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BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2020

01-12-2020 | Nausea | Research article

The effect of a pharmacist consultation on pregnant women’s quality of life with a special focus on nausea and vomiting: an intervention study

Authors: Maria Bich-Thuy Truong, Elin Ngo, Hilde Ariansen, Ross T. Tsuyuki, Hedvig Nordeng

Published in: BMC Pregnancy and Childbirth | Issue 1/2020

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Abstract

Background

Maternal wellbeing and quality of life (QOL) are increasingly being recognized as important for healthy pregnancies. The aim of this study was to investigate the impact of a pharmacist consultation on pregnant women’s QOL focusing on nausea and vomiting in pregnancy (NVP), and patient satisfaction.

Methods

For this intervention study in 14 community pharmacies, women in early pregnancy were recruited and assigned to a pharmacist consultation (intervention) or standard care (control). The consultation aimed to address each woman’s concerns regarding medications and pregnancy-related ailments. Data were collected through online questionnaires at baseline (Q1) and during the second trimester (Q2). The intervention group completed an additional satisfaction questionnaire after the consultation was completed. The primary outcome was the impact of the intervention on the Quality of Life Scale (QOLS) scores between the first and second trimesters. The impact of the intervention was assessed by linear regression, and secondary analyses were performed to assess effect modification by NVP.

Results

Of the 340 women enrolled in the study, we analyzed data for 245. Half (170/340) of the original participants were allocated to the intervention group, of whom 131 received the pharmacist consultation. Most women (75%, 78/96) reported that the consultation was useful to a large/very large extent. The consultation had no overall impact on QOLS scores between the first and the second trimesters compared with standard care (adjusted β: 0.7, 95% CI: -2.1, 3.4). The impact of the intervention on QOLS was greater amongst women with moderate/severe NVP (adjusted β: 3.6, 95% CI: -0.6, 7.7) compared to those with no/mild NVP (adjusted β: -1.4, 95% CI: -5.1, 2.2) (interaction term study group*NVP severity, p = 0.048).

Conclusions

The pregnant women highly appreciated the pharmacist consultation, but the intervention did not affect their QOL scores compared with standard care. Future studies should further explore the effect of a pharmacist consultation specifically for NVP and on other outcomes such as use of health care services and medication use in pregnancy.

