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BMC Cancer
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Research article

Increasing incidence of central nervous system (CNS) tumors (2000–2012): findings from a population based registry in Gironde (France)

Authors: Camille Pouchieu, Anne Gruber, Emilie Berteaud, Patrice Ménégon, Pascal Monteil, Aymeri Huchet, Jean-Rodolphe Vignes, Anne Vital, Hugues Loiseau, Isabelle Baldi

Published in: BMC Cancer | Issue 1/2018

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Abstract

Background

Although some countries have observed a stabilization in the incidence of CNS, an increasing incidence has been reported from multiple studies. Recent observations point out to the heterogeneity of incidence trends according to histological subtypes, gender and age-groups. Using a high-quality regional CNS tumor registry, this article describes the trends of CNS tumor incidence for main histological subtypes, including benign and malignant tumors, in the French department of Gironde from 2000 to 2012.

Methods

Crude and age-standardized incidence rates were calculated globally, by histological subtypes, malignant status, gender and age groups. For trends, annual percent changes (APC) were obtained from a piecewise log-linear model.

Results

A total of 3515 CNS tumors was registered during the period. The incidence of overall CNS tumors was 19/100000 person-years (8.3/100000 for neuroepithelial tumors and 7.3/100000 for meningeal tumors). An increased incidence of overall CNS tumors was observed from 2000 to 2012 (APC = + 2.7%; 95%-confidence interval (CI): 1.8–3.7). This trend was mainly explained by an increase in the incidence of meningiomas over the period (APC = + 5.4%, 95%-CI: 3.8–7.0). The increased incidence rate of CNS tumors was more pronounced in female and in older patients even though the incidence rate increased in all age groups.

