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Published in: BMC Pregnancy and Childbirth 1/2020

01-12-2020 | Pre-Eclampsia | Research article

Preeclampsia management modalities and perinatal death: a retrospective study in Woldia general hospital

Authors: Kenean Getaneh Tlaye, Melese Linger Endalfer, Mesfin Wudu Kassaw, Mussie Mulugeta Gebremedhin, Yared Asmare Aynalem

Published in: BMC Pregnancy and Childbirth | Issue 1/2020

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Abstract

Background

Hypertensive disorders of pregnancy are among the most common causes of perinatal death. The disorders are highly linked to multiple factors that make prediction and prevention challenging. Early diagnosis and proper management play a crucial role in the wellbeing and life of the women and her baby. In this study, we aimed to assess the association between different management options of preeclampsia and perinatal death at a public hospital in Ethiopia.

Methods

A document review was conducted on 241 preeclamptic patients’ medical files who have been admitted and delivered in Woldia General Hospital from 2011 to 2016. The study was conducted from August 8 – September 10, 2017 in the aforementioned public hospital in Woldia town, Ethiopia. Associations were tested using Pearson chi squared test and binary logistic regression with a p-value < 0.05 considered significant.

Result

In this study, nearly 20 every 100 neonates from preeclamptic women has been died and the figure was higher (76.59% Vs 23.4%) among neonates from severe preeclamptic women than mild preeclamptic women (p = 0.01). More than two thirds of the patients (69.3%) received magnesium sulfate to prevent convulsion. Perinatal death among women with diastolic blood pressures greater than 110 mmHg at admission was nearly 3 times (Adjusted Odds Ratio (AOR) = 2.824; 95% Confidence Interval (CI) (1.154–6.038)) higher compared to women with diastolic blood pressures below 110 mmHg.

