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Open Access 01-12-2021 | SARS-CoV-2 | Research

Symptomatic SARS-COV-2 reinfection: healthcare workers and immunosuppressed individuals at high risk

Authors: Efrén Murillo-Zamora, Xóchitl Trujillo, Miguel Huerta, Mónica Ríos-Silva, Felipe Aguilar-Sollano, Oliver Mendoza-Cano

Published in: BMC Infectious Diseases | Issue 1/2021

Abstract

Background

Knowledge regarding factors predicting the SARS-COV-2 reinfection risk is scarce and it has major implications in public health policies. We aimed to identify factors associated with the risk of symptomatic SARS-COV-2 reinfection.

Methods

We conducted a nationwide retrospective cohort study and 99,993 confirmed cases of COVID-19 were analyzed.

Results

The overall risk of reinfection (28 or more elapsed days between both episodes onset) was 0.21% (incidence density, 2.5 reinfections per 100,000 person-days) and older subjects and those with the mild primary disease were at reduced risk of the event. Healthcare workers and immunosuppressed or renal patients had at greater risk of SARS-COV-2 reinfection.

Conclusions

If replicated in other populations, these results may be useful to prioritize efforts focusing on the reduction of SARS-COV-2 spread and the related burden.

Tomassini S, Kotecha D, Bird PW, Folwell A, Biju S, Tang JW. Setting the criteria for SARS-CoV-2 reinfection - six possible cases. J Infect. 2021;82(2):282–327. https://doi.org/10.1016/j.jinf.2020.08.011.CrossRefPubMed

Kellam P, Barclay W. The dynamics of humoral immune responses following SARS-CoV-2 infection and the potential for reinfection. J Gen Virol. 2020;101(8):791–7. https://doi.org/10.1099/jgv.0.001439.CrossRefPubMedPubMedCentral

Government of Mexico. COVID-19 in Mexico: General data. Available at: https://coronavirus.gob.mx/datos/. Accessed 10 Apr 2021. [Webpage in Spanish]

Murillo-Zamora E, Trujillo X, Huerta M, Ríos-Silva M, Mendoza-Cano O. Male gender and kidney illness are associated with an increased risk of severe laboratory-confirmed coronavirus disease. BMC Infect Dis. 2020;20(1):674. https://doi.org/10.1186/s12879-020-05408-6.CrossRefPubMedPubMedCentral

Anand SP, Prévost J, Nayrac M, Beaudoin-Bussières G, Benlarbi M, Gasser R, et al. Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset. Cell Rep Med. 2021;2(6): 100290. https://doi.org/10.1016/j.xcrm.2021.100290.CrossRefPubMedPubMedCentral

Hall VJ, Foulkes S, Charlett A, Atti A, Monk EJM, Simmons R, et al. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN). Lancet. 2021;397(10283):1459–69. https://doi.org/10.1016/S0140-6736(21)00675-9.CrossRefPubMedPubMedCentral

Bielicki JA, Duval X, Gobat N, Goossens H, Koopmans M, Tacconelli E, et al. Monitoring approaches for health-care workers during the COVID-19 pandemic. Lancet Infect Dis. 2020;20(10):e261–7. https://doi.org/10.1016/S1473-3099(20)30458-8.CrossRefPubMedPubMedCentral

Veronica F, Anne R, Christopher B, Kenneth C, Jon R. Incidence of COVID-19 recurrence among large cohort of healthcare employees. Ann Epidemiol. 2021;60:8–14. https://doi.org/10.1016/j.annepidem.2021.04.005.CrossRefPubMedPubMedCentral

Ko JH, Joo EJ, Park SJ, Baek JY, Kim WD, Jee J, et al. Neutralizing antibody production in asymptomatic and mild COVID-19 patients, in comparison with pneumonic COVID-19 patients. J Clin Med. 2020;9(7):2268. https://doi.org/10.3390/jcm9072268.CrossRefPubMedCentral

10.

Thng ZX, De Smet MD, Lee CS, Gupta V, Smith JR, McCluskey PJ, et al. COVID-19 and immunosuppression: a review of current clinical experiences and implications for ophthalmology patients taking immunosuppressive drugs. Br J Ophthalmol. 2021;105(3):306–10. https://doi.org/10.1136/bjophthalmol-2020-316586.CrossRefPubMed

Title: Symptomatic SARS-COV-2 reinfection: healthcare workers and immunosuppressed individuals at high risk
Authors: Efrén Murillo-Zamora
Xóchitl Trujillo
Miguel Huerta
Mónica Ríos-Silva
Felipe Aguilar-Sollano
Oliver Mendoza-Cano
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: SARS-CoV-2
COVID-19
Published in: BMC Infectious Diseases / Issue 1/2021
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-021-06643-1

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Symptomatic SARS-COV-2 reinfection: healthcare workers and immunosuppressed individuals at high risk

Abstract

Background

Methods

Results

Conclusions

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