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Open Access 01-12-2021 | Severe Acute Respiratory Syndrome Coronavirus | Review

Modes of transmission of SARS-CoV-2 and evidence for preventive behavioral interventions

Authors: Lucas Zhou, Samuel K. Ayeh, Vignesh Chidambaram, Petros C. Karakousis

Published in: BMC Infectious Diseases | Issue 1/2021

Abstract

COVID-19 is a novel disease caused by SARS-CoV-2. During the global vaccination rollout, it is vital to thoroughly understand the modes of transmission of the virus in order to prevent further spread of variants and ultimately to end the pandemic. The current literature suggests that SARS-CoV-2 is transmitted among the human population primarily through respiratory droplets and, to a lesser extent, via aerosols. Transmission appears to be affected by temperature, humidity, precipitation, air currents, pH, and radiation in the ambient environment. Finally, the use of masks or facial coverings, social distancing, and hand washing are effective public health strategies in reducing the risk of exposure and transmission. Additional research is needed to further characterize the relative benefits of specific nonpharmaceutical interventions.

Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak- A n update on the status. Military Medical Research. 2020;7. https://doi.org/10.1186/s40779-020-00240-0.

Duan S-M, Zhao X-S, Wen R-F, Huang J-J, Pi G-H, Zhang S-X, et al. Stability of SARS coronavirus in human specimens and environment and its sensitivity to heating and UV irradiation. Biomed Environ Sci. 2003;16(3):246–55.PubMed

Chidambaram V, Tun NL, Haque WZ, Majella MG, Sivakumar RK, Kumar A, et al. Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis. Bhatt GC, editor. PLoS One. 2020;15(11):e0241541.

Coronavirus (COVID-19) - Google News [Internet]. [cited 2020 Oct 25]. Available from: https://news.google.com/covid19/map?hl=en-US&mid=%2Fm%2F02j71&gl=US&ceid=US%3Aen

Seto WH, Tsang D, Yung RWH, Ching TY, Ng TK, Ho M, et al. Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS). Lancet. 2003;361(9368):1519–20. https://doi.org/10.1016/S0140-6736(03)13168-6.CrossRefPubMedPubMedCentral

Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. N Engl J Med. 2020;382(13):1199–207. https://doi.org/10.1056/NEJMoa2001316.CrossRefPubMedPubMedCentral

Asadi S, Wexler AS, Cappa CD, Barreda S, Bouvier NM, Ristenpart WD. Aerosol emission and superemission during human speech increase with voice loudness. Sci Rep. 2019;9(1):1–10.

Guo Z-D, Wang Z-Y, Zhang S-F, Li X, Li L, Li C, et al. Aerosol and surface distribution of severe acute respiratory syndrome coronavirus 2 in hospital wards, Wuhan, China, 2020. Emerg Infect Dis. 2020;26(7):1586–91.CrossRefPubMedCentral

Fernstrom A, Goldblatt M. Aerobiology and its role in the transmission of infectious diseases. J Pathogens. 2013;2013:1–13. https://doi.org/10.1155/2013/493960.CrossRef

10.

Van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. New England J Med Massachussetts Medical Society. 2020;382:1564–7.

11.

Rubens JH, Karakousis PC, Jain SK, Schwartz KL, Kim J, Garber G, et al. Stability and viability of SARS-CoV-2. N Engl J Med. 2020;382(20):1962–6. https://doi.org/10.1056/NEJMc2007942.CrossRefPubMedPubMedCentral

12.

Shen Y, Li C, Dong H, Wang Z, Martinez L, Sun Z, et al. Community outbreak investigation of SARS-CoV-2 transmission among bus riders in eastern China. JAMA Intern Med. 2020;180(12):1665–71. https://doi.org/10.1001/jamainternmed.2020.5225.CrossRefPubMedPubMedCentral

13.

How to Protect Yourself & Others | CDC [Internet]. [cited 2020 Oct 9]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html

14.

Miller SL, Nazaroff WW, Jimenez JL, Boerstra A, Buonanno G, Dancer SJ, et al. Transmission of SARS-CoV-2 by inhalation of respiratory aerosol in the Skagit Valley Chorale superspreading event. Indoor Air. 2020:ina.12751.

15.

Azimi P, Keshavarz Z, Guillermo J, Laurent C, Stephens BR, Allen JG. Mechanistic Transmission Modeling of COVID-19 on the Diamond Princess Cruise Ship Demonstrates the Importance of Aerosol Transmission. medRxiv. 2020;2020:07.13.20153049.

