Skip to main content
Top
Published in: BMC Infectious Diseases 1/2018

Open Access 01-12-2018 | Research article

Efficacy of introducing a checklist to reduce central venous line associated bloodstream infections in the ICU caring for adult patients

Authors: Dominic Wichmann, Cristina E. Belmar Campos, Stephan Ehrhardt, Timo Kock, Claudia Weber, Holger Rohde, Stefan Kluge

Published in: BMC Infectious Diseases | Issue 1/2018

Login to get access

Abstract

Background

Central line-associated bloodstream infections (CLABSI) are a major source of sepsis in modern intensive care medicine. Some years ago bundle interventions have been introduced to reduce CLABSI. The use of checklists may be an additional tool to improve the effect of these bundles even in highly specialized institutions. In this study we investigate if the introduction of a checklist reduces the frequency of CLABSI.

Methods

During the study period from October 2011 to September 2012, we investigated the effect of implementing a checklist for the placement of central venous lines (CVL). Patients were allocated either to the checklist group or to the control group, roughly in a 1:2 ratio. The frequency of CLABSI was compared between the two groups.

Results

During the study period 4416 CVL were inserted; 1518 in the checklist group and 2898 in the control group. The use of the checklist during CVL placement resulted in a lower CLABSI frequency. The incidence in the checklist group was 3.8 per 1000 catheter days as compared to 5.9 per 1000 catheter days in the control group (IRR = 0.57; p = 0.001). The use of the checklist also reduced the frequency of catheter colonisation significantly, 36.3 per 1000 catheter days in the checklist group vs 21.2 per 1000 catheter days in the control group, respectively (IRR = 0.58; p < 0.001).

