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BMC Cancer
Published in: BMC Cancer 1/2017

Open Access 01-12-2017 | Case report

Trastuzumab resumption after extremely severe cardiotoxicity in metastatic breast cancer patient: a case report

Authors: Santino Minichillo, Ilaria Gallelli, Elena Barbieri, Marta Cubelli, Daniela Rubino, Sara Quercia, Massimo Dall’Olio, Claudio Rapezzi, Claudio Zamagni

Published in: BMC Cancer | Issue 1/2017

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Abstract

Background

Trastuzumab-related cardiotoxicity has been reported in patients receiving trastuzumab concurrently with other agents, especially with anthracyclines. Cardiac function damage is generally rare, precox and mild with trastuzumab alone.

Case presentation

We report the case of a 49 year-old woman affected by metastatic breast cancer who developed trastuzumab-related cardiogenic shock due to pump failure (with LVEF of about 15%) after three months of treatment. After a long hospitalization in the cardiac intensive care unit and a proper treatment, LVEF increased to 50% and, due to a severe progression of disease, trastuzumab was resumed and continued for more than one year.

Conclusion

This is a case of particularly severe cardiotoxicity related to trastuzumab treatment, which was recovered with pharmacological treatment and the temporary discontinuation of the treatment. Trastuzumab was safely resumed after clinical and echocardiographic parameters improvement.
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Metadata
Title
Trastuzumab resumption after extremely severe cardiotoxicity in metastatic breast cancer patient: a case report
Authors
Santino Minichillo
Ilaria Gallelli
Elena Barbieri
Marta Cubelli
Daniela Rubino
Sara Quercia
Massimo Dall’Olio
Claudio Rapezzi
Claudio Zamagni
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2017
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-017-3712-8

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