Skip to main content
Top
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Review

Fertility preservation healthcare circuit and networks in cancer patients worldwide: what are the issues?

Authors: Kathleen Melan, Frederic Amant, Jacqueline Veronique-Baudin, Clarisse Joachim, Eustase Janky

Published in: BMC Cancer | Issue 1/2018

Login to get access

Abstract

Background

Fertility preservation (FP) is a major determinant of quality of life after cancer remission for women who may not have achieved their ideal family size. This article describes the FP services and strategy currently available, highlighting issues of oncofertility worldwide.

Main body of the abstract

For these patients in complex situations, health networks are essential to improve coordination of care, and the strengthening of this coordination is a major challenge to improve the performance of the health system. Two international networks have been created in order to foster scientific exchange between countries and to standardize the oncofertility healthcare circuit. However, the paucity of referral nationwide networks lead to a structural gap in health care policies.

Short conclusion

Management strategies of oncofertility in the world are still fragile and uneven. To structure the oncofertility sector, a multidisciplinary project allowing teams to collaborate is of utmost importance particularly in low and middle-income countries.
Literature
2.
go back to reference Kim S-Y, Kim SK, Lee JR, Woodruff TK. Toward precision medicine for preserving fertility in cancer patients: existing and emerging fertility preservation options for women. J Gynecol Oncol. mars 2016;27(2):e22. Kim S-Y, Kim SK, Lee JR, Woodruff TK. Toward precision medicine for preserving fertility in cancer patients: existing and emerging fertility preservation options for women. J Gynecol Oncol. mars 2016;27(2):e22.
3.
go back to reference Merlet F, Hoog-Labouret N. Integrate fertility preservation in cancer management (in part II: a personalized and integrated treatment programme to better meet the needs of patients). Oncologie. 1 sept 2014;16(1):35-38. Merlet F, Hoog-Labouret N. Integrate fertility preservation in cancer management (in part II: a personalized and integrated treatment programme to better meet the needs of patients). Oncologie. 1 sept 2014;16(1):35-38.
4.
go back to reference Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, et al. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol Off J Am Soc Clin Oncol. 20 juin 2006;24(18):2917-2931. Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, et al. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol Off J Am Soc Clin Oncol. 20 juin 2006;24(18):2917-2931.
5.
go back to reference Woodruff TK. The Oncofertility consortium--addressing fertility in young people with cancer. Nat Rev Clin Oncol. août 2010;7(8):466-475. Woodruff TK. The Oncofertility consortium--addressing fertility in young people with cancer. Nat Rev Clin Oncol. août 2010;7(8):466-475.
6.
go back to reference Bernier-Chastagner V, Bujan L, Martelli H, Poirot C, Rives N. Conséquences des traitements des cancers et préservation de la fertilité - Etat des connaissances et propositions. Institut National Du Cancer, Agence de biomédecine; 2013 Février. Bernier-Chastagner V, Bujan L, Martelli H, Poirot C, Rives N. Conséquences des traitements des cancers et préservation de la fertilité - Etat des connaissances et propositions. Institut National Du Cancer, Agence de biomédecine; 2013 Février.
7.
go back to reference Dillon KE, Gracia CR. Pediatric and young adult patients and oncofertility. Curr Treat Options in Oncol. juin 2012;13(2):161-173. Dillon KE, Gracia CR. Pediatric and young adult patients and oncofertility. Curr Treat Options in Oncol. juin 2012;13(2):161-173.
8.
go back to reference Schover LR, van der Kaaij M, van Dorst E, Creutzberg C, Huyghe E, Kiserud CE. Sexual dysfunction and infertility as late effects of cancer treatment. EJC Suppl EJC Off J EORTC Eur Organ Res Treat Cancer Al. juin 2014;12(1):41-53. Schover LR, van der Kaaij M, van Dorst E, Creutzberg C, Huyghe E, Kiserud CE. Sexual dysfunction and infertility as late effects of cancer treatment. EJC Suppl EJC Off J EORTC Eur Organ Res Treat Cancer Al. juin 2014;12(1):41-53.