Conclusions

Part of the temporal variation may be attributed to improvement in registration, diagnosis and clinical practices but also to changes in potential risk factors. Thus, etiological studies on CNS tumors are needed to clarify this rising trend.
Appendix
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Literature
1.
Fritz A, Percy C, Jack A, Shanmugaratnam K, Sobin L, Parkin D, et al. International classification of diseases for oncology. 3rd ed. Geneva: Organization; 2000.
2.
Johnson KJ, Cullen J, Barnholtz-Sloan JS, Ostrom QT, Langer CE, Turner MC, et al. Childhood brain tumor epidemiology: a brain tumor epidemiology consortium review. Cancer Epidemiol Biomark Prev. 2014;23:2716–36.CrossRef
3.
Deorah S, Lynch CF, Sibenaller ZA, Ryken TC. Trends in brain cancer incidence and survival in the United States: surveillance, epidemiology, and end results program, 1973 to 2001. Neurosurg Focus. 2006;20:E1.CrossRefPubMed
4.
Ho VKY, Reijneveld JC, Enting RH, Bienfait HP, Robe P, Baumert BG, et al. Changing incidence and improved survival of gliomas. Eur J Cancer Oxf Engl 1990. 2014;50:2309–18.
5.
Nomura E, Ioka A, Tsukuma H. Trends in the incidence of primary intracranial tumors in Osaka, Japan. Jpn J Clin Oncol. 2011;41:291–4.CrossRefPubMed
6.
Hess KR, Broglio KR, Bondy ML. Adult glioma incidence trends in the United States, 1977-2000. Cancer. 2004;101:2293–9.CrossRefPubMed
7.
Jukich PJ, McCarthy BJ, Surawicz TS, Freels S, Davis FG. Trends in incidence of primary brain tumors in the United States, 1985-1994. Neuro-Oncol. 2001;3:141–51.CrossRefPubMedPubMedCentral
8.
Smith MA, Freidlin B, Ries LA, Simon R. Trends in reported incidence of primary malignant brain tumors in children in the United States. J Natl Cancer Inst. 1998;90:1269–77.CrossRefPubMed
9.
Caldarella A, Crocetti E, Paci E. Is the incidence of brain tumors really increasing? A population-based analysis from a cancer registry. J Neuro-Oncol. 2011;104:589–94.CrossRef
10.
Arora RS, Alston RD, Eden TOB, Estlin EJ, Moran A, Geraci M, et al. Are reported increases in incidence of primary CNS tumours real? An analysis of longitudinal trends in England, 1979–2003. Eur J Cancer Oxf Engl 1990. 2010;46:1607–16.
11.
Legler JM, Ries LA, Smith MA, Warren JL, Heineman EF, Kaplan RS, et al. Cancer surveillance series [corrected]: brain and other central nervous system cancers: recent trends in incidence and mortality. J Natl Cancer Inst. 1999;91:1382–90.CrossRefPubMed
12.
Fleury A, Menegoz F, Grosclaude P, Daures JP, Henry-Amar M, Raverdy N, et al. Descriptive epidemiology of cerebral gliomas in France. Cancer. 1997;79:1195–202.CrossRefPubMed
13.
Patel S, Bhatnagar A, Wear C, Osiro S, Gabriel A, Kimball D, et al. Are pediatric brain tumors on the rise in the USA? Significant incidence and survival findings from the SEER database analysis. Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg. 2014;30:147–54.CrossRef
14.
McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M, et al. Trends in childhood brain tumor incidence, 1973-2009. J Neuro-Oncol. 2013;115:153–60.CrossRef
15.
Hjalmars U, Kulldorff M, Wahlqvist Y, Lannering B. Increased incidence rates but no space-time clustering of childhood astrocytoma in Sweden, 1973-1992: a population-based study of pediatric brain tumors. Cancer. 1999;85:2077–90.PubMed
16.
Johannesen TB, Angell-Andersen E, Tretli S, Langmark F, Lote K. Trends in incidence of brain and central nervous system tumors in Norway, 1970-1999. Neuroepidemiology. 2004;23:101–9.CrossRefPubMed
17.
McNally RJ, Kelsey AM, Cairns DP, Taylor GM, Eden OB, Birch JM. Temporal increases in the incidence of childhood solid tumors seen in Northwest England (1954-1998) are likely to be real. Cancer. 2001;92:1967–76.CrossRefPubMed
18.
Helseth A. The incidence of primary central nervous system neoplasms before and after computerized tomography availability. J Neurosurg. 1995;83:999–1003.CrossRefPubMed
19.
Davis FG, Malinski N, Haenszel W, Chang J, Flannery J, Gershman S, et al. Primary brain tumor incidence rates in four United States regions, 1985-1989: a pilot study. Neuroepidemiology. 1996;15:103–12.CrossRefPubMed
20.
Gurney JG, Wall DA, Jukich PJ, Davis FG. The contribution of nonmalignant tumors to CNS tumor incidence rates among children in the United States. Cancer Causes Control CCC. 1999;10:101–5.CrossRefPubMed
21.
Baldi I, Gruber A, Alioum A, Berteaud E, Lebailly P, Huchet A, et al. Descriptive epidemiology of CNS tumors in France: results from the Gironde registry for the period 2000-2007. Neuro-Oncol. 2011;13:1370–8.CrossRefPubMedPubMedCentral
22.
Deltour I, Johansen C, Auvinen A, Feychting M, Klaeboe L, Schüz J. Time trends in brain tumor incidence rates in Denmark, Finland, Norway, and Sweden, 1974-2003. J Natl Cancer Inst. 2009;101:1721–4.CrossRefPubMed
23.
Arora RS, Alston RD, Eden TOB, Estlin EJ, Moran A, Birch JM. Age-incidence patterns of primary CNS tumors in children, adolescents, and adults in England. Neuro-Oncol. 2009;11:403–13.CrossRefPubMedPubMedCentral
