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BMC Neurology
Published in: BMC Neurology 1/2017

Open Access 01-12-2017 | Research article

High dose vitamin D supplementation does not affect biochemical bone markers in multiple sclerosis – a randomized controlled trial

Authors: Trygve Holmøy, Jonas Christoffer Lindstrøm, Erik Fink Eriksen, Linn Hofsøy Steffensen, Margitta T. Kampman

Published in: BMC Neurology | Issue 1/2017

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Abstract

Background

People with multiple sclerosis have high risk of osteoporosis and fractures. A poor vitamin D status is a risk factor for MS, and vitamin D supplementation has been recommended both to prevent MS progression and to maintain bone health.

Methods

We assessed the effect of 20,000 IU vitamin D3 weekly compared to placebo on biochemical markers of bone metabolism in 68 persons with relapsing remitting multiple sclerosis.

Results

Serum levels of 25-hydroxyvitamin D more than doubled in the vitamin D group, and parathyroid hormone decreased in the vitamin D group compared to the placebo group at week 48 and week 96. There was however no effect on bone formation as measured by procollagen type I N propeptide (PINP), or on bone resorption as measured by C-terminal cross-linking telopeptide of type I collagen (CTX1). Neither PINP nor CTX1 predicted bone loss from baseline to week 96.

Conclusions

These findings corroborate the previously reported lack of effect of weekly high dose vitamin D supplementation on bone mass density in the same patients, and suggest that such vitamin D supplementation does not prevent bone loss in persons with MS who are not vitamin D deficient.

Trial registration

The trial was registered at ClinicalTrials.gov on April 4 2008, registration number NCT00785473.

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Metadata
Title
High dose vitamin D supplementation does not affect biochemical bone markers in multiple sclerosis – a randomized controlled trial
Authors
Trygve Holmøy
Jonas Christoffer Lindstrøm
Erik Fink Eriksen
Linn Hofsøy Steffensen
Margitta T. Kampman
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2017
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-017-0851-0

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