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Published in: BMC Infectious Diseases 1/2021

Open Access 01-12-2021 | Transthoracic Echocardiography | Case report

Pure SARS-CoV-2 related AVDS (Acute Vascular Distress Syndrome)

Authors: Vincent Jounieaux, Damien Basille, Osama Abou-Arab, Marie-Pierre Guillaumont, Claire Andrejak, Yazine Mahjoub, Daniel Oscar Rodenstein

Published in: BMC Infectious Diseases | Issue 1/2021

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Abstract

Background

SARS-CoV-2 virus which targets the pulmonary vasculature is supposed to induce an intrapulmonary right to left shunt with an increased pulmonary blood flow. Such vascular injury is difficult to observe because it is hidden by the concomitant lung injury. We report here what may be, to the best of our knowledge, the first case of a pure Covid-19 related Acute Vascular Distress Syndrome (AVDS).

Case presentation

A 43-year-old physician, tested positive for Covid-19, was addressed to the emergency unit for severe dyspnoea and dizziness. Explorations were non informative with only a doubt regarding a sub-segmental pulmonary embolism (no ground-glass lesions or consolidations related to Covid-19 disease). Dyspnoea persisted despite anticoagulation therapy and normal pulmonary function tests. Contrast-enhanced transthoracic echocardiography was performed which revealed a moderate late right-to-left shunt.