16.

Xu P, Qian H, Miao T, Yen H, Tan H, Cowling B, et al. Transmission routes of Covid-19 virus in the Diamond Princess Cruise ship. medRxiv. 2020;2020:04.09.20059113.

17.

Lu J, Gu J, Li K, Xu C, Su W, Lai Z, et al. COVID-19 outbreak associated with Air conditioning in restaurant, Guangzhou, China, 2020. Emerg Infect Dis. 2020;26(7):1628–31. https://doi.org/10.3201/eid2607.200764.CrossRefPubMedPubMedCentral

18.

Santarpia JL, Rivera DN, Herrera VL, Morwitzer MJ, Creager HM, Santarpia GW, et al. Aerosol and surface contamination of SARS-CoV-2 observed in quarantine and isolation care. Sci Rep. 2020;10(1):12732. https://doi.org/10.1038/s41598-020-69286-3.CrossRefPubMedPubMedCentral

19.

Dowell SF, Simmerman JM, Erdman DD, Wu JSJ, Chaovavanich A, Javadi M, et al. Severe acute respiratory syndrome coronavirus on hospital surfaces. Clin Infect Dis. 2004;39(5):652–7. https://doi.org/10.1086/422652.CrossRefPubMed

20.

Ong SWX, Tan YK, Chia PY, Lee TH, Ng OT, Wong MSY, et al. Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from a Symptomatic Patient. JAMA. 2020;323(16):1610–2. https://doi.org/10.1001/jama.2020.3227.CrossRefPubMedPubMedCentral

21.

Liu Y, Ning Z, Chen Y, Guo M, Liu Y, Gali NK, et al. Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature (London). 2020;582(7813):557–60. https://doi.org/10.1038/s41586-020-2271-3.CrossRef

22.

Goldman E. Exaggerated risk of transmission of COVID-19 by fomites. Lancet Infect Dis Lancet Publishing Group. 2020;20:892–3.

23.

Mondelli MU, Colaneri M, Seminari EM, Baldanti F, Bruno R. Low risk of SARS-CoV-2 transmission by fomites in real-life conditions. The Lancet Infectious Diseases. 2020;21. https://doi.org/10.1016/S1473-3099(20)30678-2.

24.

To KKW, Tsang OTY, Yip CCY, Chan KH, Wu TC, Chan JMC, et al. Consistent detection of 2019 novel coronavirus in saliva. Clin Infect Dis. 2020;71(15):841–3.CrossRef

25.

Wei J, Li Y. Airborne spread of infectious agents in the indoor environment. Am J Infect Control. 2016;44(9):S102–8. https://doi.org/10.1016/j.ajic.2016.06.003.CrossRefPubMedPubMedCentral

26.

Li J-PO, Lam DSC, Chen Y, Ting DSW. Novel coronavirus disease 2019 (COVID-19): the importance of recognising possible early ocular manifestation and using protective eyewear. Br J Ophthalmol. 2020;104(3):297–8. https://doi.org/10.1136/bjophthalmol-2020-315994.CrossRefPubMed

27.

Loon S-C, Teoh SCB, Oon LLE, Se-Thoe S-Y, Ling A-E, Leo Y-S, et al. The severe acute respiratory syndrome coronavirus in tears. Br J Ophthalmol. 2004;88(7):861–3. https://doi.org/10.1136/bjo.2003.035931.CrossRefPubMedPubMedCentral

28.

Xia J, Tong J, Liu M, Shen Y, Guo D. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. J Med Virol. 2020;92(6):589–94. https://doi.org/10.1002/jmv.25725.CrossRefPubMed

29.

Zhang W, Du R-H, Li B, Zheng X-S, Yang X-L, Hu B, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect. 2020;9(1):386–9. https://doi.org/10.1080/22221751.2020.1729071.CrossRefPubMedPubMedCentral

30.

COVID-19: Toilets dominate environmental detection of SARS-CoV-2 in a hospital - CEBM [Internet]. [cited 2020 Oct 14]. Available from: https://www.cebm.net/study/covid-19-toilets-dominate-environmental-detection-of-sars-cov-2-in-a-hospital/

31.

Ding Z, Qian H, Xu B, Huang Y, Miao T, Yen HL, et al. Toilets dominate environmental detection of severe acute respiratory syndrome coronavirus 2 in a hospital. Sci Total Environ. 2021;753:141710. https://doi.org/10.1016/j.scitotenv.2020.141710.CrossRefPubMed

32.

