of life. J Clin Oncol. 2008;26:5884–9.CrossRef Klassen AF, Klaassen R, Dix D, Pritchard S, Yanofsky R, O’Donnell M, Scott A, Sung L. Impact of caring for a child with cancer on parents’ health-related quality of life. J Clin Oncol. 2008;26:5884–9.CrossRef
16.
go back to reference Kong EH. The influence of culture on the experiences of Korean, Korean American, and Caucasian - American family caregivers of frail older adults. J Korean Acad Nurs. 2007;37:213–20.CrossRef Kong EH. The influence of culture on the experiences of Korean, Korean American, and Caucasian - American family caregivers of frail older adults. J Korean Acad Nurs. 2007;37:213–20.CrossRef
17.
go back to reference Kurtz M, Kurtz J, Given C, Given B. Concordance of cancer patient and caregiver symptom reports. Cancer Pract. 1995;4:185–90. Kurtz M, Kurtz J, Given C, Given B. Concordance of cancer patient and caregiver symptom reports. Cancer Pract. 1995;4:185–90.
18.
go back to reference Lee YJ, Kim JE, Choi YS, Hwang IC, Hwang SW, Kim YS, Kim HM, Ahn HY, Kim SJ. Quality of life discordance between terminal cancer patients and family caregivers: a multicenter study. Support Care Cancer. 2016;(7):2853–60. Lee YJ, Kim JE, Choi YS, Hwang IC, Hwang SW, Kim YS, Kim HM, Ahn HY, Kim SJ. Quality of life discordance between terminal cancer patients and family caregivers: a multicenter study. Support Care Cancer. 2016;(7):2853–60.
20.
go back to reference Liu C, Li N, Ren X, Liu D. Is traditional rural lifestyle a barrier for quality of life assessment? A case study using the Short Form 36 in a rural Chinese population. Qual Life Res. 2010;19:31–6.CrossRef Liu C, Li N, Ren X, Liu D. Is traditional rural lifestyle a barrier for quality of life assessment? A case study using the Short Form 36 in a rural Chinese population. Qual Life Res. 2010;19:31–6.CrossRef
21.
go back to reference Liu GG, Wu H, Li M, Gao C, Luo N. Chinese time trade-off values for EQ-5D health states. Value Health. 2014;17:597–604.CrossRef Liu GG, Wu H, Li M, Gao C, Luo N. Chinese time trade-off values for EQ-5D health states. Value Health. 2014;17:597–604.CrossRef
22.
go back to reference Northouse L, Williams AL, Given B, McCorkle R. Psychosocial care for family caregivers of patients with cancer. J Clin Oncol. 2012;30:1227–34.CrossRef Northouse L, Williams AL, Given B, McCorkle R. Psychosocial care for family caregivers of patients with cancer. J Clin Oncol. 2012;30:1227–34.CrossRef
23.
go back to reference OECD (2014) OECD health statistics 2014: how does China compare? OECD (2014) OECD health statistics 2014: how does China compare?
24.
go back to reference Pathirana TI, Goonawardena CSE, Wijesiriwardane I. Quality of life of caregivers and impact on the nuclear family of children with leukaemia in the National Cancer Institute of Sri Lanka. J Postgrad Inst Med. 2015;2:18.CrossRef Pathirana TI, Goonawardena CSE, Wijesiriwardane I. Quality of life of caregivers and impact on the nuclear family of children with leukaemia in the National Cancer Institute of Sri Lanka. J Postgrad Inst Med. 2015;2:18.CrossRef
25.
go back to reference Powell JL. Least absolute deviations estimation for the censored regression model. J Econ. 1984;25:303–25.CrossRef Powell JL. Least absolute deviations estimation for the censored regression model. J Econ. 1984;25:303–25.CrossRef
26.
go back to reference Räsänen P, Roine E, Sintonen H, Semberg-Konttinen V, Ryynänen OP, Roine R. Use of quality-adjusted life years for the estimation of effectiveness of health care: a systematic literature review. Int J Technol Assess Health Care. 2006;22:235.CrossRef Räsänen P, Roine E, Sintonen H, Semberg-Konttinen V, Ryynänen OP, Roine R. Use of quality-adjusted life years for the estimation of effectiveness of health care: a systematic literature review. Int J Technol Assess Health Care. 2006;22:235.CrossRef
27.