Conclusions

This case report highlights the crucial importance of the vascular component of the viral disease. The intrapulmonary shunt induced by Covid-19 which remains unrecognized because generally hidden by the concomitant lung injury, can persist for a long time. Contrast-enhanced transthoracic echocardiography is the most appropriate test to propose in case of persistent dyspnoea in Covid-19 patients.
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Literature
1.
go back to reference Couzin-Frankel J. The mystery of the pandemic's ‘happy hypoxia’. Science. 2020;368(6490):455–6.CrossRef Couzin-Frankel J. The mystery of the pandemic's ‘happy hypoxia’. Science. 2020;368(6490):455–6.CrossRef
3.
go back to reference Jounieaux V, Rodenstein DO, Mahjoub Y. On happy hypoxia and on sadly ignored AVDS in Covid-19 patients. Am J Respir Crit Care Med. 2020;202(11):1598–9.CrossRef Jounieaux V, Rodenstein DO, Mahjoub Y. On happy hypoxia and on sadly ignored AVDS in Covid-19 patients. Am J Respir Crit Care Med. 2020;202(11):1598–9.CrossRef
4.
go back to reference Mahjoub Y, Rodenstein D, Jounieaux V. Severe Covid-19 disease: rather AVDS* than ARDS? (acute vascular distress syndrome). Crit Care. 2020;24(1):327.CrossRef Mahjoub Y, Rodenstein D, Jounieaux V. Severe Covid-19 disease: rather AVDS* than ARDS? (acute vascular distress syndrome). Crit Care. 2020;24(1):327.CrossRef
5.
go back to reference Lang M, Som A, Mendoza DP, Flores EJ, Reid N, Carey D, Li MD, Witkin A, Rodriguez-Lopez JM, Shepard JO, Little BP. Hypoxaemia related to COVID-19: vascular and perfusion abnormalities on dual-energy CT. Lancet Infect Dis. 2020;20(12):1365–6.CrossRef Lang M, Som A, Mendoza DP, Flores EJ, Reid N, Carey D, Li MD, Witkin A, Rodriguez-Lopez JM, Shepard JO, Little BP. Hypoxaemia related to COVID-19: vascular and perfusion abnormalities on dual-energy CT. Lancet Infect Dis. 2020;20(12):1365–6.CrossRef
6.
go back to reference Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020;18(6):1421–4.CrossRef Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020;18(6):1421–4.CrossRef
7.
go back to reference Kanber GJ, King FW, Eshchar YR, Sharp JT. The alveolar-arterial oxygen gradient in young and elderly men during air and oxygen breathing. Am Rev Respir Dis. 1968;97(3):376–81.PubMed Kanber GJ, King FW, Eshchar YR, Sharp JT. The alveolar-arterial oxygen gradient in young and elderly men during air and oxygen breathing. Am Rev Respir Dis. 1968;97(3):376–81.PubMed
8.
go back to reference Jounieaux V, Parreira VF, Aubert G, Dury M, Delguste P, Rodenstein DO. Effects of hypocapnic hyperventilation on the response to hypoxia in normal subjects receiving intermittent positive-pressure ventilation. Chest. 2002;121(4):1141–8.CrossRef Jounieaux V, Parreira VF, Aubert G, Dury M, Delguste P, Rodenstein DO. Effects of hypocapnic hyperventilation on the response to hypoxia in normal subjects receiving intermittent positive-pressure ventilation. Chest. 2002;121(4):1141–8.CrossRef
9.
go back to reference Immink RV, Pott FC, Secher NH, van Lieshout JJ. Hyperventilation, cerebral perfusion, and syncope. J Appl Physiol. 2014;116(7):844–51.CrossRef Immink RV, Pott FC, Secher NH, van Lieshout JJ. Hyperventilation, cerebral perfusion, and syncope. J Appl Physiol. 2014;116(7):844–51.CrossRef
10.
go back to reference Mwenge GB, Rodenstein D. Oxygen is falling down, falling down... Am J Respir Crit Care Med. 2010;182(7):866–868. Mwenge GB, Rodenstein D. Oxygen is falling down, falling down... Am J Respir Crit Care Med. 2010;182(7):866–868.
11.
go back to reference Adler D, Perrig S, Takahashi H, Espa F, Rodenstein D, Pépin JL, Janssens JP. Polysomnography in stable COPD under non-invasive ventilation to reduce patient-ventilator asynchrony and morning breathlessness. Sleep Breath. 2012;16(4):1081–90.CrossRef Adler D, Perrig S, Takahashi H, Espa F, Rodenstein D, Pépin JL, Janssens JP. Polysomnography in stable COPD under non-invasive ventilation to reduce patient-ventilator asynchrony and morning breathlessness. Sleep Breath. 2012;16(4):1081–90.CrossRef
12.
go back to reference Rodríguez-Roisin R, Krowka MJ. Hepatopulmonary syndrome-a liver-induced lung vascular disorder. N Engl J Med. 2008;358(22):2378–87.CrossRef Rodríguez-Roisin R, Krowka MJ. Hepatopulmonary syndrome-a liver-induced lung vascular disorder. N Engl J Med. 2008;358(22):2378–87.CrossRef
13.
go back to reference Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–80 e8.CrossRef Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–80 e8.CrossRef
14.
go back to reference Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong JC, Turner AJ, Raizada MK, Grant MB, Oudit GY. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system. 1. Circ Res. 2020;126(10):1456–74.CrossRef Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong JC, Turner AJ, Raizada MK, Grant MB, Oudit GY. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system. 1. Circ Res. 2020;126(10):1456–74.CrossRef
15.
go back to reference Jones VG, Mills M, Suarez D, Hogan CA, Yeh D, Bradley Segal J, Nguyen EL, Barsh GR, Maskatia S, Mathew R. COVID-19 and Kawasaki disease: novel virus and novel case. Hosp Pediatr. 2020;10(6):537–40.CrossRef Jones VG, Mills M, Suarez D, Hogan CA, Yeh D, Bradley Segal J, Nguyen EL, Barsh GR, Maskatia S, Mathew R. COVID-19 and Kawasaki disease: novel virus and novel case. Hosp Pediatr. 2020;10(6):537–40.CrossRef
16.
go back to reference Akhmerov A, Marbán E. COVID-19 and the heart. Circ Res. 2020;126(10):1443–55.CrossRef Akhmerov A, Marbán E. COVID-19 and the heart. Circ Res. 2020;126(10):1443–55.CrossRef
17.
go back to reference Sun J, Aghemo A, Forner A, Valenti L. COVID-19 and liver disease. Liver Int. 2020;40(6):1278–81.CrossRef Sun J, Aghemo A, Forner A, Valenti L. COVID-19 and liver disease. Liver Int. 2020;40(6):1278–81.CrossRef
18.
go back to reference Pan XW, Xu D, Zhang H, Zhou W, Wang LH, Cui XG. Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis. Intensive Care Med. 2020;46(6):1114–6.CrossRef Pan XW, Xu D, Zhang H, Zhou W, Wang LH, Cui XG. Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis. Intensive Care Med. 2020;46(6):1114–6.CrossRef
19.
go back to reference Bouaziz JD, Duong T, Jachiet M, Velter C, Lestang P, Cassius C, Arsouze A, Domergue Than Trong E, Bagot M, Begon E, Sulimovic L, Rybojad M. Vascular skin symptoms in COVID-19: a french observational study. J Eur Acad Dermatol Venereol. 2020;34(9):e451–2.CrossRef Bouaziz JD, Duong T, Jachiet M, Velter C, Lestang P, Cassius C, Arsouze A, Domergue Than Trong E, Bagot M, Begon E, Sulimovic L, Rybojad M. Vascular skin symptoms in COVID-19: a french observational study. J Eur Acad Dermatol Venereol. 2020;34(9):e451–2.CrossRef
Metadata
Title
Pure SARS-CoV-2 related AVDS (Acute Vascular Distress Syndrome)
Authors
Vincent Jounieaux
Damien Basille
Osama Abou-Arab
Marie-Pierre Guillaumont
Claire Andrejak
Yazine Mahjoub
Daniel Oscar Rodenstein
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2021
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-021-05805-5

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