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BMC Cancer
Published in: BMC Cancer 1/2016

Open Access 01-12-2016 | Research article

Association between alcohol intake and the risk of pancreatic cancer: a dose–response meta-analysis of cohort studies

Authors: Ye-Tao Wang, Ya-Wen Gou, Wen-Wen Jin, Mei Xiao, Hua-Ying Fang

Published in: BMC Cancer | Issue 1/2016

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Abstract

Background

Studies examining the association between alcohol intake and the risk of pancreatic cancer have given inconsistent results. The purpose of this study was to summarize and examine the evidence regarding the association between alcohol intake and pancreatic cancer risk based on results from prospective cohort studies.

Methods

We searched electronic databases consisting of PubMed, Ovid, Embase, and the Cochrane Library identifying studies published up to Aug 2015. Only prospective studies that reported effect estimates with 95 % confidence intervals (CIs) for the risk of pancreatic cancer, examining different alcohol intake categories compared with a low alcohol intake category were included. Results of individual studies were pooled using a random-effects model.

Results

We included 19 prospective studies (21 cohorts) reporting data from 4,211,129 individuals. Low-to-moderate alcohol intake had little or no effect on the risk of pancreatic cancer. High alcohol intake was associated with an increased risk of pancreatic cancer (risk ratio [RR], 1.15; 95 % CI: 1.06–1.25). Pooled analysis also showed that high liquor intake was associated with an increased risk of pancreatic cancer (RR, 1.43; 95 % CI: 1.17–1.74). Subgroup analyses suggested that high alcohol intake was associated with an increased risk of pancreatic cancer in North America, when the duration of follow-up was greater than 10 years, in studies scored as high quality, and in studies with adjustments for smoking status, body mass index, diabetes mellitus, and energy intake..

