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Published in: BMC Infectious Diseases 1/2021

Open Access 01-12-2021 | Influenza | Research article

Monitoring sick leave data for early detection of influenza outbreaks

Authors: Tom Duchemin, Jonathan Bastard, Pearl Anne Ante-Testard, Rania Assab, Oumou Salama Daouda, Audrey Duval, Jérôme-Philippe Garsi, Radowan Lounissi, Narimane Nekkab, Helene Neynaud, David R. M. Smith, William Dab, Kevin Jean, Laura Temime, Mounia N. Hocine

Published in: BMC Infectious Diseases | Issue 1/2021

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Abstract

Background

Workplace absenteeism increases significantly during influenza epidemics. Sick leave records may facilitate more timely detection of influenza outbreaks, as trends in increased sick leave may precede alerts issued by sentinel surveillance systems by days or weeks. Sick leave data have not been comprehensively evaluated in comparison to traditional surveillance methods. The aim of this paper is to study the performance and the feasibility of using a detection system based on sick leave data to detect influenza outbreaks.

Methods

Sick leave records were extracted from private French health insurance data, covering on average 209,932 companies per year across a wide range of sizes and sectors. We used linear regression to estimate the weekly number of new sick leave spells between 2016 and 2017 in 12 French regions, adjusting for trend, seasonality and worker leaves on historical data from 2010 to 2015. Outbreaks were detected using a 95%-prediction interval. This method was compared to results from the French Sentinelles network, a gold-standard primary care surveillance system currently in place.

Results

Using sick leave data, we detected 92% of reported influenza outbreaks between 2016 and 2017, on average 5.88 weeks prior to outbreak peaks. Compared to the existing Sentinelles model, our method had high sensitivity (89%) and positive predictive value (86%), and detected outbreaks on average 2.5 weeks earlier.