9.
go back to reference Mahajan N, Patil M, Kaur S, Kaur S, Naidu P. The role of Indian gynecologists in oncofertility care and counselling. J Hum Reprod Sci. sept 2016;9(3):179-186. Mahajan N, Patil M, Kaur S, Kaur S, Naidu P. The role of Indian gynecologists in oncofertility care and counselling. J Hum Reprod Sci. sept 2016;9(3):179-186.
10.
go back to reference Rajendranath R, Veeraiah S, Ramesh A, Sagar TG. Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India. South Asian J Cancer. 2014;3(1):60–5.CrossRefPubMedPubMedCentral Rajendranath R, Veeraiah S, Ramesh A, Sagar TG. Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India. South Asian J Cancer. 2014;3(1):60–5.CrossRefPubMedPubMedCentral
11.
go back to reference Ben Charif A, Bouhnik A-D, Courbière B, Rey D, Préau M, Bendiane M-K, et al. Sexual health problems in French cancer survivors 2 years after diagnosis-the national VICAN survey. J Cancer Surviv Res Pract. 2016;10(3):600–9.CrossRef Ben Charif A, Bouhnik A-D, Courbière B, Rey D, Préau M, Bendiane M-K, et al. Sexual health problems in French cancer survivors 2 years after diagnosis-the national VICAN survey. J Cancer Surviv Res Pract. 2016;10(3):600–9.CrossRef
12.
go back to reference Resetkova N, Hayashi M, Kolp LA, Christianson MS. Fertility preservation for Prepubertal girls: update and current challenges. Curr Obstet Gynecol Rep. 1 déc 2013;2(4):218-225. Resetkova N, Hayashi M, Kolp LA, Christianson MS. Fertility preservation for Prepubertal girls: update and current challenges. Curr Obstet Gynecol Rep. 1 déc 2013;2(4):218-225.
13.
go back to reference Ronn R, Holzer HEG. Oncofertility in Canada: an overview of Canadian practice and suggested action plan. Curr Oncol Tor Ont. oct 2013;20(5):e465-e474. Ronn R, Holzer HEG. Oncofertility in Canada: an overview of Canadian practice and suggested action plan. Curr Oncol Tor Ont. oct 2013;20(5):e465-e474.
15.
go back to reference Dittrich R, Hackl J, Lotz L, Hoffmann I, Beckmann MW. Pregnancies and live births after 20 transplantations of cryopreserved ovarian tissue in a single center. Fertil Steril. 1 févr 2015;103(2):462-468. Dittrich R, Hackl J, Lotz L, Hoffmann I, Beckmann MW. Pregnancies and live births after 20 transplantations of cryopreserved ovarian tissue in a single center. Fertil Steril. 1 févr 2015;103(2):462-468.
16.
go back to reference Rodriguez-Wallberg KA, Tanbo T, Tinkanen H, Thurin-Kjellberg A, Nedstrand E, Kitlinski ML, et al. Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries – compilation of 20 years of multicenter experience. Acta Obstet Gynecol Scand. 1 sept 2016;95(9):1015-1026. Rodriguez-Wallberg KA, Tanbo T, Tinkanen H, Thurin-Kjellberg A, Nedstrand E, Kitlinski ML, et al. Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries – compilation of 20 years of multicenter experience. Acta Obstet Gynecol Scand. 1 sept 2016;95(9):1015-1026.
17.
go back to reference Kalousidou N, Kyvernitakis I, Waehlert L, Engelhard J, Kostev K, Ziller V. [Pregnancy after breast cancer in germany - results of a retrospective database analysis]. Z Geburtshilfe Neonatol. août 2015;219(4):176-180. Kalousidou N, Kyvernitakis I, Waehlert L, Engelhard J, Kostev K, Ziller V. [Pregnancy after breast cancer in germany - results of a retrospective database analysis]. Z Geburtshilfe Neonatol. août 2015;219(4):176-180.
19.
go back to reference Loren AW, Mangu PB, Beck LN, Brennan L, Magdalinski AJ, Partridge AH, et al. Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol Off J Am Soc Clin Oncol. 1 juill 2013;31(19):2500-2510. Loren AW, Mangu PB, Beck LN, Brennan L, Magdalinski AJ, Partridge AH, et al. Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol Off J Am Soc Clin Oncol. 1 juill 2013;31(19):2500-2510.
20.
