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Open Access 01-12-2018 | Research article

Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China

Authors: Fei He, Ren-dong Xiao, Tao Lin, Wei-min Xiong, Qiu-ping Xu, Xu Li, Zhi-qiang Liu, Bao-chang He, Zhi-jian Hu, Lin Cai

Published in: BMC Cancer | Issue 1/2018

Abstract

Background

We investigated whether BCMO1 variants and dietary patterns are associated with lung cancer risk.

Methods

Case-control study including 1166 lung cancer cases and 1179 frequency matched controls was conducted for three BCMO1 variants (rs6564851, rs12934922, and rs7501331) and four dietary patterns were investigated. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs).

Results

The rs6564851, rs12934922, and rs7501331 were not found to be associated with lung cancer risk (P > 0.05). In multivariable-adjusted models, compared to the lowest quartile of the score on the “fruits and vegetables” pattern, the highest quintile was associated with a 78.4% decreased risk (OR _{Q4 vs. Q1} = 0.216; 95% CI, 0.164–0.284; P for trend < 0.001). Other patterns were not found the association. The “fruits and vegetables” pattern was associated with a reduced risk of lung cancer with all 3 SNPs irrespective of genotypes (all P for trend< 0.001). The association for the “Frugal” pattern was associated with increased risk of lung cancer among smokers (P for interaction = 0.005). The protective effects of the “cereals/wheat and meat” pattern was more evident for squamous cell carcinoma and other histological type.

Conclusions

We did not observe associations of BCMO1 variants and lung cancer. Diets rich in fruits and vegetables may be protective against lung cancer.

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Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108. https://doi.org/10.3322/caac.21262.CrossRefPubMed

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–32. https://doi.org/10.3322/caac.21338.CrossRefPubMed

Zhao H, Fan Y, Ma S, Song X, Han B, Cheng Y, Huang C, Yang S, Liu X, Liu Y, Lu S, Wang J, Zhang S, Zhou C, Wang M, Zhang L, investigators I. Final overall survival results from a phase III, randomized, placebo-controlled, parallel-group study of gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804). J Thorac Oncol. 2015;10(4):655–64. https://doi.org/10.1097/JTO.0000000000000445.CrossRefPubMed

Filaire E, Dupuis C, Galvaing G, Aubreton S, Laurent H, Richard R, Filaire M. Lung cancer: what are the links with oxidative stress, physical activity and nutrition. Lung Cancer. 2013;82(3):383–9. https://doi.org/10.1016/j.lungcan.2013.09.009.CrossRefPubMed

Proctor RN. Tobacco and the global lung cancer epidemic. Nat Rev Cancer. 2001;1(1):82–6. https://doi.org/10.1038/35094091.CrossRefPubMed

Baena Ruiz R, Salinas HP. Diet and cancer: risk factors and epidemiological evidence. Maturitas. 2014;77(3):202–8. https://doi.org/10.1016/j.maturitas.2013.11.010.CrossRefPubMed

Bolland MJ, Grey A, Reid IR. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer. Ann Intern Med. 2014;160(9):655–6. https://doi.org/10.7326/L14-5009-4.CrossRefPubMed

Cho E, Hunter DJ, Spiegelman D, Albanes D, Beeson WL, van den Brandt PA, Colditz GA, Feskanich D, Folsom AR, Fraser GE, Freudenheim JL, Giovannucci E, Goldbohm RA, Graham S, Miller AB, Rohan TE, Sellers TA, Virtamo J, Willett WC, Smith-Warner SA. Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: a pooled analysis of 8 prospective studies. Int J Cancer. 2006;118(4):970–8. https://doi.org/10.1002/ijc.21441.CrossRefPubMed

Song J, Su H, Wang BL, Zhou YY, Guo LL. Fish consumption and lung cancer risk: systematic review and meta-analysis. Nutr Cancer. 2014;66(4):539–49. https://doi.org/10.1080/01635581.2014.894102.CrossRefPubMed

10.

Wang Y, Li F, Wang Z, Qiu T, Shen Y, Wang M. Fruit and vegetable consumption and risk of lung cancer: a dose-response meta-analysis of prospective cohort studies. Lung Cancer. 2015;88(2):124–30. https://doi.org/10.1016/j.lungcan.2015.02.015.CrossRefPubMed

11.