Conclusion

In the 5-year period, the magnitude of perinatal death among inpatient preeclamptic women was remarkably high and of which stillbirths exceeded pre-discharge early neonatal death. Utilization of magnesium sulfate tended to increase across years. Maternal diastolic blood pressure at admission was significantly associated with perinatal death.
Literature
1.
go back to reference Central Statistical Agency Addis Ababa Ethiopia, ICF International Calverton Maryland, USA. Ethiopia Demographic and Health Survey 2011. In: CSA, editor. . Addis Ababa and Calverton; 2012. Central Statistical Agency Addis Ababa Ethiopia, ICF International Calverton Maryland, USA. Ethiopia Demographic and Health Survey 2011. In: CSA, editor. . Addis Ababa and Calverton; 2012.
2.
go back to reference Lawn JE, Blencowe H, Waiswa P. Stillbirths: rates, risk factors, and acceleration towards 2030. Lancet. 2016;387(6):17. Lawn JE, Blencowe H, Waiswa P. Stillbirths: rates, risk factors, and acceleration towards 2030. Lancet. 2016;387(6):17.
3.
go back to reference Vogel JP, Souza JP, Mori R. Maternal complications and perinatal mortality: findings of the World Health Organization multicountry survey on maternal and newborn health. BJOG. 2014;121(1):13. Vogel JP, Souza JP, Mori R. Maternal complications and perinatal mortality: findings of the World Health Organization multicountry survey on maternal and newborn health. BJOG. 2014;121(1):13.
4.
go back to reference Lawn JE, Blencowe H, Oza S. Every newborn: progress, priorities, and potential beyond survival. Lancet. 2014;384(12):17. Lawn JE, Blencowe H, Oza S. Every newborn: progress, priorities, and potential beyond survival. Lancet. 2014;384(12):17.
5.
go back to reference Singhal SR, Deepika A, Nanda S. Maternal and perinatan outcome in severe preeclampsia and eclampsia. JSAFOG. 2009;1(3):8. Singhal SR, Deepika A, Nanda S. Maternal and perinatan outcome in severe preeclampsia and eclampsia. JSAFOG. 2009;1(3):8.
6.
go back to reference Vidhyadhar BB, Purushottam AG, Aditi SM. Maternal and foetal outcome in pregnancy induced hypertension: a study from rural tertiary care teaching hospital in India. Int J Biomed Res. 2011;2. Vidhyadhar BB, Purushottam AG, Aditi SM. Maternal and foetal outcome in pregnancy induced hypertension: a study from rural tertiary care teaching hospital in India. Int J Biomed Res. 2011;2.
7.
go back to reference Tuffnell DJ, Jankowicz D, Lindow SW, Lyons G, Mason GC, Russell IF. Outcome of severe preeclampsia/ eclampsia. J Obstet Gynecol. 2005;112:6. Tuffnell DJ, Jankowicz D, Lindow SW, Lyons G, Mason GC, Russell IF. Outcome of severe preeclampsia/ eclampsia. J Obstet Gynecol. 2005;112:6.
8.
go back to reference Al Inizi ST, Sharara H, Ahmed B. Eclampsia in Quatar: maternal and fetal outcomes, possible preventive measures. Mid East J Emerg Med. 2005;5:6. Al Inizi ST, Sharara H, Ahmed B. Eclampsia in Quatar: maternal and fetal outcomes, possible preventive measures. Mid East J Emerg Med. 2005;5:6.
9.
10.
go back to reference Onuh SO, Aisien AO. Maternal and fetal outcome in eclamptic patients in Benin City, Nigeria. J Obstet Gynaecol. 2004;24(7):8.CrossRef Onuh SO, Aisien AO. Maternal and fetal outcome in eclamptic patients in Benin City, Nigeria. J Obstet Gynaecol. 2004;24(7):8.CrossRef
11.
go back to reference Wolde Z, Segni H, Woldie M. Hpertensive disorders of pregnancy in Jimma University specialized hospital. Ethiop J Health Sci. 2010;21:147–54. Wolde Z, Segni H, Woldie M. Hpertensive disorders of pregnancy in Jimma University specialized hospital. Ethiop J Health Sci. 2010;21:147–54.
12.
go back to reference Seyom E, Abera M, Tesfaye M, Fentahun N. Maternal and fetal outcome of pregnancy related hypertension in Mettu Karl referral hospital, Ethiopia. J Ovarian Res. 2013;8. Seyom E, Abera M, Tesfaye M, Fentahun N. Maternal and fetal outcome of pregnancy related hypertension in Mettu Karl referral hospital, Ethiopia. J Ovarian Res. 2013;8.
13.
go back to reference Pannu D, Das B, Hazari P, Shilpa. Maternal and perinatal outcome in eclampsia and factors affecting the outcome: a study in North Indian population. Int J Reprod Contracep Obstet Gynecol. 2010;3:347–51. Pannu D, Das B, Hazari P, Shilpa. Maternal and perinatal outcome in eclampsia and factors affecting the outcome: a study in North Indian population. Int J Reprod Contracep Obstet Gynecol. 2010;3:347–51.
14.