Qiu L, Liu X, Xiao M, Xie J, Cao W, Liu Z, et al. SARS-CoV-2 is not detectable in the vaginal fluid of women with severe COVID-19 infection. Clin Infect Dis. 2020;71(15):813–7. https://doi.org/10.1093/cid/ciaa375.CrossRefPubMed

33.

Pan F, Xiao X, Guo J, Song Y, Li H, Patel DP, et al. No evidence of severe acute respiratory syndrome–coronavirus 2 in semen of males recovering from coronavirus disease 2019. Fertil Steril. 2020;113(6):1135–9. https://doi.org/10.1016/j.fertnstert.2020.04.024.CrossRefPubMedPubMedCentral

34.

Song C, Wang Y, Li W, Hu B, Chen G, Xia P, et al. Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients. Biol Reprod. 2020;103(1):4–6. https://doi.org/10.1093/biolre/ioaa050.CrossRefPubMed

35.

Li D, Jin M, Bao P, Zhao W, Zhang S. Clinical characteristics and results of semen tests among men with coronavirus disease 2019. JAMA Netw Open. 2020;3(5):e208292. https://doi.org/10.1001/jamanetworkopen.2020.8292.CrossRefPubMedPubMedCentral

36.

Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hospital Infect. 2020;104(3):246–51. https://doi.org/10.1016/j.jhin.2020.01.022.CrossRef

37.

Darnell MER, Subbarao K, Feinstone SM, Taylor DR. Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV. J Virol Methods. 2004;121(1):85–91. https://doi.org/10.1016/j.jviromet.2004.06.006.CrossRefPubMedPubMedCentral

38.

Chan KH, Peiris JSM, Lam SY, Poon LLM, Yuen KY, Seto WH. The effects of temperature and relative humidity on the viability of the SARS coronavirus. Adv Virol. 2011;2011:1–7. https://doi.org/10.1155/2011/734690.CrossRef

39.

Sobral MFF, Duarte GB, da Penha Sobral AIG, Marinho MLM, de Souza Melo A. Association between climate variables and global transmission oF SARS-CoV-2. Sci Total Environ. 2020;729:138997. https://doi.org/10.1016/j.scitotenv.2020.138997.CrossRefPubMedPubMedCentral

40.

Casanova LM, Jeon S, Rutala WA, Weber DJ, Sobsey MD. Effects of Air temperature and relative humidity on coronavirus survival on surfaces. Appl Environ Microbiol. 2010;76(9):2712–7. https://doi.org/10.1128/AEM.02291-09.CrossRefPubMedPubMedCentral

41.

Liu J, Zhou J, Yao J, Zhang X, Li L, Xu X, et al. Impact of meteorological factors on the COVID-19 transmission: a multi-city study in China. Sci Total Environ. 2020 Jul;726:138513. https://doi.org/10.1016/j.scitotenv.2020.138513.CrossRefPubMedPubMedCentral

42.

Eykelbosh A. High-humidity environments and the risk of COVID-19 transmission [internet]. 2020. Available from: https://ncceh.ca/sites/default/files/High%20Humidity%20Environments%20-%20Oct%2022%202020%20FINAL.pdf

43.

Baker RE, Yang W, Vecchi GA, Metcalf CJE, Grenfell BT. Susceptible supply limits the role of climate in the early SARS-CoV-2 pandemic. Science (American Association for the Advancement of Science). 2020;369(6501):315–9. https://doi.org/10.1126/science.abc2535.CrossRef

44.

Zaffina S, Camisa V, Lembo M, Vinci MR, Tucci MG, Borra M, et al. Accidental exposure to UV radiation produced by germicidal lamp: case report and risk assessment. Photochem Photobiol. 2012;88(4):1001–4. https://doi.org/10.1111/j.1751-1097.2012.01151.x.CrossRefPubMed

45.

Trevisan A, Piovesan S, Leonardi A, Bertocco M, Nicolosi P, Pelizzo MG, et al. Unusual high exposure to ultraviolet-C radiation. Photochem Photobiol. 2006;82(4):1077. https://doi.org/10.1562/2005-10-27-RA-728.CrossRefPubMed

46.