Anic GM, Park Y, Subar AF, Schap TE, Reedy J. Index-based dietary patterns and risk of lung cancer in the NIH-AARP diet and health study. Eur J Clin Nutr. 2016;70(1):123–9. https://doi.org/10.1038/ejcn.2015.122.CrossRefPubMed

12.

Balder HF, Goldbohm RA, van den Brandt PA. Dietary patterns associated with male lung cancer risk in the Netherlands cohort study. Cancer Epidemiol Biomark Prev. 2005;14(2):483–90. https://doi.org/10.1158/1055-9965.EPI-04-0353.CrossRef

13.

Couto E, Boffetta P, Lagiou P, Ferrari P, Buckland G, Overvad K, Dahm CC, Tjonneland A, Olsen A, Clavel-Chapelon F, Boutron-Ruault MC, Cottet V, Trichopoulos D, Naska A, Benetou V, Kaaks R, Rohrmann S, Boeing H, von Ruesten A, Panico S, Pala V, Vineis P, Palli D, Tumino R, May A, Peeters PH, Bueno-de-Mesquita HB, Buchner FL, Lund E, Skeie G, Engeset D, Gonzalez CA, Navarro C, Rodriguez L, Sanchez MJ, Amiano P, Barricarte A, Hallmans G, Johansson I, Manjer J, Wirfart E, Allen NE, Crowe F, Khaw KT, Wareham N, Moskal A, Slimani N, Jenab M, Romaguera D, Mouw T, Norat T, Riboli E, Trichopoulou A. Mediterranean dietary pattern and cancer risk in the EPIC cohort. Br J Cancer. 2011;104(9):1493–9. https://doi.org/10.1038/bjc.2011.106.CrossRefPubMedPubMedCentral

14.

De Stefani E, Boffetta P, Ronco AL, Deneo-Pellegrini H, Acosta G, Gutierrez LP, Mendilaharsu M. Nutrient patterns and risk of lung cancer: a factor analysis in Uruguayan men. Lung Cancer. 2008;61(3):283–91. https://doi.org/10.1016/j.lungcan.2008.01.004.CrossRefPubMed

15.

Gorlova OY, Weng SF, Hernandez L, Spitz MR, Forman MR. Dietary patterns affect lung cancer risk in never smokers. Nutr Cancer. 2011;63(6):842–9. https://doi.org/10.1080/01635581.2011.589958.CrossRefPubMed

16.

Gnagnarella P, Maisonneuve P, Bellomi M, Rampinelli C, Bertolotti R, Spaggiari L, Palli D, Veronesi G. Nutrient intake and nutrient patterns and risk of lung cancer among heavy smokers: results from the COSMOS screening study with annual low-dose CT. Eur J Epidemiol. 2013;28(6):503–11. https://doi.org/10.1007/s10654-013-9803-1.CrossRefPubMed

17.

Tu H, Heymach JV, Wen CP, Ye Y, Pierzynski JA, Roth JA, Wu X. Different dietary patterns and reduction of lung cancer risk: a large case-control study in the U.S. Sci Rep. 2016;6:26760. https://doi.org/10.1038/srep26760.CrossRefPubMedPubMedCentral

18.

De Stefani E, Ronco AL, Boffetta P, Deneo-Pellegrini H, Correa P, Acosta G. Nutritional patterns and lung cancer risk in Uruguayan men. Cancer Ther. 2006;4:153–62.

19.

Sun Y, Li Z, Li J, Li Z, Han J. A healthy dietary pattern reduces lung Cancer risk: a systematic review and meta-analysis. Nutrients. 2016;8(3):134. https://doi.org/10.3390/nu8030134.CrossRefPubMedPubMedCentral

20.

van Helden YG, Heil SG, van Schooten FJ, Kramer E, Hessel S, Amengual J, Ribot J, Teerds K, Wyss A, Lietz G, Bonet ML, von Lintig J, Godschalk RW, Keijer J. Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene. Cell Mol Life Sci. 2010;67(12):2039–56. https://doi.org/10.1007/s00018-010-0341-7.CrossRefPubMedPubMedCentral

21.

