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BMC Infectious Diseases

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Open Access 01-12-2021 | Diabetic Foot | Research article

C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study

Authors: Carly L. Botheras, Steven J. Bowe, Raquel Cowan, Eugene Athan

Published in: BMC Infectious Diseases | Issue 1/2021

Abstract

Background

Staphylococcus aureus (S. aureus) bacteraemia is increasingly acquired from community settings and is associated with a mortality rate of up to 40% following complications. Identifying risk factors for complicated S. aureus bacteraemia would aid clinicians in targeting patients that benefit from expedited investigations and escalated care.

Methods

In this prospective observational cohort study, we aimed to identify risk factors associated with a complicated infection in community-onset S. aureus bacteraemia. Potential risk factors were collected from electronic medical records and included: - patient demographics, symptomology, portal of entry, and laboratory results.

Results

We identified several potential risk factors using univariate analysis. In a multiple logistic regression model, age, haemodialysis, and entry point from a diabetic foot ulcer were all significantly protective against complications. Conversely, an unknown entry point of infection, an entry point from an indwelling medical device, and a C-reactive protein concentration of over 161 mg/L on the day of admission were all significantly associated with complications.

Conclusions

We conclude that several factors are associated with complications including already conducted laboratory investigations and portal of entry of infection. These factors could aid the triage of at-risk patients for complications of S. aureus bacteraemia.

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Title: C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study
Authors: Carly L. Botheras
Steven J. Bowe
Raquel Cowan
Eugene Athan
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Diabetic Foot
Published in: BMC Infectious Diseases / Issue 1/2021
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-021-05962-7

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