Buonanno M, Welch D, Shuryak I, Brenner DJ. Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses. Sci Rep. 2020;10(1):10285. https://doi.org/10.1038/s41598-020-67211-2.CrossRefPubMedPubMedCentral

47.

Mills D, Harnish DA, Lawrence C, Sandoval-Powers M, Heimbuch BK. Ultraviolet germicidal irradiation of influenza-contaminated N95 filtering facepiece respirators. Am J Infect Control. 2018;46(7):e49–55. https://doi.org/10.1016/j.ajic.2018.02.018.CrossRefPubMedPubMedCentral

48.

Narla S, Lyons AB, Kohli I, Torres AE, Parks-Miller A, Ozog DM, et al. The importance of the minimum dosage necessary for UVC decontamination of N95 respirators during the COVID-19 pandemic. Photodermatol Photoimmunol Photomed. 2020;36(4):324–5. https://doi.org/10.1111/phpp.12562.CrossRefPubMed

49.

Doung-ngern P, Suphanchaimat R, Panjangampatthana A, Janekrongtham C, Ruampoom D, Daochaeng N, et al. Case-control study of use of personal protective measures and risk for SARS-CoV 2 infection, Thailand. Emerg Infect Dis. 2020;26(11):2607–16. https://doi.org/10.3201/eid2611.203003.CrossRefPubMedPubMedCentral

50.

Use Masks to Help Slow Spread | CDC [Internet]. [cited 2020 Oct 21]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/diy-cloth-face-coverings.html

51.

Zhang R, Li Y, Zhang AL, Wang Y, Molina MJ. Identifying airborne transmission as the dominant route for the spread of COVID-19. Proc Natl Acad Sci. 2020;117(26):14857–63. https://doi.org/10.1073/pnas.2009637117.CrossRefPubMedPubMedCentral

52.

Leung NHL, Chu DKW, Shiu EYC, Chan KH, McDevitt JJ, Hau BJP, et al. Respiratory virus shedding in exhaled breath and efficacy of face masks. Nat Med. 2020;26(5):676–80. https://doi.org/10.1038/s41591-020-0843-2.CrossRefPubMedPubMedCentral

53.

Boston hospitals show wearing face masks lowered coronavirus spread among workers during surge [Internet]. [cited 2020 Oct 21]. Available from: https://www.bostonherald.com/2020/07/15/boston-hospitals-show-universal-mask-wearing-lowered-coronavirus-spread-among-workers-during-surge/

54.

Lyu W, Wehby GL. Community use of face masks and COVID-19: evidence from a natural experiment of state mandates in the US. Health Aff. 2020;39(8):1419–25. https://doi.org/10.1377/hlthaff.2020.00818.CrossRef

55.

Fisher KA, Tenforde MW, Feldstein LR, Lindsell CJ, Shapiro NI, Files DC, et al. Community and close contact exposures associated with COVID-19 among symptomatic adults ≥18 years in 11 outpatient health care facilities — United States, July 2020. MMWR Morb Mortal Wkly Rep. 2020;69(36):1258–64. https://doi.org/10.15585/mmwr.mm6936a5.CrossRefPubMedPubMedCentral

56.

Dugdale CM, Walensky RP. Filtration Efficiency, Effectiveness, and Availability of N95 Face Masks for COVID-19 Prevention. JAMA Int Med. 2020;180:1612–3. https://doi.org/10.1001/jamainternmed.2020.4218.

57.

Milton DK, Fabian MP, Cowling BJ, Grantham ML, Mcdevitt JJ. Influenza virus aerosols in human exhaled breath: particle size, Culturability, and effect of surgical masks. PLoS Pathog. 2013;9(3):1003205.CrossRef

58.

Verma S, Dhanak M, Frankenfield J. Visualizing the effectiveness of face masks in obstructing respiratory jets. Phys Fluids. 2020;32(6):061708. https://doi.org/10.1063/5.0016018.CrossRef

59.

Chan JFW, Yuan S, Zhang AJ, Poon VKM, Chan CCS, Lee ACY, et al. Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19). Clin Infect Dis. 2020;71:2139–49. https://doi.org/10.1093/cid/ciaa644.

60.

Ng K, Poon BH, Kiat Puar TH, Shan Quah JL, Loh WJ, Wong YJ, et al. COVID-19 and the risk to health care workers: a case report. Ann Intern Med. 2020;172(11):766–7. https://doi.org/10.7326/L20-0175.CrossRefPubMed

61.