Gong X, Marisiddaiah R, Rubin LP. Beta-carotene regulates expression of beta-carotene 15,15′-monoxygenase in human alveolar epithelial cells. Arch Biochem Biophys. 2013;539(2):230–8. https://doi.org/10.1016/j.abb.2013.09.013.CrossRefPubMed

22.

Cui Y, Morgenstern H, Greenland S, Tashkin DP, Mao JT, Cai L, Cozen W, Mack TM, Lu QY, Zhang ZF. Dietary flavonoid intake and lung cancer--a population-based case-control study. Cancer. 2008;112(10):2241–8. https://doi.org/10.1002/cncr.23398.CrossRefPubMedPubMedCentral

23.

Jin YR, Lee MS, Lee JH, Hsu HK, Lu JY, Chao SS, Chen KT, Liou SH, Ger LP. Intake of vitamin A-rich foods and lung cancer risk in Taiwan: with special reference to garland chrysanthemum and sweet potato leaf consumption. Asia Pac J Clin Nutr. 2007;16(3):477–88.PubMed

24.

Lin Y, Cai L. Environmental and dietary factors and lung cancer risk among Chinese women: a case-control study in Southeast China. Nutr Cancer. 2012;64(4):508–14. https://doi.org/10.1080/01635581.2012.668743.CrossRefPubMed

25.

Leung WC, Hessel S, Meplan C, Flint J, Oberhauser V, Tourniaire F, Hesketh JE, von Lintig J, Lietz G. Two common single nucleotide polymorphisms in the gene encoding beta-carotene 15,15′-monoxygenase alter beta-carotene metabolism in female volunteers. FASEB J. 2009;23(4):1041–53. https://doi.org/10.1096/fj.08-121962.CrossRefPubMed

26.

Ferrucci L, Perry JR, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, Fried LP, Albanes D, Corsi AM, Cherubini A, Guralnik J, Bandinelli S, Singleton A, Virtamo J, Walston J, Semba RD, Frayling TM. Common variation in the beta-carotene 15,15′-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet. 2009;84(2):123–33. https://doi.org/10.1016/j.ajhg.2008.12.019.CrossRefPubMedPubMedCentral

27.

Piga R, van Dartel D, Bunschoten A, van der Stelt I, Keijer J. Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung. Toxicology. 2014;320:67–73. https://doi.org/10.1016/j.tox.2014.03.002.CrossRefPubMed

28.

van Helden YG, Godschalk RW, Swarts HJ, Hollman PC, van Schooten FJ, Keijer J. Beta-carotene affects gene expression in lungs of male and female Bcmo1 (−/−) mice in opposite directions. Cell Mol Life Sci. 2011;68(3):489–504. https://doi.org/10.1007/s00018-010-0461-0.CrossRefPubMed

29.

Lietz G, Oxley A, Leung W, Hesketh J. Single nucleotide polymorphisms upstream from the beta-carotene 15,15′-monoxygenase gene influence provitamin a conversion efficiency in female volunteers. J Nutr. 2012;142(1):161S–5S. https://doi.org/10.3945/jn.111.140756.CrossRefPubMed

30.

Bradshaw PT, Siega-Riz AM, Campbell M, Weissler MC, Funkhouser WK, Olshan AF. Associations between dietary patterns and head and neck cancer: the Carolina head and neck cancer epidemiology study. Am J Epidemiol. 2012;175(12):1225–33. https://doi.org/10.1093/aje/kwr468.CrossRefPubMedPubMedCentral

31.

Nanri A, Yoshida D, Yamaji T, Mizoue T, Takayanagi R, Kono S. Dietary patterns and C-reactive protein in Japanese men and women. Am J Clin Nutr. 2008;87(5):1488–96.CrossRefPubMed

Title: Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China
Authors: Fei He
Ren-dong Xiao
Tao Lin
Wei-min Xiong
Qiu-ping Xu
Xu Li
Zhi-qiang Liu
Bao-chang He
Zhi-jian Hu
Lin Cai
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-018-4361-2

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