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BMC Neurology
Published in: BMC Neurology 1/2014

Open Access 01-12-2014 | Research article

Improved nutritional status is related to improved quality of life in Parkinson’s disease

Authors: Jamie M Sheard, Susan Ash, George D Mellick, Peter A Silburn, Graham K Kerr

Published in: BMC Neurology | Issue 1/2014

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Abstract

Background

Quality of life is poorer in Parkinson’s disease than in other conditions and in the general population without Parkinson’s disease. Malnutrition also results in poorer quality of life. This study aimed at determining the relationship between quality of life and nutritional status.

Methods

Community-dwelling people with Parkinson’s disease >18 years old were recruited. The Patient-Generated Subjective Global Assessment (PG-SGA) assessed nutritional status. The Parkinson’s Disease Questionnaire 39 (PDQ-39) measured quality of life. Phase I was cross-sectional. The malnourished in Phase I were eligible for a nutrition intervention phase, randomised into 2 groups: standard care (SC) with provision of nutrition education materials only and intervention (INT) with individualised dietetic advice and regular weekly follow-up. Data were collected at baseline, 6 weeks, and 12 weeks.

Results

Phase I consisted of 120 people who completed the PDQ-39. Phase II consisted of 9 in the SC group and 10 in the INT group. In Phase I, quality of life was poorer in the malnourished, particularly for mobility and activities of daily living domains. There was a significant correlation between PG-SGA and PDQ-39 scores (Phase I, r s = 0.445, p = .000; Phase II, r s = .426, p = .002). In Phase II, no significant difference in the PDQ-39 total or sub-scores was observed between the INT and SC groups; however, there was significant improvement in the emotional well-being domain for the entire group, X 2 (2) = 8.84, p = .012.