24.
Lannering B, Sandström P-E, Holm S, Lundgren J, Pfeifer S, Samuelsson U, et al. Classification, incidence and survival analyses of children with CNS tumours diagnosed in Sweden 1984–2005. Acta Paediatr Oslo Nor 1992. 2009;98:1620–7.
25.
26.
Dobes M, Shadbolt B, Khurana VG, Jain S, Smith SF, Smee R, et al. A multicenter study of primary brain tumor incidence in Australia (2000-2008). Neuro-Oncol. 2011;13:783–90.CrossRefPubMedPubMedCentral
27.
Gittleman HR, Ostrom QT, Rouse CD, Dowling JA, de Blank PM, Kruchko CA, et al. Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010. Cancer. 2015;121:102–12.CrossRefPubMed
28.
BJ MC, Kruchko C, Dolecek TA. The impact of the Benign Brain Tumor Cancer Registries Amendment Act (Public Law 107–260) on non-malignant brain and central nervous system tumor incidence trends. J Regist Manag. 2013;40:32–5.
29.
Schmidt LS, Schmiegelow K, Lahteenmaki P, Träger C, Stokland T, Grell K, et al. Incidence of childhood central nervous system tumors in the Nordic countries. Pediatr Blood Cancer. 2011;56:65–9.CrossRefPubMed
30.
McCarthy BJ, Surawicz T, Bruner JM, Kruchko C, Davis F. Consensus conference on brain tumor definition for registration. November 10, 2000. Neuro-Oncologia. 2002;4:134–45.CrossRef
31.
32.
Segi M. Cancer Mortality for selected sites in 24 countries (1950–57). Sendai: Department of Public Health, Tohoku University of Medicine; 1960.
33.
Doll R, Cook P. Summarizing indices for comparison of cancer incidence data. Int J Cancer. 1967;2:269–79.CrossRefPubMed
34.
Wöhrer A, Waldhör T, Heinzl H, Hackl M, Feichtinger J, Gruber-Mösenbacher U, et al. The Austrian brain tumour registry: a cooperative way to establish a population-based brain tumour registry. J Neuro-Oncol. 2009;95:401–11.CrossRef
35.
Ostrom QT, Gittleman H, Liao P, Rouse C, Chen Y, Dowling J, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro-Oncol. 2014;16(Suppl 4):iv1–63.CrossRefPubMedPubMedCentral
36.
Darefsky AS, Dubrow R. International variation in the incidence of adult primary malignant neoplasms of the brain and central nervous system. Cancer Causes Control CCC. 2009;20:1593–604.CrossRefPubMed
37.
Kuratsu J, Takeshima H, Ushio Y. Trends in the incidence of primary intracranial tumors in Kumamoto. Japan Int J Clin Oncol. 2001;6:183–91.PubMed
38.
Ding L-X, Wang Y-X. Increasing incidence of brain and nervous tumours in urban Shanghai, China, 1983–2007. Asian Pac J Cancer Prev APJCP. 2011;12:3319–22.PubMed
39.
Etxeberria J, San Román E, Burgui R, Guevara M, Moreno-Iribas C, Urbina MJ, et al. Brain and central nervous system Cancer incidence in Navarre (Spain), 1973-2008 and projections for 2014. J Cancer. 2015;6:177–83.CrossRefPubMedPubMedCentral
40.
Fuentes-Raspall R, Vilardell L, Perez-Bueno F, Joly C, Garcia-Gil M, Garcia-Velasco A, et al. Population-based incidence and survival of central nervous system (CNS) malignancies in Girona (Spain) 1994-2005. J Neuro-Oncol. 2011;101:117–23.CrossRef
41.
Jung K-W, Ha J, Lee SH, Won Y-J, Yoo H. An updated nationwide epidemiology of primary brain tumors in republic of Korea. Brain Tumor Res Treat. 2013;1:16–23.CrossRefPubMedPubMedCentral
42.
43.
Brown M, Schrot R, Bauer K, Letendre D. Incidence of first primary central nervous system tumors in California, 2001-2005. J Neuro-Oncol. 2009;94:249–61.CrossRef
44.
Nakamura H, Makino K, Yano S, Kuratsu J-I. Kumamoto brain tumor research group. Epidemiological study of primary intracranial tumors: a regional survey in Kumamoto prefecture in southern Japan--20-year study. Int J Clin Oncol. 2011;16:314–21.CrossRefPubMed
45.
Christensen HC, Kosteljanetz M, Johansen C. Incidences of gliomas and meningiomas in Denmark, 1943 to 1997. Neurosurgery. 2003;52:1327–33. discussion 1333–1334CrossRefPubMed
46.
Provost D, Cantagrel A, Lebailly P, Jaffré A, Loyant V, Loiseau H, et al. Brain tumours and exposure to pesticides: a case-control study in southwestern France. Occup Environ Med. 2007;64:509–14.CrossRefPubMedPubMedCentral
47.
48.
Niedermaier T, Behrens G, Schmid D, Schlecht I, Fischer B, Leitzmann MF. Body mass index, physical activity, and risk of adult meningioma and glioma: a meta-analysis. Neurol. 2015;85:1342–50.CrossRef
49.
IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 102 (2013) Non-ionizing radiation, part 2: radiofrequency electromagnetic fields. Lyon: International Agency for Research on Cancer; 2013.
50.
51.
IARC. Ionizing Radiation, part 1: X- and gamma- radiation and neutrons. IARC Monogr Eval Carcinog Risks Hum. 2000;75:1–492.
Metadata
Title
Increasing incidence of central nervous system (CNS) tumors (2000–2012): findings from a population based registry in Gironde (France)
Authors
Camille Pouchieu
Anne Gruber
Emilie Berteaud
Patrice Ménégon
Pascal Monteil
Aymeri Huchet
Jean-Rodolphe Vignes
Anne Vital
Hugues Loiseau
Isabelle Baldi
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4545-9

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