Conclusion

The introduction of a checklist to improve the adherence to hygiene standards while placement of central venous lines reduced the frequency of infections significantly.
Appendix
Available only for authorised users
Literature
2.
go back to reference Magill SS, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Kainer MA, Lynfield R, Maloney M, McAllister-Hollod L, Nadle J, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370:1198–208.CrossRefPubMedPubMedCentral Magill SS, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Kainer MA, Lynfield R, Maloney M, McAllister-Hollod L, Nadle J, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370:1198–208.CrossRefPubMedPubMedCentral
3.
go back to reference Malacarne P, Boccalatte D, Acquarolo A, Agostini F, Anghileri A, Giardino M, Giudici D, Langer M, Livigni S, Nascimben E, et al. Epidemiology of nosocomial infection in 125 Italian intensive care units. Minerva Anestesiol. 2010;76:13–23.PubMed Malacarne P, Boccalatte D, Acquarolo A, Agostini F, Anghileri A, Giardino M, Giudici D, Langer M, Livigni S, Nascimben E, et al. Epidemiology of nosocomial infection in 125 Italian intensive care units. Minerva Anestesiol. 2010;76:13–23.PubMed
4.
go back to reference Ziegler MJ, Pellegrini DC, Safdar N. Attributable mortality of central line associated bloodstream infection: systematic review and meta-analysis. Infection. 2015;43:29–36.CrossRefPubMed Ziegler MJ, Pellegrini DC, Safdar N. Attributable mortality of central line associated bloodstream infection: systematic review and meta-analysis. Infection. 2015;43:29–36.CrossRefPubMed
5.
go back to reference (CDC) CfDCaP: Vital signs: central line-associated blood stream infections--United States, 2001, 2008, and 2009. MMWR Morb Mortal Wkly Rep 2011, 60:243–248. (CDC) CfDCaP: Vital signs: central line-associated blood stream infections--United States, 2001, 2008, and 2009. MMWR Morb Mortal Wkly Rep 2011, 60:243–248.
6.
go back to reference O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 2011;52:e162–93.CrossRefPubMedPubMedCentral O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 2011;52:e162–93.CrossRefPubMedPubMedCentral
7.
go back to reference Kerber CW. Changing our culture: adopting the military aviation safety system. J Neurointerv Surg. 2014;6:332–41.CrossRefPubMed Kerber CW. Changing our culture: adopting the military aviation safety system. J Neurointerv Surg. 2014;6:332–41.CrossRefPubMed
8.
go back to reference Haynes AB, Weiser TG, Berry WR, Lipsitz SR, Breizat A-HS, Dellinger EP, Herbosa T, Joseph S, Kibatala PL, Lapitan MCM, et al. A surgical safety checklist to reduce morbidity and mortality in a global population. N Engl J Med. 2009;360:491–9.CrossRefPubMed Haynes AB, Weiser TG, Berry WR, Lipsitz SR, Breizat A-HS, Dellinger EP, Herbosa T, Joseph S, Kibatala PL, Lapitan MCM, et al. A surgical safety checklist to reduce morbidity and mortality in a global population. N Engl J Med. 2009;360:491–9.CrossRefPubMed
9.
go back to reference Urbach DR, Govindarajan A, Saskin R, Wilton AS, Baxter NN. Introduction of surgical safety checklists in Ontario, Canada. N Engl J Med. 2014;370:1029–38.CrossRefPubMed Urbach DR, Govindarajan A, Saskin R, Wilton AS, Baxter NN. Introduction of surgical safety checklists in Ontario, Canada. N Engl J Med. 2014;370:1029–38.CrossRefPubMed
11.
go back to reference Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al. Surviving Sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39:165–228.CrossRefPubMed Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al. Surviving Sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39:165–228.CrossRefPubMed
12.
go back to reference Reinhart K, Brunkhorst FM, Bone HG, Bardutzky J, Dempfle CE, Forst H, Gastmeier P, Gerlach H, Grundling M, John S, et al. Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis society (deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German interdisciplinary Association of Intensive Care and Emergency Medicine (deutsche Interdisziplinare Vereinigung fur Intensiv- und Notfallmedizin (DIVI)). Ger Med Sci. 2010;8 Doc14 Reinhart K, Brunkhorst FM, Bone HG, Bardutzky J, Dempfle CE, Forst H, Gastmeier P, Gerlach H, Grundling M, John S, et al. Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis society (deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German interdisciplinary Association of Intensive Care and Emergency Medicine (deutsche Interdisziplinare Vereinigung fur Intensiv- und Notfallmedizin (DIVI)). Ger Med Sci. 2010;8 Doc14