go back to reference Wagnew M, Dessalegn M, Worku A, Nyagero J. Trends of preeclampsia/eclampsia and maternal and neonatal outcomes among women delivering in Addis Ababa selected government hospitals, Ethiopia: a retrospective cross-sectional study. Pan Afr Med J. 2016;25(2):12.PubMedPubMedCentral Wagnew M, Dessalegn M, Worku A, Nyagero J. Trends of preeclampsia/eclampsia and maternal and neonatal outcomes among women delivering in Addis Ababa selected government hospitals, Ethiopia: a retrospective cross-sectional study. Pan Afr Med J. 2016;25(2):12.PubMedPubMedCentral
15.
go back to reference Nazarius PK, Tumwesigye M, Wandabwa J, Wamuyu-Maina G, Bimenya GS, Okong P. Adverse neonatal outcomes in women with preeclampsia in Mulago Hospital, Kampala, Uganda: a cross-sectional study. Pan Africa Med J. 2009;17. Nazarius PK, Tumwesigye M, Wandabwa J, Wamuyu-Maina G, Bimenya GS, Okong P. Adverse neonatal outcomes in women with preeclampsia in Mulago Hospital, Kampala, Uganda: a cross-sectional study. Pan Africa Med J. 2009;17.
16.
go back to reference Health Federal Democratic Republic of Ethiopia Ministry of Management protocol on selected obstetrics topics. Pregnancy Induced Hypertension 2010:22. Health Federal Democratic Republic of Ethiopia Ministry of Management protocol on selected obstetrics topics. Pregnancy Induced Hypertension 2010:22.
17.
go back to reference Mooij R, Lugumila J, Mwashambwa MY, Mwampagatwa IH, van Dillen J, Stekelenburg J. Characteristics and outcomes of patients with eclampsia and severe pre-eclampsia in a rural hospital in Western Tanzania: a retrospective medical record study. BMC Pregnancy Childbirth. 2012;15. Mooij R, Lugumila J, Mwashambwa MY, Mwampagatwa IH, van Dillen J, Stekelenburg J. Characteristics and outcomes of patients with eclampsia and severe pre-eclampsia in a rural hospital in Western Tanzania: a retrospective medical record study. BMC Pregnancy Childbirth. 2012;15.
18.
go back to reference Sibai BM. Magnesium sulfate prophylaxis in preeclampsia: Lessons learned from recent trials. Am J Obstet Gynecol. 2004;190. Sibai BM. Magnesium sulfate prophylaxis in preeclampsia: Lessons learned from recent trials. Am J Obstet Gynecol. 2004;190.
19.
go back to reference Barber D, Xing G, Towner D. Expectant management of severe eclampsia between 24–32 weeks gestation: a ten-year review: The 29th Annual Meeting of the Society for Maternal-Fetal Medicine; 2009. Barber D, Xing G, Towner D. Expectant management of severe eclampsia between 24–32 weeks gestation: a ten-year review: The 29th Annual Meeting of the Society for Maternal-Fetal Medicine; 2009.
20.
go back to reference Endeshaw G, Berhan Y. Perinatal Outcome in Women with Hypertensive Disorders of Pregnancy: a retrospective cohort study. Int Scholarly Res Notices. 2013;2015:8. Endeshaw G, Berhan Y. Perinatal Outcome in Women with Hypertensive Disorders of Pregnancy: a retrospective cohort study. Int Scholarly Res Notices. 2013;2015:8.
21.
go back to reference Ananth CV, Basso O. Impact of pregnancy-induced hypertension on stillbirth and neonatal mortality in first and higher order births: a population- based study. NIH Public Access. 2010;21:118–23. Ananth CV, Basso O. Impact of pregnancy-induced hypertension on stillbirth and neonatal mortality in first and higher order births: a population- based study. NIH Public Access. 2010;21:118–23.
22.
go back to reference Judy A, Chao L, Girsen A, O’Malley K, Lyell D, Blumenfeld Y, Butwick A, El-Sayed Y. Maternal characteristics and neonatal outcomes in women with eclampsia versus severe preeclampsia. Am J Obstet Gynecol. 2014;192(1):S188–90.CrossRef Judy A, Chao L, Girsen A, O’Malley K, Lyell D, Blumenfeld Y, Butwick A, El-Sayed Y. Maternal characteristics and neonatal outcomes in women with eclampsia versus severe preeclampsia. Am J Obstet Gynecol. 2014;192(1):S188–90.CrossRef
23.
go back to reference Thangaratinam S, Datta A, Ismail KMK, Khan KS. What is the accuracy of blood pressure in predicting complications in pre-eclampsia? Arch Dis Child Fetal Neonatal Ed. 2011;96(1):9.CrossRef Thangaratinam S, Datta A, Ismail KMK, Khan KS. What is the accuracy of blood pressure in predicting complications in pre-eclampsia? Arch Dis Child Fetal Neonatal Ed. 2011;96(1):9.CrossRef
Metadata
Title
Preeclampsia management modalities and perinatal death: a retrospective study in Woldia general hospital
Authors
Kenean Getaneh Tlaye
Melese Linger Endalfer
Mesfin Wudu Kassaw
Mussie Mulugeta Gebremedhin
Yared Asmare Aynalem
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Pre-Eclampsia
Published in
BMC Pregnancy and Childbirth / Issue 1/2020
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-020-02909-9

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