Top

BMC Nephrology

Published in:

Open Access 01-12-2018 | Research article

Comparing the vascular thromboembolic events following arteriovenous fistula in Chinese population with end-stage renal diseases receiving Clopidogrel versus Beraprost sodium therapy: a retrospective cohort study

Authors: Yu Zhou, Ling Du, Bo Tu, Qiquan Lai, Xiaonan Du, Bo Xu, Fan Zhang, Mingdong Zhao, Ziming Wan, Jiajie Lai

Published in: BMC Nephrology | Issue 1/2018

Abstract

Background

To assess the time to first on-study vascular thromboembolic events (VTEs) of clopidogrel (CL) or beraprost sodium (BPS) in Chinese population with end-stage renal disease (ESRD) treated with arteriovenous fistula (AVF) surgery.

Methods

From Jan 2009 to May 2015, 346 ESRD cases suffering an AVF surgery and undergoing oral administration of 75 mg CL (initial dose of 300 mg), 1 time/day, for 4 weeks or 40 μg BPS, 3 times/day, for 4 weeks were retrospectively assessed. The primary outcome was time to first on-study VTE.

Results

In total, 222 ESRD cases (CL, n = 112; BPS, n = 110) were assessed, with a median follow-up time of 38.1 months (range, 37–40 months). The mean time to first on-study VTE was 1.2 weeks (0.5–2.3) and 1.8 weeks (1.2–3.8) for CL and BPS, respectively (HR 0.27, 95% CI 0.16–1.45; P = 0.00). An increased incidence of VTEs was found during the 1th-month follow-up, with rates of 14.2 and 5.5% for CL and BPS, respectively (P = 0.03). The difference persisted over time, with rates of 24.1 and 11.8% at final follow-up, respectively (P = 0.02).

Conclusion

CL with an increased risk of VTEs tended to have a VTE within the 1st month after cessation compared with BPS.

Salako AA, Badmus TA, Igbokwe MC, David RA, Laoye A, Akinbola IA, et al. Experience with arteriovenous fistula creation for maintenance hemodialysis in a tertiary Hospital in South-Western Nigeria. Saudi J Kidney Dis Transpl. 2018;29(4):924–9. https://doi.org/10.4103/1319-2442.239628.CrossRefPubMed

Pataniappan S, Subbiah V, Gopalan VR, Kumar PV, Vinothan RJS. Observational study of the efficacy of supraclavicular brachial plexus block for arteriovenous fistula creation. Indian J Anaesth. 2018;62(8):616–20. https://doi.org/10.4103/ija.IJA_293_18.CrossRef

McGrogan DG, Stringer S, Cockwell P, Jesky M, Ferro C, Maxwell AP, et al. Arterial stiffness alone does not explain arteriovenous fistula outcomes. J Vasc Access. 2018;19(1):63–8. https://doi.org/10.5301/jva.5000791.CrossRefPubMed

Kocaaslan C, Kehlibar T, Yilmaz M, Mehmetoglu ME, Gunay R, Aldag M, et al. Outcomes of arteriovenous fistula for hemodialysis in octogenarian population. Vascular. 2018;26(5):509–14. https://doi.org/10.1177/1708538118762067.CrossRefPubMed

Mannava K, Money SR. Current management of peripheral arterial occlusive disease - a review of pharmacologic agents and other interventions. Am J Cardiovasc Drugs. 2007;7(1):59–66. https://doi.org/10.2165/00129784-200707010-00005.CrossRefPubMed

Ihara K, Ohashi A, Inoshita S. Risk of heparin-induced immediate-type hypersensitivity during arteriovenous fistula placement. Intern Med. 2018;57(16):2365–9. https://doi.org/10.2169/internalmedicine.9705-17.CrossRefPubMedPubMedCentral

Douglass A, Allen C, Presson A, Sarfati MR, Griffin CL, Smith BK, et al. Patient-reported outcomes in patients with end-stage renal disease: is quality of life affected when catheters are used for hemodialysis versus arteriovenous fistulas? J Vasc Surg. 2018;67(6):E200-E. https://doi.org/10.1016/j.jvs.2018.03.291.CrossRef

Diandra JC, Lo ZJ, Ang WW, Feng JF, Narayanan S, Tan GWL, et al. A review of arteriovenous fistulae creation in octogenarians. Ann Vasc Surg. 2018;46:331–6. https://doi.org/10.1016/j.avsg.2017.07.021.CrossRefPubMed

Tham WP, Burgmans MC, Tan BS, Tay KH, Irani FG, Gogna A, et al. Percutaneous endovascular treatment to salvage non-maturing arteriovenous fistulas in a multiethnic Asian population. Ann Acad Med Singap. 2017;46(2):64–71.PubMed

10.

Kim M, Kim JU, Kim SM, Kim H. Effectiveness of beraprost sodium in maintaining vascular access patency in patients on hemodialysis. Int Urol Nephrol. 2017;49(7):1287–95. https://doi.org/10.1007/s11255-017-1586-y.CrossRefPubMed

11.

Shehab N, Sperling LS, Kegler SR, Budnitz DS. National estimates of emergency department visits for hemorrhage-related adverse events from Clopidogrel plus aspirin and from warfarin. Arch Intern Med. 2010;170(21):1926–33. https://doi.org/10.1001/archinternmed.2010.407.CrossRefPubMed

12.

Kelly RP, Close SL, Farid NA, Winters KJ, Shen L, Natanegara F, et al. Pharmacokinetics and pharmacodynamics following maintenance doses of prasugrel and clopidogrel in Chinese carriers of CYP2C19 variants. Br J Clin Pharmacol. 2012;73(1):93–105. https://doi.org/10.1111/j.1365-2125.2011.04049.x.CrossRefPubMedPubMedCentral

13.

Ii M, Hoshiga M, Fukui R, Negoro N, Nakakoji T, Nishiguchi F, et al. Beraprost sodium regulates cell cycle in vascular smooth muscle cells through cAMP signaling by preventing down-regulation of p27(Kip1). Cardiovasc Res. 2001;52(3):500–8. https://doi.org/10.1016/s0008-6363(01)00411-4.CrossRefPubMed

14.

Cheng Q, Zhao YJ. The reasons for the failure of the primary arteriovenous fistula surgery in patients with end-stage renal disease (vol 16, pg S74, 2015). J Vasc Access. 2016;17(1):101. https://doi.org/10.5301/jva.2016.15410.CrossRef

15.

Patel ST, Hughes J, Mills JL. Failure of arteriovenous fistula maturation: an unintended consequence of exceeding Dialysis outcome quality initiative guidelines for hemodialysis access. J Vasc Surg. 2003;38(3):439–45. https://doi.org/10.1016/s0741-5214(03)00732-8.CrossRefPubMed

16.

Romaozinho C, Escada L, Macario F. Arteriovenous fistula: Survival impact on patients with end-stage renal disease initiating hemodialysis. Am J Kidney Dis. 2006;47(4):A52-A.CrossRef

17.

Raje N, Terpos E, Willenbacher W, Shimizu K, Garcia-Sanz R, Durie B, et al. Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study. Lancet Oncol. 2018;19(3):370–81. https://doi.org/10.1016/s1470-2045(18)30072-x.CrossRefPubMed

18.

Fischer MJ, Ho PM, McDermott K, Lowy E, Parikh CR. Chronic kidney disease is associated with adverse outcomes among elderly patients taking clopidogrel after hospitalization for acute coronary syndrome. BMC Nephrol. 2013;14. https://doi.org/10.1186/1471-2369-14-107.

19.

Tanner NC, Da Silva A. Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts. Cochrane Database Syst Rev. 2015;(7). https://doi.org/10.1002/14651858.CD002786.pub3.

20.

Fifi JT, Brockington C, Narang J, Leesch W, Ewing SL, Bennet H, et al. Clopidogrel resistance is associated with thromboembolic complications in patients undergoing neurovascular stenting. AJNR Am J Neuroradiol. 2013;34(4):716–20. https://doi.org/10.3174/ajnr.A3405.CrossRefPubMed

21.

Dember LM, Beck GJ, Allon M, Delmez JA, Dixon BS, Greenberg A, et al. Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis - a randomized controlled trial. JAMA. 2008;299(18):2164–71. https://doi.org/10.1001/jama.299.18.2164.CrossRefPubMedPubMedCentral

22.

Gersch MS. Clopidogrel decreases arteriovenous fistula thrombosis but does not improve fistula maturation. Nat Clin Pract Nephrol. 2008;4(9):476–7. https://doi.org/10.1038/ncpneph0908.CrossRefPubMed

23.

Chemla ES, Morsy M. A European perspective on the Dialysis access consortium (DAC) study regarding the effects of Clopidogrel on early failure of arteriovenous fistulas for hemodialysis. J Vasc Access. 2008;9(4):229–30.CrossRef

24.

Lee T, Ullah A, Allon M, Succop P, El-Khatib M, Munda R, et al. Decreased cumulative access survival in arteriovenous fistulas requiring interventions to promote maturation. Clin J Am Soc Nephrol. 2011;6(3):575–81. https://doi.org/10.2215/cjn.06630810.CrossRefPubMedPubMedCentral

25.

Arenas MD, Perez R, Rodriguez JA. Embolism as a cause of early thrombosis of arteriovenous fistula for hemodialysis. Nefrologia. 2017;37(5):556–7. https://doi.org/10.1016/j.nefro.2016.12.005.CrossRefPubMed

26.

Tong XY, Hou XY, Wason C, Kopel T, Cohen RA, Dember LM. Smooth muscle nitric oxide responsiveness and clinical maturation of hemodialysis arteriovenous fistulae. Am J Pathol. 2017;187(9):2095–101. https://doi.org/10.1016/j.ajpath.2017.05.006.CrossRefPubMedPubMedCentral

27.

Coleman CI, Tuttle LA, Teevan C, Baker WL, White CM, Reinhart KM. Antiplatelet agents for the prevention of arteriovenous fistula and graft thrombosis: a meta analysis. Int J Clin Pract. 2010;64(9):1239–44. https://doi.org/10.1111/j.1742-1241.2009.02329.x.CrossRefPubMed

28.

Moriya H, Ishioka K, Honda K, Oka M, Maesato K, Ikee R, et al. Beraprost sodium, an orally active prostaglandin I-2 analog, improves renal Anemia in hemodialysis patients with peripheral arterial disease. Ther Apher Dial. 2010;14(5):472–6. https://doi.org/10.1111/j.1744-9987.2010.00814.x.CrossRefPubMed

29.

Shimamura M, Miyakawa J, Doi M, Okada K, Kurumatani H, Mori Y, et al. The pharmacokinetics of Beraprost sodium following single Oral administration to subjects with impaired kidney function. J Clin Pharmacol. 2017;57(4):524–35. https://doi.org/10.1002/jcph.835.CrossRefPubMed

30.

Hochholzer W, Trenk D, Fromm MF, Valina CM, Stratz C, Bestehorn HP, et al. Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with Clopidogrel in patients undergoing elective coronary stent placement. J Am Coll Cardiol. 2010;55(22):2427–34. https://doi.org/10.1016/j.jacc.2010.02.031.CrossRefPubMed

31.

Floyd JS, Kaspera R, Marciante KD, Weiss NS, Heckbert SR, Lumley T, et al. A screening study of drug-drug interactions in Cerivastatin users: an adverse effect of Clopidogrel. Clin Pharmacol Ther. 2012;91(5):896–904. https://doi.org/10.1038/clpt.2011.295.CrossRefPubMed

32.

Bavare CS, Street TK, Peden EK, Davies MG, Naoum JJ. Stent grafts can convert unusable upper arm arteriovenous fistulas into a functioning hemodialysis access: a retrospective case series. Front Surg. 2017;4. https://doi.org/10.3389/fsurg.2017.00013.

33.

Yuo TH, Chaer RA, Dillavou ED, Leers SA, Makaroun MS. Patients started on hemodialysis with tunneled dialysis catheter have similar survival after arteriovenous fistula and arteriovenous graft creation. J Vasc Surg. 2015;62(6):1590. https://doi.org/10.1016/j.jvs.2015.07.076.CrossRefPubMedPubMedCentral

Title: Comparing the vascular thromboembolic events following arteriovenous fistula in Chinese population with end-stage renal diseases receiving Clopidogrel versus Beraprost sodium therapy: a retrospective cohort study
Authors: Yu Zhou
Ling Du
Bo Tu
Qiquan Lai
Xiaonan Du
Bo Xu
Fan Zhang
Mingdong Zhao
Ziming Wan
Jiajie Lai
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Nephrology / Issue 1/2018
Electronic ISSN: 1471-2369
DOI: https://doi.org/10.1186/s12882-018-1166-0

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Comparing the vascular thromboembolic events following arteriovenous fistula in Chinese population with end-stage renal diseases receiving Clopidogrel versus Beraprost sodium therapy: a retrospective cohort study

Abstract

Background

Methods

Results

Conclusion

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2018

Short-term dexamethasone treatment transiently, but not permanently, attenuates fibrosis after acute-to-chronic kidney injury

Emergence of an Israel faith-based community organization facilitating live donor kidney transplantation

The KDIGO acute kidney injury guidelines for cardiac surgery patients in critical care: a validation study

Transplant renal artery stenosis caused by the stretch of an artey branch: a case report and literature review

Severe renal Fanconi and management strategies in Arthrogryposis-Renal dysfunction-Cholestasis syndrome: a case report

Measurement of glomerular filtration rate in patients undergoing obesity surgery

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page