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BMC Neurology
Published in: BMC Neurology 1/2018

Open Access 01-12-2018 | Research article

Is traumatic brain injury a risk factor for neurodegeneration? A meta-analysis of population-based studies

Authors: Chi-Hsien Huang, Chi-Wei Lin, Yi-Che Lee, Chih-Yuan Huang, Ru-Yi Huang, Yi-Cheng Tai, Kuo-Wei Wang, San-Nan Yang, Yuan-Ting Sun, Hao-kuang Wang

Published in: BMC Neurology | Issue 1/2018

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Abstract

Background

To determine the association of prior traumatic brain injury (TBI) with subsequent diagnosis of neurodegeneration disease.

Methods

All studies from 1980 to 2016 reporting TBI as a risk factor for diagnoses of interest were identified by searching PubMed, Embase, study references, and review articles. The data and study design were assessed by 2 investigators independently. A meta-analysis was performed by RevMan 5.3.

Results

There were 18 studies comprising 3,263,207 patients. Meta-analysis revealed a significant association of prior TBI with subsequent dementia. The pooled odds ratio (OR) for TBI on development of dementia, FTD and TDP-43 associated disease were 1.93 (95% CI 1.47–2.55, p < 0.001), 4.44 (95% CI 3.86–5.10, p < 0.001), and 2.97 (95% CI 1.35–6.53, p < 0.001). However, analyses of individual diagnoses found no evidence that the risk of Alzheimer’s disease, and Parkinson’s disease in individuals with previous TBI compared to those without TBI.

Conclusions

History of TBI is not associated with the development of subsequent neurodegeneration disease. Care must be taken in extrapolating from these results because no suitable criteria define post TBI neurodegenerative processes. Therefore, further research in this area is needed to confirm these questions and uncover the link between TBI and neurodegeneration disease.
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Metadata
Title
Is traumatic brain injury a risk factor for neurodegeneration? A meta-analysis of population-based studies
Authors
Chi-Hsien Huang
Chi-Wei Lin
Yi-Che Lee
Chih-Yuan Huang
Ru-Yi Huang
Yi-Cheng Tai
Kuo-Wei Wang
San-Nan Yang
Yuan-Ting Sun
Hao-kuang Wang
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2018
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-018-1187-0

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