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BMC Neurology
Published in: BMC Neurology 1/2015

Open Access 01-12-2015 | Research article

Validation of NINDS-CSN neuropsychological battery for vascular cognitive impairment in Chinese stroke patients

Authors: Xiangliang Chen, Adrian Wong, Ruidong Ye, Lulu Xiao, Zhaojun Wang, Ying Lin, Fang Yang, Hua Li, Ting Feng, Lihui Duan, Yunfei Han, Qiliang Dai, Juan Du, Gelin Xu, Vincent Mok, Yunyun Xiong, Xinfeng Liu

Published in: BMC Neurology | Issue 1/2015

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Abstract

Background

The NINDS-Canadian Stroke Network (NINDS-CSN) recommended a neuropsychological battery of three protocols to diagnose vascular cognitive impairment (VCI), however, due to culture and language differences, the battery cannot be directly used in China. Validation of the battery in mandarin Chinese is lacking. Our study investigated the reliability and validity of the adapted Chinese versions of the battery in stroke patients with high probability of VCI.

Methods

Fifty mild stroke patients (median of National Institute of Health Stroke Scale [NIHSS] score, 2) and 50 stroke-free normal controls were recruited. All subjects’ demographics, clinical history, and stroke severity were recorded. The NINDS-CSN neuropsychological protocols were adapted into the Chinese versions. External validity, defined as the ability of the protocol summary scores to differentiate stroke patients from controls, was determined using the area under the curve (AUC) of the receiver operating characteristics curve. We also evaluated internal consistency and intra-rater reliability.

Results

Stroke patients performed significantly poorer than controls on all three protocols (F statistics between 24.9 and 31.4, P < 0.001). External validity evaluated by AUCs was 0.88 (95% confidence interval [CI], 0.81-0.95), 0.88 (95% CI, 0.81-0.94), and 0.86 (95% CI, 0.79-0.94) for the 60-min, 30-min and 5-min protocols, respectively. Cronbach’s alpha of the cognitive tests was 0.87 for all subjects. Intra-rater reliability was acceptable with intraclass correlation coefficients 0.90, 0.83 and 0.75 for the 60-min, 30-min and 5-min protocols, respectively.

Conclusions

The adapted Chinese versions of three NINDS-CSN neuropsychological protocols were valid and reliable for assessing VCI in Chinese patients with mild stroke.
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Metadata
Title
Validation of NINDS-CSN neuropsychological battery for vascular cognitive impairment in Chinese stroke patients
Authors
Xiangliang Chen
Adrian Wong
Ruidong Ye
Lulu Xiao
Zhaojun Wang
Ying Lin
Fang Yang
Hua Li
Ting Feng
Lihui Duan
Yunfei Han
Qiliang Dai
Juan Du
Gelin Xu
Vincent Mok
Yunyun Xiong
Xinfeng Liu
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2015
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-015-0270-z

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