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BMC Nephrology

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Open Access 01-12-2019 | Prostate Cancer | Research article

Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient Sample

Authors: Chen Ning, Xinyi Hu, Fangming Liu, Jun Lin, Jian Zhang, Zhipeng Wang, Yichen Zhu

Published in: BMC Nephrology | Issue 1/2019

Abstract

Background

Chronic kidney disease (CKD) and end stage renal disease (ESRD) are not well characterized in prostate cancer patients. This study aimed to examine the clinical characteristics and postsurgical outcomes of patients with or without CKD and ESRD undergoing radical prostatectomy for prostate cancer.

Methods

This population-based, retrospective study used patient data from the Nationwide Inpatient Sample, the largest all-payer US inpatient care database. From 2005 to 2014, 136,790 male patients aged > 20 years diagnosed with prostate cancer and who received radical prostatectomy were included. Postoperative complications, postoperative acute kidney injury (AKI) and urinary complications, and length of hospital stay were compared between patients with or without underlying CKD and ESRD.

Results

After adjusting for relevant factors, the CKD group had a significantly higher risk of postoperative complications than the non-CKD group. In addition, the CKD group had a 5-times greater risk of postoperative AKI and urinary complications than the non-CKD group. Both CKD and ESRD groups had significantly longer hospital stays than the non-CKD group. Patients receiving RARP had a lower risk of postoperative complications than those who received open radical prostatectomy, regardless of having CKD or not. Both non-CKD and CKD patients receiving RARP had shorter hospital stays than those who received open surgery.

Conclusions

Prostate cancer patients with underlying CKD had significantly greater risk of postoperative complications, postoperative AKI and urinary complications, and longer hospital stays than those without CKD. The use of RARP significantly shortened hospital stays and reduced complications for these patients.

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Title: Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient Sample
Authors: Chen Ning
Xinyi Hu
Fangming Liu
Jun Lin
Jian Zhang
Zhipeng Wang
Yichen Zhu
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Prostate Cancer
Acute Kidney Injury
Prostate Cancer
Prostatectomy
Prostatectomy
Chronic Kidney Disease
Acute Kidney Injury
Published in: BMC Nephrology / Issue 1/2019
Electronic ISSN: 1471-2369
DOI: https://doi.org/10.1186/s12882-019-1455-2

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Results

Conclusions

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