13.
go back to reference Pazin GJ, Saul S, Thompson ME. Blood culture positivity: suppression by outpatient antibiotic therapy in patients with bacterial endocarditis. Arch Intern Med. 1982;142:263–8.PubMed Pazin GJ, Saul S, Thompson ME. Blood culture positivity: suppression by outpatient antibiotic therapy in patients with bacterial endocarditis. Arch Intern Med. 1982;142:263–8.PubMed
14.
go back to reference Cockerill FR, Wilson JW, Vetter EA, Goodman KM, Torgerson CA, Harmsen WS, Schleck CD, Ilstrup DM, Washington JA, Wilson WR. Optimal testing parameters for blood cultures. Clin Infect Dis. 2004;38:1724–30.CrossRefPubMed Cockerill FR, Wilson JW, Vetter EA, Goodman KM, Torgerson CA, Harmsen WS, Schleck CD, Ilstrup DM, Washington JA, Wilson WR. Optimal testing parameters for blood cultures. Clin Infect Dis. 2004;38:1724–30.CrossRefPubMed
15.
go back to reference Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O'Grady NP, Raad II, Rijnders BJ, Sherertz RJ, Warren DK. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;49:1–45.CrossRefPubMedPubMedCentral Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O'Grady NP, Raad II, Rijnders BJ, Sherertz RJ, Warren DK. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;49:1–45.CrossRefPubMedPubMedCentral
16.
go back to reference Bone RC, Sprung CL, Sibbald WJ. Definitions for sepsis and organ failure. Crit Care Med. 1992;20:724–6.CrossRefPubMed Bone RC, Sprung CL, Sibbald WJ. Definitions for sepsis and organ failure. Crit Care Med. 1992;20:724–6.CrossRefPubMed
17.
go back to reference Dick AW, Perencevich EN, Pogorzelska-Maziarz M, Zwanziger J, Larson EL, Stone PW. A decade of investment in infection prevention: a cost-effectiveness analysis. Am J Infect Control. 2015;43:4–9.CrossRefPubMedPubMedCentral Dick AW, Perencevich EN, Pogorzelska-Maziarz M, Zwanziger J, Larson EL, Stone PW. A decade of investment in infection prevention: a cost-effectiveness analysis. Am J Infect Control. 2015;43:4–9.CrossRefPubMedPubMedCentral
18.
go back to reference Mutters R, Mutters NT. Hygiene and infection control measures in intensive care units. Med Klin Intensivmed Notfmed. 2016;111:261–6.CrossRefPubMed Mutters R, Mutters NT. Hygiene and infection control measures in intensive care units. Med Klin Intensivmed Notfmed. 2016;111:261–6.CrossRefPubMed
19.
go back to reference DePalo VA, McNicoll L, Cornell M, Rocha JM, Adams L, Pronovost PJ. The Rhode Island ICU collaborative: a model for reducing central line-associated bloodstream infection and ventilator-associated pneumonia statewide. Qual Saf Health Care. 2010;19:555–61.PubMed DePalo VA, McNicoll L, Cornell M, Rocha JM, Adams L, Pronovost PJ. The Rhode Island ICU collaborative: a model for reducing central line-associated bloodstream infection and ventilator-associated pneumonia statewide. Qual Saf Health Care. 2010;19:555–61.PubMed
20.
go back to reference Sacks GD, Diggs BS, Hadjizacharia P, Green D, Salim A, Malinoski DJ. Reducing the rate of catheter-associated bloodstream infections in a surgical intensive care unit using the Institute for Healthcare Improvement Central Line Bundle. Am J Surg. 2014;207:817–23.CrossRefPubMed Sacks GD, Diggs BS, Hadjizacharia P, Green D, Salim A, Malinoski DJ. Reducing the rate of catheter-associated bloodstream infections in a surgical intensive care unit using the Institute for Healthcare Improvement Central Line Bundle. Am J Surg. 2014;207:817–23.CrossRefPubMed
21.
go back to reference Zachariah P, Furuya EY, Edwards J, Dick A, Liu H, Herzig CT, Pogorzelska-Maziarz M, Stone PW, Saiman L. Compliance with prevention practices and their association with central line-associated bloodstream infections in neonatal intensive care units. Am J Infect Control. 2014;42:847–51.CrossRefPubMedPubMedCentral Zachariah P, Furuya EY, Edwards J, Dick A, Liu H, Herzig CT, Pogorzelska-Maziarz M, Stone PW, Saiman L. Compliance with prevention practices and their association with central line-associated bloodstream infections in neonatal intensive care units. Am J Infect Control. 2014;42:847–51.CrossRefPubMedPubMedCentral
22.