go back to reference Ethics Committee of American Society for Reproductive Medicine. Fertility preservation and reproduction in patients facing gonadotoxic therapies: a committee opinion. Fertil Steril. nov 2013;100(5):1224-1231. Ethics Committee of American Society for Reproductive Medicine. Fertility preservation and reproduction in patients facing gonadotoxic therapies: a committee opinion. Fertil Steril. nov 2013;100(5):1224-1231.
21.
go back to reference Coccia PF, Pappo AS, Altman J, Bhatia S, Borinstein SC, Flynn J, et al. Adolescent and young adult oncology, version 2.2014. J Natl Compr Cancer Netw JNCCN. janv 2014;12(1):21-32; quiz 32. Coccia PF, Pappo AS, Altman J, Bhatia S, Borinstein SC, Flynn J, et al. Adolescent and young adult oncology, version 2.2014. J Natl Compr Cancer Netw JNCCN. janv 2014;12(1):21-32; quiz 32.
22.
go back to reference Clinical management planning for fertility preservation in female cancer patient. Stochholm: European Society of Human Reproduction and Embryology (ESHRE); 2011 juill. Clinical management planning for fertility preservation in female cancer patient. Stochholm: European Society of Human Reproduction and Embryology (ESHRE); 2011 juill.
23.
go back to reference Peccatori FA, Azim HA, Orecchia R, Hoekstra HJ, Pavlidis N, Kesic V, et al. Cancer, pregnancy and fertility: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol Off J Eur Soc Med Oncol. oct 2013;24 Suppl 6:vi160-vi170. Peccatori FA, Azim HA, Orecchia R, Hoekstra HJ, Pavlidis N, Kesic V, et al. Cancer, pregnancy and fertility: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol Off J Eur Soc Med Oncol. oct 2013;24 Suppl 6:vi160-vi170.
24.
go back to reference Kim SS, Donnez J, Barri P, Pellicer A, Patrizio P, Rosenwaks Z, et al. Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer. J Assist Reprod Genet. juin 2012;29(6):465-468. Kim SS, Donnez J, Barri P, Pellicer A, Patrizio P, Rosenwaks Z, et al. Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer. J Assist Reprod Genet. juin 2012;29(6):465-468.
25.
go back to reference Forman EJ, Anders CK, Behera MA. A nationwide survey of oncologists regarding treatment-related infertility and fertility preservation in female cancer patients. Fertil Steril. oct 2010;94(5):1652-1656. Forman EJ, Anders CK, Behera MA. A nationwide survey of oncologists regarding treatment-related infertility and fertility preservation in female cancer patients. Fertil Steril. oct 2010;94(5):1652-1656.
26.
go back to reference Köhler TS, Kondapalli LA, Shah A, Chan S, Woodruff TK, Brannigan RE. Results from the survey for preservation of adolescent reproduction (SPARE) study: gender disparity in delivery of fertility preservation message to adolescents with cancer. J Assist Reprod Genet. mars 2011;28(3):269-277. Köhler TS, Kondapalli LA, Shah A, Chan S, Woodruff TK, Brannigan RE. Results from the survey for preservation of adolescent reproduction (SPARE) study: gender disparity in delivery of fertility preservation message to adolescents with cancer. J Assist Reprod Genet. mars 2011;28(3):269-277.
27.
go back to reference Curado MP. Cancer incidence in African continent. Hands on to produce more information. J Afr Cancer Afr J Cancer. févr 2014;6(1):1-2. Curado MP. Cancer incidence in African continent. Hands on to produce more information. J Afr Cancer Afr J Cancer. févr 2014;6(1):1-2.
28.
go back to reference Harwood K. Egg freezing: a breakthrough for reproductive autonomy? Bioethics. janv 2009;23(1):39-46. Harwood K. Egg freezing: a breakthrough for reproductive autonomy? Bioethics. janv 2009;23(1):39-46.
29.
go back to reference Geue K, Richter D, Schmidt R, Sender A, Siedentopf F, Brähler E, et al. The desire for children and fertility issues among young German cancer survivors. J Adolesc Health Off Publ Soc Adolesc Med. mai 2014;54(5):527-535. Geue K, Richter D, Schmidt R, Sender A, Siedentopf F, Brähler E, et al. The desire for children and fertility issues among young German cancer survivors. J Adolesc Health Off Publ Soc Adolesc Med. mai 2014;54(5):527-535.
30.
