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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2021

01-12-2021 | Coxsackievirus | Research article

Intestinal microbiota has important effect on severity of hand foot and mouth disease in children

Authors: Chenguang Shen, Yi Xu, Jingkai Ji, Jinli Wei, Yujin Jiang, Yang Yang, Minghui Yang, Huaxin Huang, Rongrong Zou, Chunxiao Fang, Fansen Zeng, Fengxia Yang, Xinfa Wang, Jing Yuan, Jianmin Li, Xianfeng Wang, Huanming Yang, Sitang Gong, Hui Wang, Huimin Xia, Jinmin Ma, Yingxia Liu

Published in: BMC Infectious Diseases | Issue 1/2021

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Abstract

Background

The incidence of hand foot and mouth disease (HFMD) has increased in recent years, making it a very common childhood illness worldwide. The relationship between different enterovirus genotypes and disease severity is not clearly understood. Given that enteroviruses are transmitted through the gastrointestinal tract, we hypothesized that variation in intestinal microorganisms of the host might play a role in the prognosis of HFMD.

Methods

We carried out a meta-transcriptomic-wide association study of fecal samples obtained from a cohort of children (254 patients, 227 tested positive for enterovirus, including 16 patients co-infectied with 2 kinds of enterovirus) with mild and severe HFMD and healthy controls.

Results

We found there was no significant difference in the amount of each virus type between the mild and severe cases. Genes of enterovirus 71 (EV71) and coxsackievirus A (CV-A) from the severe and mild cases did not show significant clustering. Clostridium sp. L2-50 and Bacteroides stercoris ATCC 43183 were enriched in the guts of children with severe HFMD and KEGG enrichment was found between mild and severe cases.

Conclusions

Intestinal microorganisms appear to interact with enterovirus to determine the progression of HFMD. Genes of Bacteroides and Clostridium may be used as predictive markers for a more efficient prognosis and intervention. The enrichment of intestinal bacteria genes with functions may facilitate the development of severe symptoms for HFMD patients.
Appendix
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Metadata
Title
Intestinal microbiota has important effect on severity of hand foot and mouth disease in children
Authors
Chenguang Shen
Yi Xu
Jingkai Ji
Jinli Wei
Yujin Jiang
Yang Yang
Minghui Yang
Huaxin Huang
Rongrong Zou
Chunxiao Fang
Fansen Zeng
Fengxia Yang
Xinfa Wang
Jing Yuan
Jianmin Li
Xianfeng Wang
Huanming Yang
Sitang Gong
Hui Wang
Huimin Xia
Jinmin Ma
Yingxia Liu
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2021
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-021-06748-7

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