Skip to main content
Top
Published in: BMC Nephrology 1/2015

Open Access 01-12-2015 | Case report

Streptococcus uberis and Staphylococcus aureus forefoot and blood stream co-infection in a haemodialysis patient: a case report

Authors: Christine Valentiny, Harald Dirschmid, Karl Lhotta

Published in: BMC Nephrology | Issue 1/2015

Login to get access

Abstract

Background

Streptococcus uberis, the most frequent cause of mastitis in lactating cows, is considered non-pathogenic for humans. Only a few case reports have described human infections with this microorganism, which is notoriously difficult to identify.

Case presentation

We report the case of a 75-year-old male haemodialysis patient, who developed a severe foot infection with osteomyelitis and bacteraemia. Both Streptococcus uberis and Staphylococcus aureus were identified in wound secretion and blood samples using mass spectrometry. The presence of Streptococcus uberis was confirmed by superoxide dismutase A sequencing. The patient recovered after amputation of the forefoot and antibiotic treatment with ampicillin/sulbactam. He had probably acquired the infection while walking barefoot on cattle pasture land.

Conclusion

This is the first case report of a human infection with Streptococcus uberis with identification of the microorganism using modern molecular technology. We propose that Staphylococcus aureus co-infection was a prerequisite for deep wound and bloodstream infection with Streptococcus uberis.
Literature
1.
go back to reference Leigh JA. Streptococcus uberis: a permanent barrier to the control of bovine mastitis? Vet J. 1999;157(3):225–38.CrossRefPubMed Leigh JA. Streptococcus uberis: a permanent barrier to the control of bovine mastitis? Vet J. 1999;157(3):225–38.CrossRefPubMed
2.
go back to reference Overesch G, Stephan R, Perreten V. Antimicrobial susceptibility of gram-positive udder pathogens from bovine mastitis milk in Switzerland. Schweiz Arch Tierheilkd. 2013;155(6):339–50.CrossRefPubMed Overesch G, Stephan R, Perreten V. Antimicrobial susceptibility of gram-positive udder pathogens from bovine mastitis milk in Switzerland. Schweiz Arch Tierheilkd. 2013;155(6):339–50.CrossRefPubMed
3.
go back to reference Zadoks RN, Tikofsky LL, Boor KJ. Ribotyping of Streptococcus uberis from a dairy's environment, bovine feces and milk. Vet Microbiol. 2005;109(3–4):257–65.CrossRefPubMed Zadoks RN, Tikofsky LL, Boor KJ. Ribotyping of Streptococcus uberis from a dairy's environment, bovine feces and milk. Vet Microbiol. 2005;109(3–4):257–65.CrossRefPubMed
4.
go back to reference Zhang Y, Gladysheva IP, Houng AK, Reed GL. Streptococcus uberis plasminogen activator (SUPA) activates human plasminogen through novel species-specific and fibrin-targeted mechanisms. J Biol Chem. 2012;287(23):19171–6.CrossRefPubMedPubMedCentral Zhang Y, Gladysheva IP, Houng AK, Reed GL. Streptococcus uberis plasminogen activator (SUPA) activates human plasminogen through novel species-specific and fibrin-targeted mechanisms. J Biol Chem. 2012;287(23):19171–6.CrossRefPubMedPubMedCentral
5.
go back to reference Gülen DKA, Aydin M, Tanriverdi Y. Urinary tract infections caused by streptococcus uberis: apathogen of bovine mastitis-report of seven cases. Afr J Microbiol Res. 2013;7(30):3908–12. Gülen DKA, Aydin M, Tanriverdi Y. Urinary tract infections caused by streptococcus uberis: apathogen of bovine mastitis-report of seven cases. Afr J Microbiol Res. 2013;7(30):3908–12.
6.
go back to reference Lazinska B, Ciszek M, Rokosz A, Sawicka-Grzelak A, Paczek L, Luczak M. Bacteriological urinalysis in patients after renal transplantation. Pol J Microbiol. 2005;54(4):317–21.PubMed Lazinska B, Ciszek M, Rokosz A, Sawicka-Grzelak A, Paczek L, Luczak M. Bacteriological urinalysis in patients after renal transplantation. Pol J Microbiol. 2005;54(4):317–21.PubMed
7.
go back to reference Sarkar TK, Murarka RS, Gilardi GL. Primary Streptococcus viridans pneumonia. Chest. 1989;96(4):831–4.CrossRefPubMed Sarkar TK, Murarka RS, Gilardi GL. Primary Streptococcus viridans pneumonia. Chest. 1989;96(4):831–4.CrossRefPubMed
8.
go back to reference Murdoch DRSL, MacFarlane MR. Human wound infection with streptococcus uberis. Clinical Microbiology Newsletter. 1997;19(22):174. 175.CrossRef Murdoch DRSL, MacFarlane MR. Human wound infection with streptococcus uberis. Clinical Microbiology Newsletter. 1997;19(22):174. 175.CrossRef
9.
go back to reference Kessel S, Wittenberg CE. Joint infection in a young patient caused by Streptococcus uberis, a pathogen of bovine mastitis—a case report. Z Orthop Unfall. 2008;146(4):507–9.PubMed Kessel S, Wittenberg CE. Joint infection in a young patient caused by Streptococcus uberis, a pathogen of bovine mastitis—a case report. Z Orthop Unfall. 2008;146(4):507–9.PubMed
10.
go back to reference Bouskraoui M, Benbachir M, Abid A. Streptococcus uberis endocarditis in an infant with atrioventricular defect. Arch Pediatr. 1999;6(4):481.CrossRefPubMed Bouskraoui M, Benbachir M, Abid A. Streptococcus uberis endocarditis in an infant with atrioventricular defect. Arch Pediatr. 1999;6(4):481.CrossRefPubMed
11.
go back to reference Velez-Montoya R, Rascon-Vargas D, Mieler WF, Fromow-Guerra J, Morales-Canton V. Intravitreal ampicillin sodium for antibiotic-resistant endophthalmitis: streptococcus uberis first human intraocular infection report. J Ophthalmol. 2010. doi:10.1155/2010/169739. Velez-Montoya R, Rascon-Vargas D, Mieler WF, Fromow-Guerra J, Morales-Canton V. Intravitreal ampicillin sodium for antibiotic-resistant endophthalmitis: streptococcus uberis first human intraocular infection report. J Ophthalmol. 2010. doi:10.1155/2010/169739.
12.
go back to reference Sanchez J, Moreno JJ, Roldan A, Ildefonso JA, Florensa J. Hepatic abscess caused by Streptococcus uberis. Enferm Infecc Microbiol Clin. 1991;9(3):189–90.PubMed Sanchez J, Moreno JJ, Roldan A, Ildefonso JA, Florensa J. Hepatic abscess caused by Streptococcus uberis. Enferm Infecc Microbiol Clin. 1991;9(3):189–90.PubMed
13.
go back to reference Raemy A, Meylan M, Casati S, Gaia V, Berchtold B, Boss R, et al. Phenotypic and genotypic identification of streptococci and related bacteria isolated from bovine intramammary infections. Acta Vet Scand. 2013;55:53.CrossRefPubMedPubMedCentral Raemy A, Meylan M, Casati S, Gaia V, Berchtold B, Boss R, et al. Phenotypic and genotypic identification of streptococci and related bacteria isolated from bovine intramammary infections. Acta Vet Scand. 2013;55:53.CrossRefPubMedPubMedCentral
14.
go back to reference Alber J, El-Sayed A, Lammler C, Hassan AA, Zschock M. Polymerase chain reaction mediated identification of Streptococcus uberis and Streptococcus parauberis using species-specific sequences of the genes encoding superoxide dismutase A and chaperonin 60*. J Vet Med B Infect Dis Vet Public Health. 2004;51(4):180–4.CrossRefPubMed Alber J, El-Sayed A, Lammler C, Hassan AA, Zschock M. Polymerase chain reaction mediated identification of Streptococcus uberis and Streptococcus parauberis using species-specific sequences of the genes encoding superoxide dismutase A and chaperonin 60*. J Vet Med B Infect Dis Vet Public Health. 2004;51(4):180–4.CrossRefPubMed
17.
go back to reference Fortin M, Messier S, Pare J, Higgins R. Identification of catalase-negative, non-beta-hemolytic, gram-positive cocci isolated from milk samples. J Clin Microbiol. 2003;41(1):106–9.CrossRefPubMedPubMedCentral Fortin M, Messier S, Pare J, Higgins R. Identification of catalase-negative, non-beta-hemolytic, gram-positive cocci isolated from milk samples. J Clin Microbiol. 2003;41(1):106–9.CrossRefPubMedPubMedCentral
18.
go back to reference Toma L, Di Domenico EG, Prignano G, Ensoli F. Comment on “Intravitreal ampicillin sodium for antibiotic-resistant endophthalmitis: streptococcus uberis first human intraocular infection report”. J Ophthalmol. 2014. doi:10.1155/2014/395480. Toma L, Di Domenico EG, Prignano G, Ensoli F. Comment on “Intravitreal ampicillin sodium for antibiotic-resistant endophthalmitis: streptococcus uberis first human intraocular infection report”. J Ophthalmol. 2014. doi:10.1155/2014/395480.
19.
go back to reference Huang WT, Chang LY, Hsueh PR, Lu CY, Shao PL, Huang FY, et al. Clinical features and complications of viridans streptococci bloodstream infection in pediatric hemato-oncology patients. J Microbiol Immunol Infect. 2007;40(4):349–54.PubMed Huang WT, Chang LY, Hsueh PR, Lu CY, Shao PL, Huang FY, et al. Clinical features and complications of viridans streptococci bloodstream infection in pediatric hemato-oncology patients. J Microbiol Immunol Infect. 2007;40(4):349–54.PubMed
Metadata
Title
Streptococcus uberis and Staphylococcus aureus forefoot and blood stream co-infection in a haemodialysis patient: a case report
Authors
Christine Valentiny
Harald Dirschmid
Karl Lhotta
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2015
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-015-0069-6

Other articles of this Issue 1/2015

BMC Nephrology 1/2015 Go to the issue