Conclusion

Sick leave surveillance could be a sensitive, specific and timely tool for detection of influenza outbreaks.
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Literature
1.
go back to reference Groenewold MR, Konicki DL, Luckhaupt SE, Gomaa A, Koonin LM. Exploring National Surveillance for Health-Related Workplace Absenteeism: Lessons Learned From the 2009 Influenza A Pandemic. Disaster Med Public Health Preparedness. 2013;7(2):160–6.CrossRef Groenewold MR, Konicki DL, Luckhaupt SE, Gomaa A, Koonin LM. Exploring National Surveillance for Health-Related Workplace Absenteeism: Lessons Learned From the 2009 Influenza A Pandemic. Disaster Med Public Health Preparedness. 2013;7(2):160–6.CrossRef
3.
go back to reference German RR, Lee LM, Horan JM, Milstein RL, Pertowski CA, Waller MN, et al. Updated guidelines for evaluating public health surveillance systems: recommendations from the Guidelines Working Group. MMWR Recomm Rep. 2001;50(RR-13):1–35 quiz CE1–7.PubMed German RR, Lee LM, Horan JM, Milstein RL, Pertowski CA, Waller MN, et al. Updated guidelines for evaluating public health surveillance systems: recommendations from the Guidelines Working Group. MMWR Recomm Rep. 2001;50(RR-13):1–35 quiz CE1–7.PubMed
6.
go back to reference Bollaerts K, Antoine J, Robesyn E, Van Proeyen L, Vomberg J, Feys E, et al. Timeliness of syndromic influenza surveillance through work and school absenteeism. Arch Public Health. 2010;68(3):115–20.PubMedCentralCrossRef Bollaerts K, Antoine J, Robesyn E, Van Proeyen L, Vomberg J, Feys E, et al. Timeliness of syndromic influenza surveillance through work and school absenteeism. Arch Public Health. 2010;68(3):115–20.PubMedCentralCrossRef
7.
9.
go back to reference Quenel P, Dab W, Hannoun C, Cohen JM. Sensitivity, Specificity and predictive Values of Health Service Based Indicators for the Surveillance of Influenza A Epidemics. Int J Epidemiol. 1994;23(4):849–55.PubMedCrossRef Quenel P, Dab W, Hannoun C, Cohen JM. Sensitivity, Specificity and predictive Values of Health Service Based Indicators for the Surveillance of Influenza A Epidemics. Int J Epidemiol. 1994;23(4):849–55.PubMedCrossRef
11.
go back to reference Valleron AJ, Bouvet E, Garnerin P, Ménarès J, Heard I, Letrait S, et al. A computer network for the surveillance of communicable diseases: the French experiment. Am J Public Health. 1986;76(11):1289–92.PubMedPubMedCentralCrossRef Valleron AJ, Bouvet E, Garnerin P, Ménarès J, Heard I, Letrait S, et al. A computer network for the surveillance of communicable diseases: the French experiment. Am J Public Health. 1986;76(11):1289–92.PubMedPubMedCentralCrossRef
13.
go back to reference Costagliola D, Flahault A, Galinec D, Garnerin P, Menares J, Valleron AJ. A routine tool for detection and assessment of epidemics of influenza-like syndromes in France. Am J Public Health. 1991;81(1):97–9.PubMedPubMedCentralCrossRef Costagliola D, Flahault A, Galinec D, Garnerin P, Menares J, Valleron AJ. A routine tool for detection and assessment of epidemics of influenza-like syndromes in France. Am J Public Health. 1991;81(1):97–9.PubMedPubMedCentralCrossRef
14.
go back to reference Souty C, Jreich R, Le Strat Y, Pelat C, Boëlle PY, Guerrisi, et al. Performances of statistical methods for the detection of seasonal influenza epidemics using a consensus-based gold standard. Epidemiol Infect. 2018;146(2):168–76.PubMedCrossRef Souty C, Jreich R, Le Strat Y, Pelat C, Boëlle PY, Guerrisi, et al. Performances of statistical methods for the detection of seasonal influenza epidemics using a consensus-based gold standard. Epidemiol Infect. 2018;146(2):168–76.PubMedCrossRef
15.
go back to reference Retel O, Fortin N, Henry V, Hubert B, Faisant M, Casamatta D, et al. Contribution des associations SOS Médecins à une surveillance locale de la grippe saisonnière en France. Bull épidémiol hebd. 2014;28:466–72. Retel O, Fortin N, Henry V, Hubert B, Faisant M, Casamatta D, et al. Contribution des associations SOS Médecins à une surveillance locale de la grippe saisonnière en France. Bull épidémiol hebd. 2014;28:466–72.
16.
go back to reference Buehler JW, Hopkins RS, Overhage JM, Sosin DM, Tong V, CDC Working Group. Framework for evaluating public health surveillance systems for early detection of outbreaks: recommendations from the CDC Working Group. MMWR Recomm Rep. 2004;53(RR-5):1–11.PubMed Buehler JW, Hopkins RS, Overhage JM, Sosin DM, Tong V, CDC Working Group. Framework for evaluating public health surveillance systems for early detection of outbreaks: recommendations from the CDC Working Group. MMWR Recomm Rep. 2004;53(RR-5):1–11.PubMed
17.
go back to reference Heffernan R, Mostashari F, Das D, Karpati A, Kulldorff M, Weiss D. Syndromic surveillance in public health practice, New York City. Emerging Infect Dis. 2004;10(5):858–64.CrossRef Heffernan R, Mostashari F, Das D, Karpati A, Kulldorff M, Weiss D. Syndromic surveillance in public health practice, New York City. Emerging Infect Dis. 2004;10(5):858–64.CrossRef
18.
go back to reference Drumright LN, SDW F, Elliot AJ, Catchpole M, Pebody RG, Atkins M, et al. Assessing the use of hospital staff influenza-like absence (ILA) for enhancing hospital preparedness and national surveillance. BMC Infect Dis. 2015;15:110.PubMedPubMedCentralCrossRef Drumright LN, SDW F, Elliot AJ, Catchpole M, Pebody RG, Atkins M, et al. Assessing the use of hospital staff influenza-like absence (ILA) for enhancing hospital preparedness and national surveillance. BMC Infect Dis. 2015;15:110.PubMedPubMedCentralCrossRef
19.
go back to reference Noufaily A, Enki DG, Farrington P, Garthwaite P, Andrews N, Charlett A. An improved algorithm for outbreak detection in multiple surveillance systems. Stat Med. 2013;32(7):1206–22.PubMedCrossRef Noufaily A, Enki DG, Farrington P, Garthwaite P, Andrews N, Charlett A. An improved algorithm for outbreak detection in multiple surveillance systems. Stat Med. 2013;32(7):1206–22.PubMedCrossRef
20.
go back to reference Farrington CP, Andrews NJ, Beale AD, Catchpole MA. A Statistical Algorithm for the Early Detection of Outbreaks of Infectious Disease. J R Stat Soc Series A. 1996;159(3):547–63.CrossRef Farrington CP, Andrews NJ, Beale AD, Catchpole MA. A Statistical Algorithm for the Early Detection of Outbreaks of Infectious Disease. J R Stat Soc Series A. 1996;159(3):547–63.CrossRef
21.
23.
go back to reference Santillana M, Nguyen AT, Louie T, Zink A, Gray J, Sung I, et al. Cloud-based Electronic Health Records for Real-time, Region-specific Influenza Surveillance. Sci Rep. 2016;6(1):25732.PubMedPubMedCentralCrossRef Santillana M, Nguyen AT, Louie T, Zink A, Gray J, Sung I, et al. Cloud-based Electronic Health Records for Real-time, Region-specific Influenza Surveillance. Sci Rep. 2016;6(1):25732.PubMedPubMedCentralCrossRef
24.
go back to reference Mao K, Zhang H, Yang Z. Can a Paper-Based Device Trace COVID-19 Sources with Wastewater-Based Epidemiology? Environ Sci Technol. 2020;54(7):3733–5.PubMedCrossRef Mao K, Zhang H, Yang Z. Can a Paper-Based Device Trace COVID-19 Sources with Wastewater-Based Epidemiology? Environ Sci Technol. 2020;54(7):3733–5.PubMedCrossRef
25.
go back to reference Lazer D, Kennedy R, King G, Vespignani A. The Parable of Google Flu: Traps in Big Data Analysis. Science. 2014;343(6176):1203–5.PubMedCrossRef Lazer D, Kennedy R, King G, Vespignani A. The Parable of Google Flu: Traps in Big Data Analysis. Science. 2014;343(6176):1203–5.PubMedCrossRef
Metadata
Title
Monitoring sick leave data for early detection of influenza outbreaks
Authors
Tom Duchemin
Jonathan Bastard
Pearl Anne Ante-Testard
Rania Assab
Oumou Salama Daouda
Audrey Duval
Jérôme-Philippe Garsi
Radowan Lounissi
Narimane Nekkab
Helene Neynaud
David R. M. Smith
William Dab
Kevin Jean
Laura Temime
Mounia N. Hocine
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
Influenza
Published in
BMC Infectious Diseases / Issue 1/2021
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-020-05754-5

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