go back to reference Ren X, Meng H, Liu C, Wu J, Dong B, Li N. Family structure and support for the oldest old: a cross-sectional study in Dujiangyan, China. Fam Med Commun Health. 2015;3:5–14.CrossRef Ren X, Meng H, Liu C, Wu J, Dong B, Li N. Family structure and support for the oldest old: a cross-sectional study in Dujiangyan, China. Fam Med Commun Health. 2015;3:5–14.CrossRef
28.
go back to reference Romito F, Goldzweig G, Cormio C, Hagedoorn M, Andersen BL. Informal caregiving for cancer patients. Cancer. 2013;119:2160–9.CrossRef Romito F, Goldzweig G, Cormio C, Hagedoorn M, Andersen BL. Informal caregiving for cancer patients. Cancer. 2013;119:2160–9.CrossRef
29.
go back to reference Santo EARE, Gaíva MAM, Espinosa MM, Barbosa DA, Belasco AGS. Taking care of children with cancer: evaluation of the caregivers’ burden and quality of life. Rev Lat Am Enfermagem. 2011;19:515–22.CrossRef Santo EARE, Gaíva MAM, Espinosa MM, Barbosa DA, Belasco AGS. Taking care of children with cancer: evaluation of the caregivers’ burden and quality of life. Rev Lat Am Enfermagem. 2011;19:515–22.CrossRef
30.
go back to reference Shuiyuan X, Desen Y. The effect of social support on physical and psychological health. J Chin Psychiatry. 1987;1:183–7. Shuiyuan X, Desen Y. The effect of social support on physical and psychological health. J Chin Psychiatry. 1987;1:183–7.
31.
go back to reference Sneha LM, Sai J, Ashwini S, Ramaswamy S, Rajan M, Scott JX. Financial burden faced by families due to out-of-pocket expenses during the treatment of their cancer children: an Indian perspective. Indian J Med Paediatr Oncol. 2017;38:4–9.CrossRef Sneha LM, Sai J, Ashwini S, Ramaswamy S, Rajan M, Scott JX. Financial burden faced by families due to out-of-pocket expenses during the treatment of their cancer children: an Indian perspective. Indian J Med Paediatr Oncol. 2017;38:4–9.CrossRef
32.
go back to reference Son KY, Lee CH, Park SM, Lee CH, Oh SI, Oh B, Tak SH, Cho B, Lee K, Lee SH. The factors associated with the quality of life of the spouse caregivers of patients with cancer: a cross-sectional study. J Palliat Med. 2012;15:216–24.CrossRef Son KY, Lee CH, Park SM, Lee CH, Oh SI, Oh B, Tak SH, Cho B, Lee K, Lee SH. The factors associated with the quality of life of the spouse caregivers of patients with cancer: a cross-sectional study. J Palliat Med. 2012;15:216–24.CrossRef
33.
go back to reference Sorensen J, Davidsen M, Gudex C, Pedersen KM, Bronnum-Hansen H. Danish EQ-5D population norms. Scand J Public Health. 2009;37:467–74.CrossRef Sorensen J, Davidsen M, Gudex C, Pedersen KM, Bronnum-Hansen H. Danish EQ-5D population norms. Scand J Public Health. 2009;37:467–74.CrossRef
34.
go back to reference Statistics HPBo. Heilongjiang statistical yearbook. Peking: China Statistics Press; 2015. Statistics HPBo. Heilongjiang statistical yearbook. Peking: China Statistics Press; 2015.
35.
go back to reference Stenberg U, Ruland CM, Miaskowski C. Review of the literature on the effects of caring for a patient with cancer. Psycho-Oncology. 2009;19:1013–25.CrossRef Stenberg U, Ruland CM, Miaskowski C. Review of the literature on the effects of caring for a patient with cancer. Psycho-Oncology. 2009;19:1013–25.CrossRef
37.
go back to reference Sullivan PW, Ghushchyan VH. EQ-5D scores for diabetes-related comorbidities. Value Health. 2016;19:1002–8.CrossRef Sullivan PW, Ghushchyan VH. EQ-5D scores for diabetes-related comorbidities. Value Health. 2016;19:1002–8.CrossRef
38.
go back to reference Sullivan PW, Ghushchyan VH, Globe G, Sucher B. Health-related quality of life associated with systemic corticosteroids. Qual Life Res. 2017;26:1037–58.CrossRef Sullivan PW, Ghushchyan VH, Globe G, Sucher B. Health-related quality of life associated with systemic corticosteroids. Qual Life Res. 2017;26:1037–58.CrossRef
39.