Radonovich LJ, Simberkoff MS, Bessesen MT, Brown AC, Cummings DAT, Gaydos CA, et al. N95 respirators vs medical masks for preventing influenza among health care personnel: a randomized clinical trial. JAMA. 2019;322(9):824–33. https://doi.org/10.1001/jama.2019.11645.CrossRefPubMedPubMedCentral

62.

CDC calls on Americans to wear masks to prevent COVID-19 spread | CDC Online Newsroom | CDC [Internet]. [cited 2020 Oct 21]. Available from: https://www.cdc.gov/media/releases/2020/p0714-americans-to-wear-masks.html

63.

Hendrix MJ, Walde C, Findley K, Trotman R. Absence of apparent transmission of SARS-CoV-2 from two stylists after exposure at a hair salon with a universal face covering policy — Springfield, Missouri, may 2020. MMWR Morb Mortal Wkly Rep. 2020;69(28):930–2. https://doi.org/10.15585/mmwr.mm6928e2.CrossRefPubMed

64.

Qian H, Miao T, Liu L, Zheng X, Luo D, Li Y. Indoor transmission of SARS-CoV-2. Indoor Air. 2020:ina.12766.

65.

Bundgaard H, Bundgaard JS, Raaschou-Pedersen DET, von Buchwald C, Todsen T, Norsk JB, et al. Effectiveness of adding a mask recommendation to other public health measures to prevent SARS-CoV-2 infection in Danish mask wearers. Ann Intern Med. 2020;18:M20–6817.

66.

Abbasi K. The curious case of the Danish mask study. BMJ. 2020;371:m4586.CrossRef

67.

COVID-19 Pandemic Planning Scenarios | CDC [Internet]. [cited 2020 Nov 6]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/planning-scenarios.html

68.

Ing AJ, Cocks C, Green JP. COVID-19: in the footsteps of Ernest Shackleton. Thorax. 2020;75(8):693–4. https://doi.org/10.1136/thoraxjnl-2020-215091.CrossRefPubMed

69.

Bai Y, Yao L, Wei T, Tian F, Jin D-Y, Chen L, et al. Presumed asymptomatic carrier transmission of COVID-19. JAMA. 2020;323(14):1406–7. https://doi.org/10.1001/jama.2020.2565.CrossRefPubMedPubMedCentral

70.

Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med. 2020;382(10):970–1. https://doi.org/10.1056/NEJMc2001468.CrossRefPubMedPubMedCentral

71.

He X, Lau EHY, Wu P, Deng X, Wang J, Hao X, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020;26(5):672–5. https://doi.org/10.1038/s41591-020-0869-5.CrossRefPubMed

72.

Li Y, Liang M, Gao L, Ayaz Ahmed M, Uy JP, Cheng C, et al. Face masks to prevent transmission of COVID-19: A systematic review and metaanalysis. Am J Infect Control. 2020. https://doi.org/10.1016/j.ajic.2020.12.007.

73.

Tabatabaeizadeh S-A. Airborne transmission of COVID-19 and the role of face mask to prevent it: a systematic review and meta-analysis. Eur J Med Res. 2021;26(1):1. https://doi.org/10.1186/s40001-020-00475-6.CrossRefPubMedPubMedCentral

74.

Tabah A, Ramanan M, Laupland KB, Buetti N, Cortegiani A, Mellinghoff J, et al. Personal protective equipment and intensive care unit healthcare worker safety in the COVID-19 era (PPE-SAFE): An international survey. J Crit Care. 2020;59:70–5. https://doi.org/10.1016/j.jcrc.2020.06.005.CrossRefPubMedPubMedCentral

75.

wei LC, fen LX, fang JZ. 2019-nCoV transmission through the ocular surface must not be ignored. Lancet Lancet Publishing Group. 2020;395:e39.

76.

Chu DK, Akl EA, Duda S, Solo K, Yaacoub S, Schünemann HJ, et al. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet (British edition). 2020;395(10242):1973–87.

77.

Is 6 feet enough space for social distancing? | Live Science [Internet]. [cited 2020 Oct 21]. Available from: https://www.livescience.com/coronavirus-six-feet-enough-social-distancing.html

78.

van den Berg P, Schechter-Perkins EM, Jack RS, Epshtein I, Nelson R, Oster E, et al. Effectiveness of three versus six feet of physical distancing for controlling spread of COVID-19 among primary and secondary students and staff: A retrospective, state-wide cohort study. Clin Infect Dis [Internet]. 2021;(ciab230) [cited 2021 Apr 1]. Available from: https://doi.org/10.1093/cid/ciab230.