go back to reference Barcroft J, Dayoub N, Thong KJ. Fifteen year follow-up of embryos cryopreserved in cancer patients for fertility preservation. J Assist Reprod Genet. nov 2013;30(11):1407-1413. Barcroft J, Dayoub N, Thong KJ. Fifteen year follow-up of embryos cryopreserved in cancer patients for fertility preservation. J Assist Reprod Genet. nov 2013;30(11):1407-1413.
31.
go back to reference Lee S, Oktay K. Does higher starting dose of FSH stimulation with letrozole improve fertility preservation outcomes in women with breast cancer? Fertil Steril. oct 2012;98(4):961-4.e1. Lee S, Oktay K. Does higher starting dose of FSH stimulation with letrozole improve fertility preservation outcomes in women with breast cancer? Fertil Steril. oct 2012;98(4):961-4.e1.
32.
go back to reference Garcia-Velasco JA, Domingo J, Cobo A, Martínez M, Carmona L, Pellicer A. Five years’ experience using oocyte vitrification to preserve fertility for medical and nonmedical indications. Fertil Steril juin. 2013;99(7):1994–9.CrossRef Garcia-Velasco JA, Domingo J, Cobo A, Martínez M, Carmona L, Pellicer A. Five years’ experience using oocyte vitrification to preserve fertility for medical and nonmedical indications. Fertil Steril juin. 2013;99(7):1994–9.CrossRef
33.
go back to reference Donnez J, Dolmans M-M, Pellicer A, Diaz-Garcia C, Sanchez Serrano M, Schmidt KT, et al. Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation. Fertil Steril. mai 2013;99(6):1503-1513. Donnez J, Dolmans M-M, Pellicer A, Diaz-Garcia C, Sanchez Serrano M, Schmidt KT, et al. Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation. Fertil Steril. mai 2013;99(6):1503-1513.
34.
go back to reference Dolmans M-M, Jadoul P, Gilliaux S, Amorim CA, Luyckx V, Squifflet J, et al. A review of 15 years of ovarian tissue bank activities. J Assist Reprod Genet mars. 2013;30(3):305–14.CrossRef Dolmans M-M, Jadoul P, Gilliaux S, Amorim CA, Luyckx V, Squifflet J, et al. A review of 15 years of ovarian tissue bank activities. J Assist Reprod Genet mars. 2013;30(3):305–14.CrossRef
35.
go back to reference Yee S, Buckett W, Campbell S, Yanofsky R, Barr RD. A national study of the provision of oncofertility services to female patients in Canada. J Obstet Gynaecol Can JOGC J Obstet Gynecol Can JOGC. sept 2012;34(9):849-858. Yee S, Buckett W, Campbell S, Yanofsky R, Barr RD. A national study of the provision of oncofertility services to female patients in Canada. J Obstet Gynaecol Can JOGC J Obstet Gynecol Can JOGC. sept 2012;34(9):849-858.
36.
go back to reference Ghorbani B, Madahi P, Shirazi E, Ardekani HS, Kamali K. Iranian oncologists’ attitude towards fertility preservation in a sample group. J Reprod Infertil. janv 2011;12(1):33-36. Ghorbani B, Madahi P, Shirazi E, Ardekani HS, Kamali K. Iranian oncologists’ attitude towards fertility preservation in a sample group. J Reprod Infertil. janv 2011;12(1):33-36.
37.
go back to reference Préaubert L, Poggi P, Pibarot M, Delotte J, Thibault E, Saias-Magnan J, et al. [Fertility preservation among patients with cancer: report of a French regional practical experience]. J Gynecol Obstet Biol Reprod (Paris). mai 2013;42(3):246-251. Préaubert L, Poggi P, Pibarot M, Delotte J, Thibault E, Saias-Magnan J, et al. [Fertility preservation among patients with cancer: report of a French regional practical experience]. J Gynecol Obstet Biol Reprod (Paris). mai 2013;42(3):246-251.
38.
go back to reference Cannell E. Postcode lottery for fertility-preservation facilities. Lancet Oncol. 1 mars 2008;9(3):206. Cannell E. Postcode lottery for fertility-preservation facilities. Lancet Oncol. 1 mars 2008;9(3):206.
39.
go back to reference Adams E, Hill E, Watson E. Fertility preservation in cancer survivors: a national survey of oncologists’ current knowledge, practice and attitudes. Br J Cancer. 30 avr 2013;108(8):1602-1615. Adams E, Hill E, Watson E. Fertility preservation in cancer survivors: a national survey of oncologists’ current knowledge, practice and attitudes. Br J Cancer. 30 avr 2013;108(8):1602-1615.
40.
go back to reference Zebrack BJ, Casillas J, Nohr L, Adams H, Zeltzer LK. Fertility issues for young adult survivors of childhood cancer. Psychooncology. oct 2004;13(10):689-699. Zebrack BJ, Casillas J, Nohr L, Adams H, Zeltzer LK. Fertility issues for young adult survivors of childhood cancer. Psychooncology. oct 2004;13(10):689-699.