go back to reference Sun S, Chen J, Johannesson M, Kind P, Xu L, Zhang Y, Burström K. Population health status in China: EQ-5D results, by age, sex and socio-economic status, from the National Health Services Survey 2008. Qual Life Res. 2010;20:309–20.CrossRef Sun S, Chen J, Johannesson M, Kind P, Xu L, Zhang Y, Burström K. Population health status in China: EQ-5D results, by age, sex and socio-economic status, from the National Health Services Survey 2008. Qual Life Res. 2010;20:309–20.CrossRef
40.
go back to reference Suwen F, Jun L, Fang Y, Zhishu Z. Relative factors of life quality of principle caregivers of gynecologic cancer patients. Chin J Nurs. 2006;41:402–4. Suwen F, Jun L, Fang Y, Zhishu Z. Relative factors of life quality of principle caregivers of gynecologic cancer patients. Chin J Nurs. 2006;41:402–4.
41.
go back to reference Tang YY, Chen SP. Health promotion behaviors in Chinese family caregivers of patients with stroke. Health Promot Int. 2002;17:329–39.CrossRef Tang YY, Chen SP. Health promotion behaviors in Chinese family caregivers of patients with stroke. Health Promot Int. 2002;17:329–39.CrossRef
42.
go back to reference Xiangdong W, Xilin W, Hong M. Rating scales for mental health. Beijing: Chinese Mental Health Journal; 1999. Xiangdong W, Xilin W, Hong M. Rating scales for mental health. Beijing: Chinese Mental Health Journal; 1999.
43.
go back to reference Yamazaki S, Sokejima S, Mizoue T, Eboshida A, Fukuhara S. Health-related quality of life of mothers of children with leukemia in Japan. Qual Life Res. 2005;14:1079–85.CrossRef Yamazaki S, Sokejima S, Mizoue T, Eboshida A, Fukuhara S. Health-related quality of life of mothers of children with leukemia in Japan. Qual Life Res. 2005;14:1079–85.CrossRef
44.
go back to reference Yang SM, Li JY, Gale RP, Huang XJ. The mystery of chronic lymphocytic leukemia (CLL): why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology? Blood Rev. 2015;29:205–13.CrossRef Yang SM, Li JY, Gale RP, Huang XJ. The mystery of chronic lymphocytic leukemia (CLL): why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology? Blood Rev. 2015;29:205–13.CrossRef
45.
go back to reference Yeh PM, Wierenga ME, Yuan SC. Influences of psychological well-being, quality of caregiver-patient relationship, and family support on the health of family caregivers for cancer patients in Taiwan. Asian Nurs Res. 2009;3:154–66.CrossRef Yeh PM, Wierenga ME, Yuan SC. Influences of psychological well-being, quality of caregiver-patient relationship, and family support on the health of family caregivers for cancer patients in Taiwan. Asian Nurs Res. 2009;3:154–66.CrossRef
46.
go back to reference Yu H, Li L, Liu C, Huang W, Zhou J, Fu W, Ma Y, Li S, Chang Y, Liu G, Wu Q. Factors associated with the quality of life of family caregivers for leukemia patients in China. Health Qual Life Outcomes. 2017;15:55.CrossRef Yu H, Li L, Liu C, Huang W, Zhou J, Fu W, Ma Y, Li S, Chang Y, Liu G, Wu Q. Factors associated with the quality of life of family caregivers for leukemia patients in China. Health Qual Life Outcomes. 2017;15:55.CrossRef
47.
go back to reference Zuoji Z. Manual of behavioral medicine scale. Beijing: Chin Med Multimedia Press; 2005. Zuoji Z. Manual of behavioral medicine scale. Beijing: Chin Med Multimedia Press; 2005.
Metadata
Title
Health utility scores of family caregivers for leukemia patients measured by EQ-5D-3L: a cross-sectional survey in China
Authors
Hongjuan Yu
Huan Zhang
Jinjin Yang
Chaojie Liu
Chengfang Lu
Hongbin Yang
Weidong Huang
Jin Zhou
Wenqi Fu
Linmei Shi
Yan Yan
Guoxiang Liu
Limin Li
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4855-y

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