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BMC Cancer
Published in: BMC Cancer 1/2015

Open Access 01-12-2015 | Research article

Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)

Authors: Klaus Kramer, Uwe Knippschild, Benjamin Mayer, Kira Bögelspacher, Hanno Spatz, Doris Henne-Bruns, Abbas Agaimy, Matthias Schwab, Michael Schmieder

Published in: BMC Cancer | Issue 1/2015

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Abstract

Background

Risk classification and prediction of prognosis in GIST is still a matter of debate. Data on the impact of age and gender as potential confounding factors are limited. Therefore we comprehensively investigated age and gender as independent risk factors for GIST.

Methods

Two independent patient cohorts (cohort I, n = 87 [<50 years]; cohort II, n = 125 [≥50 years]) were extracted from the multicentre Ulmer GIST registry including a total of 659 GIST patients retrospectively collected in 18 collaborative German oncological centers. Based on demographic and clinicopathological parameters and a median follow-up time of 4.3 years (range 0.56; 21.33) disease-specific-survival (DSS), disease-free-survival (DFS) and overall survival (OS) were calculated.

Results

GIST patients older than fifty years showed significantly worse DSS compared to younger patients (p = 0.021; HR = 0.307, 95% CI [0.113; 0.834]). DSS was significantly more favorable in younger female GIST patients compared with elderly females (p = 0.008). Female gender resulted again in better prognosis in younger patients (p = 0.033).

Conclusions

Patient age (<50 years) and female gender were significantly associated with a more favourable prognosis in GIST. Extended studies are warranted to confirm our clinical results and to elucidate underlying pathophysiological mechanisms.
Appendix
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Metadata
Title
Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)
Authors
Klaus Kramer
Uwe Knippschild
Benjamin Mayer
Kira Bögelspacher
Hanno Spatz
Doris Henne-Bruns
Abbas Agaimy
Matthias Schwab
Michael Schmieder
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2015
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-015-1054-y

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