Conclusions

Malnourished people with Parkinson’s disease had poorer quality of life than the well-nourished, and improvements in nutritional status resulted in quality of life improvements. Attention to nutritional status is an important component of quality of life and therefore the total care of people with Parkinson’s disease.
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Literature
1.
Vailas LI, Nitzke SA, Becker M, Gast J: Risk indicators for malnutrition are associated inversely with quality of life for participants in meal programs for older adults. J Am Diet Assoc. 1998, 98: 548-553. 10.1016/S0002-8223(98)00123-0.CrossRefPubMed
2.
Schrag A, Jahanshahi M, Quinn N: How does Parkinson’s disease affect quality of life? A comparison with quality of life in the general population. Mov Disord. 2000, 15: 1112-1118. 10.1002/1531-8257(200011)15:6<1112::AID-MDS1008>3.0.CO;2-A.CrossRefPubMed
3.
Karlsen KH, Larsen JP, Tandberg E, Mæland JG: Influence of clinical and demographic variables on quality of life in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1999, 66: 431-435. 10.1136/jnnp.66.4.431.CrossRefPubMedPubMedCentral
4.
Fargel M, Grobe B, Oesterle E, Hastedt C, Rupp M: Treatment of Parkinson’s disease: a survey of patients and neurologists. Clin Drug Investig. 2007, 27: 207-212. 10.2165/00044011-200727030-00004.CrossRefPubMed
5.
Gage H: The relative health related quality of life of veterans with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2003, 74: 163-169. 10.1136/jnnp.74.2.163.CrossRefPubMedPubMedCentral
6.
Zach M, Friedman A, Sławek J, Derejko M: Quality of life in Polish patients with long-lasting Parkinson’s disease. Mov Disord. 2004, 19: 667-672. 10.1002/mds.10698.CrossRefPubMed
7.
Post B, Muslimovic D, van Geloven N, Speelman JD, Schmand B, de Haan RJ: Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson’s disease. Mov Disord. 2011, 26: 449-456. 10.1002/mds.23467.CrossRefPubMed
8.
Gallagher DA, Lees AJ, Schrag A: What are the most important nonmotor symptoms in patients with Parkinson’s disease and are we missing them?. Mov Disord. 2010, 25: 2493-2500. 10.1002/mds.23394.CrossRefPubMed
9.
Kleiner-Fisman G, Stern MB, Fisman DN: Health-related quality of life in Parkinson disease: Correlation between Health Utilities Index III and Unified Parkinson’s Disease Rating Scale (UPDRS) in U.S. male veterans. Heal Qual Life Outcomes. 2010, 8: 91-100. 10.1186/1477-7525-8-91.CrossRef
10.
Sjödahl Hammarlund C, Hagell P, Nilsson MH: Motor and non-motor predictors of illness-related distress in Parkinson’s disease. Parkinsonism Relat Disord. 2012, 18: 299-302. 10.1016/j.parkreldis.2011.10.015.CrossRefPubMed
11.
Marras C, McDermott MP, Rochon PA, Tanner CM, Naglie G, Lang AE: Predictors of deterioration in health-related quality of life in Parkinson’s disease: Results from the DATATOP trial. Mov Disord. 2008, 23: 653-659. 10.1002/mds.21853.CrossRefPubMed
12.
Behari M, Srivastava AK, Pandey RM: Quality of life in patients with Parkinson’s disease. Parkinsonism Relat Disord. 2005, 11: 221-226. 10.1016/j.parkreldis.2004.12.005.CrossRefPubMed
13.
Chapuis S, Ouchchane L, Metz O, Gerbaud L, Durif F: Impact of the motor complications of Parkinson’s disease on the quality of life. Mov Disord. 2005, 20: 224-230. 10.1002/mds.20279.CrossRefPubMed
14.
Factors impacting on quality of life in Parkinson’s disease: Results from an international survey. Mov Disord. 2002, 17: 60-67. 10.1002/mds.10010.
15.
Encarnacion EV, Hauser RA: Levodopa-induced dyskinesias in Parkinson’s disease: Etiology, impact on quality of life, and treatments. Eur Neurol. 2008, 60: 57-66. 10.1159/000131893.CrossRefPubMed
16.
Pe´chevis M, Clarke CE, Vieregge P, Khoshnood B, Deschaseaux-Voinet C, Berdeaux G, Zieglere M: Effects of dyskinesias in Parkinson’s disease on quality of life and health-related costs: a prospective European study. Eur J Neurol. 2005, 12: 956-963. 10.1111/j.1468-1331.2005.01096.x.CrossRef
17.
Gómez-Esteban JC, Zarranz JJ, Lezcano E, Tijero B, Luna A, Velasco F, Rouco I, Garamendi I: Influence of motor symptoms upon the quality of life of patients with Parkinson’s disease. Eur Neurol. 2007, 57: 161-165. 10.1159/000098468.CrossRefPubMed
18.
Olin AÖ, Koochek A, Ljungqvist O, Cederholm T: Nutritional status, well-being and functional ability in frail elderly service flat residents. Eur J Clin Nutr. 2005, 59: 263-270. 10.1038/sj.ejcn.1602067.CrossRef
19.
Keller HH, Østbye T, Goy R: Nutritional risk predicts quality of life in elderly community-living Canadians. J Gerontol A Biol Sci Med Sci. 2004, 59A: 68-74. 10.1093/gerona/59.1.M68.CrossRef
20.
Isenring E, Bauer J, Capra S: The scored Patient-Generated Subjective Global Assessment (PG-SGA) and its association with quality of life in ambulatory patients receiving radiotherapy. Eur J Clin Nutr. 2003, 57: 305-309. 10.1038/sj.ejcn.1601552.CrossRefPubMed
21.
Davidson W, Ash S, Capra S, Bauer J: Weight stabilisation is associated with improved survival duration and quality of life in unresectable pancreatic cancer. Clin Nutr. 2004, 23: 239-247. 10.1016/j.clnu.2003.07.001.CrossRefPubMed
22.
Campbell KL, Ash S, Bauer JD: The impact of nutrition intervention on quality of life in pre-dialysis chronic kidney disease patients. Clin Nutr. 2008, 27: 537-544. 10.1016/j.clnu.2008.05.002.CrossRefPubMed
23.
Sheard JM, Ash S, Silburn PA, Kerr GK: Prevalence of malnutrition in Parkinson’s disease: a systematic review. Nutr Rev. 2011, 69: 520-532. 10.1111/j.1753-4887.2011.00413.x.CrossRefPubMed
24.
Sheard JM, Ash S, Silburn PA, Kerr GK: Nutritional status in Parkinson’s disease patients undergoing deep brain stimulation surgery: A pilot study. J Nutr Health Aging. 2013, 17: 148-151. 10.1007/s12603-012-0386-4.CrossRefPubMed
25.
Sheard JM, Ash S, Mellick GD, Silburn PA, Kerr GK: Malnutrition in a sample of community-dwelling people with Parkinson’s disease. PLoS One. 2013, 8: e53290-10.1371/journal.pone.0053290.CrossRefPubMedPubMedCentral
26.
Fereshtehnejad S-M, Ghazi L, Shafieesabet M, Shahidi GA, Delbari A, Lökk J: Motor, psychiatric and fatigue features associated with nutritional status and its effects on quality of life in Parkinson’s disease patients. PLoS One. 2014, 9: e91153-10.1371/journal.pone.0091153.CrossRefPubMedPubMedCentral
27.
Hickson M, Frost G: An investigation into the relationships between quality of life, nutritional status and physical function. Clin Nutr. 2004, 23: 213-221. 10.1016/S0261-5614(03)00127-4.CrossRefPubMed
28.
Ravasco P, Monteiro-Grillo I, Vidal PM, Camilo ME: Dietary counseling improves patient outcomes: a prospective, randomized, controlled trial in colorectal cancer patients undergoing radiotherapy. J Clin Oncol. 2005, 23: 1431-1438. 10.1200/JCO.2005.02.054.CrossRefPubMed
29.
Ravasco P, Monteiro-Grillo I, Marques Vidal P, Camilo ME: Impact of nutrition on outcome: a prospective randomized controlled trial in patients with head and neck cancer undergoing radiotherapy. Head Neck. 2005, 27: 659-668. 10.1002/hed.20221.CrossRefPubMed
30.
Sheard JM, Ash S, Mellick GD, Silburn PA, Kerr GK: Markers of disease severity are associated with malnutrition in Parkinson’s disease. PLoS One. 2013, 8: e57986-10.1371/journal.pone.0057986.CrossRefPubMedPubMedCentral
31.
Ottery F: Patient-Generated Subjective Global Assessment. Clin Guid to Oncol Nutr. Edited by: McCallum PD. 2000, American Dietetic Association, Chicago, 11-23.
32.
Detsky AS, McLaughlin JR, Baker JP, Johnston N, Whittaker S, Mendelson RA: What is subjective global assessment of nutritional status?. JPEN J Parenter Enteral Nutr. 1987, 11: 8-13. 10.1177/014860718701100108.CrossRefPubMed
33.
Peto V, Jenkinson C, Fitzpatrick R, Greenhail R: The development and validation of a short measure of functioning and well being for individuals with Parkinson’s disease. Qual Life Res. 1995, 4: 241-248. 10.1007/BF02260863.CrossRefPubMed
34.
Watterson C, Fraser A, Banks M, Isenring E, Miller M, Silvester C, Hoevenaars R, Bauer J, Vivanti A, Ferguson M: Evidence based practice guidelines for the nutritional management of malnutrition in adult patients across the continuum of care. Nutr Diet. 2009, 66: S1-S34. 10.1111/j.1747-0080.2009.01383.x.CrossRef
35.
White JV, Guenter P, Jensen G, Malone A, Schofield M: Consensus statement of the Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition: Characteristics recommended for the identification and documentation of adult malnutrition (undernutrition). J Acad Nutr Diet. 2012, 112: 730-738. 10.1016/j.jand.2012.03.012.CrossRefPubMed
36.
Peto V, Jenkinson C, Fitzpatrick R: Determining minimally important differences for the PDQ-39 Parkinson’s disease questionnaire. Age Ageing. 2001, 30: 299-302. 10.1093/ageing/30.4.299.CrossRefPubMed
37.
Visvanathan R, Macintosh C, Callary M, Penhall R, Horowitz M, Chapman I: The nutritional status of 250 older Australian recipients of domiciliary care services and its association with outcomes at 12 months. J Am Geriatr Soc. 2003, 51: 1007-1011. 10.1046/j.1365-2389.2003.51317.x.CrossRefPubMed
38.
Bannerman E, Miller MD, Daniels LA, Cobiac L, Giles LC, Whitehead C, Andrews GR, Crotty M: Anthropometric indices predict physical function and mobility in older Australians: The Australian Longitudinal Study of Ageing. Public Health Nutr. 2002, 5: 655-662. 10.1079/PHN2002336.CrossRefPubMed
39.
Neumann SA, Miller MD, Daniels L, Crotty M: Nutritional status and clinical outcomes of older patients in rehabilitation. J Hum Nutr Diet. 2005, 18: 129-136. 10.1111/j.1365-277X.2005.00596.x.CrossRefPubMed
40.
Mackenzie AE, Chang AM: Predictors of quality of life following stroke. Disabil Rehabil. 2002, 24: 259-265. 10.1080/09638380110081805.CrossRefPubMed
41.
Grosset KA, Grosset DG: Patient-perceived involvement and satisfaction in Parkinson’s disease: effect on therapy decisions and quality of life. Mov Disord. 2005, 20: 616-619. 10.1002/mds.20393.CrossRefPubMed
42.
Lezcano E, Gómez-Esteban JC, Zarranz JJ, Lambarri I, Madoz P, Bilbao G, Pomposo I, Garibi J: Improvement in quality of life in patients with advanced Parkinson’s disease following bilateral deep-brain stimulation in subthalamic nucleus. Eur J Neurol. 2004, 11: 451-454. 10.1111/j.1468-1331.2004.00804.x.CrossRefPubMed
43.
Den Oudsten BL, Van Heck GL, De Vries J: Quality of life and related concepts in Parkinson’s disease: a systematic review. Mov Disord. 2007, 22: 1528-1537. 10.1002/mds.21567.CrossRefPubMed
44.
Lee MA, Walker RW, Hildreth AJ, Prentice WM: Individualized assessment of quality of life in idiopathic Parkinson’s disease. Mov Disord. 2006, 21: 1929-1934. 10.1002/mds.21099.CrossRefPubMed
45.
Kim MY, Dahlberg A, Hagell P: Respondent burden and patient-perceived validity of the PDQ-39. Acta Neurol Scand. 2006, 113: 132-137. 10.1111/j.1600-0404.2005.00549.x.CrossRefPubMed
46.
Bachmann CG, Zapf A, Brunner E, Trenkwalder C: Dopaminergic treatment is associated with decreased body weight in patients with Parkinson’s disease and dyskinesias. Eur J Neurol. 2009, 16: 895-901. 10.1111/j.1468-1331.2009.02617.x.CrossRefPubMed
47.
Sharma JC, Ross IN, Rascol O, Brooks D: Relationship between weight, levodopa and dyskinesia: the significance of levodopa dose per kilogram body weight. Eur J Neurol. 2008, 15: 493-496. 10.1111/j.1468-1331.2008.02106.x.CrossRefPubMed
48.
Sharma JC, Macnamara L, Hasoon M, Vassallo M, Ross I: Cascade of levodopa dose and weight-related dyskinesia in Parkinson’s disease (LD-WD-PD cascade). Parkinsonism Relat Disord. 2006, 12: 499-505. 10.1016/j.parkreldis.2006.07.002.CrossRefPubMed
Metadata
Title
Improved nutritional status is related to improved quality of life in Parkinson’s disease
Authors
Jamie M Sheard
Susan Ash
George D Mellick
Peter A Silburn
Graham K Kerr
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2014
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-014-0212-1

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