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Published in: BMC Cancer 1/2017

Open Access 01-12-2017 | Research article

Functional significance of CD105-positive cells in papillary renal cell carcinoma

Authors: Damian Matak, Klaudia K. Brodaczewska, Cezary Szczylik, Irena Koch, Adam Myszczyszyn, Monika Lipiec, Slawomir Lewicki, Lukasz Szymanski, Robert Zdanowski, Anna M. Czarnecka

Published in: BMC Cancer | Issue 1/2017

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Abstract

Background

CD105 was postulated as a renal cell carcinoma (RCC) stem cell marker, and CD133 as a putative RCC progenitor. Hypoxia, a natural microenvironment that prevails in tumors, was also incorporated into the study, especially in terms of the promotion of hypothetical stem-like cell properties.

Methods

Within this study, we verify the existence of CD105+ and CD133+ populations in selected papillary subtype RCC (pRCC) cell lines. Both populations were analyzed for correlation with stem-like cell properties, such as stemness gene expression, and sphere and colony formation. For the preliminary analysis, several RCC cell lines were chosen (786-O, SMKT-R2, Caki-2, 796-P, ACHN, RCC6) and the control was human kidney cancer stem cells (HKCSC) and renal cells of embryonic origin (ASE-5063). Four cell lines were chosen for further investigation: Caki-2 (one of the highest numbers of CD105+ cells; primary origin), ACHN (a low number of CD105+ cells; metastatic origin), HKCSC (putative positive control), and ASE-5063 (additional control).

Results

In 769-P and RCC6, we could not detect a CD105+ population. Hypoxia variously affects pRCC cell growth, and mainly diminishes the stem-like properties of cells. Furthermore, we could not observe the correlation of CD105 and/or CD133 expression with the enhancement of stem-like properties.

Conclusions

Based on this analysis, CD105/CD133 cannot be validated as cancer stem cell markers of pRCC cell lines.
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Metadata
Title
Functional significance of CD105-positive cells in papillary renal cell carcinoma
Authors
Damian Matak
Klaudia K. Brodaczewska
Cezary Szczylik
Irena Koch
Adam Myszczyszyn
Monika Lipiec
Slawomir Lewicki
Lukasz Szymanski
Robert Zdanowski
Anna M. Czarnecka
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2017
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-016-2985-7

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