79.

Gallaway MS, Rigler J, Robinson S, Herrick K, Livar E, Komatsu KK, et al. Trends in COVID-19 incidence after implementation of mitigation measures — Arizona, January 22–august 7, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(40):1460–3. https://doi.org/10.15585/mmwr.mm6940e3.CrossRefPubMedPubMedCentral

80.

Ferretti L, Wymant C, Kendall M, Zhao L, Nurtay A, Abeler-Dörner L, et al. Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing. Science (American Association for the Advancement of Science). 2020;368(6491):eabb6936.CrossRef

81.

Kupferschmidt K. Why do some COVID-19 patients infect many others, whereas most don’t spread the virus at all? Science; 2020.

82.

Park SY, Kim YM, Yi S, Lee S, Na BJ, Kim CB, et al. Coronavirus disease outbreak in call center, South Korea. Emerg Infect Dis. 2020;26(8):1666–70. https://doi.org/10.3201/eid2608.201274.CrossRefPubMedPubMedCentral

83.

Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations [Internet]. [cited 2020 Oct 14]. Available from: https://www.who.int/news-room/commentaries/detail/modes-of-transmission-of-virus-causing-covid-19-implications-for-ipc-precaution-recommendations

84.

Cleaning And Disinfecting Your Home | CDC [Internet]. [cited 2020 Oct 14]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/disinfecting-your-home.html

85.

WHO | WASH and COVID-19. WHO. 2020;

86.

Kratzel A, Todt D, V’kovski P, Steiner S, Gultom M, Thao TTN, et al. Inactivation of severe acute respiratory syndrome coronavirus 2 by WHO-recommended hand rub formulations and alcohols. Emerg Infect Dis. 2020;26(7):1592–5. https://doi.org/10.3201/eid2607.200915.CrossRefPubMedPubMedCentral

87.

Su Z, Wen J, McDonnell D, Goh E, Li X, Šegalo S, et al. Vaccines are not yet a silver bullet: The imperative of continued communication about the importance of COVID-19 safety measures. Brain Behav Immun Health. 2021;12:100204.CrossRefPubMedPubMedCentral

88.

Garcia-Beltran WF, Lam EC, St. Denis K, Nitido AD, Garcia ZH, Hauser BM, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccineinducedhumoral immunity. Cell. 2021;184. https://doi.org/10.1016/j.cell.2021.03.013.

89.

Mukandavire Z, Nyabadza F, Malunguza NJ, Cuadros DF, Shiri T, Musuka G. Quantifying early COVID-19 outbreak transmission in South Africa and exploring vaccine efficacy scenarios. Shaman J, editor. PLoS One. 2020;15(7):e0236003.

90.

Shen M, Zu J, Fairley CK, Pagán JA, An L, Du Z, et al. Projected COVID-19 epidemic in the United States in the context of the effectiveness of a potential vaccine and implications for social distancing and face mask use. Vaccine. 2021;39:2295–302. https://doi.org/10.1016/j.vaccine.2021.02.056.

Title: Modes of transmission of SARS-CoV-2 and evidence for preventive behavioral interventions
Authors: Lucas Zhou
Samuel K. Ayeh
Vignesh Chidambaram
Petros C. Karakousis
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Severe Acute Respiratory Syndrome Coronavirus
SARS-CoV-2
COVID-19
Published in: BMC Infectious Diseases / Issue 1/2021
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-021-06222-4

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10-04-2024 Myocardial Infarction News

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Illustration of figure on mountain summit/© Orapun / Stock.adobe.com, STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

At a glance: The STEP trials

Springer Medicine

Abstract

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Other articles of this Issue 1/2021

Clinical characteristics of 14 COVID-19 deaths in Tianmen, China: a single-center retrospective study

Complicated Trichosporon asahii mastoiditis in immunocompetent child

Pulmonary tuberculosis screening in anti-retroviral treated adults living with HIV in Kenya

Monitoring HIV testing and pre-exposure prophylaxis information seeking by combining digital and traditional data

A wind speed threshold for increased outdoor transmission of coronavirus: an ecological study

Hepatitis B virus infection and its associated factors among medical waste collectors at public health facilities in eastern Ethiopia: a facility-based cross-sectional study

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Highlights from the ACC 2024 Congress

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