41.
go back to reference Salih SM, Elsarrag SZ, Prange E, Contreras K, Osman RG, Eikoff JC, et al. Evidence to incorporate inclusive reproductive health measures in guidelines for childhood and adolescent cancer survivors. J Pediatr Adolesc Gynecol. avr 2015;28(2):95-101. Salih SM, Elsarrag SZ, Prange E, Contreras K, Osman RG, Eikoff JC, et al. Evidence to incorporate inclusive reproductive health measures in guidelines for childhood and adolescent cancer survivors. J Pediatr Adolesc Gynecol. avr 2015;28(2):95-101.
42.
go back to reference Kim J, Oktay K, Gracia C, Lee S, Morse C, Mersereau JE. Which patients pursue fertility preservation treatments? A multi-center analysis of the predictors of fertility preservation in women with breast cancer. Fertil Steril. mars 2012;97(3):671-676. Kim J, Oktay K, Gracia C, Lee S, Morse C, Mersereau JE. Which patients pursue fertility preservation treatments? A multi-center analysis of the predictors of fertility preservation in women with breast cancer. Fertil Steril. mars 2012;97(3):671-676.
43.
go back to reference Letourneau JM, Smith JF, Ebbel EE, Craig A, Katz PP, Cedars MI, et al. Racial, socioeconomic, and demographic disparities in access to fertility preservation in young women diagnosed with cancer. Cancer. 15 sept 2012;118(18):4579-4588. Letourneau JM, Smith JF, Ebbel EE, Craig A, Katz PP, Cedars MI, et al. Racial, socioeconomic, and demographic disparities in access to fertility preservation in young women diagnosed with cancer. Cancer. 15 sept 2012;118(18):4579-4588.
44.
go back to reference Huyghe E, Sui D, Odensky E, Schover LR. Needs assessment survey to justify establishing a reproductive health clinic at a comprehensive cancer center. J Sex Med janv. 2009;6(1):149–63.CrossRef Huyghe E, Sui D, Odensky E, Schover LR. Needs assessment survey to justify establishing a reproductive health clinic at a comprehensive cancer center. J Sex Med janv. 2009;6(1):149–63.CrossRef
45.
go back to reference Bouhnik A-D, Bendiane M-K, Cortaredona S, Sagaon Teyssier L, Rey D, Berenger C, et al. The labour market, psychosocial outcomes and health conditions in cancer survivors: protocol for a nationwide longitudinal survey 2 and 5 years after cancer diagnosis (the VICAN survey). BMJ Open. 24 mars 2015;5(3). Bouhnik A-D, Bendiane M-K, Cortaredona S, Sagaon Teyssier L, Rey D, Berenger C, et al. The labour market, psychosocial outcomes and health conditions in cancer survivors: protocol for a nationwide longitudinal survey 2 and 5 years after cancer diagnosis (the VICAN survey). BMJ Open. 24 mars 2015;5(3).
46.
go back to reference Armuand GM, Rodriguez-Wallberg KA, Wettergren L, Ahlgren J, Enblad G, Höglund M, et al. Sex differences in fertility-related information received by young adult cancer survivors. J Clin Oncol Off J Am Soc Clin Oncol. 10 juin 2012;30(17):2147-2153. Armuand GM, Rodriguez-Wallberg KA, Wettergren L, Ahlgren J, Enblad G, Höglund M, et al. Sex differences in fertility-related information received by young adult cancer survivors. J Clin Oncol Off J Am Soc Clin Oncol. 10 juin 2012;30(17):2147-2153.
47.
go back to reference Corney RH, Swinglehurst AJ. Young childless women with breast cancer in the UK: a qualitative study of their fertility-related experiences, options, and the information given by health professionals. Psychooncology. janv 2014;23(1):20-26. Corney RH, Swinglehurst AJ. Young childless women with breast cancer in the UK: a qualitative study of their fertility-related experiences, options, and the information given by health professionals. Psychooncology. janv 2014;23(1):20-26.
Metadata
Title
Fertility preservation healthcare circuit and networks in cancer patients worldwide: what are the issues?
Authors
Kathleen Melan
Frederic Amant
Jacqueline Veronique-Baudin
Clarisse Joachim
Eustase Janky
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4046-x

Other articles of this Issue 1/2018

BMC Cancer 1/2018 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine