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Open Access 01-12-2018 | Research article

Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study

Authors: Peipei Yu, Jie Jiao, Guoshun Chen, Wenhui Zhou, Huanling Zhang, Hui Wu, Yanhong Li, Guizhen Gu, Yuxin Zheng, Yue Yu, Shanfa Yu

Published in: BMC Medical Genetics | Issue 1/2018

Abstract

Background

Noise-induced hearing loss (NIHL) is a complex, irreversible disease caused by the interaction of genetic and environmental factors. In recent years, a great many studies have been done to explore the NIHL susceptibility genes among humans. So far, high powerful detections have been founded that genes of potassium ion channel genes (KCNQ4 and KCNE1), catalase (CAT), protocadherin 15 (PCDH15), myosin 14 (MYH14) and heart shock protein (HSP70) which have been identified in more than one population may be associated with the susceptibility to NIHL. As for metabolic glutamate receptor7 gene (GRM7), a lot of researches mainly focus on age-related hearing loss (ARHL) and the results have shown that the polymorphisms of GRM7 are linked to the development of ARHL. However, little is known about the association of GRM7 and the susceptibility to NIHL. Therefore, the aim of this study was to explore the effect of GRM7 polymorphisms on the susceptibility to NIHL.

Methods

A nested case-control study based on the cohort in a Chinese steel factory was implemented in 292 cases and 584 controls matched with the same sex, the age difference ≤ 5 years old, the same type of work, duration of occupational noise exposure ≤2 years. Five single nucleotide polymorphisms (SNPs) of GRM7 were gained through selecting and genotyping SNPs. Conditional logistic regression analysis was used to assess the main effect of GRM7 polymorphisms on the susceptibility to NIHL and the gene-by-environment interaction. Furthermore, the gene-by-gene interactions were analyzed by generalized multiple dimensionality reduction (GMDR).

Results

This research discovered for the first time that the mutant allele C in rs1485175 of the GMR7 may decrease individuals’ susceptibility to NIHL. The interaction between rs1485175 and cumulative noise exposure (CNE) at high level was found after the stratification according to CNE (p/p_bon = 0.014/0.007, OR = 0.550, 95% CI: 0.340–0.891). Permutation test of GMDR suggested that rs1920109, rs1485175 and rs9826579 in GRM7 might interact with each other in the process of developing NIHL (p = 0.037).

Conclusions

The results suggest that the mutant allele C of rs1485175 in GRM7 may reduce the susceptibility to NIHL in Chinese Han population.

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Basner M, Babisch W, Davis A, Brink M, Clark C, Janssen S, Stansfeld S. Auditory and non-auditory effects of noise on health. Lancet. 2014;383(9925):1325–32.CrossRefPubMed

Corvalan. aPUJLSTC: Chapter 21 Selected occupational risk factors. comparative quantification of Health risks. global and regional Burden of disease attributable to selected major risk factors. 2004, Vol 2(1651–1802.

WHO: Protecting workers' health. 2014. [http://www.who.int/mediacentre/factsheets/fs389/en/]. Accessed 25 June 2017.

Leigh JP. Hearing impairment among noise-exposed workers - United States, 2003-2012. Milbank Q. 2011;89(4):728–72.CrossRefPubMedPubMedCentral

NIOSH: NIOSE AND HEARING LOSS PREVENTION. [https://www.cdc.gov/niosh/topics/noise/prevention.html]. 2016. Assessed 26/06/2017.

SF Y, Chen G, Jiao J, GZ G, Zhang HL, Wang XM, Zhou WH, Wu H, Li YH, Zheng YX. A cohort study on occupational noise induced hearing loss in workers at an iron and steel plant. Chinese Journal of Preventive Medicine. 2017;51(1):13–9.

Konings A, Van Laer L, Van Camp G. Genetic studies on noise-induced hearing loss: a review. Ear Hear. 2009;30(2):151–9.CrossRefPubMed

Delmaghani S, Defourny J, Aghaie A, Beurg M, Dulon D, Thelen N, Perfettini I, Zelles T, Aller M, Meyer A, et al. Hypervulnerability to sound exposure through impaired adaptive proliferation of peroxisomes. Cell. 2015;163(4):894–906.CrossRefPubMed

Kozel PJ, Davis RR, Krieg EF, Shull GE, Erway LC. Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice. Hear Res. 2002;164(1–2):231–9.CrossRefPubMed

10.

Housley GD, Morton-Jones R, Vlajkovic SM, Telang RS, Paramananthasivam V, Tadros SF, Wong AC, Froud KE, Cederholm JM, Sivakumaran Y, et al. ATP-gated ion channels mediate adaptation to elevated sound levels. Proc Natl Acad Sci U S A. 2013;110(18):7494–9.CrossRefPubMedPubMedCentral

11.

Holme RH, Steel KP. Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation. J Assoc Res Otolaryngol. 2004;5(1):66–79.CrossRefPubMed

12.

Ohlemiller KK, McFadden SL, Ding DL, Flood DG, Reaume AG, Hoffman EK, Scott RW, Wright JS, Putcha GV, Salvi RJ. Targeted deletion of the cytosolic cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss. Audiol Neurootol. 1999;4(5):237–46.CrossRefPubMed

13.

Ohlemiller KK, McFadden SL, Ding D-L, Lear PM, Ho Y-S. Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. J Assoc Res Otolaryngol. 2000;1(3):243–54.CrossRefPubMedPubMedCentral

14.

Van Laer L, Carlsson PI, Ottschytsch N, Bondeson ML, Konings A, Vandevelde A, Dieltjens N, Fransen E, Snyders D, Borg E, et al. The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss. Hum Mutat. 2006;27(8):786–95.CrossRefPubMed

15.

Pawelczyk M, Van Laer L, Fransen E, Rajkowska E, Konings A, Carlsson PI, Borg E, Van Camp G, Sliwinska-Kowalska M. Analysis of gene polymorphisms associated with K ion circulation in the inner ear of patients susceptible and resistant to noise-induced hearing loss. Ann Hum Genet. 2009;73(Pt 4):411–21.CrossRefPubMed

16.

Konings A, Van Laer L, Wiktorek-Smagur A, Rajkowska E, Pawelczyk M, Carlsson PI, Bondeson ML, Dudarewicz A, Vandevelde A, Fransen E, et al. Candidate gene association study for noise-induced hearing loss in two independent noise-exposed populations. Ann Hum Genet. 2009;73(2):215–24.CrossRefPubMed

17.

Yang M, Tan H, Yang Q, Wang F, Yao H, Wei Q, Tanguay RM, Wu T. Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. Cell Stress Chaperones. 2006;11(3):233–9.CrossRefPubMedPubMedCentral

18.

Li YH, Yu SF, Gu GZ, Chen GS, Zheng YX, Jiao J, Zhou WH, Wu H, Zhang ZR, Zhang HL, et al. Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: a case-control study. PLoS One. 2017;12(2):e0171722.CrossRefPubMedPubMedCentral

19.

Yang QY, XR X, Jiao J, Zheng YX, He LH, SF Y, GZ G, Chen GS, Zhou WH, Wu H, et al. Genetic variation in EYA4 on the risk of noise-induced hearing loss in Chinese steelworks firm sample. Occup Environ Med. 2016;73(12):823–8.PubMed

20.

XR X, Yang QY, Jiao J, He LH, SF Y, JingWang J, GZ G, Chen GS, Zhou WH, Wu H, et al. Genetic variation in POU4F3 and GRHL2 associated with noise-induced hearing loss in Chinese population: a case-control study. Int J Environ Res Public Health. 2016;13(561):14.

21.

Friedman RA, Laer LV, Huentelman MJ, Sheth SS, Eyken EV, Corneveaux JJ, Tembe WD, Halperin RF, Thorburn AQ, Thys S, et al. GRM7 variants confer susceptibility to age-related hearing impairment. Hum Mol Genet. 2009;18(4):785–96.CrossRefPubMed

22.

Newman DL, Fisher LM, Ohmen J, Parody R, Fong CT, Frisina ST, Mapes F, Eddins DA, Robert Frisina D, Frisina RD, Friedman RA. GRM7 variants associated with age-related hearing loss based on auditory perception. Hear Res. 2012;294(1–2):125–32.CrossRefPubMedPubMedCentral

23.

Van Laer L, Huyghe JR, Hannula S, Van Eyken E, Stephan DA, Maki-Torkko E, Aikio P, Fransen E, Lysholm-Bernacchi A, Sorri M, et al. A genome-wide association study for age-related hearing impairment in the Saami. Eur J Hum Genet. 2010;18(6):685–93.CrossRefPubMedPubMedCentral

24.

Puel JL. Chemical synaptic transmission in the cochlea. Prog Neurobiol. 1995;47(6):449–76.CrossRefPubMed

25.

Hakuba N, Koga K, Gyo K, Usami SI, Tanaka K. Exacerbation of noise-induced hearing loss in mice lacking the glutamate transporter GLAST. J Neurosci. 2000;20(23):8750–3.PubMed

26.

Pujol R, J-L Puel, D'aldin CG, Eyblin M. Pathophysiology of the glutamatergic synapses in the cochlea. Acta Otolaryngol. 2009;113(3):330–4.

27.

Steinbach S, Lutz J. Glutamate induces apoptosis in cultured spiral ganglion explants. Biochem Biophys Res Commun. 2007;357(1):14–9.CrossRefPubMed

28.

Eybalin M, Norenberg MD, Renard N. Glutamine synthetase and glutamate metabolism in the guinea pig cochlea. Hear Res. 1996;101(1–2):93–101.CrossRefPubMed

29.

Henderson D, Bielefeld EC, Harris KC, BH H. The role of oxidative stress in noise-induced hearing loss. Ear Hear. 2006;27(1):1–19.CrossRefPubMed

30.

Luo HJ, Yang T, Jin XJ, Pang XH, Li JP, Chai YC, Li L, Zhang Y, Zhang LP, Zhang ZH, et al. Association of GRM7 variants with different phenotype patterns of age-related hearing impairment in an elderly male Han Chinese population. PLoS One. 2013;8(10):e77153.CrossRefPubMedPubMedCentral

31.

Williams CJ, Dexter DT. Neuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative disease. J Neurochem. 2014;129(1):4–20.CrossRefPubMed

32.

Burr H, Lund SP, Bügel Sperling B, Kristensen TS, Poulsen OM. Smoking and height as risk factors for prevalence and 5-year incidence of hearing loss. A questionnaire-based follow-up study of employees in Denmark aged 18–59 years exposed and unexposed to noise. Int J Audiol. 2009;44(9):531–9.CrossRef

33.

Tao L, Davis R, Heyer N, Yang Q, Qiu W, Zhu L, Li N, Zhang H, Zeng L, Zhao Y. Effect of cigarette smoking on noise-induced hearing loss in workers exposed to occupational noise in China. Noise Health. 2013;15(62):67–72.CrossRefPubMed

34.

Upile T, Sipaul F, Jerjes W, Singh S, Nouraei SA, El Maaytah M, Andrews P, Graham J, Hopper C, Wright A: The acute effects of alcohol on auditory thresholds. BMC Ear Nose Throat Disord 2007, 7(4.

35.

Przewozny T, Gojska-Grymajlo A, Kwarciany M, Gasecki D, Narkiewicz K. Hypertension and cochlear hearing loss. Blood Press. 2015;24(4):199–205.CrossRefPubMed

36.

Hammer MS, Swinburn TK, Neitzel RL. Environmental noise pollution in the United States: developing an effective public health response. Environ Health Perspect. 2014;122(2):115–9.PubMed

37.

Lie A, Skogstad M, AH, Johannessen, Tynes T, Mehlum IS, Nordby K-C, Engdahl B, Tambs K: Occupational noise exposure and hearing: a systematic review. Int Arch Occup Environ Health 201689):351–372.

Title: Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study
Authors: Peipei Yu
Jie Jiao
Guoshun Chen
Wenhui Zhou
Huanling Zhang
Hui Wu
Yanhong Li
Guizhen Gu
Yuxin Zheng
Yue Yu
Shanfa Yu
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Medical Genetics / Issue 1/2018
Electronic ISSN: 1471-2350
DOI: https://doi.org/10.1186/s12881-017-0515-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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