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BMC Cancer
Published in: BMC Cancer 1/2016

Open Access 01-12-2016 | Research article

Evaluating early response of cervical cancer under concurrent chemo-radiotherapy by intravoxel incoherent motion MR imaging

Authors: Li Zhu, Lijing Zhu, Hua Shi, Huanhuan Wang, Jing Yan, Baorui Liu, Weibo Chen, Jian He, Zhengyang Zhou, Xiaofeng Yang, Tian Liu

Published in: BMC Cancer | Issue 1/2016

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Abstract

Background

Intravoxel incoherent motion (IVIM) MR imaging has been applied in researches of various diseases, however its potential in cervical cancer patients has not been fully explored. The purpose of this study was to investigate the feasibility of IVIM MR imaging to monitor early treatment response in patients receiving concurrent chemo-radiotherapy (CCRT) for advanced cervical cancers.

Methods

Twenty-one patients receiving CCRT for advanced cervical cancer were prospectively enrolled. MR examinations including IVIM imaging (with 14 b values, 0 ~ 1000 s/mm2) were performed at 4 time points: 1-week prior to, 2-week and 4-week during, as well as immediately post CCRT (within 1 week). The apparent diffusion coefficient (ADC) maps were derived from the mono-exponential model, while the diffusion coefficient (D), perfusion fraction (f) and pseudo-diffusion coefficient (D*) maps were calculated from the bi-exponential model. Dynamic changes of ADC, D, f and D* in cervical cancers were investigated as early surrogate markers for treatment response.

Results

ADC and D values increased throughout the CCRT course. Both f and D* increased in the first 2 to 3 weeks of CCRT and started to decrease around 4 weeks of CCRT. Significant increase of f value was observed from prior to CCRT (f 1 = 0.12 ± 0.52) to two-week during CCRT (f 2 = 0.20 ± 0.90, p = 0.002).

Conclusions

IVIM MR imaging has the potential in monitoring early tumor response induced by CCRT in patients with cervical cancers.
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Metadata
Title
Evaluating early response of cervical cancer under concurrent chemo-radiotherapy by intravoxel incoherent motion MR imaging
Authors
Li Zhu
Lijing Zhu
Hua Shi
Huanhuan Wang
Jing Yan
Baorui Liu
Weibo Chen
Jian He
Zhengyang Zhou
Xiaofeng Yang
Tian Liu
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2016
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-016-2116-5

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