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BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2016

Open Access 01-12-2016 | Study protocol

Use of metabolomics for the identification and validation of clinical biomarkers for preterm birth: Preterm SAMBA

Authors: Jose G. Cecatti, Renato T. Souza, Karolina Sulek, Maria L. Costa, Louise C. Kenny, Lesley M. McCowan, Rodolfo C. Pacagnella, Silas G. Villas-Boas, Jussara Mayrink, Renato Passini Jr, Kleber G. Franchini, Philip N. Baker, for the Preterm SAMBA and SCOPE study groups

Published in: BMC Pregnancy and Childbirth | Issue 1/2016

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Abstract

Background

Spontaneous preterm birth is a complex syndrome with multiple pathways interactions determining its occurrence, including genetic, immunological, physiologic, biochemical and environmental factors. Despite great worldwide efforts in preterm birth prevention, there are no recent effective therapeutic strategies able to decrease spontaneous preterm birth rates or their consequent neonatal morbidity/mortality. The Preterm SAMBA study will associate metabolomics technologies to identify clinical and metabolite predictors for preterm birth. These innovative and unbiased techniques might be a strategic key to advance spontaneous preterm birth prediction.

Methods/design

Preterm SAMBA study consists of a discovery phase to identify biophysical and untargeted metabolomics from blood and hair samples associated with preterm birth, plus a validation phase to evaluate the performance of the predictive modelling. The first phase, a case–control study, will randomly select 100 women who had a spontaneous preterm birth (before 37 weeks) and 100 women who had term birth in the Cork Ireland and Auckland New Zealand cohorts within the SCOPE study, an international consortium aimed to identify potential metabolomic predictors using biophysical data and blood samples collected at 20 weeks of gestation. The validation phase will recruit 1150 Brazilian pregnant women from five participant centres and will collect blood and hair samples at 20 weeks of gestation to evaluate the performance of the algorithm model (sensitivity, specificity, predictive values and likelihood ratios) in predicting spontaneous preterm birth (before 34 weeks, with a secondary analysis of delivery before 37 weeks).

Discussion

The Preterm SAMBA study intends to step forward on preterm birth prediction using metabolomics techniques, and accurate protocols for sample collection among multi-ethnic populations. The use of metabolomics in medical science research is innovative and promises to provide solutions for disorders with multiple complex underlying determinants such as spontaneous preterm birth.
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Metadata
Title
Use of metabolomics for the identification and validation of clinical biomarkers for preterm birth: Preterm SAMBA
Authors
Jose G. Cecatti
Renato T. Souza
Karolina Sulek
Maria L. Costa
Louise C. Kenny
Lesley M. McCowan
Rodolfo C. Pacagnella
Silas G. Villas-Boas
Jussara Mayrink
Renato Passini Jr
Kleber G. Franchini
Philip N. Baker
for the Preterm SAMBA and SCOPE study groups
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2016
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-016-1006-9

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