Conclusions

Low-to-moderate alcohol intake was not significantly associated with the risk of pancreatic cancer, whereas high alcohol intake was associated with an increased risk of pancreatic cancer. Furthermore, liquor intake in particular was associated with an increased risk of pancreatic cancer.
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Literature
1.
Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.1, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2014. Available from: http://​globocan.​iarc.​fr, accessed on 16/01/2015.
2.
Everhart J, Wright D. Diabetes mellitus as a risk factor for pancreatic cancer. JAMA. 1995;273:1605–9.CrossRefPubMed
3.
Villeneuve PJ, Johnson KC, Hanley AJG, et al. Canadian cancer registries epidemiology research group. Alcohol, tobacco, and coffee consumption and the risk of pancreatic cancer: results from the Canadian Enhanced Surveillance System case–control project. Eur J Cancer Prev. 2000;9:49.CrossRefPubMed
4.
Patel AV, Rodriguez C, Bernstein L, et al. Obesity, recreational physical activity, and risk of pancreatic cancer in a large US cohort. Cancer Epidemiol Biomarkers Prev. 2005;14:459–66.CrossRefPubMed
5.
6.
Tramacere I, Scotti L, Jenab M, et al. Alcohol drinking and pancreatic cancer risk: a meta-analysis of the dose-risk relation. Int J Cancer. 2010;126:1474–86.PubMed
7.
Michaud DS, Vrieling A, Jiao L, et al. Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan). Cancer Causes Control. 2010;21(8):1213–25.CrossRefPubMedPubMedCentral
8.
Genkinger JM, Spiegelman D, Anderson KE, et al. Alcohol intake and pancreatic cancer risk: a pooled analysis of fourteen cohort studies. Cancer Epidemiol Biomarkers Prev. 2009;18:765–76.CrossRefPubMedPubMedCentral
9.
Rohrmann S, Linseisen J, Vrieling A, et al. Ethanol intake and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes Control. 2009;20(5):785–94.CrossRefPubMedPubMedCentral
10.
Lin Y, Tamakoshi A, Kawamura T, et al. Risk of pancreatic cancer in relation to alcohol drinking, coffee consumption and medical history: finding from the Japan collaborative cohort study for evaluation of cancer risk. In J Cancer. 2002;99:742–6.
11.
Michaud DS, Giovannucci E, Willett WC, et al. Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States Cohorts. Cancer Epidemiol Biomarkers Prev. 2001;10:429–37.PubMed
12.
American Cancer Society. Cancer Facts and Figures. Atlanta, GA: American Cancer Society; 2009.
13.
Kuzmickiene I, Everatt R, Virviciute D, et al. Smoking and other risk factors for pancreatic cancer: A cohort study in men in Lithuania. Cancer Epidemiol. 2013;37:133–9.CrossRefPubMed
14.
Baglietto L, Giles GG, English DR, et al. Alcohol consumption and risk of glioblastoma; evidence from the Melbourne Collaborative Cohort Study. Int J Cancer. 2011;128:1929–34.CrossRefPubMed
15.
Nakamura K, Nagata C, Wada K, et al. Cigarette smoking and other lifestyle factors in relation to the risk of pancreatic cancer death: a prospective cohort study in Japan. Jpn J Clin Oncol. 2011;41(2):225–31.CrossRefPubMed
16.
Gapstur SM, Jacobs EJ, Deka A, et al. Association of alcohol intake with pancreatic cancer mortality in never smokers. Arch Intern Med. 2011;171(5):444–51.CrossRefPubMed
17.
Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA. 2000;283:2008–12.CrossRefPubMed
18.
Wells G, Shea B, O’Connell D. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa (ON): Ottawa Hospital Research Institute; 2009. Available:http://​www.​ohri.​ca/​programs/​clinical epidemiology/oxford.htm.
19.
20.
Cooper H, Hedges LV, Valentine JC. Handbook of research synthesis and meta-analysis. Russell Sage Foundation; 2009.
21.
Greenland S, Robins JM. Estimation of a common effect parameter from sparse follow-up data. Biometrics. 1985;41:55–68.CrossRefPubMed
22.
23.
Ades AE, Lu G, Higgins JP. The interpretation of random-effects metaanalysis in decision models. Med Decis Making. 2005;25:646–54.CrossRefPubMed
24.
Orsini N, Bellocco R, Greenland S. Generalized least squares for trend estimation of summarized dose–response data. Stata J. 2006;6:40–57.
25.
Greenland S, Longnecker MP. Methods for trend estimation from summarized dose–response data, with applications to meta-analysis. Am J Epidemiol. 1992;135:1301–9.CrossRefPubMed
26.
Deeks JJ, Higgins JPT, Altman DG. Analyzing data and undertaking meta-analyses. In: Higgins J, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions 5.0.1. Oxford, UK: The Cochrane Collaboration; 2008. chap 9.
27.
28.
Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–58.CrossRefPubMed
29.
Tobias A. Assessing the influence of a single study in meta-analysis. Stata Tech Bull. 1999;47:15–7.
30.
31.
Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–101.CrossRefPubMed
32.
Shibata A, Mack TM, Paganini-Hill A, et al. A prospective study of pancreatic cancer in the elderly. Int J Cancer. 1994;58:46–9.CrossRefPubMed
33.
Stolzenberg-Solomon RZ, Pietinen P, Barrett MJ, et al. Dietary and other methyl-group availability factors and pancreatic cancer risk in a cohort of male smokers. Am J Epidemiol. 2001;153:680–7.CrossRefPubMed
34.
Heinen MM, Verhage BAJ, Ambergen TAJ, et al. Alcohol consumption and risk of pancreatic cancer in the Netherlands Cohort Study. Am J Epidemiol. 2009;169:1233–42.CrossRefPubMed
35.
Jiao L, Silverman DT, Schairer C, et al. Alcohol use and risk of pancreatic cancer: the NIH-AARP Diet and Health Study. Am J Epidemiol. 2009;169:1043–51.CrossRefPubMedPubMedCentral
36.
Harnack LJ, Anderson KE, Zheng W, et al. Smoking, alcohol, coffee, and tea intake and incidence of cancer of the exocrine pancreas: the Iowa Women’s Health Study. Cancer Epidemiol Biomarkers Prev. 1997;6:1081–6.PubMed
37.
Stevens RJ, Roddam AW, Spencer EA, et al. Factors associated with incident and fatal pancreatic cancer in a cohort of middle-aged women. Int J Cancer. 2009;124:2400–5.CrossRefPubMed
38.
Bandera EV, Freudenheim JL, Marshall JR, et al. Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States). Cancer Causes Control. 1997;8:828–40.CrossRefPubMed
39.
Calton BA, Stolzenberg-Solomon RZ, Moore SC, et al. A prospective study of physical activity and the risk of pancreatic cancer among women (United States). BMC Cancer. 2008;8:63.CrossRefPubMedPubMedCentral
40.
Chang ET, Canchola AJ, Lee VS, et al. Wine and other alcohol consumption and risk of ovarian cancer in the California Teachers Study cohort. Cancer Causes Control. 2007;18:91–103.CrossRefPubMedPubMedCentral
41.
Silvera SAN, Rohan TE, Jain M, et al. Glycemic index, glycemic load, and pancreatic cancer risk (Canada). Cancer Causes Control. 2005;16:431–6.CrossRefPubMed
42.
Prorok PC, Andriole GL, Bresalier RS, et al. Design of the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial. Control Clin Trials. 2000;21:273S–309.CrossRefPubMed
43.
Larsson SC, Håkansson N, Giovannucci E, et al. Folate intake and pancreatic cancer incidence: a prospective study of Swedish women and men. J Natl Cancer Inst. 2006;98:407–13.CrossRefPubMed
44.
Dufour MC, Adamson MD. The epidemiology of alcohol-induced pancreatitis. Pancreas. 2003;27(4):286–90.CrossRefPubMed
45.
Gukovskaya AS, Mouria M, Gukovsky I, et al. Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats. Gastroenterology. 2002;122(1):106–18.CrossRefPubMed
46.
Pandol SJ, Periskic S, Gukovsky I, et al. Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide. Gastroenterology. 1999;117(3):706–16.CrossRefPubMed
47.
Zheng W, McLaughlin JK, Gridley G, et al. A cohort study of smoking, alcohol consumption, and dietary factors for pancreatic cancer (United States). Cancer Causes Control. 1993;4(5):477–82.CrossRefPubMed
48.
Devos-Comby L, Lange JE. “My drink is larger than yours”? A literature review of self- defined drink sizes and standard drinks. Curr Drug Abuse Rev. 2008;1(2):162–76.CrossRefPubMed
Metadata
Title
Association between alcohol intake and the risk of pancreatic cancer: a dose–response meta-analysis of cohort studies
Authors
Ye-Tao Wang
Ya-Wen Gou
Wen-Wen Jin
Mei Xiao
Hua-Ying Fang
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2016
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-016-2241-1

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