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BMC Nephrology
Published in: BMC Nephrology 1/2015

Open Access 01-12-2015 | Case report

A case of membranoproliferative glomerulonephritis associated withcurved fibril deposition

Authors: Ikuyo Narita, Michiko Shimada, Takeshi Fujita, Reiichi Murakami, Masayuki Nakamura, Norio Nakamura, Hideaki Yamabe, Ken Okumura

Published in: BMC Nephrology | Issue 1/2015

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Abstract

Background

It is sometimes challenging to diagnose unsusual cases of fibrillary glomerulonephritis (FGN) and immunotactoid glomerulopathy (ITG), the rare causes of nephrotic syndrome.

Case presentation

A 75-year-old Japanese woman presented with nephrotic syndrome, microhematuria and renal insufficiency. Renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) with IgM and weak C3 deposition. Congo red stain was negative. Electron microscopy demonstrated massive fibrils in the subendothelium, mesangium and subepithelium. The fibrils were partially parallel, partially curved and 17 nm in diameter. Cryoglobulin, hepatitis B virus (HBV) antigen, hepatitis C virus (HCV) antibody or antinuclear antibody were negative.

Conclusion

We report a case of MPGN associated with peculiar non-amyloid fibril deposition corresponding to neither FGN nor ITG.
Literature
1.
2.
Korbet SM, Schwartz MM, Lewis EJ. Immuotactoid glomerulopathy (fibrillary glomerulonephritis). Clin J Am Soc Nephrol. 2006;1(6):1351–6.CrossRefPubMed
3.
Ivanyi B, Degrell P. Fibrillary glomerulonephritis and immunotactoid glomerulopathy. Nephrol Dial Transplant. 2004;19(9):2166–70.CrossRefPubMed
4.
Alpers CE, Kowalewska J. Fibrillary glomerulonephritis and immunotactoid glomerulopathy. J Am Soc Nephrol. 2008;19(1):34–7.CrossRefPubMed
5.
Pronovost PH, Brady HR, ME G, Espinoza O, Rennke HG. Clinical features, predictors of disease progression and results of renal. Nephrol Dial Transplant. 1996;11:837–42.CrossRefPubMed
6.
Joh K, Aizawa S, Takahashi T, Hatakeyama M, Muto S, Asano Y, et al. Microlamellar structures in lobular glomerulonephritis associated with monoclonal IgG lambda paraproteinemia. A case report and review of the literature. Acta Pathol Jpn. 1990;40(12):913–21.PubMed
7.
Jain S, Chhabra D. A case of immunotactoid glomerulopathy with rapid progression to end-stage renal disease. TheScientificWorldJOURNAL. 2009;9:1348–54.CrossRefPubMed
8.
Hugh RB. Fibrillary glomerulopathy. Kidney Int. 1998;53(1998):1421–9.
9.
Rosenstock JL, Markowitz GS, Valeri AM, Sacchi G, Appel GB, D’Agati VD. Fibrillary and immunotactoid glomerulonephritis Distinct. Kidney Int. 2003;63(4):1450–61.CrossRefPubMed
10.
Dickenmann M, Schaub S, Nickeleit V, Mihatsch M, Steiger J, Brunner F. Fibrillary glomerulonephritis: early diagnosis associated with steroid responsiveness. Am J Kidney Dis. 2002;40(3):E9.CrossRefPubMed
11.
Kinomura M, Maeshima Y, Kodera R, Morinaga H, Saito D, Nakao K, et al. A case of immunotactoid glomerulopathy exhibiting nephrotic syndrome successfully treated with corticosteroids and antihypertensive therapy. Clin Exp Nephrol. 2009;13(4):378–84.CrossRefPubMed
Metadata
Title
A case of membranoproliferative glomerulonephritis associated withcurved fibril deposition
Authors
Ikuyo Narita
Michiko Shimada
Takeshi Fujita
Reiichi Murakami
Masayuki Nakamura
Norio Nakamura
Hideaki Yamabe
Ken Okumura
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2015
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-015-0147-9

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