Trial registration

Retrospectively registered in ClinicalTrials.gov (identifier: NCT04182750, registration date: December 2, 2019).
Appendix
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Literature
1.
Lagadec N, Steinecker M, Kapassi A, Magnier AM, Chastang J, Robert S, et al. Factors influencing the quality of life of pregnant women: a systematic review. BMC Pregnancy Childbirth. 2018;18(1):455.PubMedPubMedCentralCrossRef
2.
Heitmann K, Nordeng H, Havnen GC, Solheimsnes A, Holst L. The burden of nausea and vomiting during pregnancy: severe impacts on quality of life, daily life functioning and willingness to become pregnant again - results from a cross-sectional study. BMC Pregnancy Childbirth. 2017;17(1):75.PubMedPubMedCentralCrossRef
3.
Tan A, Lowe S, Henry A. Nausea and vomiting of pregnancy: effects on quality of life and day-to-day function. Aust N Z J Obstet Gynaecol. 2018;58(3):278–90.PubMedCrossRef
4.
Munch S, Korst LM, Hernandez GD, Romero R, Goodwin TM. Health-related quality of life in women with nausea and vomiting of pregnancy: the importance of psychosocial context. J Perinatol. 2011;31(1):10–20.PubMedCrossRef
5.
Einarson TR, Piwko C, Koren G. Quantifying the global rates of nausea and vomiting of pregnancy: a meta analysis. J Popul Ther Clin Pharmacol. 2013;20(2):e171–83.PubMed
6.
Havnen GC, Truong MB, Do MH, Heitmann K, Holst L, Nordeng H. Women's perspectives on the management and consequences of hyperemesis gravidarum - a descriptive interview study. Scand J Prim Health Care. 2019;37(1):30–40.PubMedPubMedCentralCrossRef
7.
8.
Lynch MM, Amoozegar JB, McClure EM, Squiers LB, Broussard CS, Lind JN, et al. Improving safe use of medications during pregnancy: the roles of patients, physicians, and pharmacists. Qual Health Res. 2017;27(13):2071–80.PubMedPubMedCentralCrossRef
9.
Hameen-Anttila K, Jyrkka J, Enlund H, Nordeng H, Lupattelli A, Kokki E. Medicines information needs during pregnancy: a multinational comparison. BMJ Open. 2013;3(4):e002594.PubMedPubMedCentralCrossRef
10.
Kamali S, Ahmadian L, Khajouei R, Bahaadinbeigy K. Health information needs of pregnant women: information sources, motives and barriers. Health Inf Libr J. 2018;35(1):24–37.CrossRef
11.
Ceulemans M, Van Calsteren K, Allegaert K, Foulon V. Beliefs about medicines and information needs among pregnant women visiting a tertiary hospital in Belgium. Eur J Clin Pharmacol. 2019;75(7):995–1003.PubMedCrossRef
12.
13.
Truong MB, Ngo E, Ariansen H, Tsuyuki RT, Nordeng H. Community pharmacist counseling in early pregnancy-results from the SafeStart feasibility study. PLoS One. 2019;14(7):e0219424.PubMedPubMedCentralCrossRef
14.
Bjelke M, Martinsson AK, Lendahls L, Oscarsson M. Using the internet as a source of information during pregnancy - a descriptive cross-sectional study in Sweden. Midwifery. 2016;40:187–91.PubMedCrossRef
15.
Jacobs EJA, van Steijn ME, van Pampus MG. Internet usage of women attempting pregnancy and pregnant women in the Netherlands. Sex Reprod Healthc. 2019;21:9–14.PubMedCrossRef
16.
Ellis L, Roberts L. Exploring the use and quality of internet discussion forums in pregnancy: a qualitative analysis. Birth. 2020;47(1):153–61.PubMedCrossRef
17.
Lagan BM, Sinclair M, Kernohan WG. What is the impact of the internet on decision-making in pregnancy? A global study. Birth. 2011;38(4):336–45.PubMed
18.
El-Ibiary SY, Raney EC, Moos M-K. The pharmacist's role in promoting preconception health. J Am Pharm Assoc (2003). 2014;54(5):e288–303.CrossRef
19.
Forinash AB, Chamness D, Yancey AM, Koerner J, Mathews K, Miller C, et al. Impact of clinical pharmacy on asthma in pregnancy in a maternal-fetal care clinic: a pilot study. J Pharm Technol. 2016;32(6):240–4.PubMedCentralCrossRef
20.
Smedberg J, Brathen M, Waka MS, Jacobsen AF, Gjerdalen G, Nordeng H. Medication use and drug-related problems among women at maternity wards-a cross-sectional study from two Norwegian hospitals. Eur J Clin Pharmacol. 2016;72(7):849–57.PubMedCrossRef
21.
Silva NMO, Gnatta MR, Visacri MB, Ferracini AC, Mazzola PG, Parpinelli MÂ, et al. Pharmacist interventions in high-risk obstetric inpatient unit: a medication safety issue. Int J Qual Health Care. 2018;30(7):530–6.PubMedCrossRef
22.
Milosavljevic A, Aspden T, Harrison J. Community pharmacist-led interventions and their impact on patients' medication adherence and other health outcomes: a systematic review. Int J Pharm Pract. 2018;26(5):387–97.PubMedCrossRef
23.
Presley B, Groot W, Pavlova M. Pharmacy-led interventions to improve medication adherence among adults with diabetes: a systematic review and meta-analysis. Res Social Adm Pharm. 2018.
24.
25.
Wahl AK, Rustoen T, Hanestad BR, Lerdal A, Moum T. Quality of life in the general Norwegian population, measured by the quality of life scale (QOLS-N). Qual Life Res. 2004;13(5):1001–9.PubMedCrossRef
26.
Boutron I, Altman DG, Moher D, Schulz KF, Ravaud P, Group CN. CONSORT statement for randomized trials of nonpharmacologic treatments: a 2017 update and a CONSORT extension for nonpharmacologic trial abstracts. Ann Intern Med. 2017;167(1):40–7.PubMedCrossRef