go back to reference Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, Sexton B, Hyzy R, Welsh R, Roth G, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006;355:2725–32.CrossRefPubMed Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, Sexton B, Hyzy R, Welsh R, Roth G, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006;355:2725–32.CrossRefPubMed
23.
go back to reference Lutz JT, Diener IV, Freiberg K, Zillmann R, Shah-Hosseini K, Seifert H, Berger-Schreck B, Wisplinghoff H. Efficacy of two antiseptic regimens on skin colonization of insertion sites for two different catheter types: a randomized, clinical trial. Infection. 2016;44:707–12.CrossRefPubMedPubMedCentral Lutz JT, Diener IV, Freiberg K, Zillmann R, Shah-Hosseini K, Seifert H, Berger-Schreck B, Wisplinghoff H. Efficacy of two antiseptic regimens on skin colonization of insertion sites for two different catheter types: a randomized, clinical trial. Infection. 2016;44:707–12.CrossRefPubMedPubMedCentral
24.
go back to reference Luzzati R, Merelli M, Ansaldi F, Rosin C, Azzini A, Cavinato S, Brugnaro P, Vedovelli C, Cattelan A, Marina B, et al. Nosocomial candidemia in patients admitted to medicine wards compared to other wards: a multicentre study. Infection. 2016;44:747–55.CrossRefPubMed Luzzati R, Merelli M, Ansaldi F, Rosin C, Azzini A, Cavinato S, Brugnaro P, Vedovelli C, Cattelan A, Marina B, et al. Nosocomial candidemia in patients admitted to medicine wards compared to other wards: a multicentre study. Infection. 2016;44:747–55.CrossRefPubMed
25.
go back to reference Marik PE, Flemmer M, Harrison W. The risk of catheter-related bloodstream infection with femoral venous catheters as compared to subclavian and internal jugular venous catheters: a systematic review of the literature and meta-analysis. Crit Care Med. 2012;40:2479–85.CrossRefPubMed Marik PE, Flemmer M, Harrison W. The risk of catheter-related bloodstream infection with femoral venous catheters as compared to subclavian and internal jugular venous catheters: a systematic review of the literature and meta-analysis. Crit Care Med. 2012;40:2479–85.CrossRefPubMed
26.
go back to reference Nagashima G, Kikuchi T, Tsuyuzaki H, Kawano R, Tanaka H, Nemoto H, Taguchi K, Ugajin K. To reduce catheter-related bloodstream infections: is the subclavian route better than the jugular route for central venous catheterization? J Infect Chemother. 2006;12:363–5.CrossRefPubMed Nagashima G, Kikuchi T, Tsuyuzaki H, Kawano R, Tanaka H, Nemoto H, Taguchi K, Ugajin K. To reduce catheter-related bloodstream infections: is the subclavian route better than the jugular route for central venous catheterization? J Infect Chemother. 2006;12:363–5.CrossRefPubMed
27.
go back to reference Lorente L, Henry C, Martin MM, Jimenez A, Mora ML. Central venous catheter-related infection in a prospective and observational study of 2,595 catheters. Crit Care. 2005;9:R631–5.CrossRefPubMedPubMedCentral Lorente L, Henry C, Martin MM, Jimenez A, Mora ML. Central venous catheter-related infection in a prospective and observational study of 2,595 catheters. Crit Care. 2005;9:R631–5.CrossRefPubMedPubMedCentral
28.
go back to reference LeMaster CH, Schuur JD, Pandya D, Pallin DJ, Silvia J, Yokoe D, Agrawal A, Hou PC. Infection and natural history of emergency department-placed central venous catheters. Ann Emerg Med. 2010;56:492–7.CrossRefPubMed LeMaster CH, Schuur JD, Pandya D, Pallin DJ, Silvia J, Yokoe D, Agrawal A, Hou PC. Infection and natural history of emergency department-placed central venous catheters. Ann Emerg Med. 2010;56:492–7.CrossRefPubMed
29.
go back to reference Parienti JJ, Mongardon N, Megarbane B, Mira JP, Kalfon P, Gros A, Marque S, Thuong M, Pottier V, Ramakers M, et al. Intravascular complications of central venous catheterization by insertion site. N Engl J Med. 2015;373:1220–9.CrossRefPubMed Parienti JJ, Mongardon N, Megarbane B, Mira JP, Kalfon P, Gros A, Marque S, Thuong M, Pottier V, Ramakers M, et al. Intravascular complications of central venous catheterization by insertion site. N Engl J Med. 2015;373:1220–9.CrossRefPubMed
Metadata
Title
Efficacy of introducing a checklist to reduce central venous line associated bloodstream infections in the ICU caring for adult patients
Authors
Dominic Wichmann
Cristina E. Belmar Campos
Stephan Ehrhardt
Timo Kock
Claudia Weber
Holger Rohde
Stefan Kluge
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2018
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-018-3178-6

Other articles of this Issue 1/2018

BMC Infectious Diseases 1/2018 Go to the issue