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BMC Neurology

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Open Access 01-12-2018 | Research article

Ventriculoperitoneal shunts in non-HIV cryptococcal meningitis

Authors: Jia Liu, Zhuo-lin Chen, Min Li, Chuan Chen, Huan Yi, Li Xu, Feng Tan, Fu-hua Peng

Published in: BMC Neurology | Issue 1/2018

Abstract

Background

Persistent and uncontrollable intracranial hypertension (ICH) and difficulty in reducing Cryptococcus count are severe problems in cryptococcal meningitis (CM) patients. The therapeutic effects of ventriculoperitoneal shunts (VPS) in non-HIV CM patients are not fully known, and the procedure is somewhat unusual. Here, our study offers a review to investigate the role of VPS in non-HIV CM.

Methods

We retrospectively collected data on 23 non-HIV CM patients with and without ventriculomegaly from 2010 to 2016. Their demographic data, clinical manifestations, cerebrospinal fluid (CSF) features and outcomes were analysed.

Results

We found that non-HIV CM patients without ventriculomegaly were older, had earlier treatment times and had shorter symptom durations than CM patients with ventriculomegaly. In both groups, headache, vomiting, fever and loss of vision were the most common clinical features. CSF pressure and Cryptococcus count were significantly decreased after operation. VPS could provide sustained relief from ICH symptoms such as headache. 13% of patients had poor outcomes because of serious underlying disease, while 87% of patients had good outcomes.

Conclusions

The use of a VPS is helpful in decreasing ICH and fungal overload in non-HIV CM patients, and VPS should be performed before CM patients present with symptoms of severe neurological deficit.

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Title: Ventriculoperitoneal shunts in non-HIV cryptococcal meningitis
Authors: Jia Liu
Zhuo-lin Chen
Min Li
Chuan Chen
Huan Yi
Li Xu
Feng Tan
Fu-hua Peng
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2018
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-018-1053-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Ventriculoperitoneal shunts in non-HIV cryptococcal meningitis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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