27.
Bai G, Raat H, Jaddoe VWV, Mautner E, Korfage IJ. Trajectories and predictors of women's health-related quality of life during pregnancy: a large longitudinal cohort study. PLoS One. 2018;13(4):e0194999.PubMedPubMedCentralCrossRef
28.
Morin M, Claris O, Dussart C, Frelat A, de Place A, Molinier L, et al. Health-related quality of life during pregnancy: a repeated measures study of changes from the first trimester to birth. Acta Obstet Gynecol Scand. 2019;98(10):1282–91.PubMedCrossRef
29.
Chang SR, Chen KH, Lin MI, Lin HH, Huang LH, Lin WA. A repeated measures study of changes in health-related quality of life during pregnancy and the relationship with obstetric factors. J Adv Nurs. 2014;70(10):2245–56.PubMedCrossRef
30.
31.
Wahl A, Burckhardt C, Wiklund I, Hanestad BR. The Norwegian version of the quality of life scale (QOLS-N). A validation and reliability study in patients suffering from psoriasis. Scand J Caring Sci. 1998;12(4):215–22.PubMed
32.
Koren G, Piwko C, Ahn E, Boskovic R, Maltepe C, Einarson A, et al. Validation studies of the pregnancy unique-quantification of Emesis (PUQE) scores. J Obstet Gynaecol. 2005;25(3):241–4.PubMedCrossRef
33.
Birkeland E, Stokke G, Tangvik RJ, Torkildsen EA, Boateng J, Wollen AL, et al. Norwegian PUQE (pregnancy-unique quantification of Emesis and nausea) identifies patients with hyperemesis gravidarum and poor nutritional intake: a prospective cohort validation study. PLoS One. 2015;10(4):e0119962.PubMedPubMedCentralCrossRef
34.
Ebrahimi N, Maltepe C, Bournissen FG, Koren G. Nausea and vomiting of pregnancy: using the 24-hour pregnancy-unique quantification of Emesis (PUQE-24) scale. J Obstet Gynaecol Can. 2009;31(9):803–7.PubMedCrossRef
35.
Mardby AC, Lupattelli A, Hensing G, Nordeng H. Consumption of alcohol during pregnancy-a multinational European study. Women Birth. 2017;30(4):e207–e13.PubMedCrossRef
36.
Esposito G, Ambrosio R, Napolitano F, Di Giuseppe G. Women's knowledge, attitudes and behavior about maternal risk factors in pregnancy. PLoS One. 2015;10(12):e0145873.PubMedPubMedCentralCrossRef
37.
38.
Ragland D, Briggs GG, Wasik M, Kelsey JJ, Ferreira E, Abe-Fukushima W, et al. Obstetrical opportunities: will pharmacy ever realize them? Ann Pharmacother. 2012;46(2):297–300.PubMedCrossRef
39.
Reidenbach M, Bade L, Bright D, DiPietro MN, Ellis A. Preconception care needs among female patients of childbearing age in an urban community pharmacy setting. J Am Pharm Assoc (2003). 2019;59(4S):S52–s.CrossRef
40.
Dipietro NA, Bright DR. Medication Therapy Management and Preconception Care: Opportunities for Pharmacist Intervention. Inov Pharm. 2014;5(1):Article 141.CrossRef
41.
Ebrahimi N, Maltepe C, Einarson A. Optimal management of nausea and vomiting of pregnancy. Int J Women's Health. 2010;2:241–8.CrossRef
42.
Chang SR, Chen KH, Lin MI, Lin HH, Huang LH, Lin WA. A reapted measure study of changes in health-realted quality of life during pregnancy and the relationship with obstetric factors. J Adv Nurs. 2014;70(10):2245–56.PubMedCrossRef
43.
Bai G, Raat H, Jaddoe VWV, Mautner E, Korfage IJ. Trajectories and predictors of women’s health-realted quality of life during pregnancy: a large lonitudinal cohort study. PLoS One. 2018;13(4):e0194999.PubMedPubMedCentralCrossRef
44.
Morin M, Claris O, Dussart C, Frelat A, de Place A, Molinier L, et al. Health-related quality of life during pregnancy: a repeated measure study of changes from the first trimester to birth. Acta Obstet Gynecol Scan. 2019;98(10):1282–91.CrossRef
45.
Guillory J, Niederdeppe J, Kim H, Pollak JP, Graham M, Olson C, et al. Does social support predict pregnant mothers' information seeking behaviors on an educational website? Matern Child Health J. 2014;18(9):2218–25.PubMedPubMedCentralCrossRef
46.
Durand H, Hayes P, Morrissey EC, Newell J, Casey M, Murphy AW, et al. Medication adherence among patients with apparent treatment-resistant hypertension: systematic review and meta-analysis. J Hypertens. 2017;35(12):2346–57.PubMedCrossRef
47.
Lacasse A, Berard A. Validation of the nausea and vomiting of pregnancy specific health related quality of life questionnaire. Health Qual Life Outcomes. 2008;6:32.PubMedPubMedCentralCrossRef
48.
Mogos MF, August EM, Salinas-Miranda AA, Sultan DH, Salihu HM. A systematic review of quality of life measures in pregnant and postpartum mothers. Appl Res Qual Life. 2013;8(2):219–50.PubMedCrossRef
49.
Metadata
Title
The effect of a pharmacist consultation on pregnant women’s quality of life with a special focus on nausea and vomiting: an intervention study
Authors
Maria Bich-Thuy Truong
Elin Ngo
Hilde Ariansen
Ross T. Tsuyuki
Hedvig Nordeng
Publication date
01-12-2020
Publisher
BioMed Central
Keywords
Nausea
Vomiting
Published in
BMC Pregnancy and Childbirth / Issue 1/2020
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-020-03472-z

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