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BMC Nephrology
Published in: BMC Nephrology 1/2020

Open Access 01-12-2020 | Kidney Transplantation | Research article

Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation

Authors: Rao Chen, Haifeng Wang, Lei Song, Jianfei Hou, Jiawei Peng, Helong Dai, Longkai Peng

Published in: BMC Nephrology | Issue 1/2020

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Abstract

Background

Delayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed to predict the incidence of DGF and evaluate its effect on graft survival.

Methods

This retrospective study on kidney transplantation was conducted from January 1, 2018, to December 31, 2019, at the Second Xiangya Hospital of Central South University. We classified recipients whose operations were performed in different years into training and validation cohorts and used data from the training cohort to analyze predictors of DGF. A nomogram was then constructed to predict the likelihood of DGF based on these predictors.

Results

The incidence rate of DGF was 16.92%. Binary logistic regression analysis showed correlations between the incidence of DGF and cold ischemic time (CIT), warm ischemic time (WIT), terminal serum creatine (Scr) concentration, duration of pretransplant dialysis, primary cause of donor death, and usage of LifePort. The internal accuracy of the nomogram was 83.12%. One-year graft survival rates were 93.59 and 99.74%, respectively, for the groups with and without DGF (P < 0.05).

Conclusion

The nomogram established in this study showed good accuracy in predicting DGF after deceased donor kidney transplantation; additionally, DGF decreased one-year graft survival.
Appendix
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Metadata
Title
Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation
Authors
Rao Chen
Haifeng Wang
Lei Song
Jianfei Hou
Jiawei Peng
Helong Dai
Longkai Peng
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2020